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从肝论治取穴针灸通过调控JAK2/STAT3途径对膝骨关节炎大鼠关节软骨的保护作用

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中医药导报 2024年第7期30卷 45-48,53页

作者：樊远志张峻峰陈威李艳吴耀持上海市第六人民医院上海200233

目的:探究从肝论治取穴针灸通过调控JAK2/STAT3途径对膝骨关节炎(OA)大鼠关节软骨的保护作用。方法:60只SD大鼠随机分为对照组、OA组、OA+针灸组,每组20只,通过手术构建右膝OA模型。OA+针灸组大鼠接受从肝论治取穴针灸4周。检测软骨退... 详细信息

目的:探究从肝论治取穴针灸通过调控JAK2/STAT3途径对膝骨关节炎(OA)大鼠关节软骨的保护作用。方法:60只SD大鼠随机分为对照组、OA组、OA+针灸组,每组20只,通过手术构建右膝OA模型。OA+针灸组大鼠接受从肝论治取穴针灸4周。检测软骨退化情况、关节炎症,以及JAK2/STAT3转录和蛋白水平。结果:OA组大鼠OARSI评分高于对照组(P<0.05);干预后,OA+针灸组大鼠OARSI评分低于OA组(P<0.05)。OA组大鼠透明软骨(HC)厚度低于对照组,钙化软骨(CC)厚度高于对照组(P<0.05);干预后,OA+针灸组大鼠HC厚度高于OA组,CC厚度低于OA组(P<0.05)。OA组大鼠白细胞介素-1β(IL-1β)、IL-6、JAK2 mRNA、STAT3 mRNA、JAK2蛋白、STAT3蛋白水平均高于对照组(P<0.05);干预后,OA+针灸组大鼠IL-1β、IL-6、JAK2 mRNA、STAT3 mRNA、JAK2蛋白、STAT3蛋白水平均低于OA组(P<0.05)。结论:从肝论治取穴针灸可通过调控JAK2/STAT3途径发挥对OA大鼠膝关节软骨的保护作用。

关键词：膝骨关节炎从肝论治针灸 JAK2 STAT3 软骨大鼠

Effect of electroacupuncture on muscle state and infrared thermogram changes in patients with acute lumbar muscle sprain

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Journal of Traditional Chinese Medicine 2015年第5期35卷 499-506页

作者： Fan Yuanzhi wu yaochi Department of Acupuncture Tuina and TraumatologyShanghai Jiao Tong University Affiliated Sixth People's Hospital

OBJECTIVE:To observe the effect of electroacupuncture(EA) on force-displacement value(FDV)of muscle state and the temperature index of infrared thermogram in patients with acute lumbar muscle ***:Patients with acute lumbar muscle sprain were randomly divided into a medication group and an EA *** medication group(n-60) were treated with diclofenac sodium dual release enteric-coated capsules,75 mg per day for *** EA group(n = 60) received EA at bilateral Houxi(SI 3),Jiaji(EX-B2),and Ashi points,at 20-30 mm depth and 10-25 Hz frequency for 20 min daily for 7 *** states were determined by measuring FDVs of the bilateral lumbar muscle with a Myotonometer fast muscle state *** temperature index of the lumbar skin was measured before and after treatment with a Fluke Ti30 non-refrigerated focal plane infrared thermal imaging ***:There were no significant pre-treatment differences between the medication group and the EA group in mean FDV(P = 0.052) or temperature index of the lumbar skin(P = 0.25).The cure rate was 63.3%in the EA group and 53.3%in the medication *** total efficacy in the EA group(93.3%) was not significantly different from that in the medication group(86.6%,P = 0.204).After treatment,the mean FDV of the lumbar muscle significantly increased in both groups(P < 0.05 for both groups);the FDV increase in the EA group was significantly higher than in the medication group(P = 0.015).The temperature index was also significantly increased in both groups(P < 0.05 for both groups);the infrared thermogram in the EA group indicated significantly greater recovery compared to the medication group(P = 0.026).CONCLUSION:Both EA and diclofenac sodium markedly improved acute lumbar sprain,but EA better improved the rehabilitation and regeneration of FDVs and temperature index of infrared thermogram of the muscle.

关键词： Lumbar sprain Electroacupuncture Force-displacement value Muscular state Infrared thermogram

Effect of warm acupuncture on nitric oxide synthase and calcitonin gene-related peptide in a rat model of lumbar nerve root compression

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Neural Regeneration Research 2009年第6期4卷 449-454页

作者： yaochi wu Yiqun Mi Peng Zhang Junfeng Zhang Wei Chen Department of Acupuncture Massage and Traumatology Sixth People's Hospital Affiliated to Shanghai Jiao Tong University Shanghai 200233 China

BACKGROUND： Varying degrees of inflammatory responses occur during lumbar nerve root compression. Studies have shown that nitric oxide synthase （NOS） and calcitonin gene-related peptide （CGRP） are involved in secondary disc inflammation. OBJECTIVE： To observe the effects of warm acupuncture on the ultrastructure of inflammatory mediators in a rat model of lumbar nerve root compression, including NOS and CGRP contents. DESIGN, TIME AND SETTING： Randomized, controlled study, with molecular biological analysis, was performed at the Experimental Center, Sixth People＇s Hospital Affiliated to Shanghai Jiao Tong University, between September 2006 and April 2007. MATERIALS： Acupuncture needles and refined Moxa grains were purchased from Shanghai Taicheng Technology Development Co., Ltd., China; Mobic tablets were purchased from Shanghai Boehringer Ingelheim Pharmaceuticals Co., Ltd., China; enzyme linked immunosorbent assay （ELISA） kits for NOS and CGRP were purchased from ADL Biotechnology, Inc., USA. METHODS： A total of 50, healthy, adult Sprague-Dawley rats, were randomly divided into five groups normal, model, warm acupuncture, acupuncture, and drug, with 10 rats in each group. Rats in the four groups, excluding the normal group, were used to establish models of lumbar nerve root compression. After 3 days, Jiaji points were set using reinforcing-reducing manipulation in the warm acupuncture group. Moxa grains were burned on each needle, with 2 grains each daily. The acupuncture group was the same as the warm acupuncture group, with the exception of non-moxibustion. Mobic suspension （3.75 mg/kg） was used in the oral drug group, once a day. Treatment of each group lasted for 14 consecutive days. Modeling and medication were not performed in the normal group. MAIN OUTCOME MEASURES： The ultrastructure of damaged nerve roots was observed with transmission electron microscopy; NOS and CGRP contents were measured using ELISA. RESULTS： The changes of the radicular ultramicrostr

关键词： warm acupuncture nerve root compression model ultrastructure nitric oxide synthase calcitonin gene-related peptide

Acupuncture at the “Huatuojiaji” point affects nerve root regional interleukin-1 level in a rat model of lumbar nerve root compression

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Neural Regeneration Research 2008年第8期3卷 881-884页

作者： yaochi wu Junfeng Zhang Chongmiao Wang Yanyan Xie Jinghui Zhou Sixth People＇s Hospital Affiliated to Shanghai Jiao Tong University Shanghai 200233 China

BACKGROUND：It has been shown that interleukin-1 （IL-1） may cause inflammatory reactions, which stimulate the nerve root of patients with lumbar intervertebral disc protrusion and leads to pain. Whether the clinical curative effects of acupuncture in the treatment of lumbar and leg pain are linked to an inhibition of local IL-1 secretion is unknown. OBJECTIVE： To assess the influence of acupuncture on IL-1, this study was designed to verify the effects of acupuncture at the ＂Huatuojiaji （Extra）＂ point on the nerve root in a rat model of lumbar nerve root compression, compared with administration of meloxicam, a non-steroidal anti-inflammatory drug. DESIGN, TIME AND SETTING： Randomized, controlled, molecular biology experiment, performed at the Experimental Center, Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University between September 2005 and April 2006. MATERIALS： Forty healthy adult Sprague Dawley rats of either gender were included in this study. The rats were randomly and evenly divided into the following four groups： normal control, model, acupuncture and meloxicam groups. Lumbar nerve root compression was induced in rats in the model, acupuncture, and meloxicam groups by inserting a specially made silicon rubber slice at the juncture of the L5 nerve root and the dural sac. The acupuncture needle （pattern number N3030, 30#, 1.5 inch） was purchased from Suzhou Medical Appliance Factory, China. IL-1 enzyme linked immunosorbent assay （ELISA） kit was purchased from Santa Cruz Biotechnology, Inc., USA. METHODS： The acupuncture group was acupunctured at the ＂Huatuojiaji＂ point, which is lateral to the compressed L5-6 nerve root, with an acupuncture depth of 0.5 cm. There were two treatment courses, each of involved seven 20-minute acupuncture sessions, one session a day. The meloxicam group was administered intragastrically 3.75 mg/kg meloxicam （5 mg meloxicam /10 mL physiological saline）. Rats in the normal control group and model group received an int

关键词： acupuncture interleukin-1 "Huatuojiaji" point lumbar nerve root compression models,animal

Pestle needling at Yāoyángguān-Bāzhèn points for intractable lumbodynia after lumbar disc herniation surgery: A randomized controlled trial

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World Journal of Acupuncture-Moxibustion 2019年第3期29卷 194-199页

作者： Junfeng ZHANG yaochi wu Shisheng LI Yijun SUN Acupuncture-Moxibustion Tuina and Orthopedics DepartmentShanghai Sixth People's HospitalShanghai 200233China

Objective:To observe the differences of clinical efficacy of intractable lumbodynia after lumbar disc herniation surgery treated by pestle needling at Yāoyángguān Bāzhèn points,electroacupuncture and western ***:A total of 210 patients with intractable lumbodynia after lumbar disc herniation were randomly divided into pestle needle group,electroacupuncture group and western medication group,with 70 cases in each *** pestle needle group was treated with pestle needle poking Yāoyángguān-Bāzhèn(GV3-Bāzhèn)*** electroacupuncture group was treated with conventional electroacupuncture,and the western medication group was treated with oral diclofenac sodium dual release enteric-coated capsules(Difene).The pestle needle group and the electroacupuncture group were treated once a day,and there was 1 day of rest after 6 days of treatment,and a course of treatment included 7 days,and a total of 3 courses of treatment were *** western medication group took 1 Difene capsule(75 mg)at a time,with once a day continuing for 21 *** Analog Scale(VAS),Pain Rating Index(PRI)and Present Pain Intensity(PPI)were used to observe the improvement of pain before and after treatment,and the waist muscle tone was examined and the clinical efficacy was ***:The post-treatment VAS,PRI,and PPI scores of the three groups were all lower than pretreatment,and the differences were statistically significant(all P0.05).Meanwhile,they were all lower than the electroacupuncture group,and the differences were statistically significant(both P<0.05).After treatment,the waist muscle tone of the three groups was higher than that pre-treatment,and the differences were statistically significant(all P<0.05).After treatment,the waist muscle tone of the pestle needle group was higher than the electroacupuncture gro

关键词： Lumbar disc herniation After surgery Intractable lumbodynia Low backache Pestle needle Bāzhèn points Randomized controlled trial(RCT)

Long-Term Continuous Light Exposure Affects Body Weight and Blood Glucose Associated with Inflammation in Female Rats

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Journal of Biosciences and Medicines 2016年第9期4卷 11-24页

作者： Xuezhi Kang Lina Jia Xu Zhang Yaming Li Yi Chen Xueyong Shen yaochi wu Acupuncture Moxibustion and Tuina Traumatology of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai China College of Acupuncture and Moxibustion Shanghai University of Traditional Chinese Medicine Shanghai China Department of Traditional Chinese Medicine Huadong Hospital Affiliated to Fudan University Shanghai China

Studies have indicated that night lights interfere with the circadian rhythm in the human body and threaten human health. Our previous studies indicated that continuous light exposure severely damages the reproductive endocrine system of female rats resembles polycystic ovary syndrome in women. In this study, we used the continuous measurement method to observe changes in the basal physiological indicators of female rats in an abnormal light exposure environment. Our study results indicated that in female rats: 1) the body temperature first continuously and gradually increased followed by a gradually decrease;2) the increase in body weight slowed down at the late stage of the experimental process;3) the random blood glucose level increased, and the fasting serum insulin level decreased;and 4) the serum C-reactive protein level increased. Our study investigated for the first time the correlation between the duration of continuous light exposure in female rats and the continuously measured basal physiological indicators and preliminarily discussed the effect of continuous light exposure on female basal metabolism and the possible inflammation mechanism. We propose that long-term continuous exposure to night lights in females severely damages their immune and metabolic systems.

关键词： Continuous Light Exposure Body Weight Blood Glucose Inflammation Comparative Study

CRMP2与Ubc9在电针缓解慢性压迫性损伤模型大鼠神经病理性疼痛中的作用

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针灸临床杂志 2023年第12期39卷 71-76页

作者：樊远志张峻峰吴耀持上海市第六人民医院上海200233

目的:探讨电针对慢性压迫性损伤(CCI)模型大鼠神经病理性疼痛的缓解作用及相关机制。方法:选取雄性SD大鼠40只,随机数字表法分为假手术组、模型组、电针组与电针+激活剂组,每组10只。构建慢性压迫性损伤(CCI)大鼠模型,并按组别进行相应... 详细信息

目的:探讨电针对慢性压迫性损伤(CCI)模型大鼠神经病理性疼痛的缓解作用及相关机制。方法:选取雄性SD大鼠40只,随机数字表法分为假手术组、模型组、电针组与电针+激活剂组,每组10只。构建慢性压迫性损伤(CCI)大鼠模型,并按组别进行相应干预。测定大鼠痛觉敏感性,采用酶联免疫吸附测定(ELISA)法检测血清中IL-1β、IL-6和IL-8表达水平,RT-qPCR检测大鼠脊髓中CRMP2、Ubc9 mRNA及Western bolting检测大鼠脊髓中坍塌反应调节蛋白2(CRMP2)、泛素结合酶9(Ubc9)蛋白水平。结果:CCI大鼠模型建成后,各组大鼠PWLD均显著升高且>4 s,差异具有统计学意义(P<0.05);在给予大鼠相应干预后,与假手术组比较,模型组大鼠患健侧PWLD显著升高,差异具有统计学意义(P<0.05);与模型组比较,电针组和电针+激活剂组大鼠患健侧PWLD更低,差异具有统计学意义(P<0.05);与假手术组比较,模型组大鼠血清IL-1β、IL-6和IL-8水平升高,差异具有统计学意义(P<0.05);与模型组比较,电针组和电针+激活剂组大鼠血清IL-1β、IL-6和IL-8水平降低,差异具有统计学意义(P<0.05);与假手术组比较,模型组大鼠脊髓CRMP2、Ubc9 mRNA和蛋白表达水平更低,差异具有统计学意义(P<0.05);与模型组比较,电针组和电针+激活剂组大鼠脊髓CRMP2、Ubc9 mRNA和蛋白表达水平更高,差异具有统计学意义(P<0.05);电针+激活剂组各指标均优于电针组,差异具有统计学意义(P<0.05)。结论:电针可有效缓解CCI模型大鼠神经病理性疼痛,其作用机制可能是电针刺激穴位后引起机体CRMP2、Ubc9表达水平增加,抑制炎症反应,诱导镇痛。

关键词：坍塌反应调节蛋白2 泛素结合酶9 电针慢性压迫性损伤神经病理性疼痛

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针药结合治疗更年期综合征临床研究

中华中医药学刊 2015年第1期33卷 128-131页

作者：口锁堂吴耀持上海交通大学附属第六人民医院上海201306

目的:观察温通针法针刺四关穴配合甘麦大枣汤对更年期综合征的治疗作用。方法:更年期综合征患者160例按就诊先后顺序按数字随机表随机分为针药组(80例)和对照组(80例),针药组取合谷、关冲穴,手法采用温通针法针;中药口服甘麦大枣汤。对... 详细信息

目的:观察温通针法针刺四关穴配合甘麦大枣汤对更年期综合征的治疗作用。方法:更年期综合征患者160例按就诊先后顺序按数字随机表随机分为针药组(80例)和对照组(80例),针药组取合谷、关冲穴,手法采用温通针法针;中药口服甘麦大枣汤。对照组采用甘麦大枣汤口服;治疗前后采用临床疗效、改良Kupperman积分和心理状态测定对烦躁及其他症状的程度及治疗结果等进行比较。结果:疗效:针药组92.5%、对照组87.5%,两种方法治疗更年期综合征在临床疗效方面有明显差异性(P<0.05),但在改良Kupperman积分和心理状态测定方面治疗前后,比较有明显差异性(P<0.05),两组间比较有明显差异性(P<0.05)。结论:两种疗法方法对更年期综合征都有治疗作用,但温通针法针刺四关穴结合口服甘麦大枣汤疗效优于单纯口服甘麦大枣汤(P<0.05)。

关键词：更年期综合征针刺四关穴甘麦大枣汤

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中医药适宜技术社区推广与应用十年回眸

上海医药 2015年第20期36卷 3-6页

作者：吴耀持上海交通大学附属第六人民医院上海200233

中医药适宜技术以其"简、便、验、廉、效"的特点,不仅受到广大患者的欢迎,也特别符合社区卫生服务发展的方向。它对社区慢性病防治、降低社区居民医疗费用及减轻社区居民就医负担等均有益处。上海在这10年间集中推出24项上海市基层中医... 详细信息

中医药适宜技术以其"简、便、验、廉、效"的特点,不仅受到广大患者的欢迎,也特别符合社区卫生服务发展的方向。它对社区慢性病防治、降低社区居民医疗费用及减轻社区居民就医负担等均有益处。上海在这10年间集中推出24项上海市基层中医药适宜技术,积聚和整合了上海市中医药适宜技术的资源与精华,在广大社区的推广与应用已经取得了显著的成效,并将继续发挥其独特的作用。

关键词：中医药适宜技术社区推广应用十年回顾