检索结果-南通市图书馆

5'-Monophosphate-activated protein kinase (AMPK) improves autophagic activity in diabetes and diabetic complications

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2016年第1期6卷 20-25页

作者： fan yao Ming Zhang Li Chen Department of Pharmacology College of Basic Medical SciencesJilin University School of Nursing Jilin University

Diabetes mellitus(DM),an endocrine disorder,will be one of the leading causes of death world-wide in about two *** injuries and disorders of energy metabolism are two key factors in the pathogenesis of diabetes,which also become the important causes for the process of diabetic *** is a key enzyme in maintaining metabolic homeostasis and has been implicated in the activation of autophagy in distinct *** increasing number of researchers have confirmed that autophagy is a potential factor to affect or induce diabetes and its complications nowadays,which could remove cytotoxic proteins and dysfunctional *** review will summarize the regulation of autophagy and AMPK in diabetes and its complications,and explore how AMPK stimulates autophagy in different diabetic syndromes.A deeper understanding of the regulation and activity of AMPK in autophagy would enhance its development as a promising therapeutic target for diabetes treatment.

关键词： Diabetes Autophagy AMP-activated protein kinases Diabetic complications

A pilot scale anoxic/oxic membrane bioreactor(A/O MBR) for woolen mill dyeing wastewater treatment

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2003年第4期15卷 449-455页

作者： ZHENG Xiang fan yao bo WEI Yuan song Department of Water Pollution Control Technology Research Center for Eco Environmental SciencesChinese Academy of SciencesBeijing 100085China.

A pilot scale(10 m 3/d) anoxic/oxic membrane bioreactor(A/O MBR) was tested for dyeing wastewater treatment of woolen mill without wasting sludge in 125 days operation. Results showed that the effluent quality was excellent, i.e. effluent COD less than 25 mg/L, BOD 5 under 5 mg/L, turbidity lower than 0 65 NTU, and colour less than 30 DT, and met with the reuse water standard of China. The removal rates of COD, BOD 5, colour, and turbidity were 92 4%, 98 4%, 74% and 98 9%, respectively. Constant flux operation mode was carried out in this study, and backwash was effective for reducing membrane fouling and maintaining constant flux. Membrane fouling had heavy impact on energy consumption. More attention should be paid on pipe selection and design for the sidestream MBR system, too.

关键词： activated sludge backwash constant flux dyeing wastewater treatment membrane bioreactor (MBR) woolen mill

Attractive natural products with strained cyclopropane and/or cyclobutane ring systems

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2016年第9期59卷 1126-1141页

作者： yao-Yue fan Xin-Hua Gao Jian-Min Yue Shanghai Institute of Materia Medica Chinese Academy of Sciences

The strained cyclopropane and/or cyclobutane subunits occurred in many complex natural products including terpenoids, steroids and alkaloids. Natural products with cyclopropane and/or cyclobutane motifs not only furnished fascinating structures, but also exhibited versatile biological activities, such as cytotoxic, anti-HIM antimicrobial, antiviral, and immunosuppressive effects. This review covered a large array of structurally unique natural products with strained cyclopropane and/or cyclobutane motifs and summarized their structural features, distributions, biological activities, as well as biogenetic considerations.

关键词： natural products cyclopropane-containing cyclobutane-containing biological activity biosynthetic pathway

Catalytic Performance of Graphite Oxide Supported Au Nanoparticles in Aerobic Oxidation of Benzyl Alcohol： Support Effect

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Physics 2017年第1期30卷 90-96,I0002页

作者： Yu-jia Huo fan-fan yao Yun-sheng Ma Department of Chemical Physics University of Science and Technology of China Hefei 230026 China

Various Au/GO catalysts were prepared by depositing Au nanoparticles on thermally- and chemically-treated graphite oxide （GO） supports using a sol-immobilization method. The surface chemistry and structure of GO supports were characterized by a series of analytical techniques including X-ray photoelectron spectroscopy, temperature-programmed desorption and Raman spectroscopy. The results show that thermal and chemical treatments have large influence on the presence of surface oxygenated groups and the crystalline structure of GO supports. A strong support effect was observed on the catalytic activity of Au/GO catalysts in the liquid phase aerobic oxidation of benzyl alcohol. Compared to the amount and the type of surface oxygen functional groups, the ordered structure of GO supports may play a more important role in determining the catalytic performance of Au/GO catalysts.

关键词： Gold nanoparticles Graphite oxide Catalyst Benzyl alcohol oxidation X-ray photoelectron spectroscopy Temperature-programmed desorption Raman

On the Subjectivity of Spatial Deixis in the Language of English News

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

学术界 2015年第5期 286-291页

作者： Gong Weidong fan yao School of Foreign Languages Yantai University

The thesis discusses how subjectivity is shown through spatial deixis in the language of English *** on Langacker' s Construal Theory,especially the aspect of construal perspective,the thesis employs the conceptualization in Cognitive Linguistics to explain the cause of subjectivity in English ***,it makes a further philosophical and social analysis of the motivation of subjectivity in news *** the one hand,subjectivity is a basic attribute which helps people to cognize and reflect *** the other hand,subjectivity is an important criterion for one to judge whether the nature of the news is "objective" or not.

关键词：语言学新闻英语空间

cGAS-like receptors: new RNA sensors in Drosophila

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2021年第11期6卷 3165-3166页

作者： yao fan Long Zhang fangfang Zhou School of Medicine Zhejiang University City CollegeHangzhouZhejiang310015China MOE Laboratory of Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network Life Sciences InstituteZhejiang UniversityHangzhou310058China Institute of Biology and Medical Sciences Soochow UniversitySuzhouJiangsu215123China

Recently,two back-to-back studies(Slavik et al.1 and Holleufer et al.2)were published in Nature,identifying that cGAS-like receptors(cGLRs)extensively exist in Drosophila and act as nucleic acid sensors in the antiviral immune ***,they also provided evidence demonstrating that cGLRs in Drosophila can sense dsRNA and produce 3′2′-cGAMP(cG[3′–5′]pA[2′–5′]p)as a second messenger that activates the Sting-dependent antiviral immune response.

关键词： Drosophila system. response.

Image Inpainting Technique Incorporating Edge Prior and Attention Mechanism

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第1期78卷 999-1025页

作者： Jinxian Bai yao fan Zhiwei Zhao Lizhi Zheng College of Information Engineering Xizang Minzu UniversityXianyang712000China

Recently,deep learning-based image inpainting methods have made great strides in reconstructing damaged ***,these methods often struggle to produce satisfactory results when dealing with missing images with large holes,leading to distortions in the structure and blurring of *** address these problems,we combine the advantages of transformers and convolutions to propose an image inpainting method that incorporates edge priors and attention *** proposed method aims to improve the results of inpainting large holes in images by enhancing the accuracy of structure restoration and the ability to recover texture *** method divides the inpainting task into two phases:edge prediction and image ***,in the edge prediction phase,a transformer architecture is designed to combine axial attention with standard *** design enhances the extraction capability of global structural features and location *** also balances the complexity of self-attention operations,resulting in accurate prediction of the edge structure in the defective *** the image inpainting phase,a multi-scale fusion attention module is *** module makes full use of multi-level distant features and enhances local pixel continuity,thereby significantly improving the quality of image *** evaluate the performance of our *** experiments are conducted on several datasets,including CelebA,Places2,and *** experiments show that our method outperforms the other mainstream ***,it improves Peak Signal-to-Noise Ratio(PSNR)and Structure Similarity Index Measure(SSIM)by 1.141~3.234 db and 0.083~0.235,***,it reduces Learning Perceptual Image Patch Similarity(LPIPS)and Mean Absolute Error(MAE)by 0.0347~0.1753 and 0.0104~0.0402,*** experiments reveal that our method excels at reconstructing images with complete structural information and c

关键词： Image inpainting transformer edge prior axial attention multi-scale fusion attention

The proteasome activator subunit PSME1 promotes HBV replication by inhibiting the degradation of HBV core protein

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第6期11卷 395-408页

作者： Yu Liu Jiaxin Yang Yanyan Wang Qiqi Zeng yao fan Ailong Huang Hui fan The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education Chongqing Medical UniversityChongqing 400016China The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University LuzhouSichuan 646000China

Chronic hepatitis B virus(HBV)infection is a leading cause of liver cirrhosis and he-patocellular carcinoma,representing a global health problem for which a functional cure is difficult to *** HBV core protein(HBc)is essential for multiple steps in the viral life *** is the building block of the nucleocapsid in which viral DNA reverse transcription oc-curs,and its mediation role in viral-host cell interactions is critical to HBV infection ***,systematic studies targeting HBc-interacting proteins remain ***,we combined HBc with the APEX2 to systematically identify HBc-related host proteins in living *** functional screening,we confirmed that proteasome activator subunit 1(PSME1)is a potent HBV-associated host ***1 expression was up-regulated upon HBV infection,and the protein level of HBc decreased after PSME1 ***,the interac-tion between PSME1 and HBc inhibited the degradation of HBc by the 26S proteasome,thereby improving the stability of the HBc ***,PSME1 silencing inhibits HBV tran-scription in the HBV infection *** findings reveal an important mechanism by which PSME1 regulates HBc proteins and may facilitate the development of new antiviral therapies targeting PSME1 function.

关键词： 26S proteasome APEX2 HBc HBV Host-viral interactions PSME1

Declining diagnostic accuracy of non-invasive fibrosis tests is associated with elevated alanine aminotransferase in chronic hepatitis B

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2018年第12期6卷 521-530页

作者： Lin Wang yao-Xin fan Xiao-Guang Dou Department of Infectious Diseases Shengjing Hospital of China Medical Uni-versity

AIM To explore the effect of alanine aminotransferase(ALT) on the performance of non-invasive fibrosis tests in chronic hepatitis B(CHB) patients. METHODS A total of 599 treatment-naive and biopsy-proven CHB patients were included in the study. The cohort was divided into the following three groups: Normal ALT(ALT ≤ 40), slightly elevated ALT(40 80). The diagnostic performance of five common non-invasive fibrosis tests for liver fibrosis(stages S2-4), including the aspartate aminotransferase(AST)-to-platelet(PLT) ratio index(APRI), fibrosis index based on 4 factors(FIB-4), King's score, Forns index and gamma-glutamyl transpeptidase(GGT)-to-PLT ratio(GPR), were evaluated for each group. RESULTS Higher ALT levels were associated with higher non-invasive fibrosis test scores. Patients with the same fibrosis stage but higher ALT levels showed higher noninvasive test scores. The areas under the receiver operating characteristics curves(AUROCs) of the noninvasive tests for prediction of ≥ S2 were higher for patients with ALT ≤ 40 U/L(range 0.705-0.755) and 40 80 U/L(range 0.604-0.701). The AUROCs for predicting ≥ S3 and S4 were higher in patients with ALT ≤ 40 U/L(range 0.736-0.814 for ≥ S3, 0.79-0.833 for S4) than in patients with 40 80 U/L(range 0.7-0.784 for ≥ S3, range 0.662-0.719 for S4). The diagnostic accuracy of the non-invasive tests decreased in a stepwise manner with the increase in *** ALT has a significant effect on the diagnostic performance of non-invasive fibrosis tests. The ALT level should be considered before performing these noninvasive tests.

关键词： Chronic hepatitis B Non-invasive tests Liver fibrosis Alanine aminotransferase Inflammation