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Ki-67 index,progesterone receptor expression,histologic grade and tumor size in predicting breast cancer recurrence risk:A consecutive cohort study

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Cancer Communications 2020年第4期40卷 181-193页

作者： Yanna Zhang Yidong Zhou Feng Mao Ru yao Qiang Sun Department of Breast Surgery Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing100730P.R.China

Background:The 21-gene recurrence score(RS)assay has been recommended by major guidelines for treatment decision in hormone receptor(HR)-positive early breast cancer(EBC).However,the genomic assay is not accessible and affordable ***,an increasing number of studies have shown that traditional immunohistochemistry(IHC)can partially or even completely replace the role of the 21-gene genomic ***,we developed and validated a predictive model(IHC3 model)combining the Ki-67 index,progesterone receptor(PR)expression,histologic grade,and tumor size to predict the recurrence risk of HR-positive ***:The data from 389 patients(development set)with HR-positive,human epidermal growth factor receptor 2-negative,lymph node non-metastasized invasive breast cancer were used to construct the IHC3 model based on the Surexam®21-gene RS and the TAILORx clinical trial *** additional 146 patients with the same characteristics constituted the validation *** predictive accuracy of the IHC3 model was compared with that of Orucevic et al.’s *** diseasefree survival(IDFS)was analyzed in the IHC3 predictive low-recurrence risk(pLR)group and the predictive high-recurrence risk(pHR)*** Pearson chi-square test,Fisher exact test,and log-rank test were used for ***:The pLR and pHR group could be easily stratified using the decision tree model without network *** accuracies of the IHC3 model were 86.1%in the development set and 87.7%in the validation *** predictive accuracy of the IHC3 model and Orucevic et al.’s nomogram for the whole cohort was 86.5%and 86.9%,*** a 52-month of median follow-up,a significant difference was found in IDFS between of the IHC3 pLR and the pHR groups(P=0.001)but not in the IDFS between the low-and high-recurrence risk groups according to the Surexam®21-gene RS and the TAILORx clinical trial criteria(P=0.556)or 21-gene binary RS group(P=0.511).Conclusions:The prop

关键词： 21-gene genomic assay breast cancer recurrence score histologic grade progesterone receptor Ki-67

Quantum chemical study on the abstraction reaction of alkylidenegermylene with oxirane and thiirane

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Science China Chemistry 2007年第3期50卷 335-344页

作者： GENG ZhiYuan yao Kun WANG YongCheng FANG Ran ZHANG XingHui JIA BaoLi Gansu Key Laboratory of Polymer Materials College of Chemistry and Chemical EngineeringNorthwest Normal UniversityLan-zhou 730070China

The mechanisms of the abstraction reaction of alkylidenegermylene with oxirane and thiirane have been characterized detail in using density functional theory, as well as ab initio method, including geometry optimization and vibrational analysis for the involved stationary points on the potential energy surface. Energies were calculated by CCSD(T)/6-311G(d)//B3LYP/6-311G(d,p) method for the involved conformations. The results show that the reaction pathways for both reactions consist of two ways: (1) the reactants can yield bent products (P1; P4) by syn-isomers; (2) the reactants can also yield three-membered products (P2; P5) by anti-isomers, which then further react with oxirane and thiirane to form the ultimate products (P3-1, P3-2; P6). Furthermore, a comparison with alkylidenecarbene, oxirane, and thiirane was done.

关键词： alkylidenegermylene ab initio density functional theory transition state

Establishment of model of visceral pain due to colorectal distension and its behavioral assessment in rats

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World Journal of Gastroenterology 2006年第17期12卷 2781-2784页

作者： Jian-Ping Yang Ming yao Xing-Hong Jiang Li-Na Wang Department of Anesthesiology the First Affiliated Hospital of Soochow University Suzhou 215006 Jiangsu Province China Laboratory of Neurobiology School of Medicine Soochow University Suzhou 215007 Jiangsu Province China

AIM： To establish a visceral pain model via colorectal distension （CRD） and to evaluate the efficiency of behavioral responses of CRD by measuring the score of abdominal withdrawal reflex （AWR） in rats. METHODS： Thirty-eight male SD rats weighing 180-240g were used to establish the visceral pain model. The rat was inserted intra-anally with a 7 cm long flexible latex balloon under ether anesthesia, and colorectal distensions by inflating the balloon with air were made 30 min after recovering from the anesthesia. Five AWR scores （AWR0 to AWR4） were used to assess the intensity of noxious visceral stimuli. It was regarded as the threshold of the minimal pressure （kPa）. For abdominal flatting was induced by colorectal distension. RESULTS： A vigorous AWR to distension of the descending colon and rectum was found in 100% of the awake rats tested. The higher the pressure of distension, the higher the score of AWR. The distension pressures of 0, 2.00, 3.33, 5.33 and 8.00 kPa produced different AWR scores （P〈0.05）. The pain threshold of AWR was constant for up to 80 min after the initial windup （first 1-3 distensions）, the mean threshold was 3.69±0.35 kPa. Systemic administration of morphine sulfate elevated the threshold of visceral pain in a dosedependent and naloxone reversible manner. CONCLUSION： Scoring the AWR during colorectal distensions can assess the intensity of noxious visceral stimulus. Flatting of abdomen （AWR 3） to CRD as the visceral pain threshold is clear, constant and reliable. This pain model and its behavioral assessment are good for research on visceral pain and analgesics.

关键词： Visceral pain Colorectal distension Rat behavior

Consecutive tracking for ballistic missile based on bearings-only during boost phase

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Journal of Systems Engineering and Electronics 2012年第5期23卷 700-707页

作者： Mei Liu Jianguo Yu Ling Yang Lu yao yaosheng Zhang School of Electronics and Information Engineering Harbin Institute of Technology Harbin 150001 E R. China No. 29 Institute China Electronics Technology Group Corporation Chengdu 610036 P. R. China

This paper proposes a modified centralized shifted Rayleigh filter（MCSRF） algorithm for tracking boost phase of ballistic missile（BM） trajectory with a highly nonlinear dynamical model based on *** paper contributes three ***,the mathematical model of an MCSRF for multiple passive sensors is ***,minimum entropy based onedimensional optimization search to adaptively adjust the probability of the different filters for real time state estimation is ***,the unscented transform（UT） is introduced to resolve the asymmetric state estimation *** results show that the proposed algorithm can consecutively track the BM precisely during the boost *** comparison with the unscented Kalman filter（UKF） algorithm,the proposed algorithm effectively reduces the tracking position and velocity root mean square（RMS） errors,which will make more sense for early precision interception.

关键词： ballistic missile(BM) bearings-only tracking unscented transform(UT) asymmetric state estimation interacting multiple modes boost phase

A nonlinear regression model applied to kinetic multi-component analysis of esters with a SAW-impedance sensor

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Chinese Journal of Chemistry 1996年第6期14卷 525-531页

作者： Cai, QY Peng, L Wang, RH Nie, LH yao, SZ HUNAN UNIV DEPT CHEM & CHEM ENGNCHANGSHA 410082HUNANPEOPLES R CHINA

A kinetic nonlinear regression model for multi-component assay of esters was proposed based on their different alkaline-catalysed hydrolysis rate. The reaction rate was determined by monitoring the conductance change in solution with a liquid-purpose surface acoustic wave impedance sensor(SAW). The model was tested theoretically and experimentally with the mixture of methyl acetate and n-propyl acetate. The experimental detection limit of methyl acetate and n-propyl acetate (within 10 min) was 0.5 mu mol/L and 1.0 mu mol/L respectively and the recovery of the sensor system ranged from 93% to 106% (n=6).

关键词： surface acoustic wave nonlinear regression ester hydrolysis assay

Research on Genesis of Pyrite near the Permian-Triassic Boundary in Meishan,Zhejiang,China

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Journal of China University of Mining and Technology 2006年第4期16卷 457-460页

作者： JIANG yao-fa TANG Yue-gang CHOU Chen-lin Department of Resourses and Geoscience China University of Mining ＆ Technology Beijing 100083 China Xuzhou Institute of A rchitectural Technology Xuzhou Jiangsu 221008 China Illinois State Geological Survey Champaign IL 61820 U.S.A

The content and crystal forms of pyrite and sulfur isotope composition of pyrite sulfur as well as its vertical distribution near the Permian-Triassic （P/T） boundary in the Meishan section, Changxing county, Zhejiang province, China were studied using geological, petrological, mineralogical and geochemical methods （techniques）. The result showed that the genesis of abundant pyrites in bed 24e2 at the uppermost part of the Changxing Formation in the Me- ishan section may be related to volcanic activity. In bed 24e2 of the Meishan section, pyrite has its highest content of 1.84% and the sulfur isotope composition has the highest 834S value at ＋2.2%0 which is very similar to that of the average value of volcanic gas, There are some volcanic products such as β-quartz, siliceous cylinders and siliceous spherules which coexisted with pyrites in beds 24e2 and 24f. It can be concluded that a large quantity of volcanic ash fell into the South China Sea and was incorporated into marine sediments during the formation of limestone at the uppermost part of the Changxing Formation. The volcanic eruption with massive amounts of H2S and SO2 gas at the end of the Permian period resulted in the enrichment of HES in the South China Sea areas, The reaction of H2S with reactive iron minerals formed the mass of abundant pyrites.

关键词： pyrites sulfur isotope β-quartz Permian-Triassic boundary volcanism

Experimental investigation of incremental reactivity of di-tert-butyl peroxide

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Chinese Science Bulletin 2007年第12期52卷 1629-1634页

作者： DU Lin XU YongFu GE MaoFa JIA Long yao Li Beijing National Laboratory for Molecular Sciences (BNLMS) State Key Laboratory for Structural Chemistry of Unstable and Stable Species Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China Graduate University of the Chinese Academy of Sciences Beijing 100039 China Research Center for Atmospheric Environment Beijing Normal University Beijing 100875 China

Large quantities of di-tert-butyl peroxide (DTBP) have been emitted into the troposphere due to human activities. Its role in the atmospheric photochemical reaction has not been understood. This study presents the results of the photochemical reactions of DTBP and NOx, which have been simulated in a self-made smog chamber under the temperature of (29±1)℃. Both the wall decays of ozone and NO2 could be neglected, compared to the results in simulative experiments. The effective intensity of UV light used in the experiments was 1.28×10-3 s-1, which was expressed by the rate constant of NO2 photolysis in purified air. The reaction mechanism was proposed according to our results and reports of other researchers. The maximum values of incremental reactivity (IR) in the three simulative ex- periments were 9.53×10-2, 5.23×10-2 and 3.78×10-2, respectively. The incremental reactivity decreased with the increase of initial concentrations of DTBP. The IR value of DTBP obtained in this study was comparable to that of acetylene reported in our previous research.

关键词：双特丁基过氧化物烟雾室光化反应光化烟雾大气化学

Tunable nano Peltier cooling device from geometric effects using a single graphene nanoribbon

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Frontiers of physics 2014年第4期9卷 472-476页

作者： Wan-Ju Li Dao-Xin yao E. W. Carlson Department of Physics Purdue University West Lafayette IN 47907 USA State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-Sen University Guangzhou 510275 China

Based on the phenomenon of curvature-induced doping in graphene we propose a class of Peltier cooling devices, produced by geometrical effects, without gating. We show how a graphene nanorib- bon laid on an array of curved nano cylinders can be used to create a targeted and tunable cooling device. Using two different approaches, the Nonequilibrium Green＇s Function （NEGF） method and experimental inputs, we predict that the cooling kW/cm2, on par with the best known techniques power of such a device can approach the order of using standard superlattice structures. The structure proposed here helps pave the way toward designing graphene electronics which use geometry rather than gating to control devices.

关键词： Peltier cooling device graphene nanoribbon superlattice structure grapheneelectronics cooling power Nonequilibrium Green's Function (NI3GE)

Relationship between the incidence of non-hepatic hyperammonemia and the prognosis of patients in the intensive care unit

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World Journal of Gastroenterology 2020年第45期26卷 7222-7231页

作者： Zhi-Peng yao Yue Li Yang Liu Hong-Liang Wang Department of Intensive Care Medicine The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina

BACKGROUND Ammonia is a normal constituent of body fluids and is found mainly through the formation of urea in the *** levels of ammonia must remain low as even slightly elevated concentrations(hyperammonemia)are toxic to the central nervous *** To examine the relationship between the incidence of non-hepatic hyperammonemia(NHH)and the prognosis of patients who were admitted to the intensive care unit(ICU).METHODS This is a prospective,observational and single-center study.A total of 364 patients who were admitted to the ICU from November 2019 to February 2020 were initially *** in the levels of blood ammonia at the time of ICU admission and after ICU admission were continuously *** addition,factors influencing the prognosis of NHH patients were *** A total of 204 patients who met the inclusion criteria were enrolled in this study,including 155 NHH patients and 44 severe-NHH *** incidence of NHH and severe-NHH was 75.98% and 21.57%,*** with severe-NHH exhibited longer length of ICU stay and higher Acute Physiologic Assessment and Chronic Health Evaluation and Sequential Organ Failure Assessment scores compared to those with mild-NHH and *** Coma Scale scores of patients with severe-NHH were than those of non-NHH *** addition,the mean and initial levels of ammonia in the blood might be helpful in predicting the prognosis of *** High blood ammonia level is frequent among NHH patients admitted to the ICU,which is related to the clinical characteristics of ***,the level of blood ammonia may be helpful for prognosis prediction.

关键词： Non-hepatic hyperammonemia Intestinal absorption Blood ammonia level Metabolism of amino acid Severe patients Intensive care unit