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Minocycline in the eradication of Helicobacter pylori infection: A systematic review and meta-analysis

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World Journal of Gastroenterology 2024年第17期30卷 2354-2368页

作者： Kai Zhou Cai-ling li Hua Zhang Bao-Jun Suo Yu-Xin Zhang Xin-Lu Ren Yu-Xin Wang Chang-Min Mi ling-ling Ma li-Ya Zhou Xue-li Tian Zhi-Qiang Song Department of Gastroenterology Peking University Third HospitalBeijing 100191China

BACKGROUND Difficulty in obtaining tetracycline,increased adverse reactions,and relatively complicated medication methods have limited the clinical application of the classic bismuth quadruple ***,the search for new alternative drugs has become one of the research *** recent years,minocycline,as a semisynthetic tetracycline,has demonstrated good potential for eradicating Helicobacter pylori(***)infection,but the systematic evaluation of its role remains *** To explore the efficacy,safety,and compliance of minocycline in eradicating *** *** We comprehensively retrieved the electronic databases of PubMed,Embase,Web of Science,China National Knowledge Infrastructure,SinoMed,and Wanfang database as of October 30,2023,and finally included 22 research reports on *** eradication with minocycline-containing regimens as per the inclusion and exclusion *** eradication rates of *** were calculated using a fixed or a random effect model,and the heterogeneity and publication bias of the studies were *** The single-arm meta-analysis revealed that the minocycline-containing regimens achieved good overall *** eradication rates,reaching 82.3%[95%confidence interval(CI):79.7%-85.1%]in the intention-to-treat analysis and 90.0%(95%CI:87.7%-92.4%)in the per-protocol *** overall safety and compliance of the minocycline-containing regimens were good,demonstrating an overall incidence of adverse reactions of 36.5%(95%CI:31.5%-42.2%).Further by traditional meta-analysis,the results showed that the minocycline-containing regimens were not statistically different from other commonly used eradication regimens in eradication rate and incidence of adverse *** of the adverse reactions were mild to moderate and well-tolerated,and dizziness was relatively prominent in the minocycline-containing regimens(16%).CONCLUSION The minocycline-containing regimens demonstrated good efficacy,safety,and

关键词： Helicobacter pylori Minocycline Eradication Safety Resistance

M6PR interacts with the HA2 subunit of influenza A virus to facilitate the fusion of viral and endosomal membranes

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Science China(life Sciences) 2024年第3期67卷 579-595页

作者： Yuzhen Hu li Jiang Guangwen Wang Yangming Song Zhibo Shan Xuyuan Wang Guohua Deng Jianzhong Shi Guobin Tian Xianying Zeng liling liu Hualan Chen Chengjun li State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069China

Influenza A virus(IAV) commandeers numerous host cellular factors for successful replication. However, very few host factors have been revealed to be involved in the fusion of viral envelope and late endosomal membranes. In this study, we identified cation-dependent mannose-6-phosphate receptor(M6PR) as a crucial host factor for the replication of IAV. We found that siRNA knockdown of M6PR expression significantly reduced the growth titers of different subtypes of IAV, and that the inhibitory effect of M6PR siRNA treatment on IAV growth was overcome by the complement of exogenously expressed M6PR. When A549 cells were treated with siRNA targeting M6PR,the nuclear accumulation of viral nucleoprotein(NP) was dramatically inhibited at early timepoints post-infection, indicating that M6PR engages in the early stage of the IAV replication cycle. By investigating the role of M6PR in the individual entry and post-entry steps of IAV replication, we found that the downregulation of M6PR expression had no effect on attachment, internalization, early endosome trafficking,or late endosome acidification. However, we found that M6PR expression was critical for the fusion of viral envelope and late endosomal membranes. Of note, M6PR interacted with the hemagglutinin(HA) protein of IAV, and further studies showed that the lumenal domain of M6PR and the ectodomain of HA2 mediated the interaction and directly promoted the fusion of the viral and late endosomal membranes,thereby facilitating IAV replication. Together, our findings highlight the importance of the M6PR–HA interaction in the fusion of viral and late endosomal membranes during IAV replication.

关键词： influenza A virus M6PR HA membrane fusion late endosome

Network Embedding Algorithm for Vulnerability Assessment of Power Transmission lines Using Integrated Structure and Attribute Information

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 351-360页

作者： Xianglong lian Tong Qian Zepeng li Xingyu Chen Wenhu Tang Q.H.Wu School of Electric Power Engineering South China University of TechnologyGuangzhou 510640China

In power systems,failures of vulnerable lines can trigger large-scale cascading failures,and vulnerability assessment is dedicated to locating these lines and reducing the risks of such *** on a structure and attribute network embedding(SANE)algorithm,a novel quantitative vulnerability analysis method is proposed to identify vulnerable lines in this ***,a two-layered random walk network with topological and electrical properties of transmission lines is ***,based on the weighted degree of nodes in the two-layered network,the inter-layer and intra-layer walking transition probabilities are developed to obtain walk ***,a Word2Vec algorithm is applied to obtain lowdimension vectors representing transmission lines,according to obtained walk sequences for calculating the vulnerability index of transmissions ***,the proposed method is compared with three widely used methods in two test *** show the network embedding based method is superior to those comparison methods and can provide guidance for identifying vulnerable lines.

关键词： Network embedding random walk transmission lines vulnerability assessment

Marangoni-flow-assisted assembly of single-walled carbon nanotube films for human motion sensing

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Fundamental Research 2024年第3期4卷 570-574页

作者： Yuguang Chen Yitan li Lu Han Hao Sun Min Lyu Zeyao Zhang Shigeo Maruyama Yan li Key Laboratory for the Physics and Chemistry of Nanodevices Beijing National Laboratory of Molecular SciencesState Key Laboratory of Rare Earth Materials Chemistry and ApplicationsCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China Bruker(Beijing)Scientific Technology Co.Ltd. Beijing 100192China Department of Mechanical Engineering The University of TokyoTokyo 113-8656Japan Peking University Shenzhen Institute Shenzhen 518057China PKU-HKUST ShenZhen-HongKong Institution Shenzhen 518057China

Single-walled carbon nanotubes(SWCNTs)present excellent electronic and mechanical properties desired in wearable and flexible *** preparation of SWCNT films is the first step for fabricating various *** work developed a scalable and feasible method to assemble SWCNT thin films on water surfaces based on Marangoni flow induced by surface tension *** films possess a large area of 40 cm×30 cm(extensible),a tunable thickness of 15∼150 nm,a high transparency of up to 96%,and a decent *** are ready to be directly transferred to various substrates,including flexible *** strain sensors were fabricated with the films on flexible *** sensors worked with high sensitivity and *** realizing multi-functional human motion sensing,including responding to voices,monitoring artery pulses,and detecting knuckle and muscle actions,the assembled SWCNT films demonstrated the potential for application in smart devices.

关键词： Single-walled carbon nanotubes Marangoni flow Assembly Interfaces Sensors

Peracetic acid catalytic activation using Co3O4 nanocluster decorated graphitic carbon nitride for cefapirin degradation in water

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Science China Technological Sciences 2024年第10期67卷 3103-3115页

作者： YIN ShiMei GAO YiXuan CHEN Long li Fan liU XiaoNa QI Fei liU Wen Beijing Key Lab for Source Control Technology of Water Pollution College of Environmental Science and EngineeringBeijing Forestry University Key Laboratory of Water and Sediment Sciences (Ministry of Education) College of Environmental Sciences and EngineeringPeking University School of Environmental Science and Engineering Taiyuan University of Technology State Environmental Protection Key Laboratory of All Material Fluxes in River Ecosystems Peking University Beijing National Laboratory for Molecular Sciences Peking University

This study innovated cobalt-based catalytic nanocomposites（CCNs） for the heterogeneous activation of peracetic acid（PAA）,a green and efficient advanced oxidation process for removing antibiotics from *** Co3O4catalysts exhibit limited activity due to stable electronic *** overcome this,CCNs were synthesized using a one-step condensation method,incorporating a size control strategy that anchors Co3O4nanoclusters within 4-5 nm onto six-fold cavity of g-C3N4,simultaneously modifying the coordination environment of *** alteration significantly enhances the adsorption energy of PAA and catalytic activity compared to commercial *** improved performance of CCN2,in particular,is attributed to a shift in the cobalt d band center towards the Fermi level,facilitating electron delocalization and transfer,enhancing Co-O bonding,and accelerating PAA ***2's superior activity,with a cefapirin（CFP） degradation kinetic rate constant(k1=0.760 min-1)～11 times that of PAA direct oxidation(k1=0.070 min-1) and～5 times that of commercial Co3O4/PAA system(k1=0.164 min-1),is due to its ability to generate dominant reactive species for antibiotic degradation,including alkoxy radicals(CH3C（=O）OO·),high valence metal(CoⅣ（=O）2+),and singlet oxygen（1O2）,with the latter two being crucial for the degradation *** degradation of CFP involved three mechanisms,including direct oxidation by PAA,decarboxylation,and open-ring reactions at nitrogen *** research provides insights into developing high-activity catalysts for efficient PAA activation and antibiotic removal,leveraging the strategy of shifting the transition metal d band center.

关键词： peracetic acid Co3O4 nanocluster high valence metal singlet oxygen cefapirin

Photocatalytic in situ H_(2)O_(2) production and activation for enhanced ciprofloxacin degradation over CeO_(2)-Co_(3)O_(4)/g-C_(3)N_(4):key role of CeO_(2)

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Rare Metals 2024年第6期43卷 2695-2707页

作者： Hong-Jie Zhu Yi-Kai Yang Ming-Hui li Lu-Ning Zou Hai-Tao Zhao Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology School of Chemistry and Chemical Engin College of Ecology and Environment Anhui Normal UniversityWuhu241002China liaocheng YiLu Advanced Materials Co. LtdLiaocheng 252000China

The abused ciprofloxacin antibiotics have caused significant environmental *** oxidative degradation of ciprofloxacin exhibits promising efficacy,it often entails excessive energy ***,it is necessary to explore an effective and ecologically sustainable degradation ***,we demonstrated that g-C_(3)N_(4) decorated with the coordinated CeO_(2)and Co_(3)O_(4)(CeO_(2)-Co_(3)O_(4)/CN)exhibited effective ciprofloxacin photodegradation via in situ H_(2)O_(2) production and activation *** indicate that the introduced CeO_(2) enhances the transference of photogenerated electrons to O_(2) by adjusting the oxygen vacancy of photocatalyst,thereby increasing the generation of superoxide radicals,which in turn generate H_(2)O_(2),resulting in a 22.4-fold increase in H_(2)O_(2) generation over g-C_(3)N_(4).Moreover,the in situ H_(2)O_(2)generation facilitated by CeO_(2) is confirmed to be essential for ciprofloxacin degradation via CeO_(2)-Co_(3)O_(4)/CN,as it provides enough oxidant for Co_(3)O_(4) to activate into hydroxyl radicals for the pollutants ***,CeO_(2)-Co_(3)O_(4)/CN achieves a ciprofloxacin degradation ratio of 97.7%within 80 *** study introduces a novel approach that combines H_(2)O_(2) generation and activation,offering an innovative perspective for achieving clean and efficient purification of antibiotic-contaminated water.

关键词： CeO_(2) In situ H_(2)O_(2)generation Ciprofloxacin degradation Photocatalyst

Concept, configuration, and application of on-board nanogrids for use in electric vehicles

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Science China(Technological Sciences) 2024年第7期67卷 2053-2073页

作者： ZHAO Bing li Yong WU Fang WAN JiangHu CAI JiuQing YANG HaiTao liU Fang College of Electrical and Information Engineering Hunan UniversityChangsha 410082China Wuhan Second Ship Design and Research Institute Wuhan 430000China School of Automation Central South UniversityChangsha 410083China

Against the backdrop of increasingly serious climate change, researchers are attempting to extend macroscale carbon reduction research to smaller scales. With the rapid development and widespread application of electric vehicles(EVs), an effective approach for carbon reduction based on EVs has the potential to be developed. To coordinate and manage the EV platform in diverse application scenarios, the concept of an on-board nanogrid(OBNG), in which a nanogrid is combined with the EV, is proposed and defined, and the characteristics summarized. A configuration that includes a physical layer with the on-board hardware system;an information layer for logical control, energy management, and communication coordination;and an application layer that can cope with different working environments is proposed. A detailed introduction to the basic architecture and management mode of each layer is provided along with information concerning the relevant technologies for coordinated operation. New ideas and approaches to improve the existing performance are proposed, and finally, combined with a background of smart and low-carbon cities, major application scenarios are envisioned.

关键词： electric vehicle nanogrid energy management hybrid energy storage power electronics converter

Carbon steel anticorrosion performance and mechanism of sodium lignosulfonate

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Rare Metals 2024年第1期43卷 356-365页

作者： Bo-Kai liao Rui-Xuan Quan Ping-Xian Feng Huan Wang Wei Wang li Niu School of Chemistry and Chemical Engineering Guangzhou Key Laboratory of Sensing Materials and DevicesJoint Institute of Guangzhou University and Institute of Corrosion Science and TechnologyGuangzhou UniversityGuangzhou 510006China

lignin is a typical biological macromolecule with a three-dimensional network structure and abundant functional groups. It has excellent ionic complexation ability and amphiphilic molecular structure *** this study, the carbon steel anticorrosion performance of sodium lignosulfonate(SLS) in an acid solution was evaluated using the weight loss method, electrochemical measurements, scanning vibration electrode technique(SVET), and surface characterization methods. SLS exhibited excellent corrosion inhibition efficiency for Q235carbon steel in 1 mol·L^(-1) HCl, reaching a maximum value of 98%. A low SLS concentration of 20 mg·L^(-1) resulted in the maximum corrosion inhibition efficiency, which remained nearly constant at higher SLS *** SVET test demonstrated that the formation of an SLS adsorption film can impede corrosion. This study confirms the significance of the application of green biomass resources in the field of metal corrosion protection and green functional materials.

关键词： lignin Sodium lignosulfonate Corrosion inhibitor Carbon Steel

Manufacturing process of water-soluble salt-based ceramic cores based on vat photopolymerization

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Journal of Advanced Ceramics 2024年第5期13卷 652-665页

作者： Yuzhen Zhang Wenyan Duan Yue Gu Xingyao Sun Shan li Bingshan liu Gong Wang Key Laboratory of Space Manufacturing Technology(SMT) Technology and Engineering Center for Space UtilizationChinese Academy of SciencesBeijing 100094China University of Chinese Academy of Sciences Beijing 100049China Ministry of Education Key Laboratory for Cross-Scale Micro and Nano Manufacturing Changchun University of Science and TechnologyChangchun 130022China

Water-soluble salt-based ceramic cores can be recycled and have excellent high-temperature chemical *** this work,vat photopolymerization was successfully applied to water-soluble salt-based ceramic cores for the first *** powder raw materials of the printing suspension were sodium chloride and ***-precision green bodies were manufactured by optimizing suspensions and *** addition,the postprocessing method was optimized according to the microstructure and mechanical *** sintered part had a high bending strength and smooth ***,the dissolution rate and moisture resistance were compared under different dissolution and storage *** to traditional manufacturing methods,vat photopolymerization enables the production of complex structures without molds and reduces production *** technology is suitable for the rapid iteration of complex structural parts and can be applied to precision parts in aerospace,military,and other technical fields with high cost-effectiveness and sustainability.

关键词： vat photopolymerization water-soluble salt-based ceramic cores defect formation control accuracy moisture rate