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An unexpected stereochemical effect of thio-substituted Asp in native chemical ligation

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Chinese Chemical Letters 2024年第8期35卷 278-281页

作者： Min Fu Pan He Sen Zhou Wenqiang liu Bo Ma Shiying Shang yaohao li Ruihan Wang Zhongping Tan State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Center of Pharmaceutical Technology School of Pharmaceutical SciencesTsinghua UniversityBeijing 100084China Chemical Engineering College Hebei Normal University of Science and TechnologyQinhuangdao 066600China

This study presents an unexpected finding that the cis isomer of β-thio-Asp exhibits higher ligation ac-tivity than the trans *** discovery sheds light on the intricate nature of native chemical ligation and highligh... 详细信息

关键词： Native chemical ligation Stereochemistry ligation activity β-Thio-Asp Intramolecular hydrogen bond

Binding of the SARS-CoV-2 spike protein to glycans

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Science Bulletin 2021年第12期66卷 1205-1214,M0004页

作者： Wei Hao Bo Ma Ziheng li Xiaoyu Wang Xiaopan Gao yaohao li Bo Qin Shiying Shang Sheng Cui Zhongping Tan NHC Key Laboratory of Systems Biology of Pathogens Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Department of Chemistry and Biochemistry and BioFrontiers Institute University of ColoradoBoulder CO 80303USA School of Pharmaceutical Sciences Tsinghua UniversityBeijing W0084China

The pandemic of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused a high number of deaths in the *** combat it,it is necessary to develop a better understanding of how the virus infects host *** normally starts with the attachment of the virus to cell-surface glycans like heparan sulfate(HS)and sialic acid-containing glycolipids/*** this study,we examined and compared the binding of the subunits and spike(S)proteins of SARS-CoV-2,SARS-Co V,and Middle East respiratory disease(MERS)-Co V to these *** results revealed that the S proteins and subunits can bind to HS in a sulfation-dependent manner and no binding with sialic acid residues was ***,this work suggests that HS binding may be a general mechanism for the attachment of these coronaviruses to host cells,and supports the potential importance of HS in infection and in the development of antiviral agents against these viruses.

关键词： SARS-CoV-2 S protein Heparan sulfate Glycan microarray Surface plasmon resonance Sulfation Sialic acid

Studies toward the Application of Peptide Amphiphile Self-Assembly in TACA-based Vaccine Development

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Studies toward the Application of Peptide Amphiphile Self-As...

水性丙烯酸乳液生产工艺及聚合反应过程的影响因素分析

第二届糖合成化学青年学术研讨会

作者：王颖璐 Xiujing Zheng yaohao li 杨冰 Ning Yuan 叶新山 Suwei Dong State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University 北京大学

＜正＞Tumor-associated carbohydrate antigen（TACA）has drawn significant attention as a target of cancer identification and *** antigen（N-acetylgalactosamine-O-glycosides of serine or threonine）are overexpressed on cancer cells of human adenocarcinomas,and lung,colon,and stomach ***,carbohydrates alone can not activate helper T lymphocytes and have limited

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广东化工 2016年第22期43卷 112-113页

作者：李耀好广东政和工程有限公司广东广州511340

水性丙烯酸乳液不但具备耐候性、耐光性、耐化学品性、稳定性的特征,同时,还具备耐碱、耐水、保色性良好、施工性能良好、污染低、防腐的特征,所以,发展速度生产和应用量在逐年增加。文章主要介绍水性丙烯酸乳液生产工艺及聚合反应过程... 详细信息

水性丙烯酸乳液不但具备耐候性、耐光性、耐化学品性、稳定性的特征,同时,还具备耐碱、耐水、保色性良好、施工性能良好、污染低、防腐的特征,所以,发展速度生产和应用量在逐年增加。文章主要介绍水性丙烯酸乳液生产工艺及聚合反应过程的影响因素分析。

关键词：水性丙烯酸乳液生产工艺影响因素

基于思维进化算法优化的BP神经网络对蒸发波导高度的预测

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海洋湖沼通报 2023年第1期45卷 18-22页

作者：李耀皓李醒飞丁乐乐杨少波天津大学精密测试技术及仪器国家重点实验室天津300072 天津大学青岛海洋技术研究院山东青岛266237 天津市勘察设计院天津300191

预先掌握海上的波导高度参数对海上作战有重要意义,然而准确探测或预测波导参数十分困难。本文使用南海铁塔波导探测平台的实测数据与ERA-Interim公开数据集,提取所需相关的水文气象要素的点数据,利用NPS模型计算波导高度值,组建数据集... 详细信息

预先掌握海上的波导高度参数对海上作战有重要意义,然而准确探测或预测波导参数十分困难。本文使用南海铁塔波导探测平台的实测数据与ERA-Interim公开数据集,提取所需相关的水文气象要素的点数据,利用NPS模型计算波导高度值,组建数据集;之后使用MEA优化的BP神经网络模型预测波导高度值。优化后的BP神经网络可避免陷入局部极小值点,预测结果有较高的准确率,且MEA在求最优个体时有比较快的收敛速度,为水平均匀的蒸发波导高度预测提供了一种方法。

关键词：蒸发波导 NPS模型神经网络

锥形术CT测量分析下颌第一磨牙拟种植区剩余牙槽嵴的骨量

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中国组织工程研究 2025年第8期29卷 1572-1577页

作者：蔡尧昊郎律黎红浙江中医药大学口腔医学院杭州口腔医院浙江省杭州市310000 中国科学技术大学附属第一医院(安徽省立医院)口腔医学中心安徽省合肥市230002 浙江中医药大学口腔医学院杭州口腔医院萧山分院浙江省杭州市310000

背景:随着口腔领域的发展与进步,口腔种植技术逐渐成为替代传统义齿的主流选择。近年来,多种骨增量技术的成熟以及口腔数字化领域的不断发展,使种植适应证不断扩大,种植手术的成功率也越来越高。但是种植手术前使用锥形术CT对剩余牙槽... 详细信息

背景:随着口腔领域的发展与进步,口腔种植技术逐渐成为替代传统义齿的主流选择。近年来,多种骨增量技术的成熟以及口腔数字化领域的不断发展,使种植适应证不断扩大,种植手术的成功率也越来越高。但是种植手术前使用锥形术CT对剩余牙槽嵴骨量进行准确测量并且个性化制定合适的种植方案,成为一部分临床医师的难题。目的:采用锥形束CT对下颌第一磨牙拟种植区剩余牙槽嵴骨量进行测量分析,为优化下颌第一磨牙区种植方案的设计提供参考。方法:采用回顾性研究设计,纳入205例下颌第一磨牙缺失患者的锥形术CT影像,测量下颌第一磨牙拟种植区剩余牙槽嵴高度及宽度,并将剩余牙槽嵴形态分为Ⅰ、Ⅱ、Ⅲ、Ⅳ4类(Ⅱ、Ⅲ、Ⅳ类剩余牙槽嵴为骨量不足),统计分析下颌第一磨牙剩余牙槽嵴高度、宽度、形态频数分布,不同性别患者下颌第一磨牙剩余牙槽嵴高度和牙槽嵴顶宽度的差异,剩余牙槽嵴高度与剩余牙槽嵴顶宽度、剩余牙槽嵴底宽度的相关性,年龄与剩余牙槽嵴顶宽度、高度的相关性。结果与结论:①下颌第一磨牙拟种植区剩余牙槽嵴高度平均为(12.14±2.96)mm,其中0.05),男性下颌第一磨牙剩余牙槽嵴顶宽度宽于女性,差异有显著性意义(P0.05);④剩余牙槽嵴形态Ⅰ类占58.05%(119/205),Ⅱ类占9.27%(19/205),Ⅲ类占20.49%(42/205),Ⅳ类占12.19%(25/205),其中多数为Ⅲ类剩余牙槽嵴骨量不足,临床医生需要根据剩余牙槽嵴类型个性化设计最佳的种植方案。

关键词：下颌第一磨牙剩余牙槽嵴形态锥形术CT 种植修复引导骨再生术牙槽骨劈开术骨移植术短种植体计算机辅助种植

The transcription factor Sox30 is involved in Nile tilapia spermatogenesis

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Journal of Genetics and Genomics 2022年第7期49卷 666-676页

作者： ling Wei yaohao Tang Xianhai Zeng Yueqin li Song Zhang li Deng lingsong Wang Deshou Wang Key Laboratory of Freshwater Fish Reproduction and Development(Ministry of Education) Key Laboratory of Aquatic Science of ChongqingSchool of Life SciencesSouthwest UniversityChongqing 400715China

Spermatogenesis is a complex process in which spermatogonial stem cells differentiate and develop into mature *** transcriptional regulatory network involved in fish spermatogenesis remains poorly ***,we demonstrate in Nile tilapia that the Sox transcription factor family member Sox30 is specifically expressed in the testes and mainly localizes to spermatocytes and ***/Cas9-mediated sox30 mutation results in abnormal spermiogenesis,reduction of sperm motility,and male *** transcriptome analysis shows that sox30 mutation alters the expression of genes involved in *** chromatin immunoprecipitation followed by high-throughput sequencing(Ch IP-seq),Ch IP-PCR,and luciferase reporter assays revealed that Sox30 positively regulates the transcription of ift140 and ptprb,two genes involved in spermiogenesis,by directly binding to their *** data,taken together,indicate that Sox30 plays an essential role in Nile tilapia spermatogenesis by directly regulating the transcription of the spermiogenesis-related genes ift140 and ptprb.

关键词： Nile tilapia Sox30 Spermatogenesis Transcriptional regulation

Effects of Bacillus subtilis KN-42 on Growth Performance,Diarrhea and Faecal Bacterial Flora of Weaned Piglets

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Effects of Bacillus subtilis KN-42 on Growth Performance,Dia...

Dietary Enterococcus faecalis LAB31 Improves Growth Performance,Reduces Diarrhea,and Increases Fecal Lactobacillus Number of Weaned Piglets

2017第二届中国畜牧生物科技大会

作者： Yuanliang Hu yaohao Dun Shenao li Shumiao Zhao Nan Peng Yunxiang liang State Key Laboratory of Agricultural Microbiology College of Life Science and Technology College of life Sciences Hubei Normal University

This research focused on the effects of different doses of Bacillus subtilis KN-42 on the growth performance,diarrhea incidence,faecal bacterial flora,and the relative number of Lactobacillus and Escherichia coli in faeces of weaned piglets to determine whether the strain can serve as a candidate antimicrobial growth promoter.A total of 360 piglets(initial BW 7.14±0.63 kg)weaned at 26±2 days of age were randomly allotted to 5 treatment groups(4 pens per treatment with 18 pigs per pen)for a 28-day *** treatments were basal diet without any antimicrobial(negative control;NC),basal diet supplemented with 120 mg/kg feed of neomycin sulfate(positive control;PC)and basal diet supplemented with 2×10(L),4×10(M)and 20×10(H)CFU/kg feed of *** *** the overall period,ADG and feed efficiency of piglets were higher in groups PC,M,and H than those in group NC(P<0.05),and all probiotics and antibiotics groups had a lower diarrhea index than group NC(P<0.05).The 16S rDNA gene-based methods were used to analyze faecal bacterial flora on day 28 of *** result of denaturing gradient gel electrophoresis(DGGE)analysis showed that supplementation of *** KN-42 to the diet changed the bacterial communities,with a higher bacterial diversity and band number in group M than in the other four ***-time PCR analysis showed that the relative number of Lactobacillus were higher in groups PC and H than in group NC(P<0.05),and the supplemented *** KN-42 to the diet also reduced the relative number of ***(P<0.05).These results suggest that dietary addition of *** KN-42 can improve the growth performance and gastrointestinal health of piglets.

关键词： Bacillus subtilis Bacterial community Diarrhea Growth performance Lactobacillus Weaned piglets

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Dietary Enterococcus faecalis LAB31 Improves Growth Performa...