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Top gate engineering of field-effect transistors based on wafer-scale two-dimensional semiconductors

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Journal of Materials Science & Technology 2022年第11期106卷 243-248页

作者： Jingyi Ma Xinyu Chen yaochen sheng Ling Tong Xiaojiao Guo Minxing Zhang Chen Luo Lingyi Zong Yin Xia Chuming sheng Yin Wang Saifei Gou Xinyu Wang Xing Wu Peng Zhou David Wei Zhang Chenjian Wu Wenzhong Bao State Key Laboratory of ASIC and System School of MicroelectronicsFudan UniversityShanghai200433China In Situ Devices Center Shanghai Key Laboratory of Multidimensional Information ProcessingEast China Normal UniversityShanghai 200241China School of Electronic Information Soochow UniversitySuzhou215006China

The investigation of two-dimensional(2D)materials has advanced into practical device applications,such as cascaded logic ***,incompatible electrical properties and inappropriate logic levels remain enormous *** this work,a doping-free strategy is investigated by top gated(TG)MoS_(2) field-effect transistors(FETs)using various metal gates(Au,Cu,Ag,and Al).These metals with different work functions provide a convenient tuning knob for controlling threshold voltage(V_(th))for MoS_(2) *** instance,the Al electrode can create an extra electron doping(n-doping)behavior in the MoS_(2) TG-FETs due to a dipole effect at the gate-dielectric *** this work,by achieving matched electrical properties for the load transistor and the driver transistor in an inverter circuit,we successfully demonstrate wafer-scale MoS_(2) inverter arrays with an optimized inverter switching threshold voltage(V_(M))of 1.5 V and a DC voltage gain of 27 at a supply voltage(V_(DD))of 3 *** work offers a novel scheme for the fabrication of fully integrated multistage logic circuits based on wafer-scale MoS_(2) film.

关键词： Two-dimensional semiconductor MoS_(2) Top gate Field effect transistor Logic inverter

Charge transport and quantum confinement in MoS2 dual-gated transistors

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Journal of Semiconductors 2020年第7期41卷 39-43页

作者： Fuyou Liao Hongjuan Wang Xiaojiao Guo Zhongxun Guo Ling Tong Antoine Riaud yaochen sheng Lin Chen Qingqing Sun Peng Zhou David Wei Zhang Yang Chai Xiangwei Jiang Yan Liu Wenzhong Bao State Key Laboratory of ASIC and System School of MicroelectronicsFudan UniversityShanghai 200433China State Key Discipline Laboratory of Wide Bandgap Semiconductor Technology School of MicroelectronicsXidian UniversityXi'an 710071China Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518057China Department of Applied Physics The Hong Kong Polytechnic UniversityHong KongChina

Semiconductive two dimensional(2D)materials have attracted significant research attention due to their rich band structures and promising potential for next-generation electrical *** this work,we investigate the MoS2 field-effect transistors(FETs)with a dual-gated(DG)architecture,which consists of symmetrical thickness for back gate(BG)and top gate(TG)*** thickness-dependent charge transport in our DG-MoS2 device is revealed by a four-terminal electrical measurement which excludes the contact influence,and the TCAD simulation is also applied to explain the experimental *** results indicate that the impact of quantum confinement effect plays an important role in the charge transport in the MoS2 channel,as it confines charge carriers in the center of the channel,which reduces the scattering and boosts the mobility compared to the single gating ***,temperature-dependent transfer curves reveal that multi-layer MoS2 DG-FET is in the phonon-limited transport regime,while single layer MoS2 shows typical Coulomb impurity limited regime.

关键词： MoS2 field effect transistors dual-gate quantum confinement Coulomb impurity

应用同位素示踪技术研究ABT4号生根粉对水稻的增产机理

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上海农业学报 1994年第4期10卷 12-17页

作者：吴惠民孙耀琛金亚放上海市农业科学院作物育种栽培研究所

应用放射性核素３２Ｐ、１４Ｃ示踪技术，以水稻为研究对象采用不同浓度ＡＢＴ４号生根粉溶液浸种和喷施秧苗，测定秧苗根系吸收功能和叶片光合速率的动态变化，阐明ＡＢＴ４号生根粉的增产作用机理。研究结果表明，经ＡＢＴ４号５～２... 详细信息

应用放射性核素３２Ｐ、１４Ｃ示踪技术，以水稻为研究对象采用不同浓度ＡＢＴ４号生根粉溶液浸种和喷施秧苗，测定秧苗根系吸收功能和叶片光合速率的动态变化，阐明ＡＢＴ４号生根粉的增产作用机理。研究结果表明，经ＡＢＴ４号５～２０ｍｇ·ｋｇ－１浓度浸种及栽前３ｄ秧苗叶面喷施处理，其根系吸收３２Ｐ的量比对照分别增加９９．５％和１１５．１％；孕穗、抽穗和灌浆期功能叶片的光合作用速率分别比对照提高８３％、４８％和５１％。从而进一步阐明了ＡＢＴ４号生根粉促进水稻新根生长、秧苗移栽后迅速活棵返青、调节地上地下部生长关系、增加物质积累、形成合理的产量结构，为在水稻栽培业中大面积推广应用ＡＢＴ４号生根粉提供了科学依据和合理的使用技术。

关键词：水稻同位素示踪技术 ABT4号生根粉光合速率

ANALYTICAL SOLUTION FOR RESPONSE OF FERROELECTRIC THIN FILM TO INFRARED RADIATION

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Acta Mechanica Solida Sinica 2010年第2期23卷 135-146页

作者： yaochen Li Changjin Yang School of Aerospace Engineering and Applied Mechanics Tongji University Shanghai 200092 China School of Urban Rail Transportation Soochow University Suzhou 215021 China

Micro-bolometer pixel is an essential element in the infrared focal plane array （IRFPA） of infrared detectors. Its response to infrared radiation is analyzed in this paper. The pixel structure is modeled as a composite laminate thin plate whose sides are measured with the thickness from 0.1-1 μm. Its middle ply is a ferroelectric thin film. Its top surface is covered with a gold or platinum infrared absorber, while the bottom surface is deposited with platinum or lanthanum-nickel. Meanwhile both surfaces are a pair of electrodes. The top surface receives infrared radiation pulses successively. For the very tiny micro bolometer pixel, it is assumed that the infrared radiation is uniformly distributed on the plate. Furthermore, as the ratio of the side length to the thickness of the plate is dramatically large, it is assumed that heat transfer only takes place across the thickness of the plate. The thermal-electric-mechanical coupling governing equations are solved in a form of Fourier series. Results of the displacement, temperature variation and electric output signals of the micro bolometer pixel structure under infrared radiation are obtained, analyzed and compared with experimental data.

关键词： ferroelectric thin film micro-bolometer pixel structure composite laminate plateinfrared radiation

A Method for Exact Calculation of the Discrepancy of Low-Dimensional Finite Point Sets(II)

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Acta Mathematica Sinica,English Series 1995年第4期11卷 422-434页

作者： yaochen Zhu Institute of Applied Mathematics Academia Sinica Beijing China

In the present paper a general formula for exact calculation of the discrepancy of an arbitrary finite point set of dimension d≥2 is explicitly given only in terms of the components of the points.

关键词： Discrepancy Finite point set Exact calculation

Variable-stiffness composite cylinder design under combined loadings by using the improved Kriging model

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Acta Mechanica Sinica 2019年第1期35卷 201-211,I0006页

作者： Jifan Zhong yaochen Zheng Jianqiao Chen Zhao Jing Department of Mechanics Huazhong University of Science and TechnologyWuhan 430074China Hubei Key Laboratory for Engineering Structural Analysis and Safety Assessment Wuhan 430074China

The large design freedom of variable-stiffness (VS) composite material presupposes its potential for wide engineering application. Previous research indicates that the design of VS cylindrical structures helps to increase the buckling load as compared to quasi-isotropic (QI) cylindrical structures. This paper focuses on the anti-buckling performance of VS cylindrical structures under combined loads and the efficient optimization design method. Two kinds of conditions, bending moment and internal pressure, and bending moment and torque are considered. Influences of the geometrical defects, ovality, on the cylinder's performances are also investigated. To increase the computational efficiency, an adaptive Kriging meta-model is proposed to approximate the structural response of the cylinders. In this improved Kriging model, a mixed updating rule is used in constructing the meta-model. A genetic algorithm (GA) is implemented in the optimization design. The optimal results show that the buckling load of VS cylinders in all cases is greatly increased as compared with a QI cylinder.

关键词： Variable-stiffness composite Optimal anti-buckling design Combined loading Ovality Kriging meta-model

Cell cycle regulation and anticancer drug discovery

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Cancer Biology & Medicine 2017年第4期14卷 348-362页

作者： Jingwen Bai yaochen Li Guojun Zhang Department of Oncology Xiang'an Hospital of Xiamen University Xiamen 361005 China Changjiang Scholar's Laboratory of Shantou University Medical College (SUMC) Shantou 515041 China The Breast Center Xiang'an Hospital of Xiamen University Xiamen 361005 China

Cellular growth,development,and differentiation are tightly controlled by a conserved biological mechanism:the cell *** cycle is primarily regulated by cyclin-dependent kinase(CDK)-cyclin complexes,checkpoint kinases,and CDK *** of the cell cycle is a hallmark of the transformation of normal cells into tumor *** its importance in tumorigenesis,several cell cycle inhibitors have emerged as potential therapeutic drugs for the treatment of cancers-both as singleagent therapy and in combination with traditional cytotoxic or molecular targeting *** this review,we discuss the mechanisms underlying cell cycle regulation and present small-molecule anticancer drugs that are under development,including both pan-CDK inhibitors and CDK4/6-selective *** addition,we provide an outline of some promising CDK inhibitors currently in preclinical and clinical trials that target cell cycle abnormalities in various cancers.

关键词： Cell cycle regulation cyclin-dependent kinases(CDK) cyclin pan-CDK inhibitors CDK4/6-selective inhibitors

The biological effect of metal ions on the granulation of aerobic granular activated sludge

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Journal of Environmental Sciences 2016年第6期28卷 252-259页

作者： Wen Hao yaochen Li Junping Lv Lisha Chen Jianrong Zhu School of Environment Beijing Normal University Beijing 100875 China State Key Laboratory of Water Simulation Beijing 100875 China

As a special biofilm structure,microbial attachment is believed to play an important role in the granulation of aerobic granular activated sludge（AGAS）.This experiment was to investigate the biological effect of Ca^2＋,Mg^2＋,Cu^2＋,Fe^2＋,Zn^2＋,and K＋which are the most common ions present in biological wastewater treatment systems,on the microbial attachment of AGAS and flocculent activated sludge（FAS）,from which AGAS is always derived,in order to provide a new strategy for the rapid cultivation and stability control of *** result showed that attachment biomass of AGAS was about 300%higher than that of FAS without the addition of metal *** metal ions had different effects on the process of microbial *** and AGAS reacted differently to the metal ions as well,and in fact,AGAS was more sensitive to the metal ***,Ca^2＋,Mg^2＋,and K＋could increase the microbial attachment ability of both AGAS and FAS under appropriate concentrations,Cu^2＋,Fe^2＋,and Zn^2＋were also beneficial to the microbial attachment of FAS at low concentrations,but Cu^2＋,Fe^2＋,and Zn^2＋greatly inhibited the attachment process of AGAS even at extremely low *** addition,the acylated homoserine lactone（AHL）-based quorum sensing system,the content of extracellular polymeric substances and the relative hydrophobicity of the sludges were greatly influenced by metal *** all these parameters had close relationships with the microbial attachment process,the microbial attachment may be affected by changes of these parameters.

关键词： Microbial attachment Metal ions Aerobic granular activated sludge Flocculent activated sludge

Opportunities and challenges of incretin-based hypoglycemic agents treating type 2 diabetes mellitus from the perspective of physiological disposition

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Acta Pharmaceutica Sinica B 2023年第6期13卷 2383-2402页

作者： yaochen Xie Qian Zhou Qiaojun He Xiaoyi Wang Jincheng Wang Center for Drug Safety Evaluation and Research Zhejiang Province Key Laboratory of Anti-Cancer Drug ResearchCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310007China Department of Pharmacy Hangzhou Medical CollegeHangzhou 310053China Department of Nephrology the First Affiliated Hospital of Huzhou Teachers Collegethe First People's Hospital of HuzhouHangzhou 313000China

The treatment of patients with diabetes mellitus, which is characterized by defective insulin secretion and/or the inability of tissues to respond to insulin, has been studied for decades. Many studies have focused on the use of incretin-based hypoglycemic agents in treating type 2 diabetes mellitus(T2DM). These drugs are classified as GLP-1 receptor agonists, which mimic the function of GLP-1,and DPP-4 inhibitors, which avoid GLP-1 degradation. Many incretin-based hypoglycemic agents have been approved and are widely used, and their physiological disposition and structural characteristics are crucial in the discovery of more effective drugs and provide guidance for clinical treatment of ***, we summarize the functional mechanisms and other information of the drugs that are currently approved or under research for T2DM treatment. In addition, their physiological disposition, including metabolism, excretion, and potential drug drug interactions, is thoroughly reviewed. We also discuss similarities and differences in metabolism and excretion between GLP-1 receptor agonists and DPP-4 inhibitors. This review may facilitate clinical decision making based on patients' physical conditions and the avoidance of drug drug interactions. Moreover, the identification and development of novel drugs with appropriate physiological dispositions might be inspired.

关键词： T2DM Incretins-based hypoglycemic agents GLP-1 receptor agonists DPP-4 inhibitors Physiological disposition Metabolism Excretion Drug drug interactions