检索结果-南通市图书馆

Successful treatment of patients with refractory idiopathic membranous nephropathy with low-dose Rituximab:A single-center experience

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2023年第3期11卷 566-575页

作者： yao-wei wang Xin-Hui wang Hong-Xia wang Ren-Huan Yu China Department of Nephrology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China

BACKGROUND The recognition of idiopathic membranous nephropathy(IMN)as an autoimmune disease has paved the way for the use of B-cell-depleting agents,such as Rituximab(RTX),which is now a first-line drug for treating IMN with proven safety and ***,the usage of RTX for the treatment of refractory IMN remains controversial and *** To evaluate the efficacy and safety of a new low-dose RTX regimen for the treatment of patients with refractory *** A retrospective study was performed on refractory IMN patients that accepted a low-dose RTX regimen(RTX,200 mg,once a month for five months)in the Xiyuan Hospital of Chinese Academy of Chinese Medical Sciences’Department of Nephrology from October 2019 to December *** assess the clinical and immune remission data,we performed a 24 h urinary protein quantification(UTP)test and measured the serum albumin(ALB)and serum creatinine(SCr)levels,phospholipase A2 receptor(PLA2R)antibody titer,and CD19+B-cell count every three *** A total of nine refractory IMN patients were *** follow-up conducted twelve months later,the results from the 24 h UTP decreased from baseline[8.14±6.05 g/d to 1.24±1.34 g/d(P<0.05)]and the ALB levels increased from baseline[28.06±8.42 g/L to 40.93±5.85 g/L(P<0.01)].Notably,after administering RTX for six months,the SCr decreased from 78.13±16.49μmol/L to 109.67±40.87μmol/L(P<0.05).All of the nine patients were positive for serum anti-PLA2R at the beginning,and four patients had normal anti-PLA2R titer levels at six *** level of CD19+B-cells decreased to 0 at three months,and CD19+B-cell count remained at 0 up until six months of *** Our low-dose RTX regimen appears to be a promising treatment strategy for refractory IMN.

关键词： Refractory nephrotic syndrome Idiopathic membranous nephropathy Low-dose rituximab

Synthesis and cytotoxic activity of novel curcumin analogues

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2008年第3期19卷 281-285页

作者： Qin Zhang yao Fu Hao wei wang Tao Gong Yong Qin Zhi Rong Zhang Key Laboratory of Drug Targeting Drug Delivery Systems Ministry of Education West China School of Pharmacy Sichuan University Chengdu 610041 China

Five novel curcumin analogues bearing different substituents at 4-position of phenyl group were synthesized. Their structures were confirmed by NMR and HRMS spectrum. Their cytotoxic activities against six tumor cell lines were tested by the standard MTT assay in vitro. The results indicated that four analogues （1A-1C, 1E） with solubilizing moieties showed selective potent cytotoxicity against HepG2, HeLa and CT26 cell lines, and analogue 1A and 1C exhibited more potent cytotoxicity than curcumin against CT26 cell line. It was suggested that introduction of appropriate substituents to 4-position of phenyl group might be a potential option for structural modification of curcumin.

关键词： Curcumin analogues Synthesis Cytotoxic activity Anti-tumor activity

A LINEAR DYNAMIC MODEL DESCRIBING LYMPH CIRCULATION

在线全文

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2009年第1期21卷 118-123页

作者： yao wei wang Sheng-zhang DING Guang-hong SHEN Xue-yong Department of Mechanics and Engineering Science Fudan University Shanghai 200433 China Shanghai Research Center of Acupuncture and Meridian Shanghai 201203 China Acupuncture Department of Shanghai University of Traditional Chinese Medicine Shanghai 200032 China

The lymph circulation plays an important role in interstitial fluid balance, protein transport, and immune system. However, its mechanism is poorly understood, and associated pathologies are mostly untreatable. By following Sungawa＇s method of discussing the heart output, a hemodynamic model of lymph circulation was set up. The model was used to demonstrate how the lymphatic fluid formation, investigate the relationship between the lymph flow rate QL and physiological parameters, and explore how local massage influences QL Computer simulation results show that QL is linearly proportional to the interstitial fluid pressure P~, which is similar to experimental observations. Comparing the simulated value of QL during the massage of different frequency with the experimental data from Ikomi shows that they are identical, which indicates that the presented model is rational to explain the mechanism of massage treatment in traditional Chinese medicine （TCM）.

关键词： lymph circulation pressure-volume circle equivalent elastance massage treatment in TCM

Boosting Oxygen Evolution Reaction Performance on NiFe‑Based Catalysts Through d‑Orbital Hybridization

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第1期17卷 281-292页

作者： Xing wang wei Pi Sheng Hu Haifeng Bao Na yao wei Luo State Key Laboratory of New Textile Materials and Advanced Processing Technology Key Laboratory of New Textile Materials and Applications of Hubei ProvinceSchool of Materials Science and EngineeringWuhan Textile UniversityWuhan 430200People’s Republic of China College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072People’s Republic of China

Anion-exchange membrane water electrolyzers(AEMWEs)for green hydrogen production have received intensive attention due to their feasibility of using earth-abundant NiFe-based *** introducing a third metal into NiFe-based catalysts to construct asymmetrical M-NiFe units,the d-orbital and electronic structures can be adjusted,which is an important strategy to achieve sufficient oxygen evolution reaction(OER)performance in ***,the ternary NiFeM(M:La,Mo)catalysts featured with distinct M-NiFe units and varying d-orbitals are reported in this *** and theoretical calculation results reveal that the doping of La leads to optimized hybridization between d orbital in NiFeM and 2p in oxygen,resulting in enhanced adsorption strength of oxygen intermediates,and reduced rate-determining step energy barrier,which is responsible for the enhanced OER *** critically,the obtained NiFeLa catalyst only requires 1.58 V to reach 1 A cm^(−2) in an anion exchange membrane electrolyzer and demonstrates excellent long-term stability of up to 600 h.

关键词： NiFe-based catalysts d-orbital coupling Oxygen evolution reaction Anion exchange membrane electrolyzer

Significance of changes of gastrointestinal peptides in blood and ileum of experimental spleen deficiency rats

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2003年第3期9卷 553-556页

作者： Li-Sheng Li Rui-yao Qu wei wang Hua Guo Department of Physiology,Capital University of Medical Sciences,100054,Beijing,China Department of Physiology Capital University of Medical Sciences 100054 Beijing China. lls@***

AIM: To explore the mechanism of spleen deficiency (SD)by studying the relationship of gastro-intestinal peptides level and ileal electro-mechanical activity of SD rats and cold restrain ***: (1) spleen deficiency (SD) model was established by feeding Houpou:Zhishi: Dahuang in the ratio of 3:3:2,3 ml/time, for 42 days. (2) The cold restrain stress model:Animals were restrained on grille and placed in a cool water at 18 °C for 3 h. (3) Substance P (SP) and vasoactive intestinal peptide (VIP) levels in all layers of initial part of ileum and blood in rats were measured by radioimmunoassays (RIA)while changes of electric activity and motility in ileum of rats were recorded with electrode and strain ***: SP levels in ileum and blood of experimental SD rats were significantly higher than that of the control groups (9.89±5.65 vs 1.22±1.18, P＜0.005, in ileum; 22.7±3.95 vs6.60±1.47, P＜0.001, in blood) while the VIP levels of theSD rats were significantly lower than that of the controls (3.50±2.01 vs9.10±4.91, P＜0.05, in ileum; 229.8±62.4 vs560.4±151.3, P＜0.001, in blood). As compared with the controls, the average frequency of slow electric waves (21.3±0.96 vs18.2±2.28, P＜0.05) and motility (21.5±0.58vs 18±2.65, P＜0.005) of SD rats increased obviously and the frequency of fast waves of SD rat also increased. In spontaneous recovery cases, SP levels recovered significantly (compared with the SD groups, 2.99±0.62 vs 9.89±5.65,P＜0.001, in ileum; 14.4±4.22 vs 22.7±3.95, P＜0.001, in blood) but did not drop to normal. After the SD rats treated with Chinese herbs (Jiawei Sijun zi Tang), SP improved (compared with SD cases, 2.20±1.25 vs9.89±5.65, (P＜0.001),in ileum; 10.7±1.88 vs 22.7±3.95, (P＜0.001), in blood)and VIP in blood also improved (compared with SD rats,485.7±229.0 vs 229.8±62.4, P＜0.01) while the amplitude of motility decreased apparently (compared with the SD rats,0.64±0.096 vs0.89±0.15, P＜0.01). The ileal SP levels of cool stress didn't change while t

关键词：胃肠缩氨酸脾缺乏症血浆回肠动物实验放射免疫法

The study between the dynamics and the X-ray anatomy and regularizing effect of gallbladder on bile duct sphincter of the dog

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2003年第5期9卷 1014-1019页

作者： Jing-Guo wei yao-Cheng wang Guo-Min Liang wei wang Bao-Ying Chen Jia-Kuan Xu Li-Jun Song Radiology Department of Tangdu Hospital,Fourth Military Medical University,Xi’an 710038,Shaanxi Province,China Radiology Department of Tangdu Hospital Fourth Military Medical University Xi''an 710038 Shaanxi Province Chin

AIM: To study the relationship between the radiological anatomy and the dynamics on bile duct sphincter in bile draining and regulatory effect of ***: Sixteen healthy dogs weighing 18 kg to 25 kg were divided randomly into control group and experimental group (cholecystectomy group). Cineradiography, manometry with perfusion, to effect of endogenous cholecystokinin and change of ultrastructure were ***: According to finding of the choledochography and manometry, in control group the intraluminal basal pressure of cephalic cyclic smooth muscle of choledochal sphincter cCS was 9.0+2.0 mmHg and that of middle oblique smooth muscle of choledochal sphincter (mOS) was 16.8+0.5 mmHg,the intraluminal basal pressure of cCS segment was obviously lower than that of mOS (P＜0.01) in the interval period of bile draining, but significant difference of intraluminal basal pressure of the mOS segment was not found between the interval period of bile draining (16.8+0.5 mmHg) and the bile flowing period (15.9±0.9 mmHg) (P＞0.05). The motility of cCS was mainly characterized by rhythmically concentric contraction, just as motility of cCS bile juice was pumped into the mOS segment in control group. And motility of mOS segment showed mainly diastolic and systolic activity of autonomically longitudinal peristalsis. There was spasmodic state in cCS and mOS segment and reaction to endogenous cholecystokinin was debased after cholecystectomy. The change of ultrastructure of cCS portion showed mainly that the myofilaments of cell line in derangement and mitochondria is ***: During fasting, the cCS portion has a function as similar cardiac 'pump' and it is main primary power source in bile draining, and mOS segment serves mainly as secondary power in bile draining. The existence of the intact gallbladder is one of the important factors in guaranteeing the functional coordination between the cCS and mOS of bile duct sphincter. There is dysfunction in t

关键词：胆管胆囊括约肌生物动力学 X线检查解剖结构动物实验胆囊切除术

Role of iron ore in enhancing gasification of iron coke:Structural evolution,influence mechanism and kinetic analysis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 58-69页

作者： Jie wang wei wang Xuheng Chen Junfang Bao Qiuyue Hao Heng Zheng Runsheng Xu School of Chemistry and Materials Science Hubei Engineering UniversityXiaogan 432000China Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081China Institue of Ironmaking Technology Baosteel Central Research InstituteShanghai 201999China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

The utilization of iron coke provides a green pathway for low-carbon *** uncover the influence mechanism of iron ore on the behavior and kinetics of iron coke gasification,the effect of iron ore on the microstructure of iron coke was ***,a comparative study of the gasification reactions between iron coke and coke was conducted through non-isothermal thermogravimetric *** findings indicate that compared to coke,iron coke exhibits an augmentation in micropores and specific surface area,and the micropores further extend and *** provides more adsorption sites for CO_(2) molecules during the gasification process,resulting in a reduction in the initial gasification temperature of iron *** the heating rate in non-isothermal gasification can enhance the reactivity of iron *** metallic iron reduced from iron ore is embedded in the carbon matrix,reducing the orderliness of the carbon structure,which is primarily responsible for the heightened reactivity of the carbon *** kinetic study indicates that the random pore model can effectively represent the gasification process of iron coke due to its rich pore ***,as the proportion of iron ore increases,the activation energy for the carbon gasification gradually decreases,from 246.2 kJ/mol for coke to 192.5 kJ/mol for iron coke 15wt%.

关键词： low-carbon ironmaking iron coke gasification structural evolution kinetic model

在线全文

学校读者我要写书评

暂无评论

基于逐维策略的布谷鸟搜索增强算法

计算机工程与科学 2017年第1期39卷 165-172页

作者：林要华王维福建农林大学计算机与信息学院 61198部队

布谷鸟搜索算法迭代运用Lévy Flights随机走动和Biased随机走动发现新个体的各维信息。当个体所有维信息生成后,算法将这些信息合成为个体并评价。在这种情况下,由于个体各维之间存在相互干扰,一些部分维进化的个体可能被放弃,从而影... 详细信息

布谷鸟搜索算法迭代运用Lévy Flights随机走动和Biased随机走动发现新个体的各维信息。当个体所有维信息生成后,算法将这些信息合成为个体并评价。在这种情况下,由于个体各维之间存在相互干扰,一些部分维进化的个体可能被放弃,从而影响算法的收敛速度以及求精能力。提出的布谷鸟搜索增强算法采用逐维评价策略接收一些部分进化的个体,可进一步增强算法的收敛速度和求精能力。在算法中,逐维评价策略作为局部搜索技术镶嵌在两个随机走动部件之后,并随机选择一些个体进行逐维更新后进行评价。实验结果说明逐维评价策略总体上能够有效且较好地改善算法的求解性能和收敛速度。

关键词：布谷鸟搜索算法逐维评价逐维改进局部搜索

NOS inhibition in the dendate gyrus improves the impairment of spatial learning and memory in AD model rats

在线全文

学校读者我要写书评

暂无评论

NOS inhibition in the dendate gyrus improves the impairment ...