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Chinese Journal of Integrative Medicine 2024年第4期30卷 379-384页

作者： XIN li TAN Guo-yao ZHANG Qiang ZHANG qun Good Clinical Practice Development Guangdong Provincial Key Laboratory of Bone and Joint Degeneration DiseasesThe Third Affiliated Hospital of Southern Medical UniversityGuangzhou(510630)China Department of Pharmacy Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou(510120)China

Phellodendron(PN)species,traditionally used in Chinese medicine for centuries,hold promise as a potential treatment for osteoporosis(OP)and osteoarthritis(OA)due to their bioactive *** bioactive compounds,including berberine and palmatine,exhibit anti-inflammatory,antioxidant,and bone-protective properties,contributing to their potential therapeutic benefits in promoting bone health and preventing bone ***,challenges such as the need for standardized preparation and dosing,limited clinical studies,and potential interactions with other medications hinder their clinical ***,the rich history of PN species in Chinese medicine provides a promising foundation for future investigation into their potential as alternative treatments for OP and *** research is needed to fully understand the underlying mechanisms of action and explore the clinical implications of PN for bone health.

关键词： Phellodendron species bone health osteoporosis osteoarthritis review

Simultaneous monitoring of the fluorescence and refractive index by surface plasmon coupled emission: A proof-of-concept study

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Chinese Chemical Letters 2023年第10期34卷 82-85页

作者： lin-Tao Xu Kai-Xin Xie Shuo-Hui Cao Yu-Hua Weng Min Chen Zhao li yao-qun li Department of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis&Instrumentation College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Department of Chemistry Taiyuan Normal UniversityJinzhong 030619China Department of Electronic Science Xiamen UniversityXiamen 361005China

Simultaneous acquisition of fluorescence property and refractive index using a single surface plasmon coupled emission(SPCE)measurement has been achieved,thus achieving synchronicity in real *** SPCE sensor was employed for monitoring the adsorption of volatile organic compounds(VOCs)by dyeencapsulated metal-organic frameworks(Dye@MOFs).Refractive index can reveal surface molecular adsorption and the fluorescence with information on refractive index can provide a comprehensive analysis of the adsorption events of VOCs on the ***,the signal intensity can be amplified by combining the responses caused by changes in refractive index and the fluorescence property in *** all-in-one method opens up a route to monitoring multiple processes simultaneously occurring on the interface.

关键词： Fluorescence with refractive index information Surface plasmon coupled emission Volatile organic compounds Dye-encapsulated metal-organic frameworks All-in-one method

血清MMP-9水平与大动脉粥样硬化型脑卒中患者颈动脉斑块新生血管的相关性研究

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中国血液流变学杂志 2024年第1期34卷 32-35,148页

作者：李超张恩迪姚丽群郑媛媛周小雪罗海龙牡丹江医学院附属红旗医院神经内科黑龙江牡丹江157011 牡丹江医学院黑龙江牡丹江157011

目的分析血清中基质金属蛋白酶-9(MMP-9)与大动脉粥样硬化型脑卒中(LAA)患者颈动脉斑块新生血管的相关性。方法选取120例经常规超声检查发现颈动脉粥样硬化斑块形成的患者作为研究对象,并根据患者在72 h内是否发生急性缺血性脑卒中分为... 详细信息

目的分析血清中基质金属蛋白酶-9(MMP-9)与大动脉粥样硬化型脑卒中(LAA)患者颈动脉斑块新生血管的相关性。方法选取120例经常规超声检查发现颈动脉粥样硬化斑块形成的患者作为研究对象,并根据患者在72 h内是否发生急性缺血性脑卒中分为实验组和对照组,两组各60例。比较两组患者不同颈动脉斑块狭窄程度、斑块回声、新生血管情况,并通过SMI检测颈部斑块新生血管情况,并分析血清中MMP-9水平与大动脉粥样硬化型脑卒中患者颈动脉斑块新生血管的关系,分析颈动脉斑块特征及相关危险因素与大动脉粥样硬化型脑梗死之间的关系。结果实验组斑块内新生血管高于对照组(P<0.05);有新生血管组UA、Lp(a)、MMP-9水平升高及糖尿病患者人数均高于无新生血管组(P<0.05)且MMP-9为主要因素。结论血清中MMP-9水平与斑块内新生血管形成密切相关,且斑块内新生血管与LAA发病率相关。

关键词：基质金属蛋白酶-9 大动脉粥样硬化型脑卒中斑块新生血管

Early monitoring values of oncogenic signalling molecules for hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2350-2361页

作者： Min yao Rong-Fei Fang qun Xie Min Xu Wen-li Sai Deng-Fu yao Department of Immunology Medical School of Nantong University and Research Center of Clinical MedicineThe Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Gastroenterology The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Infectious Diseases Haian People’s HospitalHaian 226600Jiangsu ProvinceChina Research Center of Clinical Medicine The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina

The prevention and early diagnosis of liver cancer remains a global medical *** the malignant transformation of hepatocytes,a variety of oncogenic cellular signalling molecules,such as novel high mobility group-Box 3,angiopoietin-2,Golgi protein 73,glypican-3,Wnt3a(a signalling molecule in the Wnt/β-catenin pathway),and secretory clusterin,can be expressed and secreted into the *** signalling molecules are derived from different signalling pathways and may not only participate in the malignant transformation of hepatocytes but also become early diagnostic indicators of hepatocarcinogenesis or specific targeted molecules for hepatocellular carcinoma *** article reviews recent progress in the study of several signalling molecules as sensitive biomarkers for monitoring hepatocarcinogenesis.

关键词： Hepatocarcinogenesis Cell signals Specific biomarkers Early diagnosis

A novel topology with controllable wideband baseband impedance for power amplifiers

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Frontiers of Information Technology & Electronic Engineering 2024年第2期25卷 308-315页

作者： yao yao Zhijiang DAI Mingyu li School of Intelligent Technology and Engineering Chongqing University of Science and TechnologyChongqing400065China School of Microelectronics and Communication Engineering Chongqing UniversityChongqing400065China

This paper presents a novel topology to control the baseband impedance of a power amplifier(PA)to avoid performance deterioration in concurrent dual-band *** topology can avoid pure resonance of capacitors and inductors LC,which leads to a high impedance at some frequency ***,it can be applied to transmitters that are excited by broadband *** particular,by adjusting the circuit parameters and increasing stages,the impedance of the key frequency bands can be flexibly controlled.A PA is designed to support this design *** saturated output power is around 46.7 dBm,and the drain efficiency is>68.2%(1.8-2.3 GHz).Under concurrent two-tone excitation,the drain efficiency reaches around 40%even under 5.5 dB back-off power with the tone spacing from 10 MHz to 500 *** results demonstrate that the proposed topology is capable of controlling wideband baseband impedance.

关键词： Baseband impedance Concurrent dual-band Power amplifier

Meta label associated loss for fine-grained visual recognition

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Science China(Information Sciences) 2024年第6期67卷 230-247页

作者： Yanchao li Fu XIAO Hao li qun li Shui YU School of Computer Science Nanjing University of Posts and Telecommunications School of Network Engineering Zhoukou Normal University School of Computer Science University of Technology Sydney

Recently, intensive attempts have been made to design robust models for fine-grained visual recognition, most notably are the impressive gains for training with noisy labels by incorporating a reweighting strategy into a meta-learning framework. However, it is limited to up or downweighting the contribution of an instance for label reweighting approaches in the learning process. To solve this issue, a novel noise-tolerant method with auxiliary web data is proposed. Specifically, first, the associations made from embeddings of well-labeled data with those of web data and back at the same class are measured. Next, its association probability is employed as a weighting fusion strategy into angular margin-based loss, which makes the trained model robust to noisy datasets. To reduce the influence of the gap between the well-labeled and noisy web data, a bridge schema is proposed via the corresponding loss that encourages the learned embeddings to be coherent. Lastly, the formulation is encapsulated into the meta-learning framework, which can reduce the overfitting of models and learn the network parameters to be noise-tolerant. Extensive experiments are performed on benchmark datasets, and the results clearly show the superiority of the proposed method over existing state-of-the-art approaches.

关键词： label associated loss weighting noisy samples fine-grained visual recognition noise-tolerant learning meta-learning

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Data-driven active vibration control for helicopter with trailing-edge flaps using adaptive dynamic programming

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Chinese Journal of Aeronautics 2024年第6期37卷 151-166页

作者： Yu CHEN qun ZONG Xiuyun ZHANG Jinna li School of Electrical and Information Engineering Tianjin UniversityTianjin 300072China School of Information and Control Engineering Liaoning Petrochemical UniversityFushun 113001China

The helicopter Trailing-Edge Flaps(TEFs)technology is one of the recent hot topics in morphing wing *** employing controlled deflection,TEFs can effectively reduce the vibration level of ***,designing specific vibration reduction control methods for the helicopters equipped with trailing-edge flaps is of significant practical *** paper studies the optimal control problem for helicopter-vibration systems with TEFs under the framework of adaptive dynamic programming combined with Reinforcement Learning(RL).Time-delay and disturbances,caused by complexity of helicopter dynamics,inevitably deteriorate the control performance of vibration *** solve this problem,a zero-sum game formulation with a linear quadratic form for reducing vibration of helicopter systems is presented with a virtual *** this context,an off-policy reinforcement learning algorithm is developed to determine the optimal control *** algorithm utilizes only vertical vibration load data to achieve a policy that reduces vibration,attains Nash equilibrium,and addresses disturbances while compensating for time-delay without knowledge of the dynamics of the helicopter *** effectiveness of the proposed method is demonstrated in a virtual platform.

关键词： Active control Adaptive dynamic program-ming Helicopter rotor Vibration control Zero-sum game

A Selective‑Response Hypersensitive Bio‑Inspired Strain Sensor Enabled by Hysteresis Effect and Parallel Through‑Slits Structures

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Nano-Micro Letters 2024年第2期16卷 139-153页

作者： qun Wang Zhongwen yao Changchao Zhang Honglie Song Hanliang Ding Bo li Shichao Niu Xinguan Huang Chuanhai Chen Zhiwu Han Luquan Ren Key Laboratory of Bionic Engineering(Ministry of Education) Jilin UniversityChangchunJilin 130022People’s Republic of China liaoning Academy of Materials LiaoningShenyang 110167People’s Republic of China Key Laboratory of CNC Equipment Reliability(Ministry of Education) Jilin UniversityChangchunJilin 130022People’s Republic of China

Flexible strain sensors are promising in sensing minuscule mechanical signals,and thereby widely used in various advanced ***,the effective integration of hypersensitivity and highly selective response into one flexible strain sensor remains a huge ***,inspired by the hysteresis strategy of the scorpion slit receptor,a bio-inspired flexible strain sensor(BFSS)with parallel through-slit arrays is designed and ***,BFSS consists of conductive monolayer graphene and viscoelastic styrene–isoprene–styrene block *** the synergistic effect of the bio-inspired slit structures and flexible viscoelastic materials,BFSS can achieve both hypersensitivity and highly selective frequency ***,the BFSS exhibits a high gage factor of 657.36,and a precise identification of vibration frequencies at a resolution of 0.2 Hz through undergoing different morphological changes to high-frequency vibration and low-frequency ***,the BFSS possesses a wide frequency detection range(103 Hz)and stable durability(1000 cycles).It can sense and recognize vibration signals with different characteristics,including the frequency,amplitude,and *** work,which turns the hysteresis effect into a"treasure,"can provide new design ideas for sensors for potential applications including human–computer interaction and health monitoring of mechanical equipment.

关键词： Bio-inspired strain sensors Hysteresis effect Hypersensitivity Selective frequency response Health monitoring applications

Torque limit-based Inertial Control Method Based on Delayed Support for Primary Frequency Control of Wind Turbines

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 561-570页

作者： Wei Gu Zaiyu Chen qun li Minghui Yin Qiang li Yun Zou School of Automation Nanjing University of Science and TechnologyNanjing 210094China State Grid Jiangsu Electric Power Co. Ltd.Research InstituteNanjing 211103China

To avoid the secondary frequency dip caused by the steep drop of the electrical power of wind turbines(WTs)at the end of frequency support stage,the torque limit-based iner-tial control(TliC)method sets the power reference as a linear function of rotor speed,rather than the step form for the step-wise inertial ***,the compensation effect on the frequency nadir(FN)caused by the load surge is weakened as the TliC power is no longer in the step ***,the maximum point of the frequency response component(FRC)contributed by TliC occurs earlier than the minimum point of FRC corresponding to the load surge,so that the FN cannot be adequately ***,this paper first investigates the relation between the peak and nadir times of FRCs stimulated by the TliC and load *** this basis,with the compensation principle of matching the peak and nadir times of FRCs,the improved TliC method based on delayed support is ***,the effectiveness of the proposed method is validated via the experiments on the test bench of wind-integrated power system.

关键词： Wind turbine frequency response component torque limit inertial control delayed support

A Spectrometric Setup for Synchronous Total Internal Reflection Fluorescence Measurement at the Solid/liquid Interface

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Chinese Chemical Letters 2002年第6期13卷 571-572页

作者： yao qun li Jia Ju XU Run Tang WANG li Jun YU Zhao li Department of Chemistry and the Key Laboratory of Analytical Sciences of MOE Xiamen UniversityXiamen 361005

A spectrometric setup to perform total internal reflection fluorescence (TIRF) and synchronous TIRF measurements at solid/liquid interfaces is presented. The combination of TIRF and synchronous fluorescence was proposed to analyze simultaneously different components at interfaces. The TIRF excitation, emission and synchronous spectra of a watersoluble porphyrin were obtained from water/glass interface using this setup without the existence of a surfactant.

关键词： Total internal reflection fluorescence synchronous fluorescence spectrofluorimeter meso-tetra(4-sulfonatophenyl)porphyrin.