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Ghrelin inhibits autophagy mediated by AKT/mTOR pathway to ameliorate retinal angiogenesis induced by high glucose stress

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 785-793页

作者： jiang-Li Fan Rong Li Min Zhang Chao Chen Guo-Min yao ling-Xiao Zhou Department of Ophthalmology Gongshu District People’s Hospital of Integrated Traditional Chinese and Western MedicineHangzhou 310004Zhejiang ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Xi’an Medical UniversityXi’an 710077Shaanxi ProvinceChina Department of Endocrinology the First Affiliated Hospital of Xi’an Medical UniversityXi’an 710077Shaanxi ProvinceChina Department of General Surgery the First Affiliated Hospital of Xi’an Medical UniversityXi’an 710077Shaanxi ProvinceChina

AIM:To observe the effect of ghrelin,a growth hormonereleasing peptide,on retinal angiogenesis in vitro under high glucose(HG)stress and to explore the possible mechanism of ***:Human retinal microvascular endothelial cells(HRMECs)were treated with high concentration of glucose alone or in combination with *** cell migration,tube formation and the expression of the autophagy-related proteins LC3-II/I,Beclin-1,p62,phosphorylated AKT(p-AKT)/AKT and phosphorylated mammalian target of rapamycin(p-mTOR)/mTOR were ***,to clarify the correlation between ghrelin effect and autophagy,AKT inhibitor VIII was adopted to treat HRMECs,and cell migration,tube formation as well as the protein expressions of LC3-II/I,Beclin-1 and p62 were ***:Under HG stress,ghrelin inhibited migration and tube formation of *** inhibited the increases in the protein levels of LC3-II/I,Beclin-1 and the decreases in the protein levels of p62,p-AKT/AKT and p-mTOR/mTOR induced by HG ***,under the action of AKT/mTOR pathway inhibitors,the effects of ghrelin on migration and tube formation were both *** addition,the expression of LC3-II/I and Beclin-1 were significantly up-regulated and the expression of p62 was ***:Retinal angiogenesis under in vitro HG stress can be inhibited by ghrelin through activating AKT/mTOR pathway to inhibit autophagy.

关键词： ghrelin retinal endothelial cell angiogenesis autophagy stress

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Advances in Triboelectric Nanogenerators for Blue Energy Harvesting and Marine Environmental Monitoring

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Engineering 2024年第2期33卷 204-224页

作者： Yang jiang Xi Liang Tao jiang Zhong lin Wang CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro–Nano Energy and SensorsBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 101400China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China Georgia Institute of Technology AtlantaGA 30332USA

Blue energy,which includes rainfall,tidal current,wave,and water-flow energy,is a promising renewable resource,although its exploitation is limited by current technologies and thus remains *** form of energy is mainly harvested by electromagnetic generators(EMGs),which generate electricity via Lorenz force-driven electron *** nano genera tors(TENGs)and TENG networks exhibit superiority over EMGs in low-frequency and high-entropy energy harvesting as a new approach for blue energy harvesting.A TENG produces electrical outputs by adopting the mechanism of Maxwell’s displacement *** date,a series of research efforts have been made to optimize the structure and performance of TENGs for effective blue energy harvesting and marine environmental *** the great progress that has been achieved in the use of TENGs in this context so far,continuous exploration is required in energy conversion,device durability,power management,and environmental *** review reports on advances in TENGs for blue energy harvesting and marine environmental *** introduces the theoretical foundations of TENGs and discusses advanced TENG prototypes for blue energy harvesting,including TENG structures that function in freestanding and contact-separation *** enhancement strategies for TENGs intended for blue energy harvesting are also ***,marine environmental applications of TENGs based on blue energy harvesting are discussed.

关键词： Triboelectric nanogenerator TENG networks Blue energy Energy harvesting Ocean sensors

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Nanochaperones Based on Hydrophobic Interaction and Coordination Inhibit Protein Misfolding and Fibrillation

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Chinese Journal of Polymer Science 2024年第11期 1710-1718页

作者： Hui Wang lin-lin Xu lin-Qi Shi Ru-jiang Ma Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer Chemistry State Key Laboratory of Medicinal Chemical BiologyFrontiers Science Center for New Organic Matter College of Chemistry Nankai University Haihe Laboratory of Sustainable Chemical Transformations

Amyloidosis is characterized by the deposition of fibrillar aggregates, with a specific peptide or protein as the primary component, in affected tissues or organs. Excessive proliferation and deposition of amyloid fibrils can cause organismal dysfunction and lethal pathological outcomes associated with amyloidosis. In this study, a nanochaperone(nChap-NA) was developed to inhibit protein misfolding and fibrillation by simulating the function of natural molecular chaperones. The nanochaperone was prepared by self-assembly of two block copolymers PEG-b-PCL and PCL-b-P(NIPAM-co-AANTA), which had a phase-separated surface consisting of hydrophobic PNIPAM microdomains with coordinative NTA(Zn) moieties and hydrophilic PEG chains. The hydrophobic interaction of the PNIPAM microdomain and the coordination of NTA(Zn) synergistically work together to effectively trap the amyloid monomer and block its fibrillation site. Insulin and human islet amyloid polypeptide(hIAPP) were used as model proteins to investigate the nanochaperone's inhibition of amyloid misfolding and fibrillation. It was proved that the nanochaperone could stabilize the natural conformation of the trapped insulin and hIAPP, and effectively inhibit their fibrillation. In vivo study demonstrated that the nanochaperone could effectively preserve the bioactivity of insulin and reduce the cytotoxicity caused by hIAPP aggregation. This study may provide a promising strategy for the prophylactic treatment of amyloidosis.

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Research and design of matrix operation accelerator based on reconfigurable array

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High Technology Letters 2024年第2期30卷 128-137页

作者：邓军勇 ZHANG Pan jiang lin XIE Xiaoyan DENG Jingwen School of Electronic Engineering Xi’an University of Posts and TelecommunicationsXi’an 710121P.R.China School of Computer Science and Technology Xi’an University of Science and TechnologyXi’an 710054P.R.China School of Computer Xi’an University of Posts and TelecommunicationsXi’an 710121P.R.China

In the case of massive data,matrix operations are very computationally intensive,and the memory limitation in standalone mode leads to the system *** the same time,it is difficult for matrix operations to achieve flexible switching between different requirements when implemented in *** address this problem,this paper proposes a matrix operation accelerator based on reconfigurable arrays in the context of the application of recommender systems(RS).Based on the reconfigurable array processor(APR-16)with reconfiguration,a parallelized design of matrix operations on processing element(PE)array is realized with *** experimental results show that,compared with the proposed central processing unit(CPU)and graphics processing unit(GPU)hybrid implementation matrix multiplication framework,the energy efficiency ratio of the accelerator proposed in this paper is improved by about 35×.Compared with blocked alternating least squares(BALS),its the energy efficiency ratio has been accelerated by about 1×,and the switching of matrix factorization(MF)schemes suitable for different sparsity can be realized.

关键词： matrix factorization(MF) recommender system(RS) array processor reconfigurable matrix multiplication

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Artificial optical microfingerprints for advanced anticounterfeiting

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Nano Research 2024年第5期17卷 4371-4378页

作者： Xueke Pang Qiang Zhang Jingyang Wang Xin jiang Menglin Wu Mingyue Cui Zhixia Feng Wenxin Xu Bin Song yao He Suzhou Key Laboratory of Nanotechnology and Biomedicine Institute of Functional Nano&Soft Materials&Collaborative Innovation Center of Suzhou Nano Science and Technology(NANO-CIC)Soochow UniversitySuzhou 215123China School of Sensing Science and Engineering Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment InstrumentSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Artificial optical microfingerprints,known as physically unclonable functions(PUFs)offer a groundbreaking approach for ***,these PUFs artificial optical microfingerprints suffer from a limited number of challenge-response pairs,making them vulnerable to machine learning(ML)attacks when additional error-correcting units are *** study presents a pioneering demonstration of artificial optical microfingerprints that combine the advantages of PUFs,a large encoding capacity algorithm,and reliable deep learning authentication against ML *** approach utilizes the triple-mode PUFs,incorporating bright-field,multicolor fluorescence wrinkles,and the topography of surface enhanced Raman scattering in the mechanical and optical ***,the quaternary encoding of these PUFs artificial microfingerprints allows for an encoding capacity of 6.43×10^(24082) and achieves 100%deep learning recognition ***,the PUFs artificial optical microfingerprints exhibit high resilience against ML attacks,facilitated by generative adversarial networks(GAN)(with mean prediction accuracy of~85.0%).The results of this study highlight the potential of utilizing up to three PUFs in conjunction with a GAN training system,paving the way for achieving encoded information that remains resilient to ML attacks.

关键词： artificial microfingerprints physically unclonable functions deep learning anti-counterfeiting

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Hydrogen spillover bridged dual nano-islands triggered by built-in electric field for efficient and robust alkaline hydrogen evolution at ampere-level current density

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Nano Research 2024年第6期17卷 5050-5060页

作者： Kecheng Tong Liangliang Xu Hanxu yao Xingkun Wang Canhui Zhang Fan Yang Lei Chu Jinwoo Lee Heqing jiang Minghua Huang School of Materials Science and Engineering Ocean University of ChinaQingdao 266100China Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology(KAIST)291Daejeon 34141Republic of Korea Qingdao New Energy Shandong Laboratory Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China University of Chinese Academy of Sciences Beijing 100049China

Employing the alkaline water electrolysis system to generate hydrogen holds great prospects but still poses significant challenges,particularly for the construction of hydrogen evolution reaction(HER)catalysts operating at ampere-level current ***,the unique Ru and RuP_(2)dual nano-islands are deliberately implanted on N-doped carbon substrate(denoted as Ru-RuP_(2)/NC),in which a built-in electric field(BEF)is spontaneously generated between Ru-RuP_(2)dual nano-islands driven by their work function *** and theoretical results unveil that such constructed BEF could serve as the driving force for triggering fast hydrogen spillover process on bridged Ru-RuP_(2)dual nano-islands,which could invalidate the inhibitory effect of high hydrogen coverage at ampere-level current density,and synchronously speed up the water dissociation on Ru nano-islands and hydrogen adsorption/desorption on RuP_(2)nano-islands through hydrogen spillover *** a result,the Ru-RuP_(2)/NC affords an ultra-low overpotential of 218 mV to achieve 1.0 A·cm^(−2)along with the superior stability over 1000 h,holding the great promising prospect in practical applications at ampere-level current *** importantly,this work is the first to advance the scientific understanding of the relationship between the constructed BEF and hydrogen spillover process,which could be enlightening for the rational design of the cost-effective alkaline HER catalysts at ampere-level current density.

关键词： built-in electric field hydrogen spillover dual nano-islands ampere-level current density alkaline hydrogen evolution

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Association between Serum Ferritin Levels and Metabolic-associated Fatty Liver Disease in Adults:a Cross-sectional Study Based on the NHANES

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Current Medical Science 2024年第3期44卷 494-502页

作者： jiang-hui LI Xue-yao MA Yun YI Lu-rao LI Zhi-yong XU Ying CHANG Department of Gastroenterology Zhongnan Hospital of Wuhan UniversityWuhan430071China Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases Wuhan430071China Endoscopy Center The People’s Hospital of YingshanHuanggang438799China

Objective Ferritin,initially acting as an iron-storage protein,was found to be associated with metabolic *** study was designed to investigate the association between serum ferritin and metabolic-associated fatty liver disease(MAFLD)using data from the National Health and Nutrition Examination Survey(NHANES)of the United State of *** A cross-sectional study was conducted,enrolling a total of 2145 participants from the NHANES in the 2017–2018 *** steatosis and liver fibrosis were assessed by ultrasound images and several non-invasive *** regression analysis was conducted to determine the associations between serum ferritin concentration and MAFLD and liver *** The analysis revealed that participants with higher serum ferritin levels(Q3 and Q4 groups)had a higher prevalence of MAFLD than those with the lowest serum ferritin levels[Q3 vs.Q1:OR=2.17(1.33,3.53),P<0.05 in fatty liver index(FLI);Q4 vs.Q1:OR=3.13(1.91,5.13),P<0.05 in FLI].Additionally,participants with the highest serum ferritin levels(Q4 group)displayed a higher prevalence of liver fibrosis[Q4 vs.Q1:OR=2.59(1.19,5.62),P<0.05 in liver stiffness measurement;OR=5.06(1.12,22.94),P<0.05 in fibrosis-4 index],with significantly increased risk observed in participants with concomitant diabetes[OR=7.45(1.55,35.72),P=0.012].Conclusion Our study revealed that elevated serum ferritin levels are associated with a higher prevalence of MAFLD and advanced liver fibrosis in *** serum ferritin levels combined with diabetes are important risk factors for liver fibrosis.

关键词： serum ferritin liver fibrosis metabolic-associated fatty liver disease National Health and Nutrition Examination Survey

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Role of gut microbiota in Crohn’s disease pathogenesis:Insights from fecal microbiota transplantation in mouse model

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World Journal of Gastroenterology 2024年第31期30卷 3689-3704页

作者： Qiang Wu Lian-Wen Yuan Li-Chao Yang Ya-Wei Zhang Heng-Chang yao Liang-Xin Peng Bao-Jia yao Zhi-Xian jiang Geriatric Surgery of Department of General Surgery The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND Inflammatory bowel disease,particularly Crohn’s disease(CD),has been associated with alterations in mesenteric adipose tissue(MAT)and the phenomenon termed“creeping fat”.Histopathological evaluations showed that MAT and intestinal tissues were significantly altered in patients with CD,with these tissues characterized by inflammation and *** To evaluate the complex interplay among MAT,creeping fat,inflammation,and gut microbiota in *** Intestinal tissue and MAT were collected from 12 patients with *** manifestations and protein expression levels were analyzed to determine lesion *** samples were collected from five recently treated CD patients and five control subjects and transplanted into *** intestinal and mesenteric lesions in these mice,as well as their systemic inflammatory status,were assessed and compared in mice transplanted with fecal samples from CD patients and control *** Pathological examination of MAT showed significant differences between CDaffected and unaffected colons,including significant differences in gut microbiota *** microbiota transplantation(FMT)from clinically healthy donors into mice with 2,4,6-trinitrobenzene sulfonic acid(TNBS)-induced CD ameliorated CD symptoms,whereas FMT from CD patients into these mice exacerbated CD ***,FMT influenced intestinal permeability,barrier function,and levels of proinflammatory factors and ***,FMT from CD patients intensified fibrotic changes in the colon tissues of mice with TNBS-induced *** Gut microbiota play a critical role in the histopathology of *** MAT and creeping fat may therefore have potential in the treatment of patients with CD.

关键词： Mesenteric adipose tissue Crohn’s disease Fecal microbiota transplantation Intestinal fibrosis Intestinal barrier

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Left ventricular thrombosis caused cerebral embolism during venoarterial extracorporeal membrane oxygenation support: A case report

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World Journal of Clinical Cases 2024年第5期12卷 973-979页

作者： yao-Bang Bai Feng Zhao Zhen-Hua Wu Guo-Ning Shi Nan jiang Intensive Care Unit Department of Cardiac SurgeryTianjin Chest HospitalTianjin 300222China Department of Cardiac Surgery Tianjin Chest HospitalTianjin 300222China

BACKGROUND Venoarterial(VA)extracorporeal membrane oxygenation(ECMO),an effective short-term circulatory support method for refractory cardiogenic shock,is widely ***,retrospective analyses have shown that VA-ECMO-assisted cases were associated with a relatively high mortality rate of approximately 60%.Embolization in important organs caused by complications of left ventricular thrombosis(LVT)during VA-ECMO is also an important *** the incidence of LVT during VA-ECMO is not high,the consequences of embolization are *** SUMMARY A 37-year-old female patient was admitted to hospital because of fever for 4 d and palpitations for 3 *** excluding the diagnosis of coronary heart disease,we established a diagnosis of“clinically explosive myocarditis”.The patient still had unstable hemodynamics after drug treatment supported by VA-ECMO,with heparin for *** day 4 of ECMO support,a left ventricular thro-mbus attached to the papillary muscle root of the mitral valve was found by transthoracic *** ventricular decompression was performed and ECMO was successfully removed,but the patient eventually died of multiple cerebral *** LVT with high mobility during VA-ECMO may cause embolism in important ***,a"wait and see"strategy should be avoided.

关键词： Venoarterial extracorporeal membrane oxygenation Left ventricular thrombosis Cerebral embolism Magnetic Resonance Imaging Therapy Case report

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Energetic,bio-oil,biochar,and ash performances of co-pyrolysis-gasification of textile dyeing sludge and Chinese medicine residues in response to K_(2)CO_(3),atmosphere type,blend ratio,and temperature

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Journal of Environmental Sciences 2024年第2期136卷 133-150页

作者： Gang Zhang Zhiyun Chen Tao Chen Shaojun jiang Fatih Evrendilek Shengzheng Huang Xiaojie Tang Ziyi Ding yao He Wuming Xie Jingyong Liu Engineering Research Center of None-food Biomass Efficient Pyrolysis and Utilization Technology of Guangdong Higher Education Institutes Dongguan University of TechnologyDongguan 523808China School of Environmental Science and Engineering Guangdong University of TechnologyGuangzhou 510006China School of Environment The Environmental Research InstituteMOE Key Laboratory of Theoretical Chemistry of EnvironmentSouth China Normal UniversityGuangzhou 510006China Department of Environmental Engineering Bolu Abant Izzet Baysal UniversityBolu 14052Turkey

Hazardous waste stream needs to be managed so as not to exceed stock-and rate-limited properties of its recipient *** co-pyrolysis of Chinese medicine residue(CMR)and textile dyeing sludge(TDS)and its bio-oil,biochar,and ash quality and quantity were characterized as a function of the immersion of K_(2)CO_(3),atmosphere type,blend ratio,and *** to the mono-pyrolysis of TDS,its co-pyrolysis performance with CMR(the comprehensive performance index(CPI))significantly improved by 33.9%in the N_(2)atmosphere and 33.2%in the CO_(2)*** impregnation catalyzed the co-pyrolysis at 370℃,reduced its activation energy by 77.3 kJ/mol in the N_(2)atmosphere and 134.6 kJ/mol in the CO_(2)atmosphere,and enriched the degree of coke gasification by 44.25%in the CO_(2)*** impregnation increased the decomposition rate of the co-pyrolysis by weakening the bond energy of fatty side chains and bridge bonds,its catalytic and secondary products,and its bio-oil yield by 66.19%.Its bio-oils mainly contained olefins,aromatic structural substances,and *** immersion of K_(2)CO_(3)improved the aromaticity of the copyrolytic biochars and reduced the contact between K and Si which made it convenient for Mg to react with SiO_(2)to form *** co-pyrolytic biochar surfaces mainly included-OH,-CH_(2),C=C,and *** main phases in the co-pyrolytic ash included Ca_(5)(PO_(4))_(3)(OH),Al_(2)O_(3),and magnesium-silicate.

关键词： Chemical impregnation Catalytic pyrolysis Chinese medicine residue Textile dyeing sludge Co-pyrolysis

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