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The Synthesis of 1-Aryl-5-Fluorouracil

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Chinese Chemical Letters 2000年第10期11卷 865-866页

作者： jin Zong YOU Shao Yuan chen Omar ISHRUD Yan Guang WANG yao zu chen Department of Chemistry Zhejiang UniversityHangzhou 310027 National Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhou 730000

A series of new type substituted 5-fluorouracil derivatives, 1-aryl-5-fluorouracil (4a-4f), were synthesized via diaryliodonium salts and the structure of the title compound was finally confirmed by IR, UV. H-1-NMR. M... 详细信息

关键词： synthesis 1-aryl-5-fluorouracil

A meta-regression evaluating the effectiveness and prognostic factors of oral phosphodiesterase type 5 inhibitors for the treatment of erectile dysfunction

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Asian Journal of Andrology 2016年第1期18卷 60-65页

作者： jin-Qiu Yuan chen Mao zu-yao Yang Xiao-Hong Fu Samuel Y Wong jin-Ling Tang Division of Epidemiology School of Public Health and Primary Care The Chinese University of Hang Kong Hang Kong China Shenzhen Municipal Key Laboratory for Health Risk Analysis Shenzhen Research Institute of The Chinese University of Hang Kong Shenzhen 518055 China Department of Community and Family Medicine The Chinese University of Hang Kong Hang Kong China

The effectiveness of phosphodiesterase type 5 inhibitors （PDE5-1s） for erectile dysfunction （ED） varies considerably among trials, but available studies investigating the factors that affect the effectiveness are few and findings are not consistent. A systematic search was performed in PubMed, Cochrane Library, and EMBASE to identify randomized controlled trials comparing PDE5-1s with placebo for the treatment of ED. The methodological quality of included studies was assessed by the Cochrane Collaboration＇s tool for assessing risk of bias. The associations between prespecified study-level factors and effectiveness were tested by a random effects meta-regression model. This study included 93 trials with 26 139 patients. When all PDE5-1s were grouped together, Caucasian ethnicity was associated with 15.636% （95% confidence interval [CI]： 0.858% to 32.579%） increase in risk ratio （RR） for Global Assessment Questionnaire question-1 （GAQ-1）, and 1.473 （95% CI： 0.406 to 2.338） score increase in mean difference （MD） for posttreatment International Index of Erectile Function-Erectile Function domain score （IIEF-EF）, compared to Asian ethnicity. A one-score increase in baseline IIEF-EF was associated with -5.635% （95% CI： -9.120% to -2.017%） reduction in RR for GAQ-1, and -0.229 （95% CI： -0.425 to -0.042） score decrease in MD for posttreatment IIEF-EF. In conclusion, PDE5-1s are more effective in Caucasians than Asians, and in patients with more severe ED.

关键词： erectile dysfunction meta-regression phosphodiesterase type 5 inhibitors systematic review

Review of the genus Brachytarsophrys(Anura:Megophryidae),with revalidation of Brachytarsophrys platyparietus and description of a new species from China

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Zoological Research 2020年第2期41卷 105-122页

作者： yao Li Dan-Dan Zhang Zhi-Tong Lyu Jian Wang Yu-Long Li zu-yao Liu Hong-Hui chen Ding-Qi Rao Zhi-Fang jin Chang-You Zhang Ying-Yong Wang State Key Laboratory of Biocontrol/The Museum of Biology School of Life SciencesSun Yat-Sen UniversityGuangzhouGuangdong 510275China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Jiangxi Jiulianshan National Nature Reserve GanzhouJiangxi 341700China

The genus-level recognition of monophyletic short-legged toads(Brachytarsophrys)has been recently implicated in the taxonomic debate of Megophrys sensu *** the present study,Brachytarsophrys is reasonably regarded as a distinct genus based on significant morphological differentiations and recent molecular ***,a comprehensive review of this genus is performed,with two species groups proposed based on morphological differences and phylogenetic ***,Brachytarsophrys platyparietus is removed as a synonym of Brachytarsophrys carinense and considered a valid species due to significant genetic divergence and distinct morphological *** addition,a new species,Brachytarsophrys orientalis ***.,is described based on a series of specimens collected from southeastern *** work takes the member species of the genus Brachytarsophrys to seven,suggesting that the diversity of Brachytarsophrys is *** addition,the genus levels of other monophyletic groups within the subfamily Megophryinae are discussed.

关键词： Genus level Megophryinae Morphology Phylogeny Revision

A Facile and Highly Stereosclective Reductive Dcbromination of AnhydrO-6- (R)-Hydroxyethyl- 6-Bromopenicillin

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Chinese Chemical Letters 2000年第5期11卷 385-386页

作者： Bing ZHENG jin Long WU Shao Jun XU Jian Feng SHI yao zu chen (Department of Chemistry, Zhejiang University, Hangzhou 310027 National Laboratory of Applied Organic Chemistry.Lanzhou 730000) Department of Chemistry Zhejiang University Hangzhou 310027 China Natl. Lab. of Appl. Organ. Chemistry Lanzhou 730000 China

Reductive debromination of anhydro-6-(R)-hydroxycthyl-6-(R) 7 by zinc in ammonium acetate gave 9 in 81% yield with high stcreosclectivity of 6-(α):6-(β)= 13: 1

关键词： Reductive debromination. stereoselcctivity. anhydro-6-(R)-hydroxyethyl-6-bromo- penicillin.

Changes in microRNAs expression are involved in age-related atrial structural remodeling and atrial fibrillation

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Chinese Medical Journal 2013年第8期126卷 1458-1463页

作者： XU guo-jun GAN Tian-yi TANG Bao-peng chen zu-heng Mahemuti Ailiman ZHOU Xian-hui JIANG Tao SONG Jian-guo guo Xia LI yao-dong MIAO Hai-jun ZHANG Yu LI jin-xin Department of CardiologyFirst Affiliated Hospital Xinjiang Medical UniversityUrumqi Xinjiang 830011 China Department ofAnimal Experiment First Affiliated Hospital Xinjiang Medical UniversityUrumqi Xinjiang 830011 China Laboratory of Electrophysiology First Affiliated Hospital Xinjiang Medical UniversityUrumqi Xinjiang 830011 China Department of Molecular Biology First Affiliated Hospital Xinjiang Medical UniversityUrumqi Xinjiang 830011 China

Background Small noncoding microRNAs regulate gene expression in cardiac development and disease and have been implicated in the aging process and in the regulation of extracellular matrix proteins. However, their role in age-related cardiac remodeling and atrial fibrillation （AF） was not well understood. The present study was designed to decipher molecular mechanisms underlying age-related atrial structural remodeling and AF. Methods Three groups of dogs were studied： adult and aged dogs in sinus rhythm and with persistent AF induced by rapid atrial pacing. The expressions of microRNAs were measured by quantitative real-time polymerase chain reaction. Pathohistological and ultrastructural changes were tested by light and electron microscopy. Apoptosis index of myocytes was detected by TUNEL. Results Samples of atrial tissue showed the abnormal pathohistological and ultrastructural changes, the accelerated fibrosis, and apoptosis with aging and/or in AF dogs. Compared to the adult group, the expressions of microRNAs-21 and -29 were significantly increased, whereas the expressions of microRNAs-1 and -133 showed obvious downregulation tendency in the aged group. Compared to the aged group, the expressions of microRNAs-1, -21, and -29 was significantly increased in the old group in AF; contrastingly, the expressions of microRNA-133 showed obvious downregulation tendency. Conclusion These multiple aberrantly expressed microRNAs may be responsible for modulating the transition from adaptation to pathological atrial remodeling with aging and/or in AE

关键词： atrial fibrillation aging structural remodeling microRNAs

Anticancer Drugs (V)─—Synthesis of Etoposide Derivatives

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Chemical Research in Chinese Universities 1995年第1期11卷 79-83页

作者： TIAN Xuan YAN Ze-qun LI jin-xin and chen yao-zu(National Laboratory of Applied Organic Chemistry,Lanzhou Uniuersty, Lanzhou , 730000)MU Xiao-qin(Department of Chemistry , Tianshui Teaches’ College , Tianshui , 741000) LANZHOU UNIV NATL LAB APPL ORGAN CHEMLANZHOU 730000PEOPLES R CHINA TIANSHUI TEACHERS COLL DEPT CHEMTIANSHUI 741000PEOPLES R CHINA

ＡｎｔｉｃａｎｃｅｒＤｒｕｇｓ（Ｖ）─—ＳｙｎｔｈｅｓｉｓｏｆＥｔｏｐｏｓｉｄｅＤｅｒｉｖａｔｉｖｅｓＴＩＡＮＸｕａｎ，ＹＡＮＺｅ－ｑｕｎ，ＬＩＪｉｎ－ｘｉｎａｎｄＣＨＥＮＹａｏ－ｚｕ（ＮａｔｉｏｎａｌＬａｂｏｒａｔ... 详细信息

ＡｎｔｉｃａｎｃｅｒＤｒｕｇｓ（Ｖ）─—ＳｙｎｔｈｅｓｉｓｏｆＥｔｏｐｏｓｉｄｅＤｅｒｉｖａｔｉｖｅｓＴＩＡＮＸｕａｎ，ＹＡＮＺｅ－ｑｕｎ，ＬＩＪｉｎ－ｘｉｎａｎｄＣＨＥＮＹａｏ－ｚｕ（ＮａｔｉｏｎａｌＬａｂｏｒａｔｏｒｙｏｆＡｐｐｌｉｅｄＯｒｇａｎ...

关键词： Etoposide Anticancer drugs Nitroxyl radical 5-Fluorouracil

4β-氨基-4-脱氧鬼臼毒素和4β-氨基-4-脱氧-4’-去甲基鬼臼毒素的两种新合成方法

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高等学校化学学报 2000年第7期21卷 1064-1066页

作者：陈绍瑗俞永平游金宗陈耀祖浙江大学生物系浙江大学化学系杭州310027

Two new methods for synthesis of 4β-amino-4-deoxypodophyllotoxin and 4β-amino-4-demethyl-4-deoxypodophyllotoxin have been developed. These compounds were synthesized by reduction of the corresponding 4β-anzido-podophyllotoxin derivatives with SmI2 or HCO2NH4/Pd-C in excellent yields under mild conditions with convenient manipulation.

关键词：鬼臼毒素二碘化钐甲酸铵合成抗癌活性

Anticancer Drugs ( Ⅳ )——New Derivatives of Podophyllotoxin

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Chemical Research in Chinese Universities 1993年第2期9卷 116-120页

作者： TIAN Xuan, LI jin-xin, ZHANG Ya-li chen yao-zu (National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000)LI Wen-guang (Department of Pharmacology, Lanzhou Medicine College, Lanzhou, 730000)

Four new derivatives of podophyllotoxin, N'-podophyllic acid-N-[3-(2, 2, 5, 5-te-tramethyl-pyrrolinenyloxy)] semicarbazide(GP-11, 6), podophyllic acid [3-(2,2,5,5-te-tramethyl-pyrrolinenyloxy)]hydrazone (GP-12, 7), podophyllic acid-[4-(2, 2, 6, 6-tetramethyl-1-hydroxy piperidine)]hydrazone(GP-1-OH, 8) and podophyllic acid[4-(2,2, 6, 6-tetramethyl piperidine)]hydrazone(GP-1-H, 9) were synthesized. The inhibition effect of the four new compounds on L-1210 cells were determined. The antitumor activity and toxicity of GP-1(2), GP-1-OH(8), GP-1-H(9) and VP-16-213(1) were discussed.

关键词： Podophyllotoxin Anticancer drugs Nitroxyl radical

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复配材料钝化重金属污泥试验及工程应用研究

中国环境科学 2021年第10期41卷 4857-4863页

作者：谭娟吴建强陈春郭晋川王耀祖王润中黄沈发上海市环境科学研究院上海200233 广西水工程材料与结构重点实验室广西南宁530023 上海申榕环保设备有限公司上海200032

利用多组分新型高效材料与普通硅酸盐水泥制得复配材料,开展箱涵清淤重金属(Cd、Cr、Cu、Ni、Pb和Zn)污染底泥钝化试验及工程应用研究,采用无侧限抗压强度和毒性浸出浓度评价钝化效果,进一步分析重金属赋存形态变化探讨钝化机制.结果表... 详细信息

利用多组分新型高效材料与普通硅酸盐水泥制得复配材料,开展箱涵清淤重金属(Cd、Cr、Cu、Ni、Pb和Zn)污染底泥钝化试验及工程应用研究,采用无侧限抗压强度和毒性浸出浓度评价钝化效果,进一步分析重金属赋存形态变化探讨钝化机制.结果表明,底泥:复配材料:黄沙质量配比为5:4:1时,钝化效果最佳.实际工程应用中,H型和O型固化砖抗压强度分别达10.82和10.11MPa,毒性浸出浓度远低于鉴别标准值(GB5085.3-2007),满足资源化应用要求.重金属浸出浓度与离子交换态和有机结合态占比呈正相关,有机结合态和铁锰氧化态分别为底泥和固化砖中重金属的主要赋存形态,二者占比在固化前后呈现完全相反的变化趋势,该变化对固化稳定化重金属起重要作用.除H型Cr外,其他固化砖中重金属残渣态占比均有所增加.该复配材料基于多组分物质间相互协同作用实现重金属钝化具有实际应用前景.

关键词：底泥重金属固化稳定化化学形态工程应用