检索结果-南通市图书馆

藏药湿生扁蕾提取物对四氯化碳致小鼠急性肝损伤的保护作用研究

在线全文

学校读者我要写书评

暂无评论

甘肃中医药大学学报 2018年第1期35卷 1-5页

作者：芦彦兆景明卢年华张旭东甘肃中医药大学药学院甘肃兰州730000

目的研究藏药湿生扁蕾不同溶剂提取物对四氯化碳致小鼠急性肝损伤的保护作用。方法将54只雄性小鼠随机分为空白组、模型组、联苯双酯对照组、湿生扁蕾水提取物组、湿生扁蕾醇提取物组和湿生扁蕾醇水提取物组6组,每组9只。各组分别灌服... 详细信息

目的研究藏药湿生扁蕾不同溶剂提取物对四氯化碳致小鼠急性肝损伤的保护作用。方法将54只雄性小鼠随机分为空白组、模型组、联苯双酯对照组、湿生扁蕾水提取物组、湿生扁蕾醇提取物组和湿生扁蕾醇水提取物组6组,每组9只。各组分别灌服生理盐水,联苯双酯溶液,湿生扁蕾水提取物、乙醇提取物、乙醇和水提取物,灌胃7 d后,除空白组外,其余各组均灌服1.5%四氯化碳花生油20 mL/kg造模。24 h后经眼眶静脉丛取血,检测小鼠血清谷丙转氨酶(ALT)、谷草转氨酶(AST)活性及肝组织中丙二醛(MDA)含量、谷胱甘肽过氧化物酶(GSH-Px)活性,并观察小鼠肝脏病理学改变。结果与空白组比较,模型组小鼠血清ALT,AST活性及肝组织中MDA含量明显升高,肝组织中GSH-Px活性明显降低,差异均有统计学意义(P<0.01);与模型组比较,湿生扁蕾不同溶剂提取物组及联苯双酯对照组小鼠血清ALT,AST活性及肝组织中MDA含量明显降低,肝组织中GSH-Px活性明显升高,差异均有统计学意义(P<0.05或P<0.01),其中以湿生扁蕾醇水提取物组作用最为显著(P<0.05)。肝脏病理学观察结果显示,造模后模型组肝损伤程度严重,湿生扁蕾不同溶剂提取物组肝脏病理损伤程度明显减轻。结论藏药湿生扁蕾不同溶剂提取物可减轻四氯化碳诱导的小鼠急性肝损伤,改善小鼠肝功能,作用机制可能与其清除自由基、保护肝细胞膜结构和功能的完整性、提高肝细胞内的GSH-Px活性、增强机体抗氧化能力有关。

关键词：急性肝损伤四氯化碳湿生扁蕾提取物小鼠谷丙转氨酶谷草转氨酶丙二醛谷胱甘肽过氧化物酶实验研究

在线全文

学校读者我要写书评

暂无评论

高瓦斯大采高长工作面瓦斯综合治理技术研究

中州煤炭 2012年第11期 104-106页

作者：杜广占范二杰卢延召巩义瑶岭煤业有限公司河南巩义451200

寺河煤矿4301工作面为高瓦斯大采高长工作面,回采过程中面临着巨大的安全压力。通过采用地面钻孔抽采、井下千米钻机递进掩护抽采以及本煤层顺层钻孔抽采等立体空间式的"三级"瓦斯综合治理模式,实现了地面压裂与井下瓦斯抽采相结合,建... 详细信息

寺河煤矿4301工作面为高瓦斯大采高长工作面,回采过程中面临着巨大的安全压力。通过采用地面钻孔抽采、井下千米钻机递进掩护抽采以及本煤层顺层钻孔抽采等立体空间式的"三级"瓦斯综合治理模式,实现了地面压裂与井下瓦斯抽采相结合,建立了井上下协同瓦斯抽采模式,同时井下采用"三进两回"的通风方式,有效杜绝了工作面和上隅角瓦斯超限,保证了工作面安全高效回采,实现了煤与瓦斯共采的绿色开采技术。

关键词：大采高长工作面瓦斯综合治理煤与瓦斯共采

湿生扁蕾对结肠癌微环境中HMSCs恶性增殖以及CD34、CD90的影响

在线全文

学校读者我要写书评

暂无评论

中药药理与临床 2018年第3期34卷 125-128页

作者：赵慧巧卢年华张旭东柳娜芦彦兆陈正君刘雪枫张艳霞景明甘肃中医药大学兰州730000

目的:探究湿生扁蕾乙酸乙酯部位对结肠癌微环境中人骨髓间充质干细胞(human mesenchymal stem cells,HMSCs)恶性增殖及表面标志分子CD34、CD90表达的影响。方法:通过MTT法筛选湿生扁蕾乙酸乙酯部位作用于SW480细胞和HMSCs的最佳给药剂... 详细信息

目的:探究湿生扁蕾乙酸乙酯部位对结肠癌微环境中人骨髓间充质干细胞(human mesenchymal stem cells,HMSCs)恶性增殖及表面标志分子CD34、CD90表达的影响。方法:通过MTT法筛选湿生扁蕾乙酸乙酯部位作用于SW480细胞和HMSCs的最佳给药剂量。建立SW480和HMSCs细胞Transwell非接触共培养模型,将试验分为正常对照组、肿瘤细胞对照组、共培养组和湿生扁蕾给药组,分别采用细胞计数试验、流式细胞术FCM观察各组细胞的增殖、周期及HMSCs表面标志分子CD34和CD90的表达情况。结果:湿生扁蕾乙酸乙酯部位最佳给药剂量为200μg/ml,100μl。与正常对照组相比,共培养组HMSCs增殖能力增强,G1期细胞比例明显降低,S期和G2/M期细胞比例明显升高,且HMSCs表面标志分子CD34阳性表达率升高,CD90阳性表达率降低。与共培养组相比,湿生扁蕾给药组HMSCs增殖能力降低,G1期细胞比例明显升高,S期和G2/M期细胞比例明显降低,且HMSCs表面标志分子CD34阳性表达率降低,CD90阳性表达率升高。结论:结肠癌微环境中HMSCs增殖能力增强,且HMSCs表面标志分子阳性表达率发生显著改变,提示HMSCs发生恶性增殖,且湿生扁蕾乙酸乙酯部位可抑制结肠癌微环境中HMSCs的恶性转变。

关键词：湿生扁蕾结肠癌微环境骨髓间充质干细胞增殖 CD34 CD90

在线全文

学校读者我要写书评

暂无评论

西安某商厦通风系统问题分析及改造方案

洁净与空调技术 2014年第4期 66-68页

作者：祁永胜吴志湘吕砚昭西安工程大学

西安某商厦含商业营业厅、办公用房、餐饮、娱乐、地下车库等建筑功能,属一类公共建筑。商厦的通风问题主要集中在7层餐饮区和8层电影院,因此,对餐饮区的风平衡和电影院的空气品质分别进行了分析,并提出了相应的改造方案。

关键词：商厦风平衡空气品质分析改造

在线全文

学校读者我要写书评

暂无评论

浅析分布式供热输配系统的优越性

洁净与空调技术 2015年第1期 57-60页

作者：李姣吴志湘吕砚昭林迪西安工程大学西安市建筑设计研究院中国新时代国际工程公司

对比分析了分布式供热输配系统与传统供热系统在水力工况、系统运行调节、初期投资以及节能等方面的不同,得出分布式供热输配系统能够有效地解决水力平衡、消除系统的冷热不均,提高系统的稳定性,还能够适应负荷的变化,具有良好的可调性... 详细信息

对比分析了分布式供热输配系统与传统供热系统在水力工况、系统运行调节、初期投资以及节能等方面的不同,得出分布式供热输配系统能够有效地解决水力平衡、消除系统的冷热不均,提高系统的稳定性,还能够适应负荷的变化,具有良好的可调性,并且节能节电。系统的介绍了分布式输配系统的优越性,以期这项技术能够得到更广泛的应用。

关键词：分布式供热输配系统水力平衡运行调节节能

Controllable synthesis of biomimetic wood stem nanoporous high entropy oxides catalysts for oxygen evolution reaction

在线全文

学校读者我要写书评

暂无评论

Nano Research 2025年第1期18卷 107-117页

作者： Wei Wang Weiqi Wang Huihui Wang Xing lu Jinwen Zhang Yunzhuo lu School of Materials Science and Engineering Dalian Jiaotong UniversityDalian 116028China School of Intelligence and Electronic Engineering Dalian Neusoft University of InformationDalian 116023China Guangdong Key Laboratory of Materials and Equipment in Harsh Marine Environment Guangzhou Maritime UniversityGuangzhou 510725China

Bubbles generated during the oxygen evolution reaction(OER)in water splitting readily adhere to the electrode surface,thereby impeding contact between the electrolyte and the active sites,thereby increasing the ***,it is imperative to elucidate the bubble release behavior and engineer electrodes that facilitate faster bubble *** this study,inspired by the wood stem of the Norway spruce,we synthesized a gradient nanoporous high-entropy oxide(GNP-HEO)electrode with a controllable pore *** GNP-HEO,featuring a well-controlled gradient in pore size,is achieved through a straightforward strategy combining selective laser melting with selective phase *** unique gradient nanoporous structure not only facilitates bubble release but also diminishes the bubble shielding effect in OER,thereby enhancing electrocatalytic *** affect interaction of Al,Co,Cr,Fe,and Ni,coupled with the gradient nanoporous structure,yields exceptional OER performance,evidenced by an overpotential of 250 mV at a current density of 50 mA/cm^(2) and a Tafel slope of 38.0 mV/dec in 1 M *** functional theory calculations confirm that the GNPHEO adheres to the adsorbate evolution mechanism reaction pathway and exhibits significant *** work highlights a promising approach for the design and synthesis of high-performance OER electrocatalysts.

关键词： oxygen evolution reaction high-entropy oxides selective phase dis-solution selective laser melting gradient nanoporous

From waste to wealth:Coal tar residue derived carbon materials as low-cost anodes for potassium-ion batteries

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 464-475页

作者： Zhonghua lu Jun Shen Xin Zhang Lingcong Chao Liang Chen Ding Zhang Tao Wei Shoudong Xu College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China College of Chemistry Taiyuan University of TechnologyTaiyuan 030024China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China

Carbon materials are widely recognized as highly promising electrode materials for various energy storage system *** tar residues(CTR),as a type of carbon-rich solid waste with high value-added utilization,are crucially important for the development of a more sustainable *** this study,we employed a straightforward direct carbonization method within the temperature range of 700-1000℃to convert the worthless solid waste CTR into economically valuable carbon materials as anodes for potassium-ion batteries(PIBs).The effect of carbonization temperature on the microstructure and the potassium ions storage properties of CTR-derived carbons(CTRCs)were systematically explored by structural and morphological characterization,alongside electrochemical performances *** on the co-regulation between the turbine layers,crystal structure,pore structure,functional groups,and electrical conductivity of CTR-derived carbon carbonized at 900℃(CTRC-900H),the electrode material with high reversible capacity of 265.6m Ah·g^(-1)at 50 m A·g^(-1),a desirable cycling stability with 93.8%capacity retention even after 100 cycles,and the remarkable rate performance for PIBs were ***,cyclic voltammetry(CV)at different scan rates and galvanostatic intermittent titration technique(GITT)have been employed to explore the potassium ions storage mechanism and electrochemical kinetics of *** indicate that the electrode behavior is predominantly governed by surface-induced capacitive processes,particularly under high current densities,with the potassium storage mechanism characterized by an“adsorption-weak intercalation”*** work highlights the potential of CTR-based carbon as a promising electrode material category suitable for high-performance PIBs electrodes,while also provides valuable insights into the new avenues for the high value-added utilization of CTR.

关键词： coal tar residue carbon materials anode potassium-ion batteries high value-added

Ru doping triggering reconstruction of cobalt phosphide for coupling glycerol electrooxidation with seawater electrolysis

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 317-326页

作者： Binglu Deng Jie Shen Jinxing lu Chuqiang Huang Zhuoyuan Chen Feng Peng Yunpeng Liu School of Materials Science and Hydrogen Energy Foshan University School of Chemistry and Chemical Engineering Guangzhou University Guangdong Key Laboratory for Hydrogen Energy Technologies

Seawater electrolysis is a promising approach for sustainable energy without relying on precious ***,the large-scale seawater electrolysis is hindered by low catalytic efficiency and severe anode corrosion caused by the harmful *** contrast to the oxygen evolution reaction （OER）and chlorin ion oxidation reaction （ClOR）,glycerol oxidation reaction （GOR） is more thermodynamically and kinetically favorable ***,a Ru doping cobalt phosphide （Ru-CoP2） is proposed as a robust bifunctional electrocatalyst for seawater electrolysis and GOR,for the concurrent productions of hydrogen and value-added *** in situ and ex situ characterization analyses demonstrated that Ru doping featured in the dynamic reconstruction process from Ru-CoP2to Ru-CoOOH,accounting for the superior GOR *** coupling GOR with hydrogen evolution was realized by employing Ru-CoP2as both anode and cathode,requiring only a low voltage of 1.43 V at 100 mA cm-2,which was 250 m V lower than that in alkaline *** work guides the design of bifunctional electrocatalysts for energy-efficient seawater electrolysis coupled with biomass resource upcycling.

关键词： Glycerol electrooxidation Hydrogen evolution Ru doping Cobalt phosphide Bifunctional electrocatalysts

反相高效液相色谱法测定复方湿生扁蕾结肠靶向微丸的体外释放度

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

甘肃中医药大学学报 2017年第4期34卷 19-23页

作者：陈正君卢年华赵慧巧芦彦兆陈晖景明甘肃中医药大学期刊编辑部甘肃兰州730000 甘肃中医药大学药学院甘肃兰州730000

目的对制取的具pH依赖型和酶触依赖型的微丸进行模拟体内环境试验,以判断制备复方湿生扁蕾结肠靶向微丸的可行性。方法结合反相高效液相色谱(RP-HPLC)法,以湿生扁蕾中所含木犀草素为评价指标,结合2015版《中华人民共和国药典》中释放度... 详细信息

目的对制取的具pH依赖型和酶触依赖型的微丸进行模拟体内环境试验,以判断制备复方湿生扁蕾结肠靶向微丸的可行性。方法结合反相高效液相色谱(RP-HPLC)法,以湿生扁蕾中所含木犀草素为评价指标,结合2015版《中华人民共和国药典》中释放度测定法,评价微丸在模拟胃液、小肠液、结肠液中的释药行为。结果复方湿生扁蕾微丸中木犀草素在模拟胃液和小肠液中2 h后均未见释放;在模拟结肠液中1 h后释放度为85.3%,2 h后达95.3%。结论制备的复方湿生扁蕾结肠靶向微丸释放度满足《中华人民共和国药典》要求,工艺可靠,重现好,能达到预期释药效果。

关键词：复方湿生扁蕾结肠靶向微丸释放度反相高效液相色谱