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Inflammation scores predict survival for hepatitis B virus-related hepatocellular carcinoma patients after transarterial chemoembolization

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World Journal of Gastroenterology 2015年第18期21卷 5582-5590页

作者： Dong-Sheng Zhou Li Xu yao-ling luo Feng-Ying He Jun-Ting Huang yao-Jun Zhang Min-Shan Chen Department of Hepatobiliary Surgery Sun Yat-sen University Cancer Center Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Department of Clinical Laboratory Sun Yatsen University Cancer Center

AIM:To compare the prognostic ability of inflammation scores for patients with hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC)undergoing transarterial chemoembolization(TACE).METHODS:Data of 224 consecutive patients who underwent TACE for unresectable HBV-related HCC from September 2009 to November 2011 were retrieved from a prospective *** association of inflammation scores with clinicopathologic variables and overall survival(OS)were analyzed,and receiver operating characteristic curves were generated,and the area under the curve(AUC)was calculated to evaluate the discriminatory ability of each inflammation score and staging system,including tumor-node-metastasis,Barcelona Clinic Liver Cancer,and Cancer of the Liver Italian Program(CLIP)***:The median follow-up period was 390 d,the one-,two-,and three-year OS were 38.4%,18.3%,and 11.1%,respectively,and the median OS was *** Glasgow Prognostic Score(GPS),modifed GPS,neutrophil-lymphocyte ratio,and Prognostic Index were associated with *** GPS consistently had a higher AUC value at 6 mo(0.702),12 mo(0.676),and24 mo(0.687)in comparison with other inflammation *** consistently had a higher AUC value at6 mo(0.656),12 mo(0.711),and 24 mo(0.721)in comparison with tumor-node-metastasis and Barcelona Clinic Liver Cancer staging *** analysis revealed that alanine aminotransferase,GPS,and CLIP were independent prognostic factors for *** combination of GPS and CLIP(AUC=0.777)was superior to CLIP or GPS alone in prognostic ability for ***:The prognostic ability of GPS is superior to other inflammation scores for HCC patients undergoing *** GPS and CLIP improved the prognostic power for OS.

关键词： Hepatocellular carcinoma Inflammation-based prognostic score Prognostic index Staging system Transarterial chemoembolization

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Infinitely Many Solutions for a Class of Quasi-linear Elliptic Problem

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 728-743页

作者： Xiao-yao JIA Zhen-luo LOU School of Economics and Management Zhongyuan University of TechnologyZhengzhou 450007China Mathematics and Statistics School Henan University of Science and TechnologyLuoyang 471023China

In this paper,we study the following quasi-linear elliptic equation:■where Ω?R^(N) is a bounded domain,λ>0 is a *** function ψ(|t|)t is the subcritical term,and φ(|t|)t is the critical Orlicz-Sobolev growth term with respect to φ.Under appropriate conditions on φ,ψ and φ,we prove the existence of infinitely many weak solutions for quasi-linear elliptic equation,for λ∈(0,λ_(0)),where λ_(0)> 0 is a fixed constant.

关键词： quasi-linear elliptic equations variational methods Orlicz-Sobolev spaces

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Transient breathing dynamics during extinction of dissipative solitons in mode‑locked fiber lasers

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Frontiers of Optoelectronics 2024年第1期17卷 9-19页

作者： Zichuan Yuan Si luo Ke Dai Xiankun yao Chenning Tao Qiang ling Yusheng Zhang Zuguang Guan Daru Chen Yudong Cui Hangzhou Institute of Advanced Studies Zhejiang Normal UniversityHangzhou 311231China State Key Laboratory of Modern Optical Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Optical Information Detection and Display Technology of Zhejiang Zhejiang Normal UniversityJinhua 321004China School of Physics Northwest UniversityXi’an 710127China

The utilization of the dispersive Fourier transformation approach has enabled comprehensive observation of the birth process of dissipative solitons in fiber ***,there is still a dearth of deep understanding regarding the extinction process of dissipative *** this study,we have utilized a combination of experimental and numerical techniques to thoroughly examine the breathing dynamics of dissipative solitons during the extinction process in an Er-doped mode-locked fiber *** results demonstrate that the transient breathing dynamics have a substantial impact on the extinction stage of both steady-state and breathing-state dissipative *** duration of transient breathing exhibits a high degree of sensitivity to variations in pump *** simulations are utilized to produce analogous breathing dynamics within the framework of a model that integrates equations characterizing the population inversion in a mode-locked *** results corroborate the role of Q-switching instability in the onset of breathing ***,these findings offer new possibilities for the advancement of various operational frameworks for ultrafast lasers.

关键词： Breathing soliton Fiber laser Dispersive Fourier transform Q-switched instability

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Revealing effect of Al content on oxidation of novel Co-Cr-Nb-W carbide-strengthened superalloy

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Rare Metals 2024年第9期43卷 4521-4534页

作者： Chen ling Shang-Ping Li Jie Hou He-Li luo Central Iron&Steel Research Institute Beijing 100081China Beijing GAONA Materials&Technology Co. Ltd.Beijing 100081China

The high-temperature oxidation behavior of novel Co-Cr-Nb-W carbide-strengthened wear-resistance alloys with different Al contents(1wt%,2wt%and 3wt%)at 950,1000 and 1050℃was thoroughly investigated by scanning electron microscopy,X-ray diffraction,X-ray photoelectron spectroscopy and field emission electron probe *** porous property of NbC in-situ oxidation products(Nb_(2)O_(5),Co Nb_(2)O_(6)and Co_(4)Nb_(2)O_(9))induces a multi-layered oxide scale with micropores and ***-Cr-Nb-W alloy with 1 wt%Al undergoes catastrophic oxidation and spalling above 1000℃.The outward transportation of Cr and Co is effectively restrained by a continuous Al_(2)O_(3)scale formed around NbC in-situ oxidation region when Al content reaches 3 wt%.The β-Co Al in Co-Cr-Nb-W alloy with 3 wt%Al has an oxidation priority over eutectic carbides and the alloy matrix which are both enriched with Cr,thereby preventing the formation of Cr-depletion area and improving the self-healing ability of the oxide film.A slight change in Al content has a remarkable influence on the cooperative effect of Al and Cr and multiplies the antioxidant capacity of Co-Cr-Nb-W alloy above 1000℃.

关键词： High-temperature oxidation behavior Oxidation kinetics Superalloy Wear-resistant alloy Microstructure

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Room-temperature hydrogen adsorption in Pd nanoparticle decorated UiO-66-NH2 via spillover

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Particuology 2024年第10期93卷 309-315页

作者： Jingchuan Wang Junhong luo Yong yao Jiangfeng Song Yan Shi Institute of Materials China Academy of Engineering PhysicsJiangyou621908China

To improve room-temperature hydrogen storage, palladium (Pd) nanoparticles were innovatively decorated by carbon bridge onto the amino-group functioned Zr-terephthalate metal-organic framework (MOF) UiO-66 to reduce the diffusion energy barrier and then improve the hydrogen spillover effect. Powder X-ray diffraction shows broad Pd peak and retained UiO-66-NH_(2) integrity after Pd decoration. The hydrogen uptake capacity show that UiO-66-NH_(2)-Pd exhibits best hydrogen storage performance than UiO-66-NH_(2) and pristine UiO-66. The hydrogen up taken in Pd decorated UiO-66 (UiO-66-NH_(2)-1Pd) was close to 4 wt% under 20 MPa at room temperature. Density functional theory (DFT) calculations show that hydrogen adsorption energy of UiO-66-NH_(2)-Pd was −0.5897 eV, which was much lower than that of UiO-66-NH_(2) (−0.3716 eV) and UiO-66 (−0.2975 eV). Ultimately, Pd decorated NH_(2) group functioned UiO-66 enable improve storage capacities through hydrogen spillover under ambient conditions which could satisfy the demand for sustainable energy, especially for the long-term storage energy media.

关键词： Hydrogen storage UiO-66-NH_(2) Pd decorated Spillover

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Genetic analysis of Chinese families reveals a novel truncation allele of the retinitis pigmentosa GTPase regulator gene

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International Journal of Ophthalmology(English edition) 2014年第5期7卷 753-758页

作者： Fang Hu Xiang-Yun Zeng Lin-Lin Liu yao-ling luo Yi-Ping Jiang Hui Wang Jing Xie Cheng-Quan Hu Lin Gan Liang Huang Department of Ophthalmology the First Affiliated HospitalGannan Medical University Flaum Eye Institute and Department of Ophthalmology School of Medicine and DentistryUniversity of Rochester

AIMTo make comprehensive molecular diagnosis for retinitis pigmentosa (RP) patients in a consanguineous Han Chinese family using next generation sequencing based Capture-NGS screen technology.

关键词： retinitis pigmentosa GTPase regulator retinitis pigmentosa next-generation sequencing genetic diagnosis

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A Survey of Knowledge Graph Construction Using Machine Learning

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 225-257页

作者： Zhigang Zhao Xiong luo Maojian Chen ling Ma School of Computer and Communication Engineering University of Science and Technology BeijingBeijing100083China Shunde Innovation School University of Science and Technology BeijingFoshan528399China Beijing Key Laboratory of Knowledge Engineering for Materials Science Beijing100083China

Knowledge graph(KG)serves as a specialized semantic network that encapsulates intricate relationships among real-world entities within a structured *** framework facilitates a transformation in information retrieval,transitioning it from mere string matching to far more sophisticated entity *** this transformative process,the advancement of artificial intelligence and intelligent information services is ***,the role ofmachine learningmethod in the construction of KG is important,and these techniques have already achieved initial *** article embarks on a comprehensive journey through the last strides in the field of KG via machine *** a profound amalgamation of cutting-edge research in machine learning,this article undertakes a systematical exploration of KG construction methods in three distinct phases:entity learning,ontology learning,and knowledge ***,a meticulous dissection of machine learningdriven algorithms is conducted,spotlighting their contributions to critical facets such as entity extraction,relation extraction,entity linking,and link ***,this article also provides an analysis of the unresolved challenges and emerging trajectories that beckon within the expansive application of machine learning-fueled,large-scale KG construction.

关键词： Knowledge graph(KG) semantic network relation extraction entity linking knowledge reasoning

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Superexchange and charge transfer in the nickelate superconductor La_(3)Ni_(2)O_(7) under pressure

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Science China(Physics,Mechanics & Astronomy) 2024年第11期67卷 1-8页

作者： Wéi Wú Zhihui luo Dao-Xin yao Meng Wang Center for Neutron Science and Technology Guangdong Provincial Key Laboratory of Magnetoelectric Physics and DevicesSchool of PhysicsSun Yat-sen UniversityGuangzhou 510275China

Recently, a bulk nickelate superconductor La_(3)Ni_(2)O_(7) is discovered at pressures with a remarkable high transition temperature T_(c)~ 80 K. Here, we study a Hubbard model with tight-binding parameters derived from ab initio calculations of La_(3)Ni_(2)O_(7),by employing large scale determinant quantum Monte Carlo and cellular dynamical mean-field theory. Our result suggests that the superexchange couplings in this system are comparable to that of cuprates. The system is a charge transfer insulator as the hole concentration becomes four per site at large Hubbard U. Upon hole doping, two low-energy spin-singlet bands emerge in the system exhibiting distinct correlation properties: while the one composed of the out-of-plane Ni-d_(3z^(2)-r^(2)) and O-p_(z) orbitals demonstrates strong antiferromagnetic correlations and narrow effective bandwidth, the in-plane singlet band consisting of the Ni-d_(x^(2)-y^(2)) and O-p_(x)/p_(y) orbitals is in general more itinerant. Over a broad range of hole doping, the doped holes occupy primarily the d_(x^(2)-y^(2)) and p_(x)/p_(y) orbitals, whereas the d_(3z^(2)-r^(2)) and p_(z) orbitals retain underdoped. We propose an effective t-J model to capture the relevant physics and discuss the implications of our result for comprehending the La_(3)Ni_(2)O_(7) superconductivity.

关键词： superconductivity nickelate superconductors Hubbard model superexchange charge transfer insulator quantum Monte Carlo

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Performance improvements in complementary metal oxide semiconductor devices and circuits based on fin field-effect transistors using 3-nm ferroelectric Hf_(0.5)Zr_(0.5)O_(2)

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Rare Metals 2024年第7期43卷 3242-3249页

作者： Zhao-Hao Zhang Yan-Na luo Gao-Bo Xu Jia-Xin yao Zhen-Hua Wu Hong-Bin Zhao Qing-Zhu Zhang Hua-Xiang Yin Jun luo Wen-Wu Wang Hai-ling Tu Integrated Circuit Advanced R&D Center Institute of Microelectronics of Chinese Academy of SciencesBeijing 100029China School of Integrated Circuits University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Advanced Materials for Smart Sensing General Research Institute for Nonferrous MetalsBeijing 100088China

In this work,a conventional HfO_(2) gate dielectric layer is replaced with a 3-nm ferroelectric(Fe) HZO layer in the gate stacks of advanced fin field-effect transistors(FinFETs).Fe-induced characteristics,e.g.,negative drain induced barrier lowering(N-DIBL) and negative differential resistance(NDR),are clearly observed for both p-and n-type HZO-based *** characteristics are attributed to the enhanced ferroelectricity of the 3-nm hafnium zirconium oxide(HZO) film,caused by Al doping from the TiAlC capping *** mechanism is verified for capacitors with structures similar to the *** to the enhanced ferroelectricity and N-DIBL phenomenon,the drain current(I_(DS))of the HZO-FinFETs is greater than that of HfO_(2)-FinFETs and obtained at a lower operating ***,circuits based on HZO-FinFET achieve higher performance than those based on HfO_(2)-FinFET at a low voltage drain(V_(DD)),which indicates the application feasibility of the HZO-FinFETs in the ultralow power integrated circuits.

关键词： FinFET Ferroelectric Hafnium zirconium oxide Subthreshold swing Low power

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Identification of in situ Generated Iron-Vacancy Induced Oxygen Evolution Reaction Kinetics on Cobalt Iron Oxyhydroxide

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Chinese Journal of Chemistry 2024年第4期42卷 343-350页

作者： Na yao Juan Zhu Hongnan Jia Hengjiang Cong Wei luo College of Chemistry and Molecular Sciences Wuhan UniversityWuhanHubei430072 China

Developing highly efficient and low-cost electrocatalysts towards oxygen evolution reaction(OER)is essential for practical application in water electrolyzers and rechargeable metal-air *** Fe-based oxyhydroxides are regarded as state-of-the-art non-noble OER electrocatalysts,the origin of performance enhancement derived from Fe doping remains a hot topic of considerable ***,we demonstrate that in situ generated Fe vacancies in the pristine CoFeOOH catalyst through a pre-conversion process during alkaline OER result from dynamic Fe dissolution,identifying the origin of Fe-vacancy-induced enhanced OER *** functional theory(DFT)calculations and experimental results including X-ray absorption fine-structure spectroscopy,in situ UV-Vis spectroscopy,and in situ Raman spectroscopy reveal that the Fe vacancies could significantly promote the d-band center and valence states of adjacent Co sites,alter the active site from Fe atom to Co atom,accelerate the formation of high-valent active Co^(4+)species,and reduce the energy barrier of the potential-determining step,thereby contribute to the significantly enhanced OER performance.

关键词： CoFe oxyhydroxide Oxygen evolution reaction Fe vacancy Electrocatalysis Kinetics Reaction mechanisms

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