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Exosomes derived from bone marrow mesenchymal stem cells protect the injured spinal cord by inhibiting pericyte pyroptosis

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Neural Regeneration Research 2022年第1期17卷 194-202页

作者： Yan Zhou lu-lu Wen Yan-Fei Li Kai-Min Wu Ran-Ran Duan yao-Bing yao Li-Jun Jing Zhe Gong Jun-Fang Teng Yan-jie Jia Department of Radiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina

Mesenchymal stem cell(MSC)transplantation is a promising treatment strategy for spinal cord injury,but immunological rejection and possible tumor formation limit its *** therapeutic effects of MSCs mainly depend on their release of soluble paracrine *** are essential for the secretion of these paracrine *** marrow mesenchymal stem cell-derived exosomes(BMSC-EXOs)can be substituted for BMSCs in cell ***,the underlying mechanisms remain *** this study,a rat model of T10 spinal cord injury was established using the impact ***,30 minutes and 1 day after spinal cord injury,the rats were administered 200μL exosomes via the tail vein(200μg/mL;approximately 1×106 BMSCs).Treatment with BMSC-EXOs greatly reduced neuronal cell death,improved myelin arrangement and reduced myelin loss,increased pericyte/endothelial cell coverage on the vascular wall,decreased bloodspinal cord barrier leakage,reduced caspase 1 expression,inhibited interleukin-1βrelease,and accelerated locomotor functional recovery in rats with spinal cord *** the cell culture experiment,pericytes were treated with interferon-γand tumor necrosis factor-α.Then,Lipofectamine 3000 was used to deliver lipopolysaccharide into the cells,and the cells were co-incubated with adenosine triphosphate to simulate injury in ***-treatment with BMSC-EXOs for 8 hours greatly reduced pericyte pyroptosis and increased pericyte survival *** findings suggest that BMSC-EXOs may protect pericytes by inhibiting pyroptosis and by improving blood-spinal cord barrier integrity,thereby promoting the survival of neurons and the extension of nerve fibers,and ultimately improving motor function in rats with spinal cord *** protocols were conducted with the approval of the Animal Ethics Committee of Zhengzhou University on March 16,2019.

关键词： blood-spinal cord barrier edema exosome pericyte NOD1 pro-caspase 1 pyroptosis spinal cord injury

胶原蛋白肽-焦磷酸铁复合物的构建及其补铁效果评价

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陕西科技大学学报 2025年第1期43卷 29-34页

作者：刘宁王薇贺人杰姚晓琳张琨福格森(武汉)生物科技股份有限公司湖北武汉430056 陕西科技大学食品科学与工程学院陕西西安710021

铁复合物是一种将铁元素与食品大分子结构进行组装的新型铁强化剂,具有化学稳定性和生物利用度高的优点.本课题采用均质、超声和透析处理,在焦磷酸铁(FP)的合成过程中,引入胶原蛋白肽(CPs).红外光谱测定发现,该方法成功制得CPs-FP复合物... 详细信息

铁复合物是一种将铁元素与食品大分子结构进行组装的新型铁强化剂,具有化学稳定性和生物利用度高的优点.本课题采用均质、超声和透析处理,在焦磷酸铁(FP)的合成过程中,引入胶原蛋白肽(CPs).红外光谱测定发现,该方法成功制得CPs-FP复合物.与FP相比,CPs-FP的胃肠释放率提高.缺铁性贫血大鼠实验表明,CPs-FP能够有效改善大鼠体重、血红蛋白含量、组织铁含量和其他指数,呈现浓度依赖效应.同等剂量下,CPs-FP复合物具有更高的生物利用度.

关键词：焦磷酸铁胶原蛋白肽铁复合物胃肠消化缺铁性动物

Improvement and application of GM(1,1) model based on multivariable dynamic optimization

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Journal of Systems Engineering and Electronics 2020年第3期31卷 593-601页

作者： WANG Yuhong lu jie School of Business Jiangnan UniversityWuxi 214122China

For the classical GM(1,1)model,the prediction accuracy is not high,and the optimization of the initial and background values is *** this paper,the Lagrange mean value theorem is used to construct the background value as a variable related to *** the same time,the initial value is set as a variable,and the corresponding optimal parameter and the time response formula are determined according to the minimum value of mean relative error(MRE).Combined with the domestic natural gas annual consumption data,the classical model and the improved GM(1,1)model are applied to the calculation and error comparison *** proves that the improved model is better than any other models.

关键词： grey prediction GM(1,1)model background value grey system theory

Super-Resolution Imaging by using a Metallic Rod Array in the Near Infrared Region

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Chinese Physics Letters 2012年第4期29卷 210-212页

作者： yao jie YE Yong-Hong College of Physics Science and Technology Nanjing Normal UniversityNanjing 210046

An array of metallic rods can transport details below the diffraction limit of an object from the front face to the back *** super-resolution imaging system has been studied in the microwave,mid-infrared and optical *** investigate its performance in the near infrared (1550nm) *** simulations show that the near-field components of dipole sources are transferred by the excitation and propagation of the surface plasmon mode of the *** appropriate length of rods is determined by the excited surface plasmon *** spatial resolution is greatly affected by the loss of metal.

关键词： resolution Infrared details

New method for high performance multiply-accumulator design

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第7期10卷 1067-1074页

作者： Bing-jie XIA Peng LIU Qing-dong yao Department of Information Science and Electronic Engineering Zhejiang University Hangzhou 310027 China

This study presents a new method of 4-pipelined high-performance split multiply-accumulator (MAC) architecture, which is capable of supporting multiple precisions developed for media processors. To speed up the design further, a novel partial product compression circuit based on interleaved adders and a modified hybrid partial product reduction tree (PPRT) scheme are proposed. The MAC can perform 1-way 32-bit, 4-way 16-bit signed/unsigned multiply or multiply-accumulate operations and 2-way parallel multiply add (PMADD) operations at a high frequency of 1.25 GHz under worst-case conditions and 1.67 GHz under typical-case conditions, respectively. Compared with the MAC in 32-bit microprocessor without interlocked piped stages (MIPS), the proposed design shows a great advantage in speed. Moreover, an improvement of up to 32% in throughput is achieved. The MAC design has been fabricated with Taiwan Semiconductor Manufacturing Company (TSMC) 90-nm CMOS standard cell technology and has passed a functional test.

关键词： Multiply-accumulator (MAC) Pipeline Compressor Partial product reduction tree (PPRT) Split structure

Removal of chloride from simulated acidic wastewater in the zinc production

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Chinese Journal of Chemical Engineering 2019年第5期27卷 1037-1043页

作者： Weizao Liu Li lu yao lu Xiaowei Hu Bin Liang College of Chemical Engineering Sichuan UniversityChengdu 610065China China Tin Group Co. Ltd.Liuzhou 545000China

The removal of chloride from the zinc electrolyte produced during hydrometallurgical zinc production is challenging. The ion-exchange method is a promising way to remove chloride if the resin washing wastewater can be recycled. This paper focuses on chloride removal from resin washing wastewater to enable its reuse. Various processing factors including the oxygen gas velocity, temperature, and reaction time were investigated systematically. The results show that the optimal conditions for dechlorination are an oxygen gas velocity of 0.5 L-min^-1, a reaction temperature of 80 ℃, and a reaction time of 30 min. A dechlorination efficiency of 80% with a residual chloride ion concentration less than 200 mg-L^-1 was achieved, which meets the requirements for the recycling of wastewater. The presence of manganese accelerates the dechlorination by forming a Mn^2+- MnO^2-MnO4^-Mn^2+ redox cycle. In this process, about 15 kg of the MnO2 and all of the zinc can be recovered from 100 m^3 wastewater, and the wastewater can be reused, which makes the ion-exchange method a promising technique for chloride removal.

关键词： Ion-exchange Dechlorination Ozone Zinc production Oxidation

Essential competencies for three grades of midwives in China

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International Journal of Nursing Sciences 2018年第1期5卷 18-23页

作者： Yazhen Yin jie Li Hong lu Jiasi yao Rui Hou School of Nursing Peking University Beijing China

Objective:To identify the essential competencies for different grades of midwives in ***:A nationwide modified Delphi process was implemented to amend and screen the *** expert panellists including practitioners (nurse-midwives),clinical managers,academic educators and obstetricians completed a two-round Delphi study through an electronic survey that was supplemented by an expert panel meeting for discussion of comments and ***:All panellists completed two rounds of Delphi study and at least 75% of them achieved a consensus on 224 items (W1 =0.150,W2 =0.173).Seven domains were established,namely,'Professional quality','Antenatal care','Intrapartum care','Postnatal care','Neonatal care','Gynaecological care','Public health care & Integrative competency'.Generalised maternal and neonatal knowledge and perinatal care skills were set for'junior'midwives,pathological care for'senior'ones and supervisory abilities and promotion of discipline for'expert'***:This research developed three grades of essential competencies for midwives in *** next step will be assessment in clinical settings for further *** set was in line with the concepts of International Confederation of Midwives under the domestic *** set could be adopted as a reference in developing normalised midwifery practice,education and certification.

关键词： Essential competency Grade Midwives

Catalytic Systems Containing p-Toluenesulfonic Acid for the Coupling Reaction of Formaldehyde and Methyl Formate

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Journal of Natural Gas Chemistry 2007年第3期16卷 286-292页

作者： Kebing Wang jie yao Yue Wang Gongying Wang Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 Sichuan China Graduate School of Chinese Academy of Sciences Beijing 100039 China

The coupling reaction of formaldehyde （FA） and methyl formate （MF） to form methyl glycolate （MG） and methyl methoxy acetate （MMAc）, catalyzed by p-toluenesulfonic acid （p-TsOH） as well as assisted by different kinds of solvents or Ni-containing compounds, had been investigated. The results showed that when the reaction was carried out at 140 ℃, with a molar ratio of FA to MF of 0.65 ： 1, molar fraction of p-TsOH to total feedstock of 11.0%, and reaction time of 3 h, the yield of MG and MMAc was 31.1% and 17.1%, respectively, p-TsOH catalyzed the coupling reaction by means of the synergistic catalysis of protonic acidity and soft basicity. Adding extra solvents to the reaction system was unfavorable for the reaction. The composite catalytic system consisting of p-TsOH and NiX2 （X=Cl, Br, I） exhibited a high catalytic performance for the coupling reaction, and NiX2 acted as a promoter in the reaction, whose promotion for the catalysis increased in the following order： NiCl2〈NiBr2〈NiI2. The present system is less corrosive when compared with the previous system, in which strong inorganic liquid acids were used as catalysts.

关键词： formaldehyde methyl formate methyl glycolate methyl methoxy acetate p-toluenesulfonicacid

Humidity sensor based on BiOBr synthesized under ambient condition

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Journal of Semiconductors 2022年第12期43卷 95-100页

作者： Chaofan Cao Guixian Xiao yao lu Second Affiliated Hospital Shenyang Medical CollegeShenyang 110035China State Key Laboratory of Automotive Safety and Energy School of Vehicle and MobilityTsinghua UniversityBeijing 100084China

Flexible humidity sensors are effective portable devices for human respiratory ***,the current pre-paration of sensitive materials need harsh terms and the small production output limits their ***,we report a syn-thesis method of single-crystal BiOBr nanosheets under room temperature and atmospheric pressure based on a sonochemic-al strategy.A flexible humidity sensor enabled by BiOBr nanosheets deliver efficient sensing performance,a high humidity sensit-ivity(Ig/I0=550%)with relative humidity from 40%to 100%,an excellent selectivity,and a detection response/recovery time of 11 and 6 s,*** flexible humidity sensor shows a potential application value as a wearable monitoring device for res-piratory disease prevention and health monitoring.

关键词： human breathing BiOBr nanosheets sonochemical strategy flexible humidity sensor