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Clinical features and treatment of near-work-related acquired esotropia

International Journal of Ophthalmology(English edition) 2022年第8期15卷 1338-1343页

作者： Rui-lin Guo Li-Kun Ai shi-Qiang Zhao Department of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren Hospital of Capital Medical UniversityBeijing 100730China

AIM:To investigate the characteristics of near-workrelated esotropia and the clinical efficacy of botulinum toxin type A(BTXA)injection therapy on ***:A total of 107 patients aged 15-57y with near-work-related esotropia were taken as the BTXA-treated group,and 30 other peers without near-work-related esotropia were included in the control *** participants were refractive corrected to analyse the clinical characteristics of near-work-related *** subjects were examined including Worth4 spot examination,stereoscopic vision,strabismus angle,accommodative convergence to accommodation ratio(AC/A),far and near positive and negative convergence,positive and negative fusion range,positive and negative relative *** efficacy was evaluated at a period of 10mo ***:The distant and near stereopsis were found in 84.9%and 77.5%of patients in the BTXA-treated group,*** the control group,all patients had distant and near *** incidence of taking off one's glasses to see close objects was significantly higher in the BTXA-treated group than in the control group(P<0.05).The BTXA-treated group showed a smaller range of infusion(9.84±5.72)°than the control group(22.04±8.71)°(P<0.05).The near esotropia angle of the BTXA-treated group(17.08±11.98)△was significantly smaller than the distant esotropia angle(19.07±11.68)△(P<0.05).Ten months after injection,the diplopia and esotropia of most patients underwent improvements after treatment(P<0.05).CONCLUSION:This study reveals that the accommodation function and the habit of near work without wearing spectacles are associated with near-work-related esotropia,while the length of time for near work and the onset time are independent of near-work-related ***,BTXA injection therapy plays a vital role in relieving diplopia and restoring eye position.

关键词： esotropia near-work botulinum toxin accommodation electromyography

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产教融合背景下燃料电池专业教学的建设

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电池 2024年第2期54卷 287-289页

作者：徐树正石璐郑州商学院文学与新闻传播学院河南郑州451200 首都师范大学教育学院北京100048

燃料电池技术发展迅速,传统的教学模式存在产学脱节、场景单一化等问题,已无法满足行业的需求。为提升学生学习燃料电池课程的效果,基于产教融合,提出对燃料电池课程进行专业教学体系建设,改进教学模式,建设实践教学平台,设计专业课程内... 详细信息

燃料电池技术发展迅速,传统的教学模式存在产学脱节、场景单一化等问题,已无法满足行业的需求。为提升学生学习燃料电池课程的效果,基于产教融合,提出对燃料电池课程进行专业教学体系建设,改进教学模式,建设实践教学平台,设计专业课程内容,并初步评估教学实践成效。

关键词：产教融合燃料电池专业课程设计教学实践

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论经筋针刺的辨证施治思维

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中华中医药学刊 2024年第5期42卷 61-64页

作者：吴锡董宝强林星星富昱刘紫薇史佳芯张峰辽宁中医药大学辽宁沈阳110847

经筋作为经络理论的重要组成部分,在临床上对以针灸推拿为核心的中医外治疗法发挥着重要的指导作用。经筋针刺临床应用领域众多,但缺少明确的辨证施治思维及其相关作用机制的研究。故通过释析经筋实质及发病机制,探讨经筋针刺的临床应... 详细信息

经筋作为经络理论的重要组成部分,在临床上对以针灸推拿为核心的中医外治疗法发挥着重要的指导作用。经筋针刺临床应用领域众多,但缺少明确的辨证施治思维及其相关作用机制的研究。故通过释析经筋实质及发病机制,探讨经筋针刺的临床应用方法,从中医“整体观念”及“辨证论治”角度为经筋病的诊断与治疗提供统一的辨证施治思路,并论述《内经》“解结”法应用到经筋针刺的作用机制,以期为经筋针刺理论体系的完善与发展提供新思路。

关键词：经筋经筋辨证解结辨证施治作用机制

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上海轨道交通既有线运能提升研究

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城市轨道交通研究 2024年第10期27卷 135-139页

作者：施董燕周明上海申通地铁集团有限公司技术中心上海201103 上海申通地铁集团有限公司运营管理部上海201103

[目的]通过总结上海城市轨道交通既有线运能提升改造项目的实施经验,为其提出有效的运能提升方法及具体案例。[方法]深入分析上海轨道交通既有线运能不足的主要原因及其影响因素;基于这些分析,提出运能提升的技术路线及5大核心策略;详... 详细信息

[目的]通过总结上海城市轨道交通既有线运能提升改造项目的实施经验,为其提出有效的运能提升方法及具体案例。[方法]深入分析上海轨道交通既有线运能不足的主要原因及其影响因素;基于这些分析,提出运能提升的技术路线及5大核心策略;详细介绍了上海轨道交通9号线实现1 min 50 s最小行车间隔、3号线与4号线增能改造、5号线从4节编组扩编至6节编组、6号线增能改造及增设复线等成功案例。[结果及结论]影响线路运能的主要因素包括车辆基地规模、区间通过能力、出入场能力,以及供电能力等。针对这些因素,确定了运能提升的技术路线,即从客流预测及客流特征分析入手,进行设施设备能力评估,设计行车交路方案,最终形成科学的改造方案。同时,提出了5大策略:运营管理优化、既有系统能力挖潜及改造、信号系统升级或土建局部改造、系统规模性改造及线网整体优化。

关键词：城市轨道交通运能提升线路通过能力评估既有线改造

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On the Sublinear Convergence Rate of Multi-block ADMM

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Journal of the Operations Research Society of China 2015年第3期3卷 251-274页

作者： Tian-Yi lin shi-Qian Ma Shu-Zhong Zhang Department of Systems Engineering and Engineering Management The Chinese University of Hong KongShatinNew TerritoriesHong KongChina Department of Industrial and Systems Engineering University of MinnesotaMinneapolisMN 55455USA

The alternating direction method of multipliers(ADMM)is widely used in solving structured convex optimization *** its success in practice,the convergence of the standard ADMM for minimizing the sum of N(N≥3)convex functions,whose variables are linked by linear constraints,has remained unclear for a very long ***,Chen et al.(Math Program,doi:10.1007/s10107-014-0826-5,2014)provided a counter-example showing that the ADMM for N≥3 may fail to converge without further *** the ADMM for N≥3 has been very successful when applied to many problems arising from real practice,it is worth further investigating under what kind of sufficient conditions it can be guaranteed to *** this paper,we present such sufficient conditions that can guarantee the sublinear convergence rate for the ADMM for N≥***,we show that if one of the functions is convex(not necessarily strongly convex)and the other N-1 functions are strongly convex,and the penalty parameter lies in a certain region,the ADMM converges with rate O(1/t)in a certain ergodic sense and o(1/t)in a certain non-ergodic sense,where t denotes the number of *** a by-product,we also provide a simple proof for the O(1/t)convergence rate of two-blockADMMin terms of both objective error and constraint violation,without assuming any condition on the penalty parameter and strong convexity on the functions.

关键词： Alternating direction method of multipliers Sublinear convergence rate Convex optimization

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Effect of luteolin on apoptosis and vascular endothelial growth factor in human choroidal melanoma cells

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International Journal of Ophthalmology(English edition) 2021年第2期14卷 186-193页

作者： Meng-lin shi Yu-Fen Chen Hong-Fei Liao Nanchang University Nanchang 330000Jiangxi ProvinceChina Jiangxi Province Blood Center Nanchang 330052Jiangxi ProvinceChina Jiangxi Research Institute of Ophthalmology&Visual Sciences Nanchang 330000Jiangxi ProvinceChina Department of Ophthalmology the Affiliated Eye Hospital of Nanchang UniversityNanchang 330000Jiangxi ProvinceChina

AIM:To investigate the effects of luteolin on apoptosis,the cell cycle,and the expression and secretion of vascular endothelial growth factor(VEGF)in human choroidal melanoma cells(C918 and OCM-1).METHODS:C918 and OCM-1 cells cultured in vitro were treated with various concentrations of luteolin(0,5,10,15μmol/L).Cell growth was observed with an inverted microscope,and cell cycle arrest was detected by propidium iodide(PI)staining using flow *** was detected by Hoechst33342 staining,and apoptosis rate was determined by Annexin V-FITC/PI experiments using flow *** expression of apoptosis-related proteins Bcl-2,Bax and VEGF was analyzed using Western *** levels of VEGF secreted by the cells into the supernatant was analyzed using ***:After treating with 5 to 15μmol/L luteolin for 48 h,the fusion degree of C918 and OCM-1 cells decreased,and more floating apoptotic cells *** treatment increased the G0-G1 phase ratio of the C918 and OCM-1 cells,blocked cell cycle progression,and increased the apoptosis rate of the C918 and OCM-1 *** blot showed that luteolin decreased the expression of Bcl-2 and VEGF in the C918 and OCM-1 cells and increased the expression of Bax *** ELISA results showed that 10 to 15μmol/L luteolin decreased the cell secretion of ***:Luteolin may induce apoptosis by regulating the levels of apoptosis-related proteins in C918 and OCM-1 *** can induce cell cycle arrest,decrease the expression of VEGF.

关键词： luteolin human choroidal melanoma cells apoptosis cell cycle vascular endothelial growth factor

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Seven-years post allogeneic hematopoietic stem cell transplantation pure red cell aplastic anemia cured with daratumumab:A case report and review of literature

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World Journal of Clinical Cases 2024年第24期12卷 5604-5612页

作者： Bo Deng Rui Gao Bing Yang Wen-Bing Lei Ming-Fang Xue Ji-shi Wang Peng Zhao Department of Haematology Guizhou HospitalThe First Affiliated Hospital of Sun Yat-sen UniversityGuiyang 550001Guizhou ProvinceChina Department of Hematology The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550001Guizhou ProvinceChina School of Clinical Medicine Guizhou Medical UniversityGuiyang 550001Guizhou ProvinceChina Department of Hematology The Affiliated Hospital of Guizhou Medical UniversityHematological Institute of Guizhou ProvinceGuiyang 550001Guizhou ProvinceChina

BACKGROUND Allogeneic hematopoietic stem cell transplantation(Allo-HSCT)is currently the only viable method of curing patients with acute myeloid *** 30%to 50%of patients,donors and recipients have some level of ABO blood group *** blood group incompatibility can cause antibodies against the donor's red blood cells to persist in the recipient's body,resulting in a delay of several months in the recovery of red blood cells.A number of different treatments have been reported for post-transplant pure red cell aplastic anaemia(PRCA),such as plasmapheresis,donor lymphocyte infusions,anti-thymocyte globulin,rituximab and *** SUMMARY A 41-year-old female diagnosed with acute myeloid leukaemia underwent peripheral blood allogeneic haematopoietic stem cell transplantation in November 2013 from an HLA matched unrelated *** donor was AB-positive and the recipient was *** patient was diagnosed with PRCA three months after receiving the donor stem cell *** failing multiple lines of therapy,the patient applied for *** receiving three doses of daratumumab,the patient developed a reticulocyte response and no longer required CONCLUSION The use of daratumumab anti-CD38 for the remove of plasma cells is safe and effective and may be tried for refractory patients with PRCA after undergoing allo-HSCT for ABO incompatibility.

关键词： Transplantation PRCA Daratumumab Leukemia blood-group Case report

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荜澄茄化学成分及一对新的单萜对映异构体的鉴定和抗炎活性研究

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药学学报 2024年第5期59卷 1348-1356页

作者：陆玫霖黄婉凤何宇铭王宝林袁富红张婷潘其明徐新亚何佳韩珊王琴琴杨世林高红伟广西中医药大学药学院广西南宁530200 广西中医药大学海洋药物研究院广西南宁530200 江西中医药大学药学院江西南昌330000

综合运用正相硅胶、ODS、Sephadex LH-20凝胶柱色谱,反相和手性HPLC及重结晶等分离方法从荜澄茄(山鸡椒Litsea cubeba的干燥成熟果实)甲醇浸提物中分离得到18个化合物,通过波谱数据分析和与文献对比确定化合物的结构,并通过实验和量子... 详细信息

综合运用正相硅胶、ODS、Sephadex LH-20凝胶柱色谱,反相和手性HPLC及重结晶等分离方法从荜澄茄(山鸡椒Litsea cubeba的干燥成熟果实)甲醇浸提物中分离得到18个化合物,通过波谱数据分析和与文献对比确定化合物的结构,并通过实验和量子化学计算电子圆二色谱确定对映异构体的绝对构型。分别鉴定为(+)-(R)-4-hydroxypiperitenone(1a)、(-)-(S)-4-hydroxypiperitenone(1b)、(3S,4S,6R)-3,6-dihydroxy-1-menthene(2)、(4S,5R)-4-羟基-5-异丙基-2-甲基环己-2-烯-1-酮(3)、(R)-6-羟基-3-(2-羟基异丙基)-6-甲基环己-2-烯-1-酮(4)、(4S,6R)-4-羟基-6-异丙基-3-甲基环己-2-烯-1-酮(5)、(1R,3S,4R)-3-羟基异胡薄荷醇(6)、subamone(7)、(6S)-3,7-dimethyl-7-hydroxy-2(Z)-octen-6-olide(8)、(6S)-6,7-二羟基-3,7-二甲基辛-2(Z)-烯酸甲酯(9)、holostylactone(10)、芝麻脂素(11)、二甲基罗汉松脂素(12)、p-hydroxybenzoylcarbinol(13)、丁香醛(14)、对羟基苯甲醛(15)、4-羟基-3-甲氧基苯甲醛(16)、5,4?-二羟基-7-甲氧基黄酮(17)。其中化合物1a和1b为一对新的单萜对映异构体,8和9为新天然产物,2~7、10~11和17均为首次从木姜子属植物中分离得到。化合物1~17体外抗炎活性测试结果表明,在40μmol·L-1的浓度下,化合物14具有显著的抗炎活性,对脂多糖诱导的小鼠腹腔巨噬细胞(RAW264.7)中NO的产生有抑制作用,抑制率为66.27%。

关键词：樟科山鸡椒荜澄茄单萜对映异构体抗炎

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Brassinosteroid signaling and molecular crosstalk with nutrients in plants

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遗传学报:英文版 2023年第8期50卷 541-553页

作者： Chao Han lingyan Wang Jinyang Lyu Wen shi Lianmei yao Min Fan Ming-Yi Bai The Key Laboratory of Plant Development and Environmental Adaptation Biology Ministry of EducationSchool of Life SciencesShandong UniversityQingdaoShandong 266237China

As sessile organisms,plants have evolved sophisticated mechanisms to optimize their growth and development in response to fluctuating nutrient ***(BRs)are a group of plant steroid hormones that play critical roles in plant growth and developmental processes as well as plant responses to environmental ***,multiple molecular mechanisms have been proposed to explain the integration of BRs with different nutrient signaling processes to coordinate gene expression,metabolism,growth,and ***,we review recent advances in understanding the molecular regulatory mechanisms of the BR signaling pathway and the multifaceted roles of BR in the intertwined sensing,signaling,and metabolic processes of sugar,nitrogen,phosphorus,and *** understanding and exploring these BR-related processes and mechanisms will facilitate advances in crop breeding for higher resource efficiency.

关键词： Brassinosteroids Sugar Nitrogen Phosphorus Iron

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血流导向密网支架桥接治疗神经纤维瘤病Ⅰ型相关儿童颅内动脉瘤一例

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中国脑血管病杂志 2024年第7期21卷 472-475页

作者：师林吕丙波任宝鑫王岷孙德州王东海山东大学齐鲁医院德州医院神经外科 253000

儿童颅内动脉瘤在临床上较为少见,其发病机制目前尚不明确,治疗方式也存在诸多争议。作者报道了1例采用2枚血流导向密网支架桥接治疗的神经纤维瘤病Ⅰ型相关的儿童颅内动脉瘤,并结合相关文献进行了分析,希望为探索儿童颅内动脉瘤的治疗... 详细信息

儿童颅内动脉瘤在临床上较为少见,其发病机制目前尚不明确,治疗方式也存在诸多争议。作者报道了1例采用2枚血流导向密网支架桥接治疗的神经纤维瘤病Ⅰ型相关的儿童颅内动脉瘤,并结合相关文献进行了分析,希望为探索儿童颅内动脉瘤的治疗提供有益参考。

关键词：颅内动脉瘤神经纤维瘤病Ⅰ型儿童血流导向装置

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