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Nano-Micro Letters 2025年第2期17卷 401-416页

作者： chen li Leilei liang Baoshan Zhang Yi Yang Guangbin Ji School of Electronic Science and Engineering Nanjing UniversityNanjing 210093People’s Republic of China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration ***,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@C/PDMS microwave absorption *** top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass ***,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS layer via strong magneto-electric *** theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of ***,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.

关键词： Microwave absorption Radar-infrared compatible stealth Wrinkled MXene Magneto-dielectric synergy Multifunction

重组人TNF-α诱导乳腺癌细胞ZR75-1凋亡及其机制的初步研究

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癌症 2006年第5期25卷 560-565页

作者：李瑶琛孔令洪李康生汕头大学医学院微生物学与免疫学研究室广东汕头515031 西安交通大学生命科学与技术学院癌症研究所陕西西安710061

背景与目的:肿瘤坏死因子α(TNF-α)是抗肿瘤活性较强的细胞因子,是重要的抗肿瘤生物治疗制剂之一,但由于其对人体有较严重的副作用,临床应用受到了限制。为了降低其毒副作用,同时保留其抗肿瘤能力,TNF-α的突变体——突变型471TNF-α... 详细信息

背景与目的:肿瘤坏死因子α(TNF-α)是抗肿瘤活性较强的细胞因子,是重要的抗肿瘤生物治疗制剂之一,但由于其对人体有较严重的副作用,临床应用受到了限制。为了降低其毒副作用,同时保留其抗肿瘤能力,TNF-α的突变体——突变型471TNF-α应运而生。本研究对重组人突变型471rhTNF-α与野生型rhTNF-α蛋白的抗肿瘤能力进行了比较,并对突变型471rhTNF-α诱导ZR75-1细胞发生凋亡的作用机制进行初步研究。方法:以乳腺癌细胞系ZR75-1为靶细胞,以基因组DNA琼脂糖凝胶电泳及流式细胞技术分析100"g/L突变体471rhTNF-α与100"g/L野生型rhTNF-α作用ZR75-1细胞12h,肿瘤细胞发生凋亡的情况;利用以EliSA为基础的TransAMTMNF-κBp65试剂盒检测10μg/L、50μg/L和100μg/L突变体471rhTNF-α或野生型rhTNF-α作用ZR75-1细胞4h后核因子NF-κB的活化情况。结果:2%琼脂糖凝胶电泳显示,突变体471rhTNF-α处理组的ZR75-1细胞基因组DNA呈现明显的“ladder”状分布,野生型rhTNF-α处理组的“ladder”条带明显减弱;流式细胞仪分析显示,突变型471rhTNF-α诱导的凋亡峰面积为(44.6±3.6)%,野生型rhTNF-α诱导凋亡峰面积占(24.7±2.7)%,两组差异具有显著性(P0.05)。NF-κB活化检测结果显示,50"g/L野生型rhTNF-α处理ZR75-1细胞4h后NF-κB的活化量(A值为3.27±0.1)明显高于突变型471rhTNF-α处理组(A值为1.51±0.2)。结论:突变型471rhTNF-α比野生型rhTNF-α具有更强的诱导ZR75-1细胞凋亡的能力;ZR75-1细胞内NF-κB活化明显受限是突变型471rhTNF-α诱导凋亡能力增强的主要原因之一。

关键词：乳腺肿瘤 ZR75-1细胞突变型471rhTNF-α 核因子N-αB 凋亡生物治疗

Low-temperature chlorination roasting technology for the simultaneous recovery of valuable metals from spent liCoO_(2)cathode material

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 80-91页

作者： Junjie Shi Changle Hou Jingjing Dong Dong chen Jianzhong li Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

With the continuous increase in the disposal volume of spent lithium-ion batteries(liBs),properly recycling spent liBs has become essential for the advancement of the circular *** study presents a systematic analysis of the chlorination roasting kinetics and proposes a new two-step chlorination roasting process that integrates thermodynamics for the recycling of liB cathode *** activation energy for the chloride reaction was 88.41 kJ/mol according to thermogravimetric analysis–derivative thermogravimetry data obtained by using model-free,model-fitting,and Z(α)function(αis conversion rate).Results indicated that the reaction was dominated by the first-order(F1)model when the conversion rate was less than or equal to 0.5 and shifted to the second-order(F2)model when the conversion rate exceeded *** conditions were determined by thoroughly investigating the effects of roasting temperature,roasting time,and the mass ratio of NH_(4)Cl to liCoO_(2).Under the optimal conditions,namely 400℃,20 min,and NH_(4)Cl/liCoO_(2)mass ratio of 3:1,the leaching efficiency of li and Co reached 99.43% and 99.05%,*** of the roasted products revealed that valuable metals in liCoO_(2)transformed into CoCl_(2) and ***,the reaction mechanism was elucidated,providing insights for the establishment of a novel low-temperature chlorination roasting technology based on a crystal structure *** technology can guide the development of liB recycling processes with low energy consumption,low secondary pollution,high recovery efficiency,and high added value.

关键词： spent lithium-ion battery thermodynamics chlorination roasting kinetics circular economy

Fabrication of carbon-supported Al2O3 nanoparticles via spontaneous cross-linking to enhance selective hydrogenation of furfural

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Journal of Energy Chemistry 2025年第1期100卷 612-620页

作者： Weiwei Yu Xinbao Zhang Hongyu chen Yanan Wang Shaoguo li Fucun chen Zhenni liu Xiujie li Xiangxue Zhu State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences

Selective hydrogenation of furfural to furfuryl alcohol is a great challenge in the hydrogenation field due to thermodynamic preference for hydrogenation of C=C over C=***,a novel Al2O3/C-u hybrid catalyst,composed of N-modified dendritic carbon networks supporting Al2O3nanoparticles,was successfully prepared via carbonizing the freeze-dried gel from spontaneous cross-linking of alginate,Al3+and *** obtained carbon-supported Al2O3hybrid catalyst has a high ratio （31%） of Al species in pentahedral-coordinated *** introduction of urea enhances the surface N content,the ratio of pyrrolic N,and specific surface area of catalyst,leading to improved adsorption capacity of C=O and the accessibility of active *** the furfural hydrogenation reaction with isopropyl alcohol as hydrogen donor,Al2O3/C-u catalyst achieved a 90%conversion of furfural with 98.0% selectivity to furfuryl alcohol,outperforming that of commercial γ-***,Al2O3/C-u demonstrates excellent catalytic stability in the recycling tests attributed to the synergistic effect of abundant weak Lewis acid sites and the anchoring effect of the carbon network on *** work provides an innovative and facile strategy for fabrication of carbon-supported Al2O3hybrid catalysts with rich AlVspecies,serving as a high selective hydrogenation catalyst through MPV reaction route.

关键词： Selective hydrogenation Furfural Furfuryl alcohol Cross-linking Carbon supported Al 2 O 3 MPV route

微RNA-34a在乳腺癌中的表达及其基因启动子甲基化

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肿瘤 2016年第12期36卷 1354-1361页

作者：段卫明姚利李伟陈凯陶敏陈子兴苏州大学附属第一医院肿瘤科江苏苏州215006 苏州大学附属第一医院江苏省血液研究所白血病实验室江苏苏州215006

目的 :探讨人乳腺癌组织中微RNA-34a(micro RNA-34a,mi R-34a)的表达及其临床意义,并分析mi R-34a基因启动子甲基化状态与成熟mi R-34a表达及患者生存的相关性。方法 :采用Taq Man探针-实时荧光定量PCR法检测93例乳腺癌组织及5例良性乳... 详细信息

目的 :探讨人乳腺癌组织中微RNA-34a(micro RNA-34a,mi R-34a)的表达及其临床意义,并分析mi R-34a基因启动子甲基化状态与成熟mi R-34a表达及患者生存的相关性。方法 :采用Taq Man探针-实时荧光定量PCR法检测93例乳腺癌组织及5例良性乳腺疾病标本(作为对照)中成熟mi R-34a的表达。运用Epi Tect Fast FFPE Bisulfi te试剂盒对石蜡包埋乳腺癌组织的基因组DNA进行抽提及亚硫酸盐修饰,然后采用甲基化特异性PCR法检测mi R-34a基因启动子的甲基化状态。统计学分析mi R-34a基因启动子甲基化状态与mi R-34a表达量之间的关系,并用生存曲线分析其预后意义。结果 :乳腺癌组织中成熟mi R-34a的表达水平比良性对照组明显降低(P=0.006)。mi R-34a表达水平与肿瘤大小(r=-0.312,P=0.021)、淋巴结转移(r=-0.378,P=0.004)和肿瘤分级(r=-0.341,P=0.011)均呈负相关性,而与雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)和人表皮生长因子受体2(human epidermal growth factor receptor-2,HER-2)等水平均不相关(P均>0.05)。mi R-34a基因启动子非甲基化组的成熟mi R-34a表达水平明显高于甲基化阳性单一模式组和甲基化阳性混合模式组(P值均<0.001)。与非甲基化组和甲基化阳性混合模式组相比,mi R-34a基因甲基化阳性组的乳腺癌患者无复发生存期(P<0.001,P=0.019)及总生存期(P=0.002,P<0.001)均明显缩短。结论 :在部分乳腺癌患者中,mi R-34a基因甲基化可导致mi R-34a表达下调。mi R-34a基因的甲基化状态与乳腺癌的复发及不良预后相关。

关键词：乳腺肿瘤微RNAs DNA甲基化预后 mi R-34a

改进的遗传算法在连续体结构多目标拓扑优化中的应用

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力学季刊 2008年第3期29卷 481-486页

作者：葛培明李尧臣同济大学航空航天与力学学院上海200092

连续体结构多目标拓扑优化是结构优化领域中的一个较难的研究课题。本文提出了一种改进的SPEA2多目标优化算法。该算法中采用数学形态学中的四方向链码的编码方式进行结构拓扑表达,使产生的拓扑结构清晰且无异议,完全消除了模糊的拓扑... 详细信息

连续体结构多目标拓扑优化是结构优化领域中的一个较难的研究课题。本文提出了一种改进的SPEA2多目标优化算法。该算法中采用数学形态学中的四方向链码的编码方式进行结构拓扑表达,使产生的拓扑结构清晰且无异议,完全消除了模糊的拓扑边界和棋盘格现象。提出了"质量向量"的概念,用以量化两个结构拓扑之间的相似性,从而使得不同结构拓扑之间的相似性比较成为可能。同时还将机器学习中的范例学习的思想融入到新算法中,利用前面的有限元分析结果对后来的结构分析进行指导,剔除了很多不必要的重复的计算,从而使算法的总计算量大幅度地减少。将新算法应用于悬臂和简支两类深梁的多目标拓扑优化,获得了高质量的Pareto最优解,且具有很好的分布。

关键词：遗传算法多目标优化拓扑优化

Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery

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Neural Regeneration Research 2025年第8期20卷 2181-2198页

作者： Jiali chen Yiyang li Xingping Quan Jinfen chen Yan Han li Yang Manfei Zhou Greta Seng Peng Mok Ruibing Wang Yonghua Zhao Institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmacy Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityChangshaHunan ProvinceChina Department of Electrical and Computer Engineering University of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina

Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on *** vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic ***,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery *** utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly ***,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic *** extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke *** this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification *** the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment ***,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

关键词： delivery engineering extracellular vesicles identification ischemic stroke isolation mitochondria targeting strategy therapeutic effects

Adaptive-basis decomposition-based low-rank network for efficient non-uniform motion deblurring

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Optoelectronics Letters 2025年第1期21卷 43-50页

作者： chen Lei XIONG Qingbo ZHANG Wei li Runde School of Software Henan University School of Applied Technology China University of Labor Relations

In this study, we present a unified sparsity-driven framework that significantly enhances motion deblurring performance by integrating two key components: a custom-designed dataset and a low-rank module(LRM). This framework leverages the inherent sparsity of per-pixel blur kernels to bolster both deblurring accuracy and model interpretability. Firstly, we propose an adaptive-basis decomposition-based deblurring(ADD) approach, which constructs a tailored training dataset to enhance the generalization capacity of the deblurring network. The ADD framework adaptively decomposes motion blur into sparse basis elements, effectively addressing the intricacies associated with non-uniform blurs. Secondly, an LRM is proposed to improve the interpretability of deblurring models as a plug-and-play module, primarily designed to identify and harness the intrinsic sparse features in sharp images. A series of ablation studies have been conducted to substantiate the synergistic advantages of combining the proposed ADD with the LRM for overall improvement in deblurring efficacy. Subsequently, we empirically demonstrate through rigorous experimentation that incorporating the LRM into an existing Uformer network leads to substantial enhancement in reconstruction performance. This integration yields a sparsity-guided low-rank network(SGLRN). Operating under the overarching principle of sparsity, SGLRN consistently outperforms state-of-the-art methods across multiple standard deblurring benchmarks. Comprehensive experimental results, assessed through quantitative metrics and qualitative visual evaluations, provide compelling evidence of its effectiveness. The overall deblurring results are available at Google Drive.

关键词： Image enhancement

抗倒伏甘蓝型油菜(Brassica napus L.)木质素含量及木质素合成关键基因的表达

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江苏农业学报 2011年第3期27卷 481-487页

作者：李尧臣戚存扣江苏省农业科学院经济作物研究所江苏南京210014

测定了甘蓝型油菜6个抗倒伏材料和5个易倒伏材料薹期和花期植株不同部位的木质素含量,并对木质素合成关键酶基因F5H(阿魏酸-5-羟基化酶)基因、4CL(4-香豆酸辅酶A连接酶)基因、COMT(咖啡酸/5-羟基阿魏酸-O-甲基转移酶)基因进行RT-PCR扩增... 详细信息

测定了甘蓝型油菜6个抗倒伏材料和5个易倒伏材料薹期和花期植株不同部位的木质素含量,并对木质素合成关键酶基因F5H(阿魏酸-5-羟基化酶)基因、4CL(4-香豆酸辅酶A连接酶)基因、COMT(咖啡酸/5-羟基阿魏酸-O-甲基转移酶)基因进行RT-PCR扩增,以分析抗倒伏和易倒伏材料间木质素含量的差异以及上述3个与木质素合成相关的关键酶基因的表达差异。结果显示:薹期根颈和茎部木质素含量,抗倒伏材料比易倒伏材料分别高0.95个百分点和1.90个百分点;开花期根、根颈和茎部木质素含量,抗倒伏材料比易倒伏材料分别高2.53个百分点、1.97个百分点和1.58个百分点;COMT基因在薹期和开花期的根、根颈和茎部的表达量,抗倒伏与易倒伏材料间没有明显差异;F5H基因在薹期根、茎部和开花期根部的表达量,抗倒伏材料明显高于易倒伏材料;4CL基因在薹期和开花期根、根颈的表达量,抗倒伏材料明显高于易倒伏材料;但在薹期和开花期的茎部,抗倒伏材料与易倒伏材料间4CL基因表达量差异不显著。表明,抗倒伏材料薹期和开花期根、根颈和茎部合成的木质素含量较高,F5H和4CL基因可能是与油菜抗倒伏性状相关的关键基因。

关键词：甘蓝型油菜抗倒伏木质素 COMT基因 F5H基因 4CL基因表达差异

Invasion of Artificial Vascular Graft into Duodenal Bulb after living Donor liver Transplantation

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Surgical Science 2015年第2期6卷 71-74页

作者： Yu-Ju Hung Kuo-Hua lin chen-Te Chou Chih-Jan Ko Ping-Yi lin Chia-En Hsieh Hsu-Heng Yen yao-li chen Department of Surgery Changhua Christian Hospital Changhua Chinese Taipei Department of Medical Imaging Changhua Christian Hospital Changhua Chinese Taipei Transplant Medicine & Surgery Research Centre Changhua Christian Hospital Changhua Chinese Taipei Department of Gastroenterology Changhua Christian Hospital Changhua Chinese Taipei

Artificial vessel grafts are used for outflow reconstruction in living donor liver transplantation (LDLT). We report a very rare case of invasion of an artificial vascular graft into the duodenal bulb after LDLT. A 54-year-old man underwent LDLT in August 2012. A right hemiliver without a middle hepatic vein was used as a graft. The outflow of segment V was created by anatomizing an artificial graft to the inferior vena cava. During outpatient follow-up, the patient complained of acid regurgitation but did not experience abdominal pain. Panendoscopy was arranged and it revealed that the artificial graft had invaded the duodenal bulb. Operation was performed to remove the graft and the patient discharged after fourteen days of hospital stay. Invasion of artificial vascular grafts to adjacent organs is rare, but happens in living donor liver transplantation. It may be caused by inappropriate vessel graft length and adhesion between the graft and adjacent organs.

关键词： living Donorliver Transplantation Artificialgraft