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FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： jing yao Yuan Li Xi Liu Wenping Liang Yu Li Liyong Wu Zhe Wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

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Enhancement in Magnetorheological Effect of Magnetorheological Elastomers by Surface Modification of Iron Particles

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Chinese Journal of Chemical Physics 2008年第1期21卷 87-92页

作者： Wan-quan Jiang jing-jing yao Xing-long Gong Lin Chen Department of Chemistry University of Science and Technology of China Hefei 230026 China CA5 Key Laboratory of Mechanical Behavior and Design of Materials Department of Mechanics andMechanical Engineering University of Science and Technology of China Hefei 230027 China

In order to obtain magnetorheological （MR） elastomers with high magnetorheological effect, a family of anisotropic rubber-based MR elastomers was developed using a new form of chemical modification. Three different kinds of surfactants, i.e. anionic, nonionic and compound surfactants, were employed separately to modify iron particles. The MR effect was evaluated by measuring the dynamic shear modulus of MR elastomer with a magneto-combined dynamic mechanical analyzer. Results show that the relative MR effect can be up to 188% when the iron particles are modified with 15% Span 80. Besides the surface activity of Span 80, however, such high modifying effect is partly due to the plasticizing effect of Span 80. Compared with the single surfactant, the superior surface activity of compound surfactant makes the relative MR effect reach 77% at a low content of 0.4%. Scanning electron microscope observation shows that the modification of compound surfactant results in perfect compatibility between particles and rubber matrix and special self-assembled structure of particles. Such special structure has been proved beneficial to the improvement of the relative MR effect.

关键词： Magnetorheological elastomers Shear modulus Surfactant Microstructure

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Rapid Hypoeutectic Growth Within a Highly Undercooled Liquid Under containerless Condition

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Chinese Physics Letters 2002年第4期19卷 584-587页

作者： Han Xiu-Jun, yao Wen-jing Department of Applied Physics Northwestern Polytechnical University

Rapid hypoeutectic growth from a highly undercooled liquid was accomplished by containerless processing Ni-32%Sb hypoeutectic alloy in a 3m drop tube. The containerless state during the free fall of the droplet produces substantial undercooling up to 350K (0.24TL). The growth mechanism is found to transform from primary α-Ni dendrite plus lamellar eutectic to lamellar eutectic and finally to anomalous eutectic if droplet undercooling exceeds the two thresholds of 112K and 242K, respectively. Based on the current eutectic and dendritic growth models, the eutectic coupled zone is calculated and used to explain the growth mechanism transition. Calculations also indicate that the growth of α-Ni primary dendrite was mainly controlled by solute diffusion.

关键词： growth(materials) Dendrites dendrites hypoeutectic growth solute diffusion free fall hypoeutectic alloy Undercooling EUTECTIC Growth anomalous eutectic

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Beyond pixels:Learning from multimodal hyperspectral superpixels for land cover classification

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Science China(Technological Sciences) 2022年第4期65卷 802-808页

作者： HONG DanFeng WU Xin yao jing ZHU XiaoXiang Key Laboratory of Computational Optical Imaging Technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100094China School of Computer Science(National Pilot Software Engineering School) Beijing University of Posts and TelecommunicationsBeijing 100876China Remote Sensing Technology Institute German Aerospace Center(DLR)Wessling 82234Germany Data Science in Earth Observation Technical University of MunichMunich 80333Germany

Despite tons of advanced classification models that have recently been developed for the land cover mapping task,the monotonicity of a single remote sensing data source,such as only using hyperspectral data or multispectral data,hinders the classification accuracy from being further improved and tends to meet the performance *** this reason,we develop a novel superpixel-based subspace learning model,called Supace,by jointly learning multimodal feature representations from HS and MS superpixels for more accurate LCC *** can learn a common subspace across multimodal RS data,where the diverse and complementary information from different modalities can be better combined,being capable of enhancing the discriminative ability of to-be-learned features in a more effective *** better capture semantic information of objects in the feature learning process,superpixels that beyond pixels are regarded as the study object in our Supace for *** experiments have been conducted on two popular hyperspectral and multispectral datasets,demonstrating the superiority of the proposed Supace in the land cover classification task compared with several well-known baselines related to multimodal remote sensing image feature learning.

关键词： classification hyperspectral image land cover multimodal multispectral image remote sensing subspace learning superpixels

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Degradation of Organic Pollutants in Water by Catalytic Ozonation

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Chemical Research in Chinese Universities 2007年第3期23卷 273-275页

作者： LI Xin yao Jun-hai QI jing-yao Department of Applied Chemistry School of Civil Engineer Harbin Institute of Technology Harbin 150090 P. R. China

Different series of transition metal catalysts supported on Al2O3 were prepared by the impregnation method. The catalytic activity was measured in a batch reactor with ozone as the oxidizing reagent. The experimental results indicate that Cu/Al2O3 has a very effective catalytic activity during the ozonation of organic pollutants in water. The optimum conditions for preparing Cu/Al2O3 were systematically investigated with the orthogonal testing method. Furthermore, the results also show that the surface properties of catalyst are not compulsory for effective oxidation.

关键词： Catalytic ozonation Catalyst Orthogonal experiment Water treatment

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Learning from berberine: Treating chronic diseases through multiple targets

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Science China(Life Sciences) 2015年第9期58卷 854-859页

作者： yao jing KONG WeiJia JIANG JianDong Cancer Center Union Hospital Tongji Medical College Huazhong University of Science and Technology Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences & Peking Union Medical College Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College

Although advances have been made, chemotherapy for chronic, multifactorial diseases such as cancers, Alzheimer's disease, cardiovascular diseases and diabetes is far from satisfactory. Agents with different mechanisms of action are required. The botanic compound berberine(BBR) has been used as an over-the-counter antibacterial for diarrhea in China for many decades. Recent clinical studies have shown that BBR may be therapeutic in various types of chronic diseases. This review addresses BBR's molecular mechanisms of action and clinical efficacy and safety in patients with type 2 diabetes, hyperlipidemia, heart diseases, cancers and inflammation. One of the advantages of BBR is its multiple-target effects in each of these diseases. The therapeutic efficacy of BBR may reflect a synergistic regulation of these targets, resulting in a comprehensive effect against these various chronic disorders. The safety of BBR may be due to its harmonious distribution into those targets. Although the single-target concept is still the principle for drug discovery and research, this review emphasizes the concept of a multiple target strategy, which may be an important approach toward the successful treatment of multifactorial chronic diseases.

关键词： chronic multifactorial diseases drug treatment berberine multiple-target

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Fabrication of Electrospun PVDF Nanofibers with Higher Content of Polar β Phase and Smaller Diameter by Adding a Small Amount of Dioctadecyl Dimethyl Ammonium Chloride

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Chinese Journal of Polymer Science 2017年第8期35卷 992-1000页

作者： wei xue cong lv yao jing 陈枫傅强 College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 China

In this work,the effect of dioctadecyl dimethyl ammonium chloride（DDAC,a kind of alkyl ammonium salt） on polar β phase content and the diameter of electrospun PVDF nanofibers was investigated for the first *** experimental results show that the diameter of the electrospun PVDF nanofiber could be largely reduced and the content of polar β phase also become dominant immediately by just adding a little amount of *** the mass fraction of DDAC reached 4%,the content of polar β phase increased by about 39.1% compared with PVDF nanofibers without ***,the crystallinity of PVDF nanofibers also increased with the addition of *** on the results,the possible mechanism of cooperative effect between electrospinning and DDAC on fiber diameter and formation of β phase in PVDF was discussed.

关键词： Diameter crystalline crystallinity polar cooperative adding Polar ammonium alkyl attributed

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Tuning the reversible chemisorption of hydroxyl ions to promote the electrocatalysis on ultrathin metal-organic framework nanosheets

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Journal of Energy Chemistry 2022年第2期31卷 71-77页

作者： Hong Yu yao jing Cheng-Feng Du Jiong Wang State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsNorthwestern Polytechnical UniversityXi’an 710072ShaanxiChina Institute of Advanced Synthesis Northwestern Polytechnical UniversityXi’an 710072ShaanxiChina

Interfacial engineering to alter the configuration of active sites in heterogeneous catalysts is a potential strategy for activity enhancement,but it remains unelucidated for metal-organic frameworks(MOFs).Here,we demonstrate that the surface of two-dimensional Co-based MOF is modified by decorating Ag quantum dots(QDs)simply through in-situ reduction of Ag+*** oxygen evolution reaction(OER),it reveals that the catalysis is mediated by the reversible redox of Co sites between Co^(3+) and Co^(4+) states coupling with transfer of OH*** decoration of Ag QDs decreases the redox potential of Co sites,and thus effectively decreases the overpotential of *** TOFs of Co sites are increased by 77 times to reach 5.4 s^(-1) at an overpotential of 0.35 *** attribute the activity enhancement to the tuning of the coupling process between Co sites and OHions during the redox of Co sites by Ag QDs decoration based on Pourbaix analysis.

关键词： 2D metal-organic frameworks Interfacial engineering Pourbaix analysis Chemisorption of hydroxyl ions Oxygen evolution reaction

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Sodium cellulose sulfate: A promising biomaterial used for microcarriers' designing

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Frontiers of Chemical Science and Engineering 2019年第1期13卷 46-58页

作者： Qing-Xi Wu Yi-Xin Guan Shan-jing yao Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China School of Life Sciences Anhui UniversityAnhui Key Laboratory of Modem BiomanufacturingKey Laboratory of Eco-engineering and Biotechnology of Anhui ProvinceHefei 230601China

Due to a worldwide focus on sustainable materials for human health and economy services, more and more natural renewable biomass are regarded as promising materials that could replace synthetic polymers and reduce global dependence on petroleum resources. Cellulose is known as the most abundant renewable polymer in nature, varieties of cellulose-based products have been developed and have gained growing interest in recent years. In this review, a kind of water-soluble cellulose derivative, i.e., sodium cellulose sulfate (NaCS) is introduced. Details about NaCS's physicochemical properties like solubility, biocompatibility, biodegradability, degree of substitution, etc. are systematically elaborated. And promising applications of NaCS used as biomaterials for microcarriers' designing, such as microcell- carriers, micro-drug-carriers, etc., are presented.

关键词： sodium cellulose sulfate biomaterial physicochemical properties microcarriers

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Modelling and Dynamic Characteristics for a Non-metal Pressurized Reservoir with Variable Volume

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Chinese Journal of Mechanical Engineering 2022年第2期35卷 159-173页

作者： Pei Wang jing yao Baidong Feng Mandi Li Dingyu Wang School of Mechanical Engineering Yanshan UniversityQinhuangdao 066004China Advanced Manufacturing Forming Technology and Equipment Qinhuangdao 066004China Hebei Provincial Key Laboratory of Heavy Fluid Power Transmission and Control Yanshan UniversityQinhuangdao 066004China

With the increasing demand to reduce emissions and save energy,hydraulic reservoirs require new architecture to optimize their weight,space,and *** open reservoirs are large,heavy,and easily polluted,and threaten the operation of hydraulic systems.A closed reservoir provides the advantages of small volume and light weight,compared to open *** this study,a non-metallic pressure reservoir with variable volume is designed and manufactured for closed-circuit hydraulic *** reservoir housing is made of rubber,and the Mooney-Rivlin model is chosen based on the rubber strain *** FEA simulation for the reservoir is performed using ANSYS Workbench to obtain the structural *** major contribution is the establishment of mathematical models for this reservoir,including the volume equation changing with height,flow equation,and force balance equation,to explore the output characteristics of this *** on these results,simulation models were built to analyze the output characteristics of the ***,the test rig of a conventional hydraulic system was transformed into a closed-circuit asymmetric hydraulic system for the reservoir,and preliminary verification experiments were conducted on *** results demonstrate that the designed reservoir can absorb and discharge oil and supercharge pump inlet to benefit system *** changes in the volume and pressure with displacements under different volume ratios and frequencies were obtained,which verified the accuracy of the mathematical *** to its lightweight design and small volume,the reservoir can replace conventional open reservoirs,and this lays a foundation for future theoretical research on this reservoir.

关键词： Hydraulic reservoir Variable volume Pressure reservoir Non-metal Lightweight

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