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Correlation between cerebral cortex changes and clinical features in patients with neuromyelitis optica spectrum disorder with normal-appearing brain tissue:a case-control study

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Neural Regeneration Research 2023年第11期18卷 2520-2525页

作者： Chuxin Huang yanyu li Yanjing Chen Xuan liao Huiting Zhang Zhiyuan Wang Jun liu Wei Lu Department of Radiology the Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina Department of Neurology the Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina Department of Radiology Wuhan No.1 HospitalWuhanHubei ProvinceChina MR Scientific Marketing Siemens Healthineers Ltd.WuhanHubei ProvinceChina Department of Medical Ultrasound Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaHunan ProvinceChina Clinical Research Center for Medical Imaging in Hunan Province ChangshaHunan ProvinceChina

Neuro myelitis optica spectrum disorder(NMOSD) is an inflammatory demyelinating disease of the central nervous system.However,whether and how cortical changes occur in NMOSD with normal-appearing brain tissue,or whether any cortical changes correlate with clinical chara cteristics,is not completely clear.The current study recruited 43 patients with NMOSD who had normal-appearing brain tissue and 45 healthy controls matched for age,sex,and educational background from December 2020 to February 2022.A surface-based morphological analysis of high-resolution T1-weighted structural magnetic resonance images was used to calculate the cortical thickness,sulcal depth,and gyrification index.Analysis showed that cortical thickness in the bilate ral rostral middle frontal gyrus and left superior frontal gyrus was lower in the patients with NMOSD than in the control participants.Subgroup analysis of the patients with NMOSD indicated that compared with those who did not have any optic neuritis episodes,those who did have such episodes exhibited noticeably thinner cortex in the bilateral cuneus,superior parietal co rtex,and pericalcarine co rtex.Correlation analysis indicated that co rtical thickness in the bilateral rostral middle frontal gyrus was positively correlated with scores on the Digit Symbol Substitution Test and negatively correlated with scores on the Trail Making Test and the Expanded Disability Status Scale.These results are evidence that cortical thinning of the bilateral regional frontal cortex occurs in patients with NMOSD who have normal-appearing brain tissue,and that the degree of thinning is correlated with clinical disability and cognitive function.These findings will help im prove our understanding of the imaging chara cteristics in NMOSD and their potential clinical significance.

关键词： cognitive function cortical thickness Expanded Disability Status Scale gyrification magnetic resonance imaging neuromyelitis optica spectrum disorder normal-appearing brain tissue rostral middle frontal gyrus sulcal depth superior frontal gyrus

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Animal models of stroke

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Animal Models and Experimental Medicine 2021年第3期4卷 204-219页

作者： yanyu li Jingjing Zhang Affiliated Hospital of Guangdong Medical University&Key Laboratory of Zebrafish Model for Development and Diseases of Guangdong Medical University ZhanjiangChina

Stroke is a devastating disease with high morbidity and mortality.Animal models are indispensable tools that can mimic stroke processes and can be used for investigating mechanisms and developing novel therapeutic regimens.As a heterogeneous disease with complex pathophysiology,mimicking all aspects of human stroke in one animal model is impossible.Each model has unique strengths and weaknesses.Models such as transient or permanent intraluminal thread occlusion middle cerebral artery oc-clusion(MCAo)models and thromboembolic models are the most commonly used in simulating human ischemic stroke.The endovascular filament occlusion model is characterized by easy manipulation and accurately controllable reperfusion and is suitable for studying the pathogenesis of focal ischemic stroke and reperfusion in-jury.Although the reproducibility of the embolic model is poor,it is more conveni-ent for investigating thrombolysis.Rats are the most frequently used animal model for stroke.This review mainly outlines the stroke models of rats and discusses their strengths and shortcomings in detail.

关键词： animal models cerebral hemorrhage ischemia stroke

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Study of aerosol characteristics and sources using MAX-DOAS measurement during haze at an urban site in the Fenwei Plain

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Journal of Environmental Sciences 2021年第9期33卷 1-13页

作者： Xiaomei li Pinhua Xie Ang li Jin Xu Hongmei Ren Bo Ren yanyu li Jie li Key laboratory of Environmental Optics and Technology Anhui Institute of Optics and Fine MechanicsHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China CAS Center for Excellence in Urban Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China Institute of Atmospheric Physics Chinese Academy of ScienceBeijing 100029China

Atmospheric aerosols have effects on atmospheric radiation assessments,global climate change,local air quality and visibility.In particular,aerosols are more likely transformed and accumulated in winter.In this paper,we used the Multi-Axis Differential Optical Absorption Spectroscopy(MAX-DOAS)instrument to study the characteristics of aerosol type and contributions of PM_(2.5) chemical components to aerosol extinction(AE),vertical distribution of aerosols,and source.From December 30,2018 to January 27,2019,we conducted MAX-DOAS observations on Sanmenxia.The proportion of PM_(2.5) to PM10 was 69.48%-95.39%,indicating that the aerosol particles were mainly fine particles.By analyzing the ion data and modifying Interagency Monitoring of Protected Visual Environments(IMPROVE)method,we found that nitrate was the largest contributor to AE,accounting for 31.51%,28.98%,and 27.95%of AE on heavily polluted,polluted,and clean days,respectively.NH4+,OC,and SO42-were also major contributors to AE.The near-surface aerosol extinction retrieved from MAX-DOAS measurement the PM_(2.5) and PM10 concentrations measured by an Unmanned Aerial Vehicle(UAV)have the same trend in vertical distribution.AE increased about 3 times from surface to 500 m.With the backward trajectory of the air mass during the haze,we also found that the continuous heavy pollution was mainly caused by transport of polluted air from the northeast,then followed by local industrial emissions and other sources of emissions under continuous and steady weather conditions.

关键词： MAX-DOAS Aerosol optical depth(AOD) Aerosol extinction(AE) Haze PM_(2.5) IMPROVE

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Environmental behavior, human health effect, and pollution control of heavy metal(loid)s toward full life cycle processes

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Eco-Environment & Health 2022年第4期1卷 229-243页

作者： Haoyu Deng Yuling Tu Han Wang Ziyi Wang yanyu li liyuan Chai Wenchao Zhang Zhang lin School of Metallurgy and Environment Central South UniversityChangsha 410083China Chinese National Engineering Research Center for Control&Treatment of Heavy Metal Pollution Changsha 410083China School of Environment and Energy Guangdong Provincial Key Laboratory of Solid Wastes Pollution Control and RecyclingSouth China University of TechnologyGuangdong 510006China

Heavy metal(loid)s(HMs)have caused serious environmental pollution and health risks.Although the past few years have witnessed the achievements of studies on environmental behavior of HMs,the related toxicity mechanisms,and pollution control,their relationship remains a mystery.Researchers generally focused on one topic independently without comprehensive considerations due to the knowledge gap between environmental science and human health.Indeed,the full life cycle control of HMs is crucial and should be reconsidered with the combination of the occurrence,transport,and fate of HMs in the environment.Therefore,we started by reviewing the environmental behaviors of HMs which are affected by a variety of natural factors as well as their physicochemical properties.Furthermore,the related toxicity mechanisms were discussed according to exposure route,toxicity mechanism,and adverse consequences.In addition,the current state-of-the-art of available technologies for pollution control of HMs wastewater and solid wastes were summarized.Finally,based on the research trend,we proposed that advanced in-operando characterizations will help us better understand the fundamental reaction mechanisms,and big data analysis approaches will aid in establishing the prediction model for risk management.

关键词： Heavy metal(loid)s Full life cycle Toxicity Environment Pollution control

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建筑工程中的施工技术及现场施工管理研究

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中国厨卫 2024年第5期23卷 99-101页

作者：李言玉郓城县垃圾处理厂山东菏泽274700

随着城市化进程的不断加快和经济的发展,建筑业已经成为了国民经济的重要组成部分。然而,由于各种因素的影响,建筑行业的发展面临着诸多挑战和困难。其中,施工技术与现场施工管理是建筑行业需要重点考虑的内容。因此,文章阐述了建筑工... 详细信息

随着城市化进程的不断加快和经济的发展,建筑业已经成为了国民经济的重要组成部分。然而,由于各种因素的影响,建筑行业的发展面临着诸多挑战和困难。其中,施工技术与现场施工管理是建筑行业需要重点考虑的内容。因此,文章阐述了建筑工程施工技术及现场施工管理的关系,并通过对施工技术和场施工管理进行分析,有效地提高了建筑项目的质量和效益,为建设高质量的城市奠定了坚实的基础。

关键词：建筑工程施工技术施工管理

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Study on driver’s braking intention identification based on functional near-infrared spectroscopy

Journal of Intelligent and Connected Vehicles

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Journal of Intelligent and Connected Vehicles 2018年第3期1卷 107-113页

作者： Lei Zhu Shuguang li Yaohua li Min Wang yanyu li Jin Yao School of Manufacturing Science and Engineering Sichuan UniversityChengduChina Department of Neurology Chengdu City First People’s HospitalChengduChina Sichuan University ChengduChina

Purpose–Cooperative driving refers to a notion that intelligent system sharing controlling with human driver and completing driving task together.One of the key technologies is that the intelligent system can identify the driver’s driving intention in real time to implement consistent driving decisions.The purpose of this study is to establish a driver intention prediction model.Design/methodology/approach–The authors used the NIRx device to measure the cerebral cortex activities for identifying the driver’s braking intention.The experiment was carried out in a virtual reality environment.During the experiment,the driving simulator recorded the driving data and the functional near-infrared spectroscopy(fNIRS)device recorded the changes in hemoglobin concentration in the cerebral cortex.After the experiment,the driver’s braking intention identification model was established through the principal component analysis and back propagation neural network.Findings–The research results showed that the accuracy of the model established in this paper was 80.39 per cent.And,the model could identify the driver’s braking intent prior to his braking operation.Research limitations/implications–The limitation of this study was that the experimental environment was ideal and did not consider the surrounding traffic.At the same time,other actions of the driver were not taken into account when establishing the braking intention recognition model.Besides,the verification results obtained in this paper could only reflect the results of a few drivers’identification of braking intention.Practical implications–This study can be used as a reference for future research on driving intention through fNIRS,and it also has a positive effect on the research of brain-controlled driving.At the same time,it has developed new frontiers for intention recognition of cooperative driving.Social implications–This study explores new directions for future brain-controlled driving and wheelchairs.Originality/value–The driver’s driving intention was predic

关键词： Machine learning fNIRS Cooperative driving Driving intention identification

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light absorption properties and potential sources of brown carbon in Fenwei Plain during winter 2018–2019

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Journal of Environmental Sciences 2021年第4期33卷 53-63页

作者： Wenyu Zhang Weigang Wang Jie li Shuangliang Ma Chaofan lian Kun li Bo Shi Mingyuan liu yanyu li QingQing Wang Yele Sun Shengrui Tong Maofa Ge State Key Laboratory for Structural Chemistry of Unstable and Stable Species Beijing National Laboratory for Molecular Sciences(BNLMS)Chemistry Academy of Sciences Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Henan Environmental Monitoring Center Station Zhengzhou 450000China Laboratory of Atmospheric Chemistry Paul Scherrer Institute(PSI)Villigen 5232Switzerland Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Department of Clinical Research Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013China

A distinctive kind of organic carbon aerosol that could absorb ultraviolet-visible radiation is called brown carbon(Br C),which has an important positive influence on radiative budget and climate change.In this work,we reported the absorption properties and potential source of Br C based on a seven-wavelength aethalometer in the winter of 2018–2019 at an urban site of Sanmenxia in Fenwei Plain in central China.Specifically,the mean value of Br C absorption coefficient was 59.6±36.0 Mm^(-1) at 370 nm and contributed 37.7%to total absorption,which made a significant impact on visibility and regional environment.Absorption coefficients of Br C showed double-peak pattern,and Br C had shown small fluctuations under haze days compared with clean days.As for the sources of Br C,Br C absorption coefficients expressed strong correlations with element carbon aerosols and primary organic carbon aerosols,indicating that most of Br C originated from primary emissions.The linear correlations between trace metal elements(K,As,Fe,Mn,Zn,and Pb)and Br C absorption coefficients further referred that the major sources of Br C were primary emissions,like coal burning,biomass burning,and vehicle emissions.The moderate relationship between Br C absorption coefficients and secondary organic aerosols suggested that secondary production of Br C also played an important role.The 120 hr backward air mass trajectories analysis and concentration-weighted trajectories analysis were also used to investigate potential sources of Br C in and around this area,which inferred most parts of Br C were derived from local emissions.

关键词： Brown carbon light absorption Potential source analysis Fenwei Plain

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缓蚀型聚邻甲苯胺-氧化石墨烯基防腐材料的制备与性能

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复合材料学报 2024年第4期41卷 1900-1913页

作者：王海花叶梦玉费贵强李焱宇王丹丹陕西科技大学化学与化工学院西安710021

为开发缓蚀剂高效利用的新途径,选取氧化石墨烯为基材、聚邻甲苯胺微胶囊为壁材、缓蚀剂2-巯基苯并噻唑为芯材,制备了缓蚀型聚邻甲苯胺-氧化石墨烯基防腐材料,并将其作为填料用于水性环氧树脂涂层(WEP)的改性。通过FTIR、XRD、XPS和SEM... 详细信息

为开发缓蚀剂高效利用的新途径,选取氧化石墨烯为基材、聚邻甲苯胺微胶囊为壁材、缓蚀剂2-巯基苯并噻唑为芯材,制备了缓蚀型聚邻甲苯胺-氧化石墨烯基防腐材料,并将其作为填料用于水性环氧树脂涂层(WEP)的改性。通过FTIR、XRD、XPS和SEM等对材料进行了结构和形貌的表征,采用紫外可见光谱对缓蚀剂的释放行为进行分析,采用万能试验机、电化学测试和盐雾实验对涂层的拉伸性能和防腐性能进行了评价。结果表明:缓蚀剂成功包覆于聚邻甲苯胺微胶囊内部,并通过共价键方式将微胶囊连接在改性氧化石墨烯表面,使缓蚀剂得到了充分利用,提高了涂层的拉伸性能、自修复性能及对腐蚀介质的屏蔽性能。紫外可见光谱测试结果表明,微胶囊在人工破损96 h后,内部缓蚀剂的释放量达78%;拉伸性能测试结果表明,与纯WEP相比,当填料加入量为0.3wt%时,涂层应力从14.281 MPa增加到24.25 MPa;SEM结果表明,被划伤的涂层在常温下放置10 h后自修复;电化学测试和盐雾实验结果表明,涂层腐蚀电位从−0.6216 V提高到−0.1554 V,腐蚀电流密度从4.271×10^(−7)A·cm^(−2)减小到1.016×10^(−11)A·cm^(−2),阻抗模量可达到1.5757×10^(9)Ω·cm^(2),在盐雾500 h后仍表现出较好的防腐性能。

关键词：氧化石墨烯聚邻甲苯胺微胶囊水性环氧树脂防腐涂层

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校长教学领导力如何影响教师差异教学能力——以教师成就动机和工作责任心为链式中介

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教育学术月刊 2024年第3期 13-22页

作者：钟勇为李檐玉韩晓琴黄慧英江苏大学教师教育学院江苏镇江212013 新加坡南洋理工大学国立教育学院江西省安远县第三中学江西安远342100

为探讨校长教学领导力对教师差异教学能力的影响路径及其作用机制,研究通过对江苏、江西等地1016名中小学教师进行调查并根据得到的数据,构建结构方程模型进行分析。研究发现,校长教学领导力可通过三个路径影响教师差异教学能力:一是校... 详细信息

为探讨校长教学领导力对教师差异教学能力的影响路径及其作用机制,研究通过对江苏、江西等地1016名中小学教师进行调查并根据得到的数据,构建结构方程模型进行分析。研究发现,校长教学领导力可通过三个路径影响教师差异教学能力:一是校长教学领导力直接影响教师差异教学能力;二是校长教学领导力间接通过教师成就动机影响教师差异教学能力;三是校长教学领导力通过影响教师成就动机进而影响教师感知的工作责任心,最终对教师差异教学能力产生影响。研究揭示了当前中小学教师较低的差异教学能力水平,并为校长教学领导力对教师的直接影响提供了进一步证据。研究还发现并阐释了链式中介模型作用机制,为有关方面认识和干预教师差异教学能力提供了必要的遵循。校长尤其农村小学校长有必要进一步改进教学领导,特别要增强其管理教学过程的能力;加强对“四低”教师尤其女性教师的心理扶持和教学指导,增强其成就动机与自我效能感;将责任担当精神嵌入到专业共同体文化建设,增强低职称教师的工作责任心。

关键词：校长教学领导力教师差异教学能力影响路径成就动机工作责任心

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A Case Report of Lupus Panniculitis in a Hemodialysis Patient with Lupus Nephritis

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Case Reports in Clinical Medicine 2021年第4期10卷 85-91页

作者： Zhi Xiao yanyu li Department of Nephrology Binzhou People’s Hospital Binzhou China

Background: Systemic lupus erythematosus and lupus nephritis are relatively common autoimmune diseases that can cause damage to multiple systems. Aim: To investigate the lupus activity of patients with lupus nephritis on hemodialysis and the combined occurrence of lupus panniculitis. Case introduction: A patient with lupus nephritis on regular hemodialysis had a symmetrical hard mass under the skin of his abdomen. After surgical resection and pathological examination, she was diagnosed with lupus panniculitis and was treated with glucocorticoids and hydroxychloroquine. After that, no new subcutaneous masses appeared, and the unresectable part of the masses did not increase. Conclusion: 1) Lupus activities in patients with lupus nephritis entering end-stage renal disease still need to be paid attention to. 2) Lupus panniculitis can occur on the skin of the abdomen, and it needs to be differentiated from connective tissue panniculitis, sclerosing panniculitis and other diseases.

关键词： Lupus Nephritis Hemodialysis Lupus Panniculitis

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