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基于TLR4/NF-κB/NLRP3通路探讨二精丸减轻AD大鼠神经炎症的作用及机制

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中国中药杂志 2023年第3期48卷 770-777页

作者：黄丽萍卢龙辉杨喜洋谢永艳徐子薇朱徐东王晶晶吴志鑫唐健富吴毅陈耀辉江西中医药大学药学院江西南昌330004 江西省人民医院江西南昌330029 莆田市第一医院福建莆田351199 国家药品监督管理局中成药质量评价重点实验室江西省药品与医疗器械质量工程研究中心江西省药品检验检测研究院江西南昌330046 江西省中药药理重点实验室江西南昌330004

研究二精丸对D-半乳糖联合β淀粉样蛋白_(25-35)(Aβ_(25-35))致阿尔茨海默病(AD)大鼠神经炎症的改善作用及可能机制。SD大鼠随机分为假手术组、模型对照组、阳性药物组(多奈哌齐,1 mg·kg^(-1))、二精丸高剂量组(9 g·kg^(-1))、二精... 详细信息

研究二精丸对D-半乳糖联合β淀粉样蛋白_(25-35)(Aβ_(25-35))致阿尔茨海默病(AD)大鼠神经炎症的改善作用及可能机制。SD大鼠随机分为假手术组、模型对照组、阳性药物组(多奈哌齐,1 mg·kg^(-1))、二精丸高剂量组(9 g·kg^(-1))、二精丸低剂量组(4.5 g·kg^(-1)),每组14只。D-半乳糖腹腔注射2周后,连续灌胃给药5周;D-半乳糖腹腔注射3周后,大鼠双侧海马注射Aβ25-35。灌胃给药4周后,新物体识别实验检测大鼠学习记忆能力。末次给药24 h后,取组织,免疫荧光法检测大鼠脑组织小胶质细胞活化情况;免疫组化检测大鼠海马CA1区Aβ1-42和磷酸化Tau404蛋白(phosphory protein Tau^(404),p-Tau404)阳性表达;酶联免疫吸附(enzyme linked immunosorbent assay,EliSA)法检测大鼠脑组织炎症因子白细胞介素1β(interleukin-1β,IL-1β)、肿瘤坏死因子α(tumor necrosis factor,TNF-α)、白细胞介素6(IL-6)水平;Western blot法检测大鼠脑组织Toll样受体4(Toll-like receptor,TLR4)/核因子κB(nuclear factor kappaB,NF-κB)/核苷酸结合寡聚化结构域样受体3(nucleotide-binding oligomerization domain-like receptors 3,NLRP3)通路相关蛋白表达。结果显示,与假手术组比较,模型对照组大鼠新物体识别指数明显下降,海马区Aβ_(1-42)沉积和p-Tau^(404)阳性蛋白显著增多,脑组织齿状回处小胶质细胞活化水平显著增高,海马组织IL-1β、TNF-α、IL-6水平明显升高;海马TLR4、p-NF-κB P65/NF-κB P65、p-IκBα/IκBα、NLRP3蛋白表达水平显著升高。与模型对照组比较,二精丸可提高大鼠新物体识别指数,减少海马区Aβ_(1-42)沉积和p-Tau^(404)阳性蛋白表达,抑制脑组织齿状回小胶质细胞活化;降低海马组织IL-1β、TNF-α、IL-6炎症因子水平;下调TLR4、p-NF-κB P65/NF-κB P65、p-IκBα/IκBα、NLRP3蛋白的表达。综上所述,二精丸可能通过改善小胶质细胞活化,降低神经炎症因子IL-1β、TNF-α、IL-6表达水平,抑制TLR4/NF-κB/NLRP3神经炎症通路,减少海马Aβ沉积和p-Tau表达,恢复海马形态结构,改善AD模型大鼠的学习记忆能力。

关键词：二精丸神经炎症阿尔茨海默病 TLR4/NF-κB/NLRP3通路小胶质细胞

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中药发酵技术传承与创新的探索

中国实验方剂学杂志 2015年第23期21卷 230-234页

作者：胥敏吴纯洁严丹李欣逸卢一黄永亮江云成都中医药大学药学院成都611137 国家中医药管理局中药炮制技术重点实验室成都611731 成都中医药大学附属医院成都610072

发酵作为一门极具特色和重要的中药炮制技术,其传承与发展应受到行业内的高度重视。传统中药发酵为自然发酵,因发酵过程靠经验掌控、易受到环境和季节变化的影响,质量难于控制且难以传承。而现代中药发酵技术在传统发酵技术的基础上结... 详细信息

发酵作为一门极具特色和重要的中药炮制技术,其传承与发展应受到行业内的高度重视。传统中药发酵为自然发酵,因发酵过程靠经验掌控、易受到环境和季节变化的影响,质量难于控制且难以传承。而现代中药发酵技术在传统发酵技术的基础上结合发酵工程等现代生物技术,已逐渐发展起来,业内学者也对其进行了大量相关研究。但科学阐释中药发酵机制、规范中药发酵技术工艺及建立适合中药发酵特点的质量标准等是中药发酵技术研究面临的共性问题。本文在综述传统中药发酵技术概况及中药发酵技术现代研究情况的基础上,分析总结影响发酵技术传承与发展的关键技术问题,并从中药发酵技术的传承与创新两方面进行了探讨。提出中药发酵技术的传承需要正确认识中药发酵理论、挖掘中药发酵技术精髓和建立中药发酵数据库等建议;发酵技术的创新需要科学阐释中药发酵机制、客观化传承中药发酵经验、规范与创新发酵工艺、完善中药发酵质量标准和拓展中药发酵新品种等,为中药发酵技术的发展提供思路与借鉴。

关键词：中药发酵技术炮制工艺质量标准数据库

不同发酵时间甜酒酿面团的超微结构与面包香气特征研究

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食品工业科技 2019年第2期40卷 29-36页

作者：吴玉新张可欣蒋慧汤晓娟徐岩黄卫宁李宁 Filip Arnaut 江南大学食品科学与技术国家重点实验室江苏无锡214122 广州焙乐道食品有限公司广东广州511400 焙乐道食品集团

本研究将不同发酵时间(0、24、48、72 h)的广西农家酒曲制备的酒酿应用到面包中,采用α-氨基态氮表征蛋白酶活力,利用激光共聚焦观察面团的超微结构,通过气质联用测定面包中的挥发性风味物质,并结合感官鉴评,对面包进行品质评价。结果表... 详细信息

本研究将不同发酵时间(0、24、48、72 h)的广西农家酒曲制备的酒酿应用到面包中,采用α-氨基态氮表征蛋白酶活力,利用激光共聚焦观察面团的超微结构,通过气质联用测定面包中的挥发性风味物质,并结合感官鉴评,对面包进行品质评价。结果表明:甜酒酿面团(FRD)发酵前后α-氨基氮含量没有显著性差异(p> 0.05),但添加有48 h甜酒酿面团的网络结构最稳定。与发酵0 h甜酒酿面包(FRB)相比,48 h甜酒酿面包中酯类、醇类物质明显增多,尤其是辛酸乙酯、壬酸乙酯以及异戊醇,赋予面包更浓郁的花香和果香。除72 h甜酒酿面包外,各组面包比容没有显著性差异(p> 0.05),48 h甜酒酿面包在感官鉴评中获得更高的分数,面包更易被接受。

关键词：甜酒酿发酵时间激光共聚焦气相色谱-质谱法

Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO

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Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen shaomin Chen Shenjian Chen xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han yan Yerevan Physics Institute YerevanArmenia Universitélibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro RioBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina wuyi University JiangmenChina Shandong University JinanChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina wuhan University WuhanChina Xi’an Jiaotong University Xi’anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-Tung University Hsinchu National United University Miao-Li Department of Physics National T

The jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main *** of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator *** this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/*** ten years of data acquisition,approximately 60,000 signal and 30,000 background events are *** large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith ***,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment.

关键词： neutrino oscillation solar neutrino JUNO

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液压支架主销轴强度校核方法分析

煤矿机械 2011年第10期32卷 26-27页

作者：闫洪元孟海岗吴刚姜立新王悦勇李云峰王旭赵世来三一重型装备有限公司沈阳110027

对比分析了2种液压支架主销轴的强度校核方法,并通过理论分析与实例计算,得出了液压支架主销轴的强度校核的合理方法,这种方法能够为液压支架主销轴的合理设计提供理论支持。

关键词：液压支架销轴强度校核

基于DPO引物检测猪流行性腹泻病毒荧光定量RT-PCR方法的建立及初步应用

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中国预防兽医学报 2019年第7期41卷 710-715页

作者：王以欣王紫薇汉武娇王丽姜艳平崔文周晗乔薪瑗唐丽杰李一经徐义刚东北农业大学动物医学学院黑龙江哈尔滨150030 农业部动物疫病病原生物学重点实验室/东北科学观测实验站黑龙江哈尔滨150030

为建立快速、准确检测猪流行性腹泻病毒(PEDV)的方法,本研究以PEDV的N基因为靶基因,基于双启动寡核苷酸引物(DPO),经过条件优化,建立了检测PEDV的荧光定量RT-PCR方法。结果显示,DPO引物的有效退火温度范围较宽(45℃~65℃);在测试的10种... 详细信息

为建立快速、准确检测猪流行性腹泻病毒(PEDV)的方法,本研究以PEDV的N基因为靶基因,基于双启动寡核苷酸引物(DPO),经过条件优化,建立了检测PEDV的荧光定量RT-PCR方法。结果显示,DPO引物的有效退火温度范围较宽(45℃~65℃);在测试的10种病毒中仅PEDV为阳性扩增结果,其余病毒为阴性结果,特异性较强;对PEDV质粒标准品的检测限可达1.64×10^1拷贝/μL,敏感性较高;组内、组间重复性结果的变异系数均小于1%,重复性较好。利用该方法对采集的272份临床仔猪腹泻样品(粪便、小肠组织)进行检测,结果显示,共检出PEDV阳性样品39份,阳性率为14.34%,与常规RT-PCR方法检测结果的阳性符合率为92.31%;本研究建立方法检测的阳性样品经PEDV N基因测序鉴定,确实均为PEDV阳性样品。本研究建立的基于DPO引物检测PEDV的荧光定量RT-PCR方法为PEDV的准确检测和流行病学调查提供技术支持。

关键词：猪流行性腹泻病毒 DPO引物荧光定量RT-PCR

基于链状Se_(m)S_(n)(2≤m+n≤4)小分子的硒硫碳复合正极材料的制备及其电化学性能

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无机化学学报 2022年第4期38卷 645-653页

作者：严奉乾景鑫国范廷云朱禾生刘闪刘晨旭吴熙丁国彧江伟伟唐昌新孙福根南昌大学光伏研究院南昌330031

将Se固溶复合到链状小硫分子S_(2~4)中,利用超微孔碳(UMC)的空间限域效应,在UMC中成功构建了链状Se_(m)S_(n)(2≤m+n≤4)小分子,并用作锂硫(li⁃S)电池正极材料。与链状S_(2~4)小分子相比,改性后的Se_(m)S_(n)(2≤m+n≤4)小分子电导率更... 详细信息

将Se固溶复合到链状小硫分子S_(2~4)中,利用超微孔碳(UMC)的空间限域效应,在UMC中成功构建了链状Se_(m)S_(n)(2≤m+n≤4)小分子,并用作锂硫(li⁃S)电池正极材料。与链状S_(2~4)小分子相比,改性后的Se_(m)S_(n)(2≤m+n≤4)小分子电导率更高,锂化能更低,放电锂化过程更容易。所制得的UMC/Se_(m)S_(n)(2≤m+n≤4)复合正极材料的放电过程为一步固相转化反应,从而有效抑制了活性物质的穿梭流失。与UMC/S_(2~4)复合正极材料相比,UMC/Se_(m)S_(n)(2≤m+n≤4)复合正极材料的电荷传递阻抗更小,放电比容量更高。因此,UMC/Se_(m)S_(n)⁃40(2≤m+n≤4,w_(SeS_(2))∶w_(UMC)=4∶6)复合正极材料在0.1C时循环100次后,比容量依然保持有844 mAh·g^(-1);在0.5C下长时间循环500次时,每次循环容量损失仅约为0.07%,表现出优异的循环稳定性。

关键词：锂硫电池硫正极硒硫固溶体小硫分子硒硫碳复合物

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小麦品种烟农999高产遗传基础解析

植物遗传资源学报 2023年第3期24卷 732-743页

作者：王矗殷岩王昊李诗慧赵春华秦冉孙晗吴永振慕岩君孔军杰许玲黄小梅辛庆国王江春崔法山东省烟台市农业科学研究院烟台265500 烟台大学生命科学学院烟台264005 鲁东大学农学院/山东省高等学校作物高产抗逆分子模块重点实验室烟台264025 烟台市土地储备和利用中心烟台264003

小麦品种烟农999具有高产、稳产、广适等特性,明确烟农999的遗传特性,挖掘其高产关键区段,可为烟农999育种及生产应用提供理论支撑。本研究利用55K小麦SNP芯片对烟农999及其46份衍生品种(系)、243份育成的小麦品种(系)为材料组成的自然... 详细信息

小麦品种烟农999具有高产、稳产、广适等特性,明确烟农999的遗传特性,挖掘其高产关键区段,可为烟农999育种及生产应用提供理论支撑。本研究利用55K小麦SNP芯片对烟农999及其46份衍生品种(系)、243份育成的小麦品种(系)为材料组成的自然群体进行了全基因组基因型鉴定,解析了其关键育种选择区段及其遗传效应,基于产量三要素优异等位基因位点组成系统解析了其高产形成的关键遗传基础。表型结果表明,烟农999高千粒重优异性状在其后代中得以优先选择保留。46份烟农999衍生品种(系)平均遗传相似系数为0.87。在全基因组水平,烟农999对F3、F5、F6及F7以上衍生品系遗传贡献率分别为84.94%、86.19%、86.67%和87.65%。46份烟农999衍生品种(系)中共检测到222个传递率在95%以上的烟农999高频率选择区段,长度变幅为5.04~108.75 Mb,其中2A包含高频率选择区段总长度最长,约为483.37 Mb;7D最短,约为13.84 Mb。222个高频率选择区段内包含135个已知的与产量性状相关的QTL,其中A基因组为80个,B和D基因组分别为48个和7个。基于自然群体单标记QTL分析共检测到1195个控制单株产量、267个控制穗粒数、790个控制千粒重和678个控制单株穗数的显著性关联SNP位点,其中烟农999基因型为增效的位点占比分别为84.02%、51.69%、94.18%和13.42%,说明烟农999已富集了单株产量和千粒重优异等位基因位点,是其高产、稳产的重要遗传基础。本研究为烟农999的分子育种亲本应用与烟农999高产基因挖掘提供理论参考。

关键词：烟农999 55K小麦SNP芯片遗传特性高产关键区段候选骨干亲本

Geometrical reconstruction of fluorescence events observed by the LHAASO experiment

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Chinese Physics C 2021年第4期45卷 416-425页

作者： F.Aharonian Q.An Axikegu L.X.Bai Y.X.Bai Y.W.Bao D.Bastieri X.J.Bi Y.J.Bi H.Cai J.T.Cai Z.Cao Z.Cao J.Chang J.F.Chang X.C.Chang B.M.Chen J.Chen L.Chen L.Chen L.Chen M.J.Chen M.L.Chen Q.H.Chen S.H.Chen S.Z.Chen T.L.Chen X.L.Chen Y.Chen N.Cheng Y.D.Cheng S.W.Cui X.H.Cui Y.D.Cui B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu D.della Volpe B.DEtorre Piazzoli X.J.Dong J.H.Fan Y.Z.Fan Z.X.Fan J.Fang J.Fang C.F.Feng L.Feng S.H.Feng Y.L.Feng B.Gao C.D.Gao Q.Gao W.Gao M.M.Ge L.S.Geng G.H.Gong Q.B.Gou M.H.Gu J.G.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He H.N.He J.C.He S.L.He X.B.He Y.He M.Heller Y.K.Hor C.Hou X.Hou H.B.Hu S.Hu S.C.Hu X.J.Hu D.H.Huang Q.L.Huang W.H.Huang X.T.Huang Z.C.Huang F.Ji X.L.Ji H.Y.Jia K.jiang Z.J.jiang C.Jin D.Kuleshov K.Levochkin B.B.li C.li C.li F.li H.B.li H.C.li H.Y.li J.li K.li W.L.li X.li X.li X.R.li Y.li Y.Z.li Z.li Z.li E.W.liang Y.F.liang S.J.lin B.liu C.liu D.liu H.liu H.D.liu J.liu J.L.liu J.L.liu J.S.liu J.Y.liu M.Y.liu R.Y.liu S.M.liu W.liu Y.N.liu Z.X.liu W.J.Long R.Lu H.K.Lv B.Q.Ma L.L.Ma X.H.Ma J.R.Mao A.Masood W.Mitthumsiri T.Montaruli Y.C.Nan B.Y..Pang P.Pattarakijwanich Z.Y.Pei M.Y.Qi D.Ruffolo V.Rulev A.Saiz L.shao O.Shchegolev X.D.Sheng J.R.Shi H.C.Song Yu.V.Stenkin V.Stepanov Q.N.Sun X.N.Sun Z.B.Sun P.H.T.Tam Z.B.tang W.W.Tian B.D.wang C.wang H.wang H.G.wang J.C.wang J.S.wang L.P.wang L.Y.wang R.N.wang W.wang W.wang X.G.wang X.J.wang X.Y.wang Y.D.wang Y.J.wang Y.P.wang Z.wang Z.wang Z.H.wang Z.X.wang D.M.Wei J.J.Wei Y.J.Wei T.Wen C.Y.wu H.R.wu S.wu W.X.wu X.F.wu S.Q.Xi J.Xia J.J.Xia G.M.Xiang G.Xiao H.B.Xiao G.G.xin Y.L.xin Y.xing D.L.xu R.X.xu L.xue D.H.yan C.W.yang F.F.yang J.Y.yang L.L.yang M.J.yang R.Z.yang S.B.yang Y.H.yao Z.G.yao Y.M.Ye L.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng M.Zha X.X.Zhai B.B.Zhang H.M.Zhang H.Y.Zhang J.L.Zhang J.W.Zhang L.Zhang L.Zhang L.X.Zhang P.F.Zhang P.F.Zhang R.Zhang S.R.Zhang S.S.Zhang X.Zhang X.P.Zhang Y.Zhang Y.Zhang Y.F.Zhang Y.L.Zhang B.Zhao J.Zhao L.Zhao L.Z.Zhao S.P.Zhao F.Zheng Y.Zheng B.Zhou H.Zhou J.N.Zhou P Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduSichuanChina State Key Laboratory of Paricle Detection and Electronics China University of Science and Technology of China HefeiAnhui 230026China Department of Engineering Physics Tsinghua UniversityBeijing 100084China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China National Space Science Center Chinese Academy of SciencesBeijing 100190China School of Physics Peking UniversityBeijing 100871China Center for Astrophysics Guangzhou UniversityGuangzhouGuangdong 510006China School of Physics and Astronomy&School of Physics(Guangzhou) Sun Yat-sen UniversityZhuhaiGuangdong 519000China School of Physical Science and Technology Guangxi UniversityNanningGuangxi 530004China Hebei Normal University ShijiazhuangHebei 050024China School of Physics and Microelectronics Zhengzhou UniversityZhengzhouHenan 450001China School of Astronomy and Space Science Nanjing UniversityNanjingJiangsu 210023China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjingJiangsu 210023China Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdaoShandong 266237China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China School of Physical Science and Technology Southwest Jiaotong UniversityChengduSichuan 610031China College of Physics Sichuan UniversityChengduSichuan 610065China Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasaTibet 850000China School of physics and technology Wuhan UniversityWuhanHubei 430072Ch

The LHAASO-WFCTA experiment,which aims to observe cosmic rays in the sub-EeV range using the fluorescence technique,uses a new generation of high-performance *** ensure that the experiment has ex-cellent detection capability associated with the measurement of the energy spectrum,the primary composition of cosmic rays,and so on,an accurate geometrical reconstruction of air-shower events is *** paper de-scribes the development and testing of geometrical reconstruction for stereo viewed events using the WFCTA(Wide Field of view Cherenkov/Fluorescence Telescope Array)*** approaches,which take full advantage ofthe WFCTA *** *** is the stereo-angular method,which uses the pointing of triggered SiPMs in the shower trajectory,and the other is the stereo-timing method,which uses the triggering time of the fired *** results show that both methods have good geometrical resolution:the resolution of the stereo-timing method is slightly better than the stereo-angular method because the resolution of the latter is slightly limited by the shower track length.

关键词： cosmic ray fluorescence telescope stereo observation geometrical reconstruction