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Transport characteristics of space charge-dominated multi-species deuterium beam in electrostatic low-energy beam line

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Nuclear Science and Techniques 2018年第4期29卷 57-65页

作者： Xiao-Long Lu Yu Zhang Jun-Run Wang Zhi-Wu Huang Zhan-Wen Ma yao yang Ze-En yao School of Nuclear Science and Technology Lanzhou University Engineering Research Center for Neutron Application Ministry of Education Lanzhou University Institute of Modern Physics Chinese Academy of Sciences

The transport characteristics of a space chargedominated multi-species deuterium beam consisting of D_1^+,D_2^+, and D_3^+ particles in an electrostatic low-energy beam line are studied. First, the envelope equations of the primary D_1^+ beam are derived considering the space charge effects caused by all particles. Second, the evolution of the envelope of the multi-species deuterium beam is simulated using the PIC code TRACK, with the results showing a significant effect of the unwanted beam on the transport of the primary beam. Finally, different injected beam parameters are used to study beam matching, and a new beam extraction system for the existing duoplasmatron source is designed to obtain the ideal injected beam parameters that allow a D_1^+ beam of up to 50 m A to pass unobstructed through the electrostatic low-energy beam transport line in the presence of an unwanted(D_2^+, D_3^+)beam of 20 m A; at the same time, distortions of the beam emittance and particle distributions are observed.

关键词： Envelope equation Space charge effects Multi-species beam Electrostatic LEBT

Effects of light intensity on leaf microstructure and growth of rape seedlings cultivated under a combination of red and blue LEDs

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Journal of Integrative Agriculture 2017年第1期16卷 97-105页

作者： yao Xu-yang LIU Xiao-ying XU Zhi-gang JIAO Xue-lei College of Agronomy Nanjing Agricultural University Nanjing 210095 P.R.China

The aim of this study was to evaluate the growth of rape （Brassica napus L.） seedlings under different light intensities to select appropriate conditions for cultivation in an indoor system. Seedlings were grown under different light intensities of red and blue light provided by light-emitting diodes （LEDs） and their self-adjustment ability and changes in leaf microstructure were evaluated. Light was supplied by red LEDs with peak wavelengths of 630 （R1） and 660 nm （R2） and by blue LEDs （B） with a peak wavelength of 445 nm （the light intensity ratio of R1：R2：B was 3：3：2）, at intensities of 400 （R1R2B400）, 300 （R1R2B300）, and 200 μmol m-2 s-1 （R1R2B200）. Natural solar light served as the control （C）. Plant height, stem diameter, root length, leaf area, and dry weight of rape seedlings gradually increased with increasing light intensity. The seedlings in the R1R2B400 treatment grew more vigorously, while those in the R1R2B200 treatment were weaker. The photosynthetic pigment contents did not differ significantly between the R1R2B400 treatment and C, but were significantly lower in the R1R2B300 and R1R2B200 treatments. The highest intercellular CO2concentration, stomatal conductance, and transpiration rate were in the R1R2B300 treatment. The highest photosynthetic rate was in the R1R2B400 treatment, and was related to more compact leaves, thicker and tidier palisade and spongy tissues, and well-developed chloroplasts. In contrast, the seedlings in the R1R2B200 treatment had disordered mesophyll cells, round chloroplasts, and fractured and fuzzy grana lamellae, all of which inhibited plant growth. In conclusion, the seedlings in the R1R2B400 treatment had well-developed leaves, which favored photosynthesis. Compared with the light intensities below 300 μmol m-2 s-1, the light intensity of 400 μmol m-2 s-1 provided by a cembination of red and blue LEDs was beneficial for cultivating strong and healthy rape seedlings in an artificial system.

关键词： light intensity rape seedlings mesophyll cell chloroplast stomata photosynthetic characteristics

Design,synthesis,and biological evaluation of novel chrysin derivatives as poly(ADP-ribose)polymerase 1(PARP1)inhibitors for the treatment of breast cancer

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Chinese Journal of Natural Medicines 2024年第5期22卷 455-465页

作者： yang yao TONG Jing XIE Xianshun CAO Hong FU Yong LUO Yong LIU Shan CHEN Wen yang Ning Hengyang Medical School University of South ChinaHengyang 421200China Emergency Department Hengyang Medical SchoolThe Second Affiliated HospitalUniversity of South ChinaHengyang 421200China Hengyang Medical School The Second Affiliated HospitalUniversity of South ChinaHengyang 421200China Hemato-oncology Department Hengyang Medical SchoolThe Second Affiliated HospitalUniversity of South ChinaHengyang 421200China Department of Breast and Thyroid Surgery Hengyang Medical SchoolThe Second Affiliated HospitalUniversity of South ChinaHengyang 421200China

In this study,we reported the discovery and structure-activity relationship analysis of chrysin derivatives as a new class of inhibitors targeting poly(ADP-ribose)polymerase 1(PARP1).Among these derivatives,compound 5d emerged as the most effective chrysin-based inhibitor of PARP1,with an IC50 value of 108 nmol·L^(-1).This compound significantly inhibited the proliferation and migration of breast cancer cell lines HCC-1937 and MDA-MB-436 by inducing DNA ***,5d induced apoptosis and caused an extended G1/S-phase in these cell *** docking studies revealed that 5d possesses a strong binding affinity toward *** vivo,in a xenograft model,5d effectively reduced tumor growth by downregulating PARP1 ***,compound 5d shows promise as a potential therapeutic agent for the treatment of BRCA wild-type breast cancer.

关键词： Chrysin derivatives PARP1 Antitumor DNA damage Small molecules

Postnatal renin-angiotensin system inhibition prevents renal damage from prenatal inflammation in rats

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Journal of Traditional Chinese Medicine 2020年第4期40卷 646-653页

作者： Guo Wei Ji Yan Han Qi yang yao Wang Fangjie yang Yongjian Deng Youcai Sun Xiongshan Li Xiaohui Institute of Materia Medica College of Pharmacy and Department of PharmacySouthwest HospitalArmy Medical University(Third Military Medical University)Chongqing 400038China Department of Cardiology The General Hospital of Western Theater Command(Chengdu Military General Hospital)Chengdu 610083China

OBJECTIVE:To assess the protective role of benazepril,an angiotensin-converting enzyme inhibitor,in renal damage caused by prenatal ***:Saline or lipopolysaccharide were administered intraperitoneally to pregnant Sprague-Dawley rats on gestation days 8,10,and *** birth,offspring received either tap water or benazepril in water between 7 and 68 *** pressure,blood urea nitrogen,creatinine,and 24-h urine volume were measured as indices of renal ***,eosin,periodic acid-Schiff,and Sirius Red staining were used to evaluate renal ***:Postnatal benazepril treatment ameliorated hypertension and restored normal 24-h urine volume and blood urea nitrogen and serum creatinine *** treatment also reduced glycoprotein accumulation and fibrosis in the glomerulus and in tubular epithelial cells and inhibited nuclear factor-kappa B ***:Together with our previous findings that postnatal inhibition of nuclear factor-kappa B activation blocks intra-renal renin-angiotensin system activation,our current data demonstrate that intra-renal activation of the renin-angiotensin system interacts with nuclear factor-kappa B activation to cause renal damage in adulthood following prenatal inflammation.

关键词： Renin-angiotensin system NF-kappa B Benazepril Prenatal inflammatory exposure

Tailoring synergetic catalytic interface of VPO/Ni_(2)P to boost hydrogen evolution under alkaline conditions

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Journal of Energy Chemistry 2022年第2期31卷 674-680页

作者： Wenli Xu Qiqi Li Wenda Zhong Bing Sun Qiang Huang Xu Nan Yinhong Gao yao yang Qin Zhang Nianjun yang Xuanke Li School of Chemistry and Chemical Engineering Wuhan University of Science and TechnologyWuhan 430081HubeiChina Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology Hunan UniversityChangsha 410082HunanChina Institute of Materials Engineering University of SiegenSiegen 57076Germany

Design of the catalyst for efficient water dissociation and hydrogen recombination is paramount in enhancement of the alkaline water electrolysis ***,we reported a delicate hierarchical(VO)_(2) P_(2)O_(7)-Ni_(2) P@NF(VPO-Ni_(2) P@NF)hybrid catalyst that operated efficiently in alkaline *** VPO and Ni_(2) P respectively act as the water dissociation promoter and the hydrogen recombination center,which synergistically propel water adsorption/dissociation and H intermediates *** resulting synergistic interfaces between VPO and Ni_(2) P are verified to afford the catalyst an outstanding performance for hydrogen evolution reaction in alkaline media with an overpotential of 154 mV at 10 mA cm^(-2),Tafel slope of 65 mV dec^(-1),and remarkable ***,the catalyst presents the potential for overall water *** work may shed fresh light on the high-performance electrocatalyst design and the application of VPO on water electrolysis.

关键词： Alkaline water electrolysis Interface engineering (VO)_(2)P_(2)O_(7) Ni_(2)P

Preventive behaviours and family inequalities during the COVID-19 pandemic:a cross-sectional study in China

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Infectious Diseases of Poverty 2021年第4期10卷 98-99页

作者： Yisheng Ye Ruijun Wu yao Ge Tao Wang Xin yao yao yang Chengxu Long Fangfei Chen Shangfeng Tang Rui Huang School of Medicine and Health Management Tongji Medical CollegeHuazhong University of Science and Technology13 Hangkong RoadWuhanChina School of Pharmacy Tongji Medical CollegeHuazhong University of Science and Technology13 Hangkong RoadWuhanChina 不详

Background The coronavirus disease 2019(COVID-19)pandemic is an international public health threat,and people's participation in disease-related preventive behaviours is the key to controlling infectious *** study aimed to assess the differences in adopting preventive behaviours among populations to explore potential individual and household factors and inequalities within *** This online survey was conducted in April *** directional stratified convenient sampling method was used to select 4704 participants from eight provinces in eastern,central,and western *** questionnaire included demographic information,household variables,and five target prevention *** chi-squared test,binary multilevel model,and Mantel–Haenszel hierarchical analysis were used for data analysis in the *** Approximately 71.2%of the participants had appropriate outdoor prevention,and 32.9%of the participants had indoor protection in *** behaviours(P<0.001)and education level(P<0.001)were positively associated with adopting preventive *** inhibiting effect of household crowding and stimulating effect of high household income on preventive behaviours were determined in this *** size was negatively associated with living area(β=-0.057,P<0.05)and living style(β=-0.077,P<0.05).Household income was positively associated with age(β=0.023,P<0.05),and relationship with friends(β=0.053,P<0.05).Vulnerable groups,such as older adults or women,are more likely to have inadequate preventive *** adults(OR=1.53,95%CI 1.09–2.15),women(OR=1.37,95%CI 1.15–1.64),and those with more than 2 suspected symptoms(OR=1.85,95%CI 1.07–3.19)were more likely to be affected by the inhibiting effect of household crowding,while the stimulating effect of high household income was limited in these *** Inequalities in COVID-19 prevention behaviours exist between families and inadequate adoption of prevention by vulnerabl

关键词： COVID-19 China Preventive behaviours Household

In situ Synthesis of Rosin Derived Chiral Derivatizing Agents for 31p NMR Assays of Amine and Alcohol Enantiomers

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Chemical Research in Chinese Universities 2013年第5期29卷 894-899页

作者： WU Qiang yao Gui-yang ZHANG Ye WANG Heng-shan yang Lin ZHU Yong-tao PAN Ying-ming Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry & Pharmaceutical Sciences of Guangxi Normal University Guilin 541004 P R. China

Chiral alcohols（3, 5） were synthesized in optically pure forms from easily available rosin acid in short-steps. A comprehensive protocol for the enantiomeric excess assays of mono- or di-functional-grouped chiral secondary amine or alcohol has been established with them used as chiral auxiliary for chiral phosphorus derivatizing agents（CPDAs） in 3Jp NMR tests. Chemical shift difference（△δp） values ranging from 4.5 to 0.15 between two dias- tereoisomers of the CPDAs and the aryl substrates were obtained. Positive △δR-S was observed for all the tested alco- hol P（III） and P（V） derivatives, while negative △δR-S was observed for all the amines.

关键词： Chiral phosphorus derivatizing agent Rosin Enantiodiscrimination 31p NMR

Mechanism and potential treatments for gastrointestinal dysfunction in patients with COVID-19

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World Journal of Gastroenterology 2022年第48期28卷 6811-6826页

作者： yang yao Zhu-Jun Liu Yu-Kun Zhang Hui-Jun Sun Chongqing Key Laboratory of Development and Utilization of Genuine Medicinal Materials in Three Gorges Reservoir Area College of Basic MedicalChongqing 404120China Department of Clinical Pharmacology College of PharmacyDalian 116044Liaoning ProvinceChina Ministry of Public Infrastructure Chongqing Three Gorges Medical CollegeChongqing 404120China Department of Basic Medicine Chongqing Three Gorges Medical CollegeChongqing 404120China Department of Business Administration Metropolitan College of Science and TechnologyChongqing 404120China State Key Laboratory of Natural and Biomimetic Drugs Department of PharmacologyPeking UniversityBeijing 100191China Department of Clinical Pharmacology College of PharmacyDalian Medical UniversityDalian 116044Liaoning ProvinceChina

The global coronavirus disease 2019(COVID-19)has become one of the biggest threats to the world since *** respiratory and gastrointestinal tracts are the main targets for severe acute respiratory syndrome coronavirus 2 infection for they highly express angiotensin-converting enzyme-2 and transmembrane protease serine *** patients suffering from COVID-19,gastrointestinal symptoms have ranged from 12%to 61%.Anorexia,nausea and/or vomiting,diarrhea,and abdominal pain are considered to be the main gastrointestinal symptoms of *** has been reported that the direct damage of intestinal mucosal epithelial cells,malnutrition,and intestinal flora disorders are involved in ***,the underlying mechanisms remain ***,in this study,we reviewed and discussed the correlated mechanisms that cause gastrointestinal symptoms in order to help to develop the treatment strategy and build an appropriate guideline for medical workers.

关键词： COVID-19 Angiotensin-converting enzyme-2 Transmembrane protease serine 2 Gastrointestinal symptom Mechanism Intestinal barrier permeability

Antioxidant Effects of Oats Avenanthramides on Human Serum

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Agricultural Sciences in China 2011年第8期10卷 1301-1305页

作者： LIU Sen yang Nan HOU Zhao-hua yao yang Lü Li ZHOU Xian-rong REN Gui-xing Institute of Comprehensive Utilization of Agricultural Products Shanxi Academy of Agriculture SciencesTaiyuan 030031P.R.China Institute of Crop Science Chinese Academy of Agricultural SciencesBeijing 100081P.R.China The General Hospital of Chinese People＇s Armed Police Forces Beijing 100039P.R.China

The antioxidant ability of capsules containing oats avenanthramides on human body was evaluated in present *** people were randomized to supplementation with oats-derived avenanthramides capsules or placebo for 1 *** lipid peroxides and antioxidant status were *** 8 capsules （containing 3.12 mg avenanthramides） groups,the levels of serum superoxide dismutase （SOD） and reduced glutathione hormone （GSH） were significantly increased by 8.4 and 17.9%,respectively （P0.05）,and malondialdehyde （MDA） level significantly decreased by 28.1%.The total cholesterol （TC）,triglyceride （TG）,and low density lipoprotein cholesterol （LDL-C） levels were lowered by 11.1,28.1,and 15.1%,respectively （P0.05）.The high density blood lipoprotein cholesterol （HDL-C） levels in the same treat was increased by 13.2%.Based on our research,it can be concluded that oats extract containing avenanthramides possessed a high antioxidative activity on *** indicated that oat avenanthramides could be used to prevent hyperlipemic and angiocardiopathy.

关键词： oats avenanthramides human serum antioxidation SOD MDA LDL-C HDL-C