检索结果-南通市图书馆

PRX1-pos.tive mes.nchymal s.em cells.drive molar morphogenes.s

在线全文

学校读者我要写书评

暂无评论

International Journal of Oral s.ience 2024年第2期16卷 293-305页

作者： Xiaoqiao Xu Xuyan Gong Lei Zhang Han Zhang yao s.n Department of Implantology Stomatological Hospital and Dental School of Tongji UniversityShanghai Engineering Research Center of Tooth Restoration and RegenerationShanghaiChina

Mammalian teeth,developing ins.parable from epithelial-mes.nchymal interaction,come in many s.apes.and the key factors.governing tooth morphology des.rve to be *** merging s.ngle-cell RNA s.quencing analys.s.with lineage tracing models.we have unearthed a captivating correlation between the contras.ing morphology of mous. molars.and the s.ecific pres.nce of PRX1^(+)cells.within *** PRX1^(+)cells.as.ume a profound res.ons.bility in s.aping tooth morphology through a remarkable divergence in dental mes.nchymal cell *** into the mechanis.s.we have dis.overed that Wnt5a,bes.owed by mes.nchymal PRX1^(+)cells.s.imulates.mes.nchymal cell proliferation while orches.rating molar morphogenes.s.through WNT s.gnaling *** los. of Wnt5a exhibits.a defect phenotype s.milar to that of *** addition of WNT5A can s.cces.fully revers. the inhibited cell proliferation and cons.quent deviant appearance exhibited in Prx1-deficient tooth *** findings.bes.ow compelling evidence of PRX1-pos.tive mes.nchymal cells.to be potential target in regulating tooth morphology.

关键词： Wnt5a mes.nchymal inhibited

Trans.ers. momentum balance of dijets.in Xe+Xe collis.ons.at the LHC

在线全文

学校读者我要写书评

暂无评论

Nuclear s.ience and Techniques 2024年第7期35卷 137-146页

作者： yao Li s.u-Wan s.en s. Wang Ben-Wei Zhang Key Laboratory of Quark&Lepton Phys.cs.MOE)and Ins.itute of Particle Phys.cs Central China Normal UniversityWuhan430079China College of s.ience China Three Gorges UniversityYichang443002China Center for As.ronomy and s.ace s.iences.and Ins.itute of Modern Phys.cs China Three Gorges UniversityYichang443002China Guangdong-Hong Kong Joint Laboratory of Quantum Matter Guangdong Provincial Key Laboratory of Nuclear ScienceSouthern Nuclear Science Computing CenterSouth China Normal UniversityGuangzhou510006China

We pres.nt a theoretical s.udy of the medium modifications.of the p_(T)balance (x_(J)) of dijets.in Xe+Xe collis.ons.at■.The initial production of dijets.was.carried out us.ng the POWHEG+PYTHIA8 pres.ription,which matches.the next-toleading-order (NLO) QCD matrix elements.with the parton s.ower (Ps. *** s.ELL model des.ribed the in-medium evolution of nucleus.nucleus.collis.ons.us.ng a trans.ort *** theoretical res.lts.of the dijet xJin the Xe+Xe collis.ons.exhibit more imbalanced dis.ributions.than thos. in the p+p collis.ons.cons.s.ent with recently reported ATLAs.*** utilizing the Interleaved Flavor Neutralis.tion,an infrared-and-collinear-s.fe jet flavor algorithm,to identify the flavor of the recons.ructed jets.we clas.ify dijets.proces.es.into three categories.gluon–gluon (gg),quark–gluon (qg),and quark–quark (qq),and inves.igated the res.ective medium modification patterns.and fraction changes.of the gg,qg,and qq components.of the dijet s.mple in Xe+Xe *** is.s.own that the increas.d fraction of qg component at a s.all x_(J)contributes.to the imbalance of the dijet;in particular,the q_(1)g_(2)(quark-jet-leading) dijets.experience more s.gnificant as.mmetric energy los. than the g_(1)q_(2)(gluon-jet-leading) dijets.travers.ng the *** comparing the■of inclus.ve,■ dijets.in Xe+Xe collis.ons.we obs.rve■.Moreover,ρ_(Xe),P_(b),the ratios.of the nuclear modification factors.of dijets.in Xe+Xe to thos. in Pb+Pb,were calculated,which indicates.that the yield s.ppres.ion of dijets.in Pb+Pb is.more pronounced than that in Xe+Xe owing to the larger radius.of the lead nucleus.

关键词： Heavy-ion collis.ons Quark-gluon plas.a Jet quenching Trans.ers. momentum balance

s.ngle-Ni-atoms.on nitrogenated humic acid bas.d porous.carbon for CO_(2) electroreduction

在线全文

学校读者我要写书评

暂无评论

Frontiers.of Chemical s.ience and Engineering 2024年第5期18卷 37-47页

作者： Delei Yu Ying Chen yao Chen Xiangchun Liu Xianwen Wei Ping Cui Anhui Key Laboratory of Coal Clean Convers.on&Utilization School of Chemistry and Chemical EngineeringAnhui University of TechnologyMa’anshan 243002Chin

tWe propos.d a facile s.nthes.s.of s.ngle-Ni-atom catalys.s.on low-cos. porous.carbon us.ng a calcina-tion method at the temperatures.of 850-1000°C,which were us.d for CO_(2) electrochemical reduction to *** porous.carbon was.prepared by carbonizing cheap and abundant humic *** s.ructural characterizations.of the as.s.nthes.zed catalys.s.and their electrocatalytic performances.were *** res.lts.s.owed that the s.ngle-Ni-atom catalys. activated at 950°C s.owed an optimum catalytic performance,and it reached a CO Faradaic efficiency of 91.9% with a CO partial current dens.ty of 6.9 mAcm^(-2)at-0.9 V *** hydrogen electrode(RHE).Additionally,the CO Faradaic efficiency and current dens.ty of the optimum catalys. changed s.ightly after 8 h of continuous.operation,s.gges.ing that it pos.es.ed an excellent *** s.ructure-activity relations.indicate that the variation in the CO_(2) electroche-mical reduction performance for the as.s.nthes.zed catalys.s.is.as.ribed to the combined effects.of the increas. in the content of pyrrolic N,the evaporation of Ni and N,the decreas. in pore volume,and the change in graphitization degree.

关键词： CO_(2) electroreduction s.ngle-Ni-atom cataly-s.s humic acid bas.d porous.carbon

Flexible piezores.s.ive pres.ure s.ns.r bas.d on a graphene-carbon nanotube-polydimethyls.loxane compos.te

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nanotechnology and Precis.on Engineering 2024年第3期7卷 35-44页

作者： Huifen Wei Xiangmeng Li Fangping yao Xinyu Feng Xijing Zhu s.anxi Provincial Key Laboratory of Advanced Manufacturing Technology North University of ChinaTaiyuan 030051China

Flexible s.ns.rs.are us.d widely in wearable devices. s.ecifically flexible piezores.s.ive s.ns.rs. which are common and eas. to ***, fabricating s.ch s.ns.rs.is.expens.ve and complex, s. propos.d here is.a s.mple fabrication approach involving a s.ns.r containing micros.ructures.replicated from a s.ndpaper template onto which polydimethyls.loxane containing a mixture of graphene and carbon nanotubes.is.s.in coated. The s.rface morphologies.of three vers.ons.of the s.ns.r made us.ng different grades.of s.ndpaper are obs.rved, and the corres.onding pres.ure s.ns.tivities.and linearity and hys.eres.s.characteris.ics.are as.es.ed and analyzed. The res.lts.s.ow that the s.ns.r made us.ng 80-mes. s.ndpaper has.the bes. s.ns.ng performance. Its.s.ns.tivity is.0.341 kPa-1in the loading range of 0–1.6 kPa, it res.onds.to s.all external loading of 100 Pa with a res.s.ance change of 10%, its.loading and unloading res.ons. times.are 0.126 and 0.2 s. res.ectively,and its.hys.eres.s.characteris.ic is.~7%, indicating that the s.ns.r has.high s.ns.tivity, fas. res.ons., and good s.ability. Thus. the pres.nted piezores.s.ive s.ns.r is.promis.ng for practical applications.in flexible wearable electronics.

关键词： Piezores.s.ive s.ns.r Flexible s.ns.r Graphene Carbon nanotube Polymer compos.te Micros.ructure

Preparation of baicalin colon-targeted granules.and its.intervention effect on ulcerative colitis.in rats

在线全文

学校读者我要写书评

暂无评论

Particuology 2024年第2期85卷 13-21页

作者： Yongqing Huang Yuxin Zhou yao s.en Jin Wang Liangliang Zhou Zhenhua Chen Jiangxi Provincial Key Laboratory of Drug Des.gn and Evaluation School of PharmacyJiangxi Science and Technology Normal UniversityNanchang330013China

Baicalin(BA)is.a flavonoid extracted from the dried root of s.utellaria baicalens.s.Georgi with excellent antioxidant and anti-inflammatory biological *** this.s.udy,Eudragit s.00 was.us.d as.the colonic target material to prepare BA colonic targeting granules.EBCGs.bas.d on plas.icizer dry powder coating technology to improve the targeting trans.ortation performance of *** vitro s.udies.s.owed that EBCGs.with pH-s.ns.tive properties.were s.cces.fully prepared by plas.icizer dry powder coating,and in vivo animal imaging s.udies.s.owed that EBCGs.could deliver BA to the colon and inhibit the releas. of BA in the upper gas.rointes.inal tract(GIT).In vivo s.udies.s.owed that EBCGs.had good therapeutic effects.in colitis.which reduced expres.ion levels.of tumor necros.s.factor alpha(TNF-α)and interleukin-1β(IL-1β)and increas.d s.peroxide dis.utas.(s.D)activities.in the colonic tis.ues.of rats.with *** conclus.on,Eudragit s.00 could be us.d for the preparation of multi-unit oral colon-targeted formulations.by plas.icizer dry powder coating technology,and our prepared EBCGs.had good colon-targeting properties.which could improve the therapeutic effect and provide a potential application for ulcerative colitis.UC).

关键词： Plas.icizer dry powder coating Colon-targeted granules.n vivo imaging Ulcerative colitis

Tribological Behaviors.of Electroles. Nickel-Boron Coating on Titanium Alloy s.rface

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chines. Journal of Mechanical Engineering 2024年第1期37卷 309-320页

作者： yao Jia Jianping Lai Jiaxin Yu Huimin Qi Yafeng Zhang Hongtu He Key Laboratory of Tes.ing Technology for Manufacturing Proces. in Minis.ry of Education State Key Laboratory of Environment-Friendly Energy MaterialsSouthwest University of Science and TechnologyMianyang 621010China

Titanium alloys.are excellent s.ructural materials.in engineering fields.but their poor tribological properties.limit their further *** plating is.an effective method to enhance the tribological performance of alloys.but it is.difficult to efficiently apply to titanium alloys.due to titanium alloy’s.s.rong chemical *** this.work,the electroles. Nickel-Boron(Ni-B)coating was.s.cces.fully depos.ted on the s.rface of titanium alloy(Ti-6AL-4V)via a new pre-treatment ***,linearly reciprocating s.iding wear tes.s.were performed to evaluate the tribological behaviors.of titanium alloy and its.electroles. Ni-B *** was.found that the Ni-B coatings.can decreas. the wear rate of the titanium alloy from 19.89×10^(−3)mm^(3)to 0.41×10^(−3)mm^(3),which attributes.to the much higher hardnes. of Ni-B *** heat treatment,the hardnes. of Ni-B coating further increas.s.corres.onding to coating crys.allization and hard phas. ***,heat treatment does.not improve the tribological performance of Ni-B coating,due to the fact that higher brittlenes. and more s.vere oxidative wear exacerbate the damage of heat-treated ***,the Ni-B coatings.heat-treated both in air and nitrogen almos. pres.nt the s.me tribological *** finding of this.work on electroles. coating would further extend the practical applications.of titanium alloys.in the engineering fields.

关键词： Electroles. coating Titanium alloy Tribology Wear Heat treatment Nanoindentation

Ins.ghts.into thermodynamic performance of a hypers.nic precooled air-breathing engine with a complicated multi-branch clos.d cycle

在线全文

学校读者我要写书评

暂无评论

Chines. Journal of Aeronautics 2024年第8期37卷 106-123页

作者： Yifan WANG Zhengping ZOU Pengcheng DU Lichao yao Huoxing LIU Yus.n XU Res.arch Ins.itute of Aero-Engine Beihang UniversityBeijing 102206China National Key Laboratory of s.ience and Technology on Aero-Engine and Aero-Thermodynamics Beihang UniversityBeijing 102206China

An advanced precooled airbreathing engine with a clos.d Brayton cycle is.a promis.ng s.lution for high-s.eed propuls.on,of which the s.nergetic Air Breathing Rocket Engine(s.BRE)is.a repres.ntative *** performance of the lates. s.BRE-4 cycle was.analyzed in this.***,a relatively complete engine performance model that cons.ders.the characteris.ics.of turbomachinery and heat exchangers.was.***,s.bol’global s.ns.tivity analys.s.of key performance parameters.was.carried out to identify the mos. influential des.gn *** s.ecific impuls.s.under different target s.ecific thrus.s.were obtained by particle s.arm optimization,of which the thermodynamic parameters.corres.onding to a s.ecific thrus. of 1.12 kN·s.kg^(-1)and a s.ecific impuls. of 3163 s.were chos.n as.the des.gn *** different control laws.were analyzed in contras.,and the charge control method had the s.ronges. ability of thrus. regulation as.well as.maintaining a favorable s.ecific impuls. ***,working characteris.ics.under the charge control and over a typical flight envelope were calculated,in which the average value of the maximum s.ecific impuls. was.as.high as.5315 *** s.udy would help to deepen the unders.anding of s.BRE-4 thermodynamic characteris.ics.and other precooled airbreathing engine cycles.with s.milar layouts.

关键词： Hypers.nic Precooled airbreathing engine Thermodynamic cycle Control law Working characteris.ics

AZGP1P2/UBA1/RBM15 Cas.ade Mediates.the Fate Determinations.of Pros.ate Cancer s.em Cells.and Promotes.Therapeutic Effect of Docetaxel in Cas.ration-Res.s.ant Pros.ate Cancer via TPM1 m6A Modification

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Res.arch 2024年第3期6卷 151-167页

作者： Hong Wang Jj Liu Xiaojun Zhu Bin Yang Zuping He Xudong yao Department of Urology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghaiChina Urologic Cancer Ins.itute School of MedicineTongji UniversityShanghaiChina. Department of Urology s.rgery The Affiliated Hospital of Inner Mongolia Medical UniversityHohhotChina. The Key Laboratory of Model Animals.and s.em Cell Biology in Hunan Province School of MedicineHunan Normal UniversityThe Engineering Research Center of Reproduction and Translational Medicine of Hunan ProvinceChangshaChina s.anghai Key Laboratory of Reproductive Medicine Shanghai Jiao Tong University School of MedicineShanghaiChina.

Pros.ate cancer(PCa)is.a common malignant tumor with high morbidity and mortality *** pros.ate cancer s.em cell(PCs.)model provides.novel ins.ghts.into the pathogenes.s.of PCa and its.therapeutic ***,the roles.and molecular mechanis.s.of s.ecific genes.in mediating fate decis.ons.of PCs.s.and carcinogenes.s.of PCa remain to be *** this.s.udy,we have explored the expres.ion,function,and mechanis. of AZGP1P2,a ps.udogene of AZGP1,in regulating the s.emnes. and apoptos.s.of PCs.s.and treatment res.s.ance of docetaxel in cas.ration-res.s.ant pros.ate cancer(CRPC).We revealed that AZGP1P2 was.downregulated in CRPC cell lines.and PCs.s.while it was.pos.tively as.ociated with progres.ion-free *** of the AZGP1P2 enhanced the s.ns.tivity of docetaxel treatment in CRPCs.via inhibiting their *** pull-down as.ociated with mas. s.ectrometry analys.s.co-immunoprecipitation as.ay,and RNA immunoprecipitation as.ay demons.rated that AZGP1P2 could bind to UBA1 and RBM15 as.a“writer”of methyltrans.eras. to form a ***1,an E1 ubiquitin-activating enzyme,contributed to RBM15 protein degradation via ubiquitination *** RNA immunoprecipitation as.ay dis.layed that RBM15 controlled the mRNA decay of TPM1 in m6A ***,a xenograft mous. model and patient-derived organoids.s.owed that the therapeutic effect of docetaxel in CRPC was.increas.d by AZGP1P2 in ***,thes. res.lts.imply that AZGP1P2 mediates.the s.emnes. and apoptos.s.of PCs.s.and promotes.docetaxel therapeutic effect by s.ppres.ing tumor growth and metas.as.s.via UBA1/RBM15-mediated TPM1 mRNA decay in CRPC.

关键词： Pros.ate TPM1 m6A

Bioins.ired s.raper-File Type Frequency-Doubling Ultras.nic Exciter

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2024年第4期21卷 1801-1816页

作者： Wens.uai Wu Mings.uo Zhang Zeming Li Guang yao Xinggang Jiang Deyuan Zhang s.hool of Mechanical Engineering and Automation Beihang UniversityBeijing100191China Ins.itute of Bionic and Micro-Nano s.s.ems Beihang UniversityBeijing100191China Guangdong Provincial Key Laboratory of Minimally Invas.ve s.rgical Ins.ruments.and Manufacturing Technology Guangdong University of TechnologyGuangzhou510006China

In the natural world,leaf-cutting ants.caus. vibrations.through their mutual s.raping of file-s.raper *** this.s.udy,we des.gned a Biomimetic Ultras.nic Exciter(BUE)that imitates.leaf-cutting *** operating characteris.ics.of the BUE were s.udied through experimental tes.ing and finite element *** res.lts.s.owed that the BUE could generate s.able ultras.nic vibrations.and that the excitation frequency only needed to be half the Output Frequency(OF).This.frequency-doubling phenomenon was.conducive to achieving BUE *** further explore the phenomenon of frequency-doubling vibration output,this.s.udy des.gned s.rapers.of five different s.zes.conducted excitation and firs.-order natural frequency meas.rement tes.s.and the corres.onding finite element *** was.found that each s.raper could operate in frequency-doubling mode,but the operating frequency and natural mode frequencies.did not corres.ond with one *** further explicate experimental and s.mulation res.lts.a two-degrees.of-freedom vibration model was.*** was.evident that the contact relations.ip between the dentate dis. and s.raper introduced s.rong nonlinear factors.into the s.s.em,accounting for the frequency-doubling phenomenon and the difference between the BUE’s.operating and mode *** BUE could be expected to facilitate the production of high-power micro-ultras.nic generators.and has.potential application value in the fields.of mechanical proces.ing,indus.rial production,and medical health.

关键词： Leaf-cutting ants Power ultras.und Nonlinear vibration Ultras.nic s.alpel Micro vibrator