检索结果-南通市图书馆

Cellphone application rehabilitation management and evaluations of cardiopulmonary function and motor development in infants with congenital heart disease:a pilot study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2023年第8期19卷 805-812页

作者： Ge-Jing-Wa Zhao Zhi-Qiang Li Yang Ma yao-bin zhu Nan Ding Han-Lu Yi Shi-Jie Li Dao-Le Yan Jin-Rui Zhang Department of Cardiovascular Surgery II Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s Health56th Nan Lishi RdBeijing100045China Department of Healthcare Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina

Congenital heart disease(CHD)has an estimated prevalence of 0.9%,with 0.3%requiring interventional or surgical intervention very early in ***,CHD surgery tends to be performed at a younger *** continued management of the condition is dependent on postoperative care and rehabilitation since the success rate of surgery has significantly increased[1,2].According to American Heart Association guidelines published in 2012.

关键词： surgery congenital younger

Genetic diagnosis history and osteoarticular phenotype of a nontransfusion secondary hemochromatosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2020年第23期8卷 5962-5975页

作者： Dan-Dan Ruan Yu-Mian Gan Tao Lu Xiao Yang yao-bin zhu Qing-Hua Yu Li-Sheng Liao Ning Lin Xin Qian Jie-Wei Luo Fa-Qiang Tang Shengli Clinical Medical College Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Management Fujian Health CollegeFuzhou 350101Fujian ProvinceChina Department of Traditional Chinese Medicine The First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina Department of Orthopedics Fujian Provincial HospitalFuzhou 350001Fujian ProvinceChina

BACKGROUND It is not easy to identify the cause of various iron overload diseases because the phenotypes ***,it is important to perform genetic testing to determine the genetic background of *** To investigate the genetic background of a patient with hemochromatosis complicated by psoriasis on both lower *** Ten years ago,a 61-year-old male presented with iron overload,jaundice,hemolytic anemia and microcytic hypochromic *** tomography of the left knee joint showed enlargement of the tibial medullary cavity and thinned bone *** resonance imaging showed hepatic hemochromatosis,extensive abnormal signals from bone marrow cavities and nodular lesions in the lateral medullary cavity of the upper left lateral *** photon emission computed tomography showed radial dots of abnormal concentration in the upper end of the left tibia and radial symmetry of abnormal concentrations in joints of the *** patient showed several hot spot mutations of the HFE and G6PD genes detected by next-generation sequencing,but no responsible gene mutation was *** thalassemia gene was detected by *** The patient was found to carry the-α4.2 and--SEA deletion mutations of the globin *** two mutations are common causes of Southeast Asianα-thalassemia,but rarely cause severe widespread non-transfusion secondary hemochromatosis *** simultaneous presence of an auxiliary superposition effect of a rare missense mutation of the PIEZO1 gene(NM_001142864,c.C4748T,p.A1583V)was ***,several rare mutations of the IFIH1,KRT8,POFUT1,FLG,KRT2,and TGM5 genes may be involved in the pathogenesis of *** The selection of genetic detection methods for hemochromatosis still needs to be based on an in-depth study of the clinical manifestations of the disease.

关键词： Hemochromatosis Hemochromatosis osteoarthropathy Next-generation sequencing Thalassemia Gap-PCR PIEZO1 gene

Model Research on the Effect of Surface Film on Ammonia Volatilization from Rice Field

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Agricultural Sciences in China 2002年第9期1卷 1029-1033页

作者： zhuANG Shun-yao, YIN bin and zhu Zhao-liang(Institute of Soil Science , Chinese Academy of Sciences , Nanjing 210008 , P.R.China) Institute of Soil Science Chinese Academy of Sciences Nanjing 210008 P.R. China

Pan and field experiments were conducted to investigate the effect of surface film on ammonia volatilization from water and paddy soil. The results showed that the addition of the surface film on floodwater reduced the rate of ammonia volatilization, however, the reduction of the latter varied greatly with its rates of addition. Jayaweera-Mikkelsen ammonia volatilization model with the introduction of a parameter Kf, a relative measure of the resistance of the surface film on ammonia volatilization, was used to elucidate the effectiveness of the surface film on lowering ammonia volatilization. The Kf value was calculated from the results ob-

关键词： Surface film Ammonia volatilization J-M model Coefficient of resistance

在线全文

学校读者我要写书评

暂无评论

粒子群算法在烧结矿配料优化中的应用

有色金属 2005年第3期57卷 51-54,61页

作者：李智姚驻斌武汉工业学院武汉430023 武汉钢铁集团公司武汉430081

运用粒子群算法和MATLAB语言,编制钢铁烧结矿配料优化计算仿真程序并经实践检验。结果表明,计算机仿真计算符合实际生产工艺要求,数据直接应用于生产,提高各种烧结矿的综合利用率,降低成本10．32％。该算法为钢铁烧结矿配料问题的优化... 详细信息

运用粒子群算法和MATLAB语言,编制钢铁烧结矿配料优化计算仿真程序并经实践检验。结果表明,计算机仿真计算符合实际生产工艺要求,数据直接应用于生产,提高各种烧结矿的综合利用率,降低成本10．32％。该算法为钢铁烧结矿配料问题的优化求解提供了新的思路和方法。

关键词：冶金技术烧结粒子群算法配料优化

SC-CO2与工业乳化炸药破岩效应的等效试验

在线全文

学校读者我要写书评

暂无评论

工程科学学报 2025年第2期47卷 249-258页

作者：蒋楠姚颖康朱斌罗学东江汉大学省部共建精细爆破国家重点实验室江汉大学爆破工程湖北省重点实验室中国地质大学(武汉)工程学院

如何定量化核算SC-CO2（超临界二氧化碳）破岩效率是非炸药类破岩技术在实际工程应用时重点关注的内容.本研究基于爆破当量理论计算和现场爆破试验的研究方法，通过工程类比法进行工业乳化炸药等效当量计算，选择典型代表性花岗岩及泥... 详细信息

如何定量化核算SC-CO2（超临界二氧化碳）破岩效率是非炸药类破岩技术在实际工程应用时重点关注的内容.本研究基于爆破当量理论计算和现场爆破试验的研究方法，通过工程类比法进行工业乳化炸药等效当量计算，选择典型代表性花岗岩及泥岩场地，设计进行了SC-CO2与工业炸药破岩效应等效对比现场试验；基于现场破岩等效现场试验测试数据，对比分析试验过程中SC-CO2与工业炸药破岩体积、破岩区域形态、大块率和单耗等破岩区域特征及参量数据.研究结果表明：当SC-CO2破岩体积较大时，其致裂破岩范围的长短轴较长，并且随着剪切片厚度的增加，泥岩场地二氧化碳单耗的下降速率增大，二氧化碳单耗是炸药单耗的6～11倍.SC-CO2破岩技术大块率较高，而炸药爆炸应力波分布均匀，大块率较小.SC-CO2破岩地表振速远小于工业炸药破岩，工业炸药爆破测点合振速值为SC-CO2破岩测点合振速值的9～11倍，SC-CO2破岩对周边环境震动影响较小.SC-CO2破岩测点合应力峰值高于工业炸药破岩，SC-CO2破岩试验中各测点合应力值为炸药破岩试验中对应测点值的1.2～1.6倍.

关键词： SC-CO2 工业炸药等效破岩动力效应破岩体积

Alternative Strategy for Development of Dielectric Calcium Copper Titanate‑Based Electrolytes for Low‑Temperature Solid Oxide Fuel Cells

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第1期17卷 310-332页

作者： Sajid Rauf Muhammad Bilal Hanif Zuhra Tayyab Matej Veis MAKYousaf Shah Naveed Mushtaq Dmitry Medvedev Yibin Tian Chen Xia Martin Motola bin zhu College of Mechatronics and Control Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China Department of Inorganic Chemistry Faculty of Natural SciencesComenius University BratislavaIlkovicova684215 BratislavaSlovakia Energy Storage Joint Research Center School of Energy and EnvironmentSoutheast UniversityNanjing 210096People’s Republic of China Hydrogen Energy Laboratory Ural Federal University620002 EkaterinburgRussia Laboratory of Electrochemical Devices Based on Solid Oxide Proton Electrolytes Institute of High Temperature Electrochemistry620066 EkaterinburgRussia School of Microelectronics Hubei UniversityWuhan 430062People’s Republic of China

The development of low-temperature solid oxide fuel cells(LT-SOFCs)is of significant importance for realizing the widespread application of *** has stimulated a substantial materials research effort in developing high oxide-ion conductivity in the electrolyte layer of *** this context,for the first time,a dielectric material,CaCu_(3)Ti_(4)O_(12)(CCTO)is designed for LT-SOFCs electrolyte application in this *** individual CCTO and its heterostructure materials with a p-type Ni_(0.8)Co_(0.15)Al_(0.05)LiO_(2−δ)(NCAL)semiconductor are evaluated as alternative electrolytes in LT-SOFC at 450–550℃.The single cell with the individual CCTO electrolyte exhibits a power output of approximately 263 mW cm^(-2) and an open-circuit voltage(OCV)of 0.95 V at 550℃,while the cell with the CCTO–NCAL heterostructure electrolyte capably delivers an improved power output of approximately 605 mW cm^(-2) along with a higher OCV over 1.0 V,which indicates the introduction of high hole-conducting NCAL into the CCTO could enhance the cell performance rather than inducing any potential short-circuiting *** is found that these promising outcomes are due to the interplay of the dielectric material,its structure,and overall properties that led to improve electrochemical mechanism in CCTO–***,density functional theory calculations provide the detailed information about the electronic and structural properties of the CCTO and NCAL and their heterostructure CCTO–*** study thus provides a new approach for developing new advanced electrolytes for LT-SOFCs.

关键词： LT-SOFCs Dielectric CaCu_(3)Ti_(4)O_(12) Semiconductor Ni_(0.8)Co_(0.15)Al_(0.05)LiO_(2−δ) Ionic conductivity Heterostructure electrolyte

Transarterial chemoembolization combined with lenvatinib and sintilimab vs lenvatinib alone in intermediate-advanced hepatocellular carcinoma

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2025年第1期17卷 52-61页

作者： Fei-Da Wu Hai-Feng Zhou Wei Yang Di zhu Bi-Fei Wu Hai-bin Shi Sheng Liu Wei-Zhong Zhou Department of Interventional Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the most common form of liver cancer that has limited treatment options and a poor *** chemoembolization(TACE)is the first-line treatment for intermediate-stage HCC but can induce tumour hypoxia,thereby promoting *** studies suggested that combining TACE with anti-angiogenic therapies and immunotherapy might im-prove ***,a tyrosine kinase inhibitor,has demonstrated superior outcomes compared to sorafenib,while immune checkpoint inhibitors such as sintilimab show potential when combined with ***,the efficacy and safety of TACE combined with lenvatinib and sintilimab(TACE+SL)compared to TACE with lenvatinib alone(TACE+L)in patients with intermediate-ad-vanced HCC has not yet been *** To evaluate the efficacy and safety of TACE+SL therapy in comparison to TACE+L therapy in patients with intermediate-advanced *** A retrospective analysis was performed on patients with intermediate-advanced HCC who received TACE plus lenvatinib with or without sintilimab between September 2019 and September *** characteristics were compared,and propensity score matching was *** survival(OS),progression-free survival(PFS),and objective response rate(ORR)were evaluated between the two groups,and adverse events were *** The study included 57 patients,with 30 in the TACE+SL group and 27 in the TACE+L *** TACE+SL group demonstrated significantly improved median PFS and OS compared to the TACE+L group(PFS:14.1 months vs 9.6 months,P=0.016;OS:22.4 months vs 14.1 months,P=0.039),along with a higher ORR(70.0%vs 55.6%).After propensity score matching,30 patients were included,with the TACE+SL group again showing longer median PFS and a trend toward improved OS(PFS:14.6 months vs 9.2 months,P=0.012;OS:23.9 months vs 16.3 months,P=0.063),and a higher ORR(73.3%vs 53.3%).No severe adverse events were *** TACE+SL demonstrat

关键词： Hepatocellular carcinoma Transarterial chemoembolization Sintilimab Lenvatinib Immunotherapy Programmed cell death 1 Prognosis

RGS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第2期31卷 113-127页

作者： Peng-Yu Chen Pei-yao Wang Bang Liu Yang-Pu Jia Zhao-Xiong Zhang Xin Liu Dao-Han Wang Yong-Jia Yan Wei-Hua Fu Feng zhu Department of General Surgery Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Department of General Surgery Jincheng People’s HospitalJincheng 048000Shanxi ProvinceChina

BACKGROUND Regulator of G protein signaling(RGS)proteins participate in tumor formation and metastasis by acting on theα-subunit of heterotrimeric G *** speci-fic effect of RGS,particularly RGS4,on the progression of gastric cancer(GC)is not yet *** To explore the role and underlying mechanisms of action of RGS4 in GC *** The prognostic significance of RGS4 in GC was analyzed using bioinformatics based public databases and verified by immunohistochemistry and quantitative polymerase chain reaction in 90 patients with *** assays were employed to assess the carcinogenic impact of RGS4,and the mechanism of its possible influence was detected by western blot analysis.A nude mouse xenograft model was established to study the effects of RGS4 on GC growth in *** RGS4 was highly expressed in GC tissues compared with matched adjacent normal *** RGS4 expression was correlated with increased tumor-node-metastasis stage,increased tumor grade as well as poorer overall survival in patients with *** experiments demonstrated that RGS4 knockdown suppressed GC cell proliferation,migration and ***,xenograft experiments confirmed that RGS4 silencing significantly inhibited tumor ***,RGS4 knockdown resulted in reduced phosphorylation levels of focal adhesion kinase,phosphatidyl-inositol-3-kinase,and protein kinase B,decreased vimentin and N-cadherin,and elevated *** High RGS4 expression in GC indicates a worse prognosis and RGS4 is a prognostic ***4 influences tumor progression via the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition.

关键词： Gastric cancer Prognosis Regulator of G protein signaling 4 Focal adhesion kinase Epithelial-mesenchymal transition

Poorly controlled type II diabetes mellitus significantly enhances postoperative chemoresistance in patients with stage III colon cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第3期31卷 29-41页

作者： Ruo-Yu Guan Jia-Wei Wu Zi-Yun Yuan Zhi-Yuan Liu Zi-zhu Liu Zhi-Cong Xiao Jing-Hui Li Cheng-Zhi Huang Jun-Jiang Wang Xue-Qing yao Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of Gastrointestinal Surgery Department of General SurgeryGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of General Surgery Guangdong Provincial People’s Hospital Ganzhou Hospital(Ganzhou Municipal Hospital)Ganzhou 341000Jiangxi ProvinceChina Shantou University Medical College Shantou 515041Guangdong ProvinceChina School of Medicine South China University of TechnologyGuangzhou 510006Guangdong ProvinceChina Gannan Medical University Ganzhou 341000Jiangxi ProvinceChina

BACKGROUND Type II diabetes mellitus(T2DM)has been associated with increased risk of colon cancer(CC)and worse prognosis in patients with *** effects of T2DM on postoperative chemoresistance rate(CRR)and long-term disease-free survival(DFS)and overall survival(OS)in patients with stage III CC who receive curative resection remain *** To investigate whether T2DM or glycemic control is associated with worse postoperative survival outcomes in stage III *** This retrospective cohort study included 278 patients aged 40-75 years who underwent surgery for stage III CC from 2018 to *** on preoperative T2DM history,the patients were categorized into non-DM(n=160)and DM groups(n=118).The latter was further divided into well-controlled(n=73)and poorly controlled(n=45)groups depending on the status of glycemic ***,OS,and CRR were compared between the groups and Cox regression analysis was used to identify risk *** Patients in the DM and non-DM groups demonstrated similar DFS,OS,and CRR(DFS:72.03%vs 78.75%,P=0.178;OS:81.36%vs 83.12%,P=0.638;CRR:14.41%vs 7.5%,P=0.063).Poorly controlled DM was associated with a significantly worse prognosis and higher CRR than well-controlled DM(DFS:62.22%vs 78.07%,P=0.021;OS:71.11%vs 87.67%,P=0.011;CRR:24.40%vs 8.22%,P=0.015).High preoperative fasting plasma glucose[DFS:Hazard ratio(HR)=2.684,Pbin levels(DFS:HR=2.344,P=0.006;OS:HR=2.119,P=0.021;CRR:HR=2.449,P=0.009)indicated significantly poor prognosis and high CRR,while T2DM history did not(DFS:HR=1.178,P=0.327;OS:HR=0.933,P=0.739;CRR:HR=0.997,P=0.581).CONCLUSION Increased preoperative fasting plasma glucose and glycosylated hemoglobin levels,but not T2DM history,were identified as risk factors associated with poor postoperative outcomes and high CRR in patients with stage III CC.

关键词： Colon cancer Chemoresistance Diabetes mellitus Prognosis Type II diabetes mellitus