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Aquaporin-3 promotes proliferation and inflammation in hepatocellular carcinoma

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Genes & Diseases 2024年第4期11卷 45-48页

作者： yao Wang Yalan Wu Xueying Li Weiwei song Fengling Zheng Xiaoying Mo Yi Luo Yun Li song Chen Huanhuan Luo School of Basic Medical Sciences Guangzhou University of Chinese MedicineGuangzhouGuangdong 510006China The School of Health Guangzhou Vocational University of Science andTechnologyGuangzhouGuangdong 510555China Zhongshan Hospital of Traditional Chinese Medicine ZhongshanGuangdong 528401China The Journal Center Guangzhou University of Chinese MedicineGuangzhouGuangdong 510006China Jiangsu Vocational College of Medicine YanchengJiangsu 224005China Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong 510006China State Key Laboratory of Dampness Syndrome of Chinese Medicine GuangzhouGuangdong 510006China

Carcinogenesis is closely associated with *** have shown that lipopolysaccharides(LPS)can contribute to hepatocellular carcinoma(HC)development by inducing IL-6 and TNF-αproduction from the hepatic progenitor cells.1 Aquaporin 3(AQP3),a water channel protein,has recently been found to play a critical role in cancer-associated inflammation.

关键词： inflammation. hepatocellular inflammation

Green carbonization of waste coffee grounds into porous C/Fe hybrids for broadband and high-efficiency microwave absorption

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Journal of Materials Science & Technology 2024年第3期170卷 1-10页

作者： Xin Wen Cui Li hui Liu Guohua Fan Yanan Tang Chuncheng Hao Lili Ma Pingan song Institute of Advanced Electrical Materials College of Materials Science and EngineeringQingdao University of Science and TechnologyQingdao 266042China Center for Future Materials University of Southern QueenslandSpringfieldQLD 4300Australia School of Agriculture and Environmental Science University of Southern QueenslandSpringfieldQLD 4300Australia

Recently great effort s have been focused on designing high-performance microwave absorbers using sustainable biomass resources,but there remains a lack of green and efficient fabrication ***,inspired by natural porous character of biomass waste,we demonstrated a green one-step route to convert waste coffee grounds into porous C/Fe hybrids,and further explored their potential applications for broadband and high-efficiency microwave *** this design,the WCG-20-750(incorporated 20 wt%Fe(C_(5)H_(7)O_(2))_(3)catalyst and carbonized at 750℃)exhibited porous microstructure with the highest char yield of 55.45 wt%.Furthermore,the as-prepared C/Fe hybrids from WCG-20-750 displayed excellent microwave absorption ***,the minimum reflection loss(RL_(min))reached to-52.86 dB and the widest effective absorption bandwidth(EAB)was 6.40 GHz at the thickness of 3.0 *** work provides an economically viable and environmentally friendly strategy to convert biomass wastes into value-added microwave absorbers,ultimately making contributions to the upcycling of renewable biomass resources and the fostering of sustainable environment.

关键词： Waste recycling Microwave absorption Green carbonization Porous carbon Biomass

Ethical concerns in aging research: perspectives of global frontline researchers

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Science China Life Sciences 2024年第10期67卷 2149-2156页

作者： yaojin Peng Lulu Ding Zhenyu Xiao Moshi song Jianwei Lv Guang-hui Liu Key Laboratory of Organ Regeneration and Reconstruction State Key Laboratory of Stem Cell and Reproductive BiologyInstitute of ZoologyChinese Academy of Sciences University of Chinese Academy of Sciences Beijing Institute for Stem Cell and Regenerative Medicine Institute for Stem Cell and Regeneration Chinese Academy of Sciences Aging Biomarker Consortium (ABC) School of Life Science Beijing Institute of Technology School of Life Sciences Xiamen University Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical University Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical University

This study investigated the ethical landscape of aging research amid the increasing global focus on extending the human lifespan and health span. Our global survey of 180 researchers across 38 jurisdictions revealed divergent perceptions of aging, a consensus regarding the feasibility of delaying aging, and multiple perspectives regarding lifespan extension. The present findings underscore a paradigm shift toward inclusive and ethically sound research, emphasizing the need for an approach that strikes a balance between basic and clinical research. In addition, this study highlighted key ethical concerns in aging research, including the effects of misleading advertising, potential inequality in access to aging interventions, and risks pertaining to the extrapolation of research findings from lower-model organisms to humans. The insights presented in this paper call for an integrated approach for overcoming the complex ethical and societal challenges in aging research to ensure responsible and equitable advancements in this burgeoning field.

关键词： aging ethical landscape ethics surveys and questionnaires

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Methyl functionalization of trimesic acid in copper-based metal-organic framework for ammonia colorimetric sensing at high relative humidity

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Chinese Chemical Letters 2024年第6期35卷 211-215页

作者： Yuxin Wang Zhengxuan song Yutao Liu Yang Chen Jinping Li Libo Li Jia yao College of Chemical Engineering and Technology Shanxi Key Laboratory of Gas Energy Efficient and Clean UtilizationTaiyuan University of TechnologyTaiyuan 030024China Department of Gastroenterology Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuan 030024China

Exhaled ammonia(NH_(3))can be used as a crucial biomarker of kidney and liver ***,the high humidity in the detection conditions remains a challenge for accurate detection by gas ***,a copper-based metal-organic framework(CH_(3)-Cu-BTC)with methyl(CH_(3)^(-))functionalization of trimesic acid was synthesized for NH_(3) colorimetric *** CH_(3)-Cu-BTC exhibited a strong response for 5 ppm NH_(3) with high selectivity under high relative humidity(75%RH).Density functional theory(DFT)simulations indicated that the NH_(3) molecules interacted more strongly with CH_(3)-Cu-BTC than H_(2)O molecules did,and the corresponding color switching was attributed to the lone-pair electron in NH_(3) changing the coordination environment of Cu^(2+)ions,leading to an obviously visible color switching response from ruby green to *** on the tailor-made pore chemistry,the precise detection of trace amounts of NH_(3) in exhaled air was realized through functionalized MOF *** strategy used in this study not only offers a new pathway for the rapid detection of low concentration NH_(3) under humid conditions,but also shows a method for early respiration diagnosis of kidney and liver diseases.

关键词： Metal-organic framework Ammonia sensing Naked-eye color switching High humidity Respiration diagnosis

Testicular volume is a noninvasive predictor of sperm retrieval failure in idiopathic nonobstructive azoospermia

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Asian Journal of Andrology 2024年第4期26卷 421-425页

作者： Hong Xiao song-Xi Tang Rui-Jie yao Yi-Lang Ding Peng Yang Qiang Chen Hai-Lin Huang Xi Chen hui-Liang Zhou Department of Andrology and Sexual Medicine First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005China.

We investigated the prognostic importance of noninvasive factors in predicting sperm retrieval failure in idiopathic nonobstructive azoospermia(iNOA).We studied 193 patients with nonobstructive azoospermia who underwent microsurgical testicular sperm *** Chi-square test and Mann–Whitney U tests for clinical parameters and seminiferous tubule distribution were used for between-group comparisons.A logistic regression analysis was conducted to identify predictors of retrieval *** under the receiver operating characteristic curve for each variable was evaluated,and the net clinical benefit was calculated using a clinical decision *** with iNOA had a lower sperm retrieval rate than those with known ***,testicular volume was an independent factor affecting sperm extraction outcomes(odds ratio=0.79,P<0.05).The testicular volume cut-off value was 6.5 ml(area under the curve:0.694).The patients with iNOA were categorized into two groups on the basis of the distribution of seminiferous tubules *** sperm retrieval rate and testicular volume were significantly different between the groups with a uniform or heterogeneous tubule *** was also a significant association between a uniform tubule distribution and testicular *** conclusion,a testicular volume of more than 6.5 ml effectively predicts microsurgical testicular sperm extraction failure due to a uniform tubule distribution in patients with iNOA.

关键词： idiopathic nonobstructive azoospermia microsurgical testicular sperm extraction sperm retrieval failure testicular volume

Microplastic and Heavy Metals Distributions in Urban Rivers Sediments,China

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Journal of Ocean University of China 2024年第4期23卷 1015-1025页

作者： song Dandan SHANG Yujun WANG Xiuli ZHUANG Yuwei GUO hui BI Shuping HU Jianjun High and New Technology Research Center of Henan Academy of Sciences Zhengzhou 450002China Henan Provincial Cartographic Institute Zhengzhou 450008China

This study investigated the distribution of microplastics and heavy metals,along with the interaction between the two in the sediments of urban rivers in *** showed that the abundance of microplastics ranged from 2412±187.5 to 7638±1312items kg^(-1)dry sediment across different survey stations,with an average abundance at(4388±713)items kg^(-1)dry *** further categorization,it was found that transparent fragments were the primary color and type of microplastics *** potential ecological risk index(RI)of heavy metals in sediments suggested a low level of ecological risk within a majority of the urban rivers *** was identified as the main potential ecological risk factor in the sediments of the studied *** was a relatively good significant linear relationship between the RI of heavy metals and the abundance of microplastics,bolstering the linkage between these two environmental ***,the concentrations of heavy metals in microplastics were not dependent on their corresponding contents in *** fact,the concentration of Cu,Cd,and As in microplastics were higher than those in the *** finding confirmed that microplastics could serve as carriers of heavy metals and introduce potential risks to aquatic wildlife and human through the food chain.

关键词： microplastic heavy metals risk assessment river sediments

Inversion method of deflection of the vertical based on SWOT wide-swath altimeter data

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Geodesy and Geodynamics 2024年第4期15卷 419-428页

作者： Xin Liu Menghao song Chao Li Guihua hui Jinyun Guo Yongjun Jia Heping Sun College of Geodesy and Geomatics Shandong University of Science and TechnologyQingdao 266590China Weicheng Branch of Natural Resources and Planning Bureau of Weifang City Weifang 261021China National Satellite Ocean Application Service Beijing 100081China State Key Laboratoryof Geodesy and Earth's Dynamics Innovation AcademyforPrecision Measurement Science and TechnologyChinese Academy of ScienceWuhan 420071China

The deflection of the vertical(DOV)is the key information in the study of ocean gravity ***,in most areas,the precision of the prime component of DoV is significantly lower than that of the meridian *** obtain higher accuracy and resolution of ocean gravity information,researchers have proposed a novel altimeter called the wide-swath *** altimeter allows for the simultaneous acquisition of high-precision and high-resolution two-dimensional measurements of sea surface height(SSH).In this paper,the Surface Water and Ocean Topography(SWOT)mission with a wide-swath altimeter on board is selected for *** cycle of swoT sea surface height data is simulated to inverse the DOV in the Arabian Sea(45°E—80°E,0°-30°N),and the inversion results are compared with those of conventional altimeter *** results demonstrate that the difference between the meridian and prime components derived from the inversion of swoT wide-swath data is minimal,significantly outperforming the inversion results of conventional nadir altimeter *** advantage of swoT wide-swath altimeter lies in its ability to use the multi-directional geoid slope at any sea surface measurement point to invert the components in the meridian and prime *** investigate the impact of this advantage on inversion precision,this paper employs a method to calculate the gradient of the geoid in multiple directions to invert DoV *** improvement effect of calculating the gradient of the geoid in multiple directions on the precision of DoV component is *** is found that the accuracy of DoV inversion has significantly improved with the increase of geodetic gradient calculation *** addition,the effects of various errors and grid spacing in SwoT wide sea surface height data on the precision of Dov inversion are also analyzed.

关键词： SWOT Wide-swath altimeter Inversion method of Dov Multi-directional Arabian sea

Exploring the Cation Regulation Mechanism for Interfacial Water Involved in the Hydrogen Evolution Reaction by In Situ Raman Spectroscopy

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Nano-Micro Letters 2024年第3期16卷 303-312页

作者： Xueqiu You Dongao Zhang Xia‑Guang Zhang Xiangyu Li Jing‑Hua Tian yao‑hui Wang Jian‑Feng Li School of Ocean Information Engineering Fujian Provincial Key Laboratory of Oceanic Information Perception and Intelligent ProcessingJimei UniversityXiamen 361021People’s Republic of China State Key Laboratory of Physical Chemistry of Solid Surfaces MOE Key Laboratory of Spectrochemical Analysis and InstrumentationiChEMCollege of Chemistry and Chemical EngineeringCollege of MaterialsCollege of EnergyXiamen UniversityXiamen 361005People’s Republic of China Key Laboratory of Green Chemical Media and Reactions Ministry of EducationCollaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsCollege of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiang 453007People’s Republic of China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005People’s Republic of China

Interfacial water molecules are the most important participants in the hydrogen evolution reaction(HER).Hence,understanding the behavior and role that interfacial water plays will ultimately reveal the HER ***,investigating interfacial water is extremely challenging owing to the interference caused by bulk water molecules and complexity of the interfacial ***,the behaviors of interfacial water in different cationic electrolytes on Pd surfaces were investigated by the electrochemistry,in situ core-shell nanostructure enhanced Raman spectroscopy and theoretical simulation *** spectral evidence reveals a red shift in the frequency and a decrease in the intensity of interfacial water as the potential is shifted in the positively *** comparing the different cation electrolyte systems at a given potential,the frequency of the interfacial water peak increases in the specified order:Li+

关键词： In situ Raman Interfacial water Hydrogen evolution reaction Cations

Rapid analysis of metal ions and organic compounds in strong acidic solutions by nano-ESI mass spectrometry

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Chinese Chemical Letters 2024年第2期35卷 516-520页

作者： Jiaquan Xu Ting Li Zhendong Yu Lili song Xiu-Xiu Xu hui Li Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation East China University of TechnologyNanchang 330013China Department of Rehabilitation Medicine The First Affiliated Hospital of Nanchang UniversityNanchang 330006China

Rapid analysis of metal ions and organic compounds in strong acidic solutions is of sustainable interest in multiple ***,complicated and time-consuming pretreatments are always required for MS analysis of the compounds in strong acidic ***,it will result in a weak signal and cause serious damage to the mass ***,a simple method inherited from nano-ESI MS was developed for rapid analysis of strong acidic ***(nL)strong acidic solution was first loaded in the nano-ESI emitter,followed by evaporation to remove the H+and leave the analytes on the wall of the nano-ESI *** evaporation process can be completed within 1 min because of the extremely tiny volume(≤1 nL)of the loaded ***,the dried analytes on the wall of the nano-ESI emitter were redissolved by loading a new solvent,followed by nano-ESI MS *** using this method,metal ions and organic compounds in the strong acidic solution can be detected with low sample consumption(1 nL),high speed(90%).Proof-of-concept applications of the present method have been successfully achieved for the analysis of gastric juice(pH of the sample=1),monitoring reaction catalyzed by strong acid(pH of the system=0),and micro-area analysis of ores(pH of the extraction solvent=0),showing great application potential in multiple fields.

关键词： Strong acidic solutions Nano-ESI MS Rapid analysis Reaction monitoring Micro-area analysis Gastric juice analysis