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Dendritic Cell as Therapeutic Vaccines against Tumors and Its Role in Therapy for Hepatocellular Carcinoma

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Cellular & Molecular Immunology 2006年第3期3卷 197-203页

作者： Kang Sun Liang Wang yanyun zhang Department of General Surgery the First Affiliated Hospital of Soochow University Suzhou 215006 China Shanghai Institute of Immunology Medical School of Shanghai Jiaotong University Shanghai 200025 China

Dendritic cells （DCs） are the most potent professional antigen-presenting cells, and capable of stimulating naive T cells and driving primary immune responses. DCs are poised to capture antigen, migrate to draining lymphoid organs, and after a process of maturation, select antigen-specific lymphocytes to which they present the processed antigen, thereby inducing immune responses. The development of protocols for the ex vivo generation of DCs may provide a rationale for designing and developing DC-based vaccination for the treatment of tumors. There are now several strategies being applied to upload antigens to DCs and manipulate DC vaccines. DC vaccines are able to induce therapeutic and protective antitumor immunity. Numerous studies indicated that hepatocellular carcinoma （HCC） immunotherapies utilizing DC-presenting tumor-associated antigens could stimulate an antitumour T cell response leading to clinical benefit without any significant toxicity. DC-based tumor vaccines have become a novel immunoadjuvant therapy for HCC. Cellular ＆ Molecular Immunology. 2006;3（3）：197-203.

关键词： dendritic cell vaccination hepatocellular carcinoma

DDQ as an effective p-type dopant for the hole-transport material X1 and its application in stable solid-state dye-sensitized solar cells

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Journal of Energy Chemistry 2018年第2期27卷 413-418页

作者： yanyun zhang Xichuan Yang Weihan Wang Xiuna Wang Licheng Sun State Key Laboratory of Fine Chemicals Dalian University of Technology (DUT) Department of Chemistry School of Chemical Science and EngineeringKTH Royal Institute of Technology

X1（Me O-TPD） is an inexpensive and easily synthesized π-conjugated molecule that has been used as a hole-transport material（HTM） in solid-state dye-sensitized solar cells（ssDSSCs）, achieving relatively high efficiency. In this paper, we characterize the physicochemical properties of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone（DDQ） and show that it is a promising p-dopant in a spin-coating solution with X1 as the HTM. The doped ssDSSCs showed an increase in short-circuit current density from 5.38 mA cm-2 to7.39 mA cm-2, and their overall power conversion efficiency increased from 2.9% to 4.3%. Also, ssDSSCs with DDQ-doped X1 were more stable than the undoped samples, demonstrating that DDQ can act as a p-type dopant in X1 as an HTM for highly efficient, stable ssDSSCs.

关键词： p-Type dopant XI DDQ ssDSSCs

Secondary solar heat gain modelling of spectral-selective glazing based on dynamic solar radiation spectrum

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Building Simulation 2023年第12期16卷 2211-2224页

作者： Peng Xue Yi Shen Sheng Ye Jinqing Peng yanyun zhang Qianqian zhang Yuying Sun Beijing Key Laboratory of Green Built Environment and Energy Efficient Technology Beijing University of TechnologyBeijing 100124China Faculty of Architecture Civil and Transportation EngineeringBeijing University of TechnologyBeijing 100124China State Grid Zhongxing CO. LTDLvyuan BranchBeijing 100761China College of Civil Engineering Hunan UniversityChangsha 410082HunanChina Key Laboratory for New Functional Materials of Ministry of Education Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China

The secondary solar heat gain,defined as the heat flows from glazing to indoor environment through longwave radiation and convection,grows with the increasing of glazing *** the rapid development and application of spectrally selective glazing,the secondary solar heat gain becomes the main way of glazing heat transfer and biggest proportion,and indicates it should not be simplified calculated ***,a dynamic secondary solar heat gain model is developed with electrochromic glazing system in this study,taking into account with three key aspects,namely,optical model,heat transfer model,and outdoor radiation *** with the traditional K-Sc model,this new model is verified by on-site experimental measurements with dynamic outdoor spectrum and *** verification results show that the root mean square errors of the interior and exterior glass surface temperature are 3.25°C and 3.33°C,respectively,and the relative error is less than 10.37%.The root mean square error of the secondary heat gain is 13.15 W/m2,and the dynamic maximum relative error is only 13.2%.The simulated and measured results have a good *** addition,the new model is further extended to reveal the variation characteristics of secondary solar heat gain under different application conditions(including orientations,locations,EC film thicknesses and weather conditions).In summary,based on the outdoor spectrum and window spectral characteristics,the new model can accurately calculate the increasing secondary solar heat gain in real time,caused by spectrally selective windows,and will provide a computational basis for the evaluation and development of spectrally selective glazing materials.

关键词： econdary solar heat gain spectral-selective glazing solar spectrum dynamic heat transfer

DC-SIGN and Immunoregulation

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Cellular & Molecular Immunology 2006年第4期3卷 279-283页

作者： Tong Zhou Yongxi Chen Li Hao yanyun zhang Department of Nephrology Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai 200025 China Shanghai Institute of Immunology and Institute of Health Sciences Shanghai Institute of Biological Sciences Shanghai Jiao Tong University Shanghai 200025 China

Dendritic cells （DCs） are known to be the most powerful professional antigen-presenting cells so far. It could activate primary immune response, and also downregulate immune response. DCs have a unique character of immunoregulation. DC-SIGN, a molecule designated as CD209, is one member of the C-type lectin superfamily. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. DC-SIGN has become hotspot of recent studies because of its important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors. These studies on DC-SIGN involved in primary and secondary immune response and relevant mechanism will certainly provide us with a new method in treating and preventing certain diseases.

关键词： DC DC-SIGN pattern recognition receptor immunoregulation

Home ranges and habitat vegetation characters in breeding season of Narcissus Flycatcher and Yellow-rumped Flycatcher

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Frontiers in Biology 2007年第3期2卷 345-350页

作者： WANG Ning zhang yanyun ZHENG Guangmei Ministry of Education Key Laboratory for Biodiversity Sciences and Ecological Engineering College of Life SciencesBeijing Normal UniversityBeijing 100875China

The home ranges of the Narcissus Flycatcher(Ficedula narcissina elisae)and the Yellow-rumped Fly-catcher(***)are measured by radio telemetry in a subalpine forest near Beijing,*** home range is calculated by 100%Minimum Convex Polygon(MCP),and the area varies from 2,000 to 5,000 *** majority of fly-catchers can be found in the bottom of valleys and the under-side of *** is fairly rare for both Flycatcher species to leave their nests more than 70 *** of the species in pair-banding and nest-detecting periods have larger home ranges than those in incubation and rearing *** levels of canopy coverage in the home ranges of Narcissus Flycatchers are significantly higher than that of Yellow-rumped *** are also more tall trees and stumps in the home ranges of Narcissus Flycatchers than in that of Yellow-rumped *** dominant tree species in the home ranges of Narcissus Flycatchers is Dahurian Birch(Betula dahurica),whereas Manchurian Walnut(Juglans mandshurica)is the dominant tree species in the home ranges of Yellow-rumped Flycatchers.

关键词： NarcissusFlycatcher Yellow-runpdeFlycatcher radiotelemetry home range habitat

Reliability of the Brownish-flanked Bush Warbler's soft song in male-male conflict

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Chinese Birds 2015年第2期6卷 107-112页

作者： Canwei Xia Boye Liu Daiping Wang Huw Lloyd yanyun zhang Ministry of Education Key Laboratory for Biodiversity and Ecological Engineering College of Life Sciences Beijing Normal University Division of Biology and Conservation Ecology School of Science and the Environment Manchester Metropolitan University

Background: Soft song is a low-amplitude song produced by many birds. Recent studies have confirmed that soft song is an aggressive signal. For example, the Brownish-flanked Bush Warblers Cettia fortipes use soft song in male-male conflicts, particularly prior to attacks. Although stable signaling systems require that signals be honest on average,models predict that cheating is an acceptable strategy for some individuals or in some ***: This study aimed to test the reliability of soft song as an aggressive signal in the brownish-flanked bush warbler. We used mounted specimens accompanied by broadcast songs or soft songs to simulate a male attempting to invade an existing ***: We found the mounted specimen that coupled playback of soft songs suffered more and quicker attacks from the territory owner and that the relationship between soft song and subsequent attack in the territory owner was far from perfect. We observed territory owners that both over-signaled(i.e., produced soft song but did not attack) and under-signaled(i.e., attacked without producing soft song). Under-signaling territory owners were relatively more commonly than were over-signaling territory owners, particularly in simulated intrusion that coupled playback of soft song with a mount ***: We discuss the cost of producing soft song and the potential benefit of the unreliable use of soft song and propose a new hypothesis for under-signaling with soft song; i.e., under-signaling territory owners might benefit from taking the initiative in fights.

关键词： Aggressive signal Brownish-flanked Bush Warbler Cost Reliability Soft song

Identification of vocal individuality in male cuckoos using different analytical techniques

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Avian Research 2017年第3期8卷 134-140页

作者： Yang Li Canwei Xia Huw Lloyd Donglai Li yanyun zhang Ministry of Education Key Laboratory for Biodiversity and Ecological Engineering College of Life Sciences Beijing Normal University School of Science and Environment Manchester Metropolitan University Provincial Key Laboratory of Animal Resource and Epidemic Disease Prevention College of Life Sciences Liaoning University

Background: Individuality in vocalizations may provide an effective tool for surveying populations of the Common Cuckoo(Cuculus canorus) but there remains few data on which technique to use to identify individuality. In this research, we compared the within-and between-individual variation in cuckoo calls using two different analytical methods, and discuss the feasibility of using call individuality to count male cuckoos within a ***: We recorded vocalization from 13 males, and measured 15 spectro-temporal variables for each call. The majority of these call variables(n = 12) have greater variation between individuals than within individual. We first calculated the similarity(Pearson's R) for each paired calls in order to find a threshold that could distinguish calls emitted from the same or different males, and then counted the number of males based on this distinction. Second, we used the more widely accepted technique of discriminant function analysis(DFA) to identify individual male cuckoos, and compared the correct rate of classifying individuals between the two analytical ***: Similarity of paired calls from the same male was significantly higher than from different males. Under a relatively broad threshold interval, we achieved a high(>90%) correct rate to distinguish calls and an accurate estimate of male numbers. Based on banded males(n = 3), we found the similarity of paired calls from different days was lower when compared with paired calls from the same day, but this change did not obscure individual identification, as similarity values of paired calls from different days were still larger than the threshold used to distinguish calls from the same or different males. DFA also yielded a high rate(91.9%) of correct classification of ***: Our study suggests that identifying individual vocalizations can form the basis of an appropriate survey method for counting male cuckoos within a population, provided the perf

关键词： Vocal individuality Avian acoustics Common Cuckoo Correlation analysis Discriminant function analysis

Comparing post-release survival and habitat use by captive-bred Cabot's Tragopan(Tragopan caboti) in an experimental test of soft-release reintroduction strategies

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Chinese Birds 2016年第3期7卷 133-141页

作者： Boye Liu Li Li Huw Lloyd Canwei Xia yanyun zhang Guangmei Zheng Ministry of Education Key Laboratory for Biodiversity and Ecological Engineering College of Life Sciences Beijing Normal University Hunan Wildlife Rescue and Breeding Center School of Science and Environment Manchester Metropolitan University

Background: Restoring a viable population by reintroduction is the ultimate goal of a large number of ex situ conservation projects for endangered animals. However, many reintroductions fail to establish a population in the wild, partly because released animals cannot acclimate to the native environment of the release site, resulting in very low survival rates. Acclimation training is a technique to resolve this problem, although it does not have positive results in all species. We tested whether acclimation training and soft-release could improve the reintroduction success for captive-bred Cabot's Tragopan(Tragopan caboti), an endangered pheasant in southern ***: Reintroduction of captive-bred Cabot's Tragopan was carried out in the Taoyuandong National Nature Reserve, China from 2010 to 2011. We built a soft-release enclosure for acclimation training in the typical montane habitat of this pheasant. Nine birds were acclimated to the environment of this release site in this cage for more than 50 days before release("trained birds"), while 11 birds remained only in the cage for 3 days prior to release("untrained birds"). Released birds were tagged with a collar ***: Post-release monitoring revealed that the survival rate of trained birds was higher than that of untrained birds after 50 days(trained: 85.7%; untrained: 20.0%). Cox regression analysis showed that there was a significant difference in the mortality rates between the trained and untrained birds. In addition, a survey of the habitat of the experimental and the control groups showed significant differences in habitat selection between the ***: Our study suggests that pre-release acclimatization training is an important factor that can lead to improved survival and habitat selection of captive-bred reintroduced tragopans.

关键词： Diet Habitat selection Post-release survival Reintroduction Survival rate

Valsartan Inhibited the Accumulation of Dendritic Cells in Rat Fibrotic Renal Tissue

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Cellular & Molecular Immunology 2006年第3期3卷 213-220页

作者： Kaiyin Wu Tong Zhou Guizhi Sun Weiming Wang Yumei zhang yanyun zhang Li Hao Nan Chen Department of Nephrology Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Joint Immunology Laboratory Institutes of Health Sciences and Shanghai Institute of Immunology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

To observe the accumulation of dendritic cells （DCs） in rat remnant kidney and its contribution to tubulointerstitial fibrosis, under influence of valsartan on DCs, a rat remnant kidney model was established by subtotal nephrectomy. Four experimental groups were included： normal, sham, model （SNx） and the group treated with Valsartan （SNxV）. Rats were killed at week 1, 4 and 12, respectively. CD1a^＋CD80^＋ DCs were assayed by double immunostaining method and the images were analyzed with Axioplan 2 microscopy. The expressions of P-selectin, TGF-β1, α-SMA, collagen Ⅲ and fibronectin were analyzed by immunohistochemistry or semi- quantitative RT-PCR, and the level of tubulointerstitial firosis （TIF） was scored. CD1a^＋CD80^＋ DCs were gradually increased among renal tubules, interstitium and vessels, especially in interstitium, and the number of DCs in model group at week 12 was much more than that in model groups at week 1 or 4. The expressions of P-selectin, TGF-β1, α-SMA, collagen Ⅲ and fibronectin in tubulointerstitial areas and the degree of TIF were increased substantially in model group at week 12. The accumulation of DCs in interstitium was well associated with the loss of renal function and the progression of tubulointerstitial fbrosis. Valsartan treatment inhibited the local accumulation of DCs and attenuated renal tubulointerstitial damage. The local DCs accumulation was related to tubulointerstitial fibrosis and renal dysfunction following renal ablation. Blockade to angiotensin II might be a potent way to attenuate renal immuno-inflammatory injury. Cellular ＆ Molecular Immunology. 2006;3（3）：213-220.

关键词： dendritic cell tubulointerstitial fibrosis nephrectomy valsartan