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Nano Research 2024年第5期17卷 4517-4524页

作者： Jiwei Li yao xie Renrui Sun Junxun Zhou Lining Sun Department of Chemistry College of SciencesShanghai UniversityShanghai 200444China Department of Physics College of SciencesShanghai UniversityShanghai 200444China School of Medicine Shanghai UniversityShanghai 200444China

Luminescence quench is common in overdoped upconversion *** methods have been proposed to counteract the adverse effects of concentration quenching on luminescence,but in upconversion nanoparticles that are highly doped with both sensitizers and activators,the factors that contribute to the diminishing of the emission cannot be summarized by a single ***,a core-shell design is used to spatially separate the sensitizer(Yb^(3+))and activator(Er^(3+))and to modulate the emission by changes in the distribution position as well as the concentration of the dopant ions in order to probe the factors affecting the *** the sensitizer ions are located in the core,the luminescence intensity of the nanoparticles is significantly weaker than that of the other distribution,which implies that the effect of sensitizer and activator on luminescence in the highly doped state has a different and more complex *** intensity of the emission is more affected by Yb^(3+)than Er^(3+),which includes not only the self-quenching of Yb^(3+),but also the dominance in the Yb^(3+)-Er^(3+)*** this finding may provide new ideas for revealing the reasons for the diminished luminescence of highly doped upconversion nanoparticles and thus for enhancing luminescence.

关键词： upconversion luminescence lanthanide ion core-shell nanoparticles concentration quenching cross-relaxation

Resist-decreasing effects of rock bolts on strength of rock mass around roadway——insight from numerical modeling

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Mining Science and Technology 2009年第4期19卷 425-429页

作者： GAO Fu-qiang xie yao-she Mining and Designing Branch Central Coal Research Institute Beijing 100013 China Department of Earth Sciences Simon Fraser University Burnaby VSC2Z9 Canada School of Mines China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

To investigate the resist-decreasing effects of rock bolts on the strength of the rock mass around a roadway, a compara- tive study has been carded out using the numerical analysis code FLAC3D. An unsupported and a rock bolt supported model have been built for comparison. Two types of rock mass strength, the uniaxial compressive strength （UCS） and the wiaxial compressive strength （TCS） of rock mass have been obtained from each model, using a prepared Fish based on the Mohr-Coulomb criterion. The results indicate that when a roadway is excavated, both the UCS and TCS in a definite local rock mass around the roadway would inevitably decrease, no matter whether the roadway is supported or not. The major decreasing region did not settle in the middle of the roadway surface, but within a deeper horizon into the rock mass. The resist-decreasing effects of rock bolts both on the UCS and the TCS of rock mass around roadway are significant.

关键词： resist-decrease rock mass strength rock bolts numerical simulation

The application of Melissa officinalis *** oil nanoemulsions protects sea bass(Lateolabrax japonicus)against myofibrillar protein and lipid oxidation during refrigeration

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Food Quality and Safety 2023年第3期7卷 447-455页

作者： yao xie Huijie Yu Xin Zhao Chuhan Bian Hao Cheng Jun Mei Jing xie College of Food Science&Technology Shanghai Ocean UniversityShanghaiChina Shanghai Professional Technology Service Platform on Cold Chain Equipment Performance and Energy Saving Evaluation Shanghai Ocean UniversityShanghaiChina National Experimental Teaching Demonstration Center for Food Science and Engineering Shanghai Ocean UniversityShanghaiChina Shanghai Engineering Research Center of Aquatic Product Processing&Preservation Shanghai Ocean UniversityShanghaiChina

Objectives:The nutrient rich sea bass is prone to oxidation of lipid and protein during *** and Methods:The research was to investigate the effect of different concentrations of Melissa officinalis *** oil(MOEO)nanoemulsions on myofibrillar protein(MP)and lipid oxidation in sea bass(Lateolabrax japonicus)during refrigeration at 4°***:The results of thiobarbituric acid reactive substances and mitochondrial membrane potential showed that carboxymethyl chitosan/locust bean gum active coating solutions incorporating 2%MOEO nanoemulsions(C/L-2M)was the most effective in inhibiting lipid oxidation that occurred in sea bass under attack by reactive oxygen ***-field nuclear magnetic resonance results showed that C/L-2M maximally slowed the conversion of bound water to free water during *** oxidation of lipids and MP disrupted the secondary and tertiary conformations of MP and accelerated protein aggregation and ***:C/L-2M slowed the oxidation of lipids and proteins by inhibiting the oxidation of reactive oxygen species.C/L-2M is a very promising preservative emulsion for the preservation of sea bass.

关键词： Lateolabrax japonicus Melissa officinalis L.essential oil lipid oxidation protein oxidation active coating solutions

Determination of Roxithromycin Tablets by Capillary Electrophoresis Employing Non-aqueous Media with Square-wave Amperometric Detection

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Chinese Chemical Letters 2002年第5期13卷 440-441页

作者： Na LI Tian yao xie Jin Yuan MO School of Chemistry and Chemical Engineering Zhongshan UniversityGuangzhou 510275

A new method of determination for roxithromycin tablets by non-aqueous capillary electrophoresis (NACE) with square-wave amperometric detection was carried out. Several parameters affecting the NACE-AD determination were studied. The data was modified by spline wavelet least square (SWLS). The method is simple, rapid and highly reliable for routine analysis.

关键词： Non-aqueous capillary electrophoresis (NACE) amperometric detection roxithromycin spline wavelet least square (SWLS).

Peginterferon alfa-2a for the treatment of chronic hepatitis C in the era of direct-acting antivirals

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Hepatobiliary & Pancreatic Diseases International 2017年第5期16卷 470-479页

作者： Yan Huang Ming-Hui Li Min Hou yao xie Shanghai Roche Pharmaceuticals Ltd. Shanghai 201203 China Liver Disease Center Beijing Ditan Hospital Capital Medical University Beijing 100015 China

BACKGROUND: The availability of novel direct-acting antivirals (DAAs) represents a new era of curative hepatitis C virus (HCV) treatment, with over 95% of patients infected with HCV genotype 1 achieving sustained virological response (SVR). Nevertheless, the majority of patients globally are unable to access these treatments because of cost and infrastructure constraints and, thus, remain untreated and uncured. DATA SOURCE: Relevant articles of peginterferon (PegIFN)-based treatments in HCV and sofosbuvir-based treatments, simeprevir, daclatasvir/asunaprevir, ritonavir-boosted paritaprevir/ombitasvir/dasabuvir, and grazoprevir/elbasvir, were searched in PubMed database, including general population and special population. RESULTS: PegIFN in combination with ribavirin remains an important and relevant option for some patients, achieving SVR rates of up to 79% in genotype 1 and 89% in genotype 2 or 3 infections, which increases for patients with favorable IL28B genotypes. Triple therapy of DAA plus PegIFN/ribavirin is effective in treating difficult-to-cure patients infected with HCV genotype 3 or with resistance-associated variants. Owing to its long history in HCV management, the efficacy, tolerability and long-term outcomes associated with PegIFN alfa-2a are well established and have been validated in large-scale studies and in clinical practice for many populations. Furthermore, emerging data show that IFN-induced SVR is associated with lower incidences of hepatocellular carcinoma compared with DAAs. On the contrary, novel DAAs have yet to be studied in special populations, and long-term outcomes, particularly tumor development and recurrence in patients with cirrhosis and/or hepatocellular carcinoma, and reactivation of HBV in dually infected patients, are still unclear. CONCLUSION: In this interferon-free era, PegIFN-based regimens remain a safe and effective option for selected HCV patients.

关键词： chronic hepatitis C direct-acting antivirals hepatitis C virus peginterferon alfa-2a ribavirin

Lanthanide-doped heterostructured nanocomposites toward advanced optical anti-counterfeiting and information storage

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Light(Science & Applications) 2022年第6期11卷 1264-1273页

作者： yao xie Yapai Song Guotao Sun Pengfei Hu Artur Bednarkiewicz Lining Sun Department of Physics College of SciencesShanghai UniversityShanghai 200444China Department of Chemistry College of SciencesShanghai UniversityShanghai 200444China School of Materials Science and Engineering Shanghai UniversityShanghai 200444China Research Center of Nano Science and Technology College of SciencesShanghai UniversityShanghai 200444China Instrumental Analysis&Research Center Shanghai UniversityShanghai 200444China Institute of Low Temperature and Structure Research Polish Academy of Sciences50-422 Wroc?awPoland

The continuously growing importance of information storage,transmission,and authentication impose many new demands and challenges for modern nano-photonic materials and information storage technologies,both in security and storage ***,luminescent lanthanide-doped nanomaterials have drawn much attention in this field because of their photostability,multimodal/multicolor/narrowband emissions,and long luminescence ***,we report a multimodal nanocomposite composed of lanthanide-doped upconverting nanoparticle and EuSe semiconductor,which was constructed by utilizing a cation exchange *** nanocomposite can emit blue and white light under 365 and 394 nm excitation,***,the nanocomposites show different colors under 980 nm laser excitation when the content of Tb3+ions is changed in the upconversion ***,the time-gating technology is used to filter the upconversion emission of a long lifetime from Tb3+or Eu3+,and the possibilities for modulating the emission color of the nanocomposites are further *** on the advantage of multiple tunable luminescence,the nanocomposites are designed as optical modules to load optical *** work enables multi-dimensional storage of information and provides new insights into the design and fabrication of next-generation storage materials.

关键词： lanthanide excitation luminescence

Progress of Microfluidics for Biology and Medicine

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Nano-Micro Letters 2013年第1期5卷 66-80页

作者： Jingdong Chen Di Chen yao xie Tao Yuan Xiang Chen Science and Technology on Micro/Nano Fabrication Laboratory Research Institute of Micro/Nano Science and TechnologyShanghai Jiao Tong University Key Laboratory for Thin Film and Microfabrication of the Ministry of Education Research Institute of Micro/Nano Science and TechnologyShanghai Jiao Tong University

Microfluidics has been considered as a potential technology to miniaturize the conventional equipments and technologies. It offers advantages in terms of small volume, low cost, short reaction time and highthroughput. The applications in biology and medicine research and related areas are almost the most extensive and profound. With the appropriate scale that matches the scales of cells, microfluidics is well positioned to contribute significantly to cell biology. Cell culture, fusion and apoptosis were successfully performed in microfluidics. Microfluidics provides unique opportunities for rare circulating tumor cells isolation and detection from the blood of patients, which furthers the discovery of cancer stem cell biomarkers and expands the understanding of the biology of metastasis. Nucleic acid amplification in microfluidics has extended to single-molecule, high-throughput and integration treatment in one chip. DNA computer which is based on the computational model of DNA biochemical reaction will come into practice from concept in the future. In addition, microfluidics offers a versatile platform for protein-protein interactions, protein crystallization and high-throughput screening. Although microfluidics is still in its infancy, its great potential has already been demonstrated and will provide novel solutions to the high-throughput applications.

关键词： Microfluidics Lab-on-a-chip Droplet High-throughput Cell Nucleic acid amplification

Conducting polymer engineered covalent organic framework as a novel electrochemical amplifier for ultrasensitive detection of acetaminophen

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Chinese Chemical Letters 2021年第6期32卷 2061-2065页

作者： yao xie Yuling Chen Xin Sun Yang Wang Yi Wang School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325001China

Two-dimensional covalent organic framework(COF)has distinctive properties that offer potential opportunities for developing advanced electrode *** this work,a core-shell material composed of TAPB-DMTP-COF(TAPB,1,3,5-tris(4-aminophenyl)benzene;DMTP,2,5-dimethoxyterephaldehyde)core and conducting polymer shell,TAPB-DMTP-COF@PANI,was synthesized solvothermally using a polymerization *** structural cha racteristics of the prepared composite were revealed by X-ray diffraction patterns(XRD),fourier transform infrared spectra(FTIR),X-ray photoelectron spectroscopy(XPS),transmission electron microscopy(TEM).The electrochemical analyses were verified by subsequent monitoring of trace levels of *** resultant composite not only facilitated acetaminophen to interact with absorption sites byπ-πstacking effect and hydrogen bonding but also overcame the poor conductivity of *** the optimal conditions,a low limit of detection of 0.032μmol/L and wide linear range of 0.10-500μmol/L were *** electrochemical platform was almost unaffected by other interfering substances,and successfully applied for the practical detection of acetaminophen in commercial tablet,human blood serum and *** enhanced performance makes this COF based core-shell composite a promising material in electrochemical senso r.

关键词： Covalent organic frameworks Conducting polymer Electrochemical sensor Ultrasensitive detection Acetaminophen

Nd^(3+)-sensitized upconversion nanoparticle coated with antimony shell for bioimaging and photothermal therapy in vitro using single laser irradiation

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Journal of Rare Earths 2022年第6期40卷 862-869,I0001页

作者： Solomon Tiruneh Dibaba yao xie Wensong Xi Artur Bednarkiewicz Wei Ren Lining Sun Research Center of Nano Science and Technology College of SciencesShanghai UniversityShanghai 200444China Physics Department International Centre for Quantum and Molecular StructuresShanghai UniversityShanghai 200444China Applied Physics Department School of Applied Natural ScienceAdama Science and Technology UniversityAdama 1888Ethiopia School of Environmental and Chemical Engineering Shanghai UniversityShanghai 200444China Institute of Low Temperature and Structure Research Polish Academy of Sciences50-422 WroclawPoland

Combining treatment and diagnosis,called theranostics,which is achieved within single nanoparticle is an ultimate goal of many ***,we developed a new nanotheranostic agent-Nd^(3+)-sensitized upconversion nanoparticles core for dual modal imaging(i.e.,upconversion luminescence imaging and magnetic resonance imaging) and antimony nanoshell for photothermal therapy(PTT).The core-shellshell upconversion nanoparticles(NaYF_(4):Yb,Er@NaYF_(4):Yb,Nd@NaGdF_(4):Nd,named as UCNP) were firstly synthesized using thermal decomposition method and then were coated by antimony shell over the surface of UCNP using simple cost and time effective new ***,the surface of UCNP@Sb nanostructures was modified with DSPE-PEG in order to enhance the water solubility and *** final nanotheranostic agent,named as UCNP@Sb-PEG,exhibits very low toxicity,good biocompatibility,very good photothermal therapeutic effect,and efficient upconversion luminescence(UCL) imaging of HeLa cells under only one laser(808 nm) *** antimony shell is quenching the upconversion emission in pristine nanotheranostic agent,but interestingly,the UCL intensity of the agent recovers progressively under 808 nm laser irradiation due to light induced degradability of antimony ***,high longitudinal relaxivity(r_(1)) obtained from the experiment approves excellent potential of the nanotheranostic agent for T_(1)-weighted magnetic resonance imaging application.

关键词： Rare earths Upconversion luminescence Nanotheranostic agent Antimony shell Bioimaging Photothermal therapy

RhoGTPases in stem cells

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Chinese Science Bulletin 2007年第22期52卷 3025-3028页

作者： yao HaiLei xie XiaoYan WANG DongMei PEI XueTao Department of Stem Cells and Regenerative Medicine Beijing Institute of Transfusion MedicineBeijing 100850 China

RhoGTPases are small molecules that control a wide variety of signal transduction pathways. Their profound function in regulating the actin cytoskeleton is well recognized. Stem cells are unique in their ability to self-renew and produce progenitor cells that can differentiate into specialized cells. RhoGTPases influence stem cell morphology and cell migration as well as stem cell self-renewal,proliferation,transplantation,homing and differentiation. In this review,the multiple roles of the RhoGTPases in stem cells are discussed.

关键词：干细胞自我更新能力转换方式调节作用