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Abnormal expression of hepatomas and circulating telomerase and its clinical values

Hepatobiliary & Pancreatic Diseases International 2005年第4期4卷 544-549页

作者： Wei Wu, Deng-Fu yao, Li-Wei Qiu, Xin-Hua Wu, Ming yao, Xiao-qin Su and Li Zou Nantong, China Research Center of Clinical Molecular Biology, Affiliated Hospital, Nantong University, Nantong 226001, China Research Center of Clinical Molecular Biology Affiliated Hospital Nantong University Nantong 226001 China.

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common malignant tumours worldwide. Te-lomerase is reactivated in various types of malignant tumors and may contribute to the development of HCC. To evaluate the role of telomerase in formation and development of HCC, we analyzed its expression status in different parts of HCC tissues and peripheral blood mono-nuclear cells (PBMCs) , and explored its clinical implications for diagnosis of HCC. METHODS: Total RNAs and telomerase were extracted from HCC and their non-cancerous tissues, and both relationships were analyzed between them. The expression of telomerase reverse transcriptase (hTERT) mRNA and telomerase activities in liver tissues and PBMCs were detected by RT-PCR and telomeric repeat amplification protocol (TRAP)-ELISA, respectively. The diagnostic values of telomerase in PBMCs were investigated in the diagnosis and differentiation of HCC. RESULTS: The specific activities of telomerase were 18.25 ±15.02 A/μg RNA in HCC tissues, and significantly higher than those in their non-cancerous tissues (8.16 ± 6.22 A/μg RNA, P <0. 05). But total RNA levels in HCC were 12.40 ±7.34 μg/mg wet liver and lower than 53.77 ± 52.02 μg/mg wet liver in their non-cancerous parts (P < 0.01). The different telomerase levels could be detected in PBMCs from patients with chronic liver diseases and control group. The enzyme activities were significantly higher in HCC than in any other groups (P <0.01). However, circulating telomerase levels were more obviously decreased in HCC patients after transcatheter arterial embolization treatment than before the treatment (P <0.01). The analysis of combined serum alpha-fetoprotein level and PBMCs telomerase was more sensitive and specific for the diagnosis of HCC. CONCLUSION: The abnormal expression of telomerase in HCC tissues and circulating PBMCs could be a useful marker to the diagnosis and prognosis of HCC.

关键词： telomerase peripheral blood TRAP-ELISA hepatocellular carcinoma

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Continuous cropping of alfalfa (Medicago sativa L.) reduces bacterial diversity and simplifies cooccurrence networks in aeolian sandy soil

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Soil Ecology Letters 2022年第2期4卷 131-143页

作者： Yanxia Xu Junjie Liu Xuefeng Liu Hong Li Zhao Yang Hongbao Wang Xinyu Huang Lan Lan Yutong An Lujun Li qin yao Guanghua Wang Branch of Animal Husbandry and Veterinary of Heilongjiang Academy of Agricultural Sciences Qiqihar 230202China Key Laboratory of Mollisols Agroecology Northeast Institute of Geography and AgroecologyChinese Academy of SciencesHarbin 130102China University of Chinese Academy of Sciences Beijing 100049China

Alfalfa is a perennial herbaceous forage legume that is remarkably and negatively affected by ***,the contribution of the changes in bacterial communities to soil sickness in alfalfa have not been ***,we investigated bacterial community structures in response to monocropped alfalfa along the *** cropping remarkably reduced bacterial alpha diversity and altered community structures,and soil pH,total P and available P were strongly associated with the changes of bacterial diversity and community ***,10 years of monocropped alfalfa might be a demarcation point separating soil bacterial community structures into two obvious groups that containing soil samples collected in less and more than 10 *** relative abundances of copiotrophic bacteria of Actinobacteria and Gammaproteobacteria significantly increased with the extension of continuous cropping years,while the oligotrophic bacteria of Armatimonadetes,Chloroflexi,Firmicutes and Gemmatimonadetes showed the opposite changing *** those altered phyla,Actinobacteria,Chloroflexi,Alphaproteobacteria and Acidobacteria were the most important bacteria which contributed 50.86%of the community variations. Additionally, the relative abundances of nitrogen fixation bacteria ofBradyrhizobium and Mesorhizobium obviously increased with continuous cropping years, while theabundances of Arthrobacter, Bacillus, Burkholderiaceae and Microbacterium with potential functionsof solubilizing phosphorus and potassium remarkably decreased after long-term continuouscropping. Furthermore, bacterial cooccurrence patterns were significantly influenced by continuouscropping years, with long-term monocropped alfalfa simplifying the complexity of the cooccurrencenetworks. These findings enhanced our understandings and provided references for forecasting howsoil bacterial communities responds to monocropped alfalfa.

关键词： Aeolian sandy soil Continuously cropped alfalfa Cooccurrence networks 10 years Functional bacteria

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父母教养方式对初中生社交焦虑的影响:同伴接纳和反刍思维的链式中介作用

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心理发展与教育 2024年第1期40卷 103-113页

作者：秦瑶彭运石湖南师范大学教育科学学院长沙410081

为探讨父母教养方式对初中生社交焦虑的影响及其作用机制,基于社交焦虑的认知行为框架,本研究构建了一个链式中介作用模型,重点考察了同伴接纳和反刍思维的链式中介作用。采用问卷法,对518名初中生的父母教养方式、同伴接纳、反刍思维... 详细信息

为探讨父母教养方式对初中生社交焦虑的影响及其作用机制,基于社交焦虑的认知行为框架,本研究构建了一个链式中介作用模型,重点考察了同伴接纳和反刍思维的链式中介作用。采用问卷法,对518名初中生的父母教养方式、同伴接纳、反刍思维及社交焦虑的情况进行调查。结果表明:(1)父母积极、消极教养方式、社交焦虑、反刍思维和同伴接纳之间两两显著相关;(2)消极父母教养(拒绝、过度保护)对子女社交焦虑有正向预测作用;(3)积极父母教养、消极父母教养对社交焦虑的影响均包括两条路径:反刍思维的单独中介作用,同伴接纳—反刍思维的链式中介效应。本研究丰富了中学生社交焦虑领域的研究成果,为预防和干预青少年社交焦虑验证了相关理论。

关键词：父母教养方式社交焦虑同伴接纳反刍思维初中生

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基于正则粒子算法的红外成像消噪处理研究

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光谱实验室 2009年第5期26卷 1078-1081页

作者：姚玉钦安阳工学院教务处

针对红外成像中的问题,应用正则粒子再采样算法实现红外成像消噪处理。首先依据序列重采样算法,从重要性密度函数中采样,而后进行粒子权重归一化,优化粒子克服衰竭现象,最后给出成像模型和精度函数。仿真结果验证了该算法的有效性。

关键词：正则粒子重采样均方根误差

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明清政治精英治理:趋势、特征及决定因素(1368—1911)

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经济学（季刊） 2021年第5期20卷 1773-1792页

作者：姚沁陈硕复旦大学经济学院 200433

我国是世界上最早建立文官制度的国家,其治理经验被众多国家借鉴。但当前针对我国官员治理的讨论主要集中在现当代,对其历史传统的研究依然缺乏系统数据及实证检验。本文试图从两方面弥补这一不足:首先,我们建立明清两代(1368—1911)10... 详细信息

我国是世界上最早建立文官制度的国家,其治理经验被众多国家借鉴。但当前针对我国官员治理的讨论主要集中在现当代,对其历史传统的研究依然缺乏系统数据及实证检验。本文试图从两方面弥补这一不足:首先,我们建立明清两代(1368—1911)10465位省部级以上官员任职信息并在此基础上构建治理稳定性指标。我们发现与明代相比,清代官员治理呈现出稳定化趋势。其次,基于ARDL模型,本文发现对宦官制度依赖程度是解释两代治理差异的重要因素。

关键词：精英选拔官员治理明清

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Dynamic Random Access Channel Allocation Scheme Based on the Pseudo-Bayesian Algorithm in OFDMA System

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China Communications 2012年第8期9卷 71-79页

作者： Huang yao Tian Hui qin Cheng Xu Lingling Zhang Jun Key Laboratory of Universal Wireless Communications Wireless Technology Innovation InstituteBeijing University of Postsand TelecommunicationsBeijing 100876P.R.China

Random Access Channel （RACH） is an uplink contention-based transport channel usually used for initial channel access, bandwidth request, etc. How to use RACH resources effectively is very important in wireless corrnunication systel In this paper, a dynamical RACH allocation scheme is proposed for Orthogonal Frequency-Division Multiple Access （OFDMA） systen. Based on the PseudoBayesian algorithm, this mechanism predicts the number of RACHs for the next frame according to the current load. A new dynamic RACH assignment algorithm and an adaptive access probability method are adopted by the proposed scheme to irrprove the utilization ratio of RACH resources and increase the successful access rate. Numerical simulation shows that the proposed strategy achieves both improvement in the utilization ratio of RACHs and reduction in the access delay compared with other RACH allocation schemes.

关键词： OFDMA system random access scheme pseudo-bayesian lmlti-channel

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基于电流探头的标准场法环天线校准及不确定度分析

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仪器仪表学报 2020年第9期41卷 37-44页

作者：秦瑶吴艳丽刘潇河南工业大学粮食信息处理与控制教育部重点实验室信息科学与工程学院郑州450000 河南省计量科学研究院郑州450000 中国计量科学研究院北京100029

标准场法是CISPR16-1-6中给出环天线校准的主要方法,将待测环天线放入可以准确计算的标准场中,根据测量电压可以推导出待测环天线的天线系数。在标准场法中,基于电流探头产生标准场的方法易于实现和操作,是一种可行的环天线校准方法,唯... 详细信息

标准场法是CISPR16-1-6中给出环天线校准的主要方法,将待测环天线放入可以准确计算的标准场中,根据测量电压可以推导出待测环天线的天线系数。在标准场法中,基于电流探头产生标准场的方法易于实现和操作,是一种可行的环天线校准方法,唯一前提是使用的电流探头需要经过精确校准,获得其准确的传输阻抗。本文详细介绍了基于电流探头的标准场法校准环天线的原理和方法,并给出4个典型频点的不确定度评定过程。实验结果表明,在350 kHz^30 MHz频率范围内,待测环天线的测量值与标称值间的差值在0.57 dB内。不确定度评定结果表明,在350 kHz^30 MHz频段内,电流探头法校准环天线的扩展不确定度小于1.22 dB(k=2)。

关键词：环天线天线系数标准场法电流探头不确定度

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对列宁“民族自决权原则”的历史考察和现实思考

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青海民族研究 2005年第3期16卷 7-10页

作者：姚爱琴西北民族大学甘肃兰州730070

民族自决权是马克思主义民族理论中的一个重要内容,在不同的历史时期和不同的民族国家中,曾经并正在发挥着不同的作用。由于民族问题的复杂性和长期性等特点,要求我们在新时期要以新的民族观来辨证地理解民族自决权,以防其被民族分裂主... 详细信息

民族自决权是马克思主义民族理论中的一个重要内容,在不同的历史时期和不同的民族国家中,曾经并正在发挥着不同的作用。由于民族问题的复杂性和长期性等特点,要求我们在新时期要以新的民族观来辨证地理解民族自决权,以防其被民族分裂主义者滥用,搞民族分裂,破坏民族团结。

关键词：列宁民族自决权

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基于极线及共面约束条件的Kinect点云配准方法

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武汉大学学报（信息科学版） 2017年第9期42卷 1271-1277页

作者：叶勤姚亚会桂坡坡同济大学测绘与地理信息学院上海200092

Kinect作为轻量级手持传感器,在室内场景恢复与模型重建中具有灵活、高效的特点。不同于大多数只基于彩色影像或只基于深度影像的重建算法,提出一种将彩色影像与深度影像相结合的点云配准算法并用于室内模型重建恢复,其过程包括相邻帧... 详细信息

Kinect作为轻量级手持传感器,在室内场景恢复与模型重建中具有灵活、高效的特点。不同于大多数只基于彩色影像或只基于深度影像的重建算法,提出一种将彩色影像与深度影像相结合的点云配准算法并用于室内模型重建恢复,其过程包括相邻帧数据的配准与整体优化。在Kinect已被精确标定的基础上,将彩色影像匹配得到的同名点构成极线约束与深度图像迭代最近点配准的点到面约束相结合,以提高相邻帧数据配准算法的精度与鲁棒性。利用相邻4帧数据连续点共面约束,对相邻帧数据配准结果进行全局优化,以提高模型重建的精度。在理论分析基础上,通过实验验证了该算法在Kinect Fusion无法实现追踪、建模的场景中鲁棒性依然较好,点云配准及建模精度符合Kinect观测精度。

关键词： Kinect 极线约束点面约束四点共面

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Effects of ninadab on NF-κB expression in lung tissue and PC Ⅲ level in bronchoalveolar lavage fluid induced by lipopolysaccharide-induced ARDS in rats

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Journal of Hainan Medical University 2018年第18期24卷 1-4页

作者： Yang Li-Xia qin-yao Jia Li Jiang Qiong Dong Department of Respiratory Nanchong Central Hospital Nanchong637000SichuanChina School of Pharmacy North Sichuan Medical CollegeNanchong637000SichuanChina

Objective: To observe effects of ninadab on NF-κB expression in lung tissue and PCⅢlevel in bronchoalveolar lavage fluid induced by lipopolysaccharide-induced ARDS in rats. Methods: Forty healthy SD rats were randomly divided into control group, group A, group B and group C, with 10 in each group. Rats in group A, group B and group C were successful in modeling. In control group, rats in group A were injected with saline only. Rats in group B were treated with nisinib at 7 days and rats in group C were treated with nisinib at 14 days. The expression of NF-κB in lung tissue, the level of β-EP in plasma and the level of PCⅢ in bronchoalveolar perfusion fluid. Results: There were significant differences in the expression of NF-κB positive cells and plasma β-EP among groups. Compared with the control group, the expression of NF-κB positive cells and plasma β-EP in group A, group B and group C were significantly higher than those in control group, Compared with group A, the expression of NF-κB positive cells and plasma β-EP in group B and group C were significantly lower than those in group A. Compared with group B, the expression of NF-κB positive cells and plasma β-EP in group C were significantly higher than those in group B. There was a significant difference between the 4 groups on the 7th, 14th and 28th days. Compared with the control group, PCⅢ levels in the 7th, 14th and 28th days in group A, group B and group C were significantly higher. Compared with group A, group B, group C, the content of PCⅢon the 7th day, the 14th day and the 28th day in group C was significantly higher. Conclusion:Nidanib on lipopolysaccharide-induced ARDS rats have a good protective effect, and its mechanism may be related to the reduction of NF-κB expression in bronchoalveolar perfusion solution PCⅢ level.

关键词： Nidanib Lipopolysaccharide-induced ARDS NF-Κb PCⅢ

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