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A machine learning model for colorectal liver metastasis post-hepatectomy prognostications: several strategies for the model evaluation

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Hepatobiliary Surgery and Nutrition 2024年第4期13卷 752-754页

作者： guang-yao li Lu-Lu Zhai Department of General Surgery The Second People’s Hospital of WuhuWuhuChina Department of General Surgery The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina

With great interest,we read the article by Lam et al.(1)entitled“A machine learning model for colorectal liver metastasis post-hepatectomy prognostications”.In this study,the authors included colorectal liver metastasis(CRLM)patients from four hospitals in Hong Kong who underwent hepatic resection,and developed a survival prediction model based on the patients’demographic,oncologic,clinicopathologic,and therapeutic characteristics using machine *** Cox proportional hazards and least absolute shrinkage and selection operator(LASSO)regression analyses,the authors successfully developed a predictive model consisting of eight predictors that could accurately predict overall survival(OS)and recurrence-free survival(RFS)after hepatectomy in patients with *** is an intriguing study with significant clinical value,and the authors deserve to be commended for their ***,there are still several issues that need to be addressed in this study.

关键词： Colorectal liver metastasis(CRLM) hepatectomy survival prediction model

Gut microbiota alteration and modulation in hepatitis B virus-related fibrosis and complications:Molecular mechanisms and therapeutic inventions

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World Journal of Gastroenterology 2022年第28期28卷 3555-3572页

作者： yao-guang li Zu-Jiang Yu Ang li Zhi-Gang Ren Department of Infectious Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Gene Hospital of Henan Province Precision Medicine CenterThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Jinan Microecological Biomedicine Shandong Laboratory Jinan 250000Shandong ProvinceChina

Hepatitis B virus(HBV)has posed a threat to public health,mainly resulting in liver *** long-term accumulation of extracellular matrix,patients with chronic hepatitis B are at high risk of developing into liver fibrosis and cirrhosis and even life-threatening hepatic *** occurrence of complications such as spontaneous bacterial peritonitis and hepatic encephalopathy greatly increases disability and *** deeper understanding of the bidirectional interaction between the liver and the gut(gut-liver axis),there is a growing consensus that the human health closely relates to the gut *** by animal and human studies,the gut microbiota alters as the HBV-related liver fibrosis initials and progresses,characterized as the decrease of the ratio between“good”and“potentially pathogenic”*** the primary disease is controlled via antiviral treatment,the gut microbiota dysfunction tends to be ***,the recovery of gut microbiota can promote the regression of liver *** strategies targeted on gut microbiota(rifaximin,probiotics,engineered probiotics and fecal microbiota transplantation)have been applied to animal models and patients,obtaining satisfactory results.

关键词： Hepatitis B virus Gut microbiota liver fibrosis liver cirrhosis Hepatic encephalopathy Fecal microbiota transplantation

APPROACH TO THE REGIONAliZATION OF A GRICULTURAL-PASTURAliZATION AROUND CHANGSHAN ISLANDS IN NORTHERN YELLOW SEA

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Chinese Geographical Science 2002年第3期12卷 218-225页

作者： ZHANG yao-guang,DONG li-jing,li Chun-ping(Institute of Marine Resource,liaon ing Normal University,Dalian 116029,P.R.China) Institute of Marine Resource Liaoning Normal University Dalian P. R. China

Based on the data of resources,environment and foundation of productio n,applying principal compo-nents-clustering quantitative analysis,this article divides the maritime space of Changshan Islands into three regions of agricultural-pasturalization,pr oviding a scientific basis for the ra tional distribution of marine culti *** three re-gions are as follows:1)The region of an agricultural-pastu ralization in the northern part of ma ritime *** includes Da Wangjia and Shicheng *** ma in production is cultivation of praw n and molluscs in sea beach,float raft culture of mussel in shallow sea and scallop,and breeding of sea cucumber in subma rine.2)The region of agricultur-al-pasturalization in the middle we stern part of maritime *** includes Da Changshan and guanglu island s,and west-ern part of Xiao Chengshan *** main production is float raft cultu re of mussel and scallop in shallow se a,and breed-ing of sea cucumber in submarine.3)The region of agricultural-pastura lization of the southeastern part of maritime *** includes the eastern part of Xiao ChangShan Island,Haiyang and Zhangzi *** main production is bre eding of abalone,sea cucumber,algaes and fish.

关键词： Changshan Islands agricultural-pasturalization of seash ore principal compo-nents-clustering analysis region alization

孔隙特征对土体内部流动特性的影响——孔隙尺度的数值研究（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2019年第12期20卷 961-978页

作者： guang-yao li Sheng DAI liang-tong ZHAN Yun-min CHEN MOE Key Laboratory of Soft Soils and Environmental Engineering Zhejiang UniversityHangzhou 310058China School of Civil and Environmental Engineering Georgia Institute of TechnologyAtlanta 30332 GAUSA

目的:研究土体内部的流动现象对岩土、农业及地质工程等领域具有重要意义。本文旨在探讨孔隙的平均直径、直径标准差、配位数及各向异性对土体内部水压、流量分布、流动模式及关键流动路径的影响,为评估土质屏障中的优势流动行为提供依... 详细信息

目的:研究土体内部的流动现象对岩土、农业及地质工程等领域具有重要意义。本文旨在探讨孔隙的平均直径、直径标准差、配位数及各向异性对土体内部水压、流量分布、流动模式及关键流动路径的影响,为评估土质屏障中的优势流动行为提供依据。创新点:1.在孔隙尺度分析孔隙特征对土体宏观渗透率及内部流动规律的影响;2.评估多个孔隙特征参数(如孔隙的平均直径、直径标准差、配位数及三种孔隙直径分布形式)对土体内部优势流动行为的影响。方法:1.将土体孔隙空间简化为由孔隙与吼道互相连接构成的球-杆模型,并通过改变孔隙和吼道的特征参数来描述复杂的孔隙结构;2.利用孔隙网络模型得到单元体内部水压和流量分布情况,为计算土体固有渗透率和评估其流动特性提供基础数据;3.基于击穿路径的概念,分析不同孔隙特征下土体内部流动的迂曲和非均匀程度;4.通过引入吼道收缩系数,调整水平或竖直吼道直径大小,评估孔隙各向异性对流动规律的影响。结论:1.土体的孔隙率和固有渗透率均随着孔隙直径平均值的增大、标准差的减小及配位数的增大而增大。2.孔隙直径的变异系数(COV)越高,土体内部水压和流量的分布越不均匀;配位数的提高会削弱水压的局部化分布但会提高流量的不均匀程度。3.随着COV的提高,击穿路径变得更加曲折;当COV由0增加到1.0时,击穿路径的迂曲度由1.00增加到大约1.71,击穿路径承担的流量占总流量的比值由2.0%提高到7.8%。4.水平与竖直吼道直径比值的提高,也会导致击穿路径迂曲度的提高;水平与竖直固有渗透率的比值和水平与竖直吼道直径的比值呈双对数线性相关。

关键词：孔隙网络模型固有渗透率流动特性孔隙特征

Predictive factors for successful sperm retrieval by microdissection testicular sperm extraction in men with nonobstructive azoospermia and a history of cryptorchidism

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Asian Journal of Andrology 2022年第5期24卷 503-508页

作者： Xing-lin Chen Yu-Ang Wei Xiao-Han Ren Xu Zhang guang-yao li Zhong-Wen Lu Dong Zhang Chao Qin Shi-Feng Su Department of Urology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210009China

This study aims to explore the factors influencing the success rate of the microdissection testicular sperm extraction(Micro-TESE)in patients with nonobstructive azoospermia(NOA)and *** data of 162 patients with cryptorchidism who underwent Micro-TESE due to infertility from December 2015 to May 2020 in the First Affiliated Hospital of Nanjing Medical University were analyzed *** the univariate analysis,significant differences in the age of patient at the time of orchidopexy(median[interquartile range,IQR]:7.0[4.0–11.0]years vs 11.5[9.0–14.5]years,Plicle-stimulating hormone(FSH;P=0.004)and testosterone(P=0.006)were observed between the successful and failed sperm extraction *** conducting the multivariate analysis,four of these factors,including unilateral/bilateral cryptorchidism(Plinical prediction model to evaluate preoperatively the success rate of Micro-TESE for patients with NOA and *** likelihood of successful sperm retrieval by Micro-TESE in men with NOA and cryptorchidism increased in patients with mild forms of cryptorchidism.

关键词： azoospermia cryptorchidism microdissection testicular sperm extraction predictive

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中国共产党执政赢得民心的历史经验

齐鲁学刊 2015年第1期 112-116页

作者：姚广利天津师范大学政治与行政学院天津300387

民心向背决定一个政党的生死存亡。纵观中国共产党的执政历程,意识形态、执政绩效、领袖魅力和民主法治是赢得民心的重要因素,但不同历史阶段几个因素的地位有所不同。这些因素的相互作用和历史变迁为党长期执政积累了丰富的经验:赢得... 详细信息

民心向背决定一个政党的生死存亡。纵观中国共产党的执政历程,意识形态、执政绩效、领袖魅力和民主法治是赢得民心的重要因素,但不同历史阶段几个因素的地位有所不同。这些因素的相互作用和历史变迁为党长期执政积累了丰富的经验:赢得民心工作是一项战略任务,执政绩效是赢得民心的基础,意识形态是赢得民心的旗帜,民主法治是赢得民心的保障,领袖魅力是赢得民心的补充。

关键词：中国共产党赢得民心因素

Scene-trait coping style of military rescuers in Wenchuan earthquake

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中国应用生理学杂志 2014年第6期30卷 538-543页

作者： li-yi ZHANG Xin-yang SUN ling-ming KONG De-hua TU liang ZHANG guang-yao li Zi-xiang SONG Chun-xia CHEN Gao-feng yao Jie SHI Prevention and Treatment Center of Psychological Diseases No. 102 Hospital of Chinese PLA Changzhou 213003 Department of Psychology and Psychiatry the Second Military Medical University Shanghai 200433 Department ofPsychiatry Ma'anshan Central Hospital Ma'anshan 243000 First Psychiatric Health Center of Civil Affairs Bureau Shanghai 201105 Department of Psychology No. 102 Hospital of Chinese PLA Changzhou 213003 Departmentof Pediatric Psychiatry No. 102 Hospital of Chinese PLA Changzhou 213003 Department of Psychology GeneralHospital of the Second Artillery Force of the PLA Beijing 100085 China

Objective This study aimed to explore the scene-trait coping style of military rescuers in Wenchuan earthquake in an effort to provide scientific evidences for mental intervention program for Chinese military *** By cluster sampling,a total of 151 military rescuers and 331 control servicemen were administered the military personnel scene-trait coping style scale(MPSTCSS).Results All active coping factor scores,and passive coping factor scores of affection,health and economy in the rescuer group were significantly higher than those in control group(Plitary tasks,military experience and personal development than those of the 21-below age subgroup,3-year minus service subgroup and the soldier subgroup,respectively(Plief servicemen can cope with stressful situations better than control group by taking active coping *** officers,servicemen older than 21 years,and servicemen with more service duration than3 years could usually take active coping style.

关键词：军事任务地震救援场景汶川风格因子得分整群抽样救援人员

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彩超诊断直肠肿瘤并子宫直肠瘘2例

中国临床医学影像杂志 2006年第8期17卷 478-479页

作者：姚广力江怡上海市浦南医院超声科上海200125

本文报道两例超声首先发现有老年直肠癌,盆腔,子宫转移伴子宫直肠瘘的患者,并讨论子宫直肠瘘的声像图表现,供同道借鉴。[第一段]

关键词：直肠肿瘤直肠瘘超声检查多普勒彩色

In vitro CULTIVATION OF 14-DAY-OLD JUVENILES OF Acylostoma duodenale TO EGG-LAYING ADULT WORMS

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Chinese Science Bulletin 1989年第2期34卷 175-176页

作者：黄先翔尹光耀李明惠 Institute of Antiparasitic Diseases Sichuan Academy of Medical Sciences Chengdu

Adults of Ancylostoma duodenale could be successfully cultivated in vitro (Yasuraoka et al., 1960; Wang et al., 1979), but cultivation of juveniles of hookworm to adult stage has not been successful until Huang et al. reported their cultivating 17-day-old juveniles of this species of hookworms into adults in 1987 (Chin. Med. J., 67(1987), 2: 96—98).

关键词： cultivation cultivated elsewhere letter until minute organs 岁君 varied genital