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慢性萎缩性胃炎不同萎缩范围中医证素分布及与肠道菌群相关性研究

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中华中医药杂志 2024年第1期39卷 435-439页

作者：黄琰钰林雪娟李星慧胡莹莹兰萌黄伟荣福建中医药大学中医学院中医证研究基地福州350122 福建省中医健康状态辨识重点实验室(福建中医药大学) 福州350122 福建省2011中医健康管理协同创新中心福州350122 福建中医药大学附属晋江中医院晋江3622011

目的:探讨慢性萎缩性胃炎(CAG)不同萎缩范围中医证素分布差异及与肠道菌群的相关性。方法:应用Kimura-Takemoto分类法将120例CAG患者进行镜下萎缩范围分级,运用证素辨证方法分析CAG不同萎缩范围的证素分布差异,并运用16S rRNA测序方法... 详细信息

目的:探讨慢性萎缩性胃炎(CAG)不同萎缩范围中医证素分布差异及与肠道菌群的相关性。方法:应用Kimura-Takemoto分类法将120例CAG患者进行镜下萎缩范围分级,运用证素辨证方法分析CAG不同萎缩范围的证素分布差异,并运用16S rRNA测序方法进行肠道菌群检测,寻找差异菌群,分析CAG病证演变特点及生物学基础。结果:证素分布情况:CAG患者常见病位证素为胃、脾、肝、心神,常见病性证素为气滞、热、阴虚、湿、痰、气虚、阳虚、阳亢、血虚、血瘀。当CAG萎缩范围从C-1发展至C-3阶段,病位证素心神的占比逐渐升高,病性证素中实性证素占比呈下降趋势,虚性证素占比呈上升趋势,呈现由实转虚、虚实夹杂的病机转化规律。CAG不同萎缩范围肠道菌群分布差异:LEfSe分析共获得4个生物标记物。物种组成情况,在属水平上,普雷沃菌属(Prevotella)在C-3组丰富度较C-1组显著富集(P<0.05),双歧杆菌属(Bifidobacterium)在C-3组丰富度较C-1组显著减少(P<0.05)。结论:CAG不同萎缩范围患者证素分布存在差异,其肠道菌群的多样性及特定菌群丰度存在差异,肠道菌群失调与CAG的发生和发展密切相关。

关键词：慢性萎缩性胃炎 Kimura-Takemoto分类法证素肠道菌群

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面向尺寸模式保护的高效对称可搜索加密方案

信息网络安全 2024年第6期24卷 843-854页

作者：李强沈援海刘天旭黄晏瑜孙建国西安电子科技大学计算机科学与技术学院西安710071 中移(杭州)信息技术有限公司杭州310023 西安电子科技大学杭州研究院杭州311231

近年来,随着云服务的普及以及对数据安全保护需求的增加,动态对称可搜索加密(DSSE)由于可以在加密数据库中进行更新和查询的特点而受到学界广泛关注。由于考虑搜索和更新效率,DSSE通常需要泄露一些信息,主要包括搜索模式、访问模式和尺... 详细信息

近年来,随着云服务的普及以及对数据安全保护需求的增加,动态对称可搜索加密(DSSE)由于可以在加密数据库中进行更新和查询的特点而受到学界广泛关注。由于考虑搜索和更新效率,DSSE通常需要泄露一些信息,主要包括搜索模式、访问模式和尺寸模式。目前,主要使用不经意随机访问机(ORAM)来保护搜索模式和访问模式,但ORAM无法保证尺寸模式泄露的安全性。文章说明了尺寸模式泄露的危害,并基于现有DSSE隐私概念提出了强前后向隐私,以达到对尺寸模式的保护目的。基于这种增强的安全性目标,文章提出了一种面向尺寸模式保护的高效对称可搜索加密方案Eurus,旨在解决现有方案中的尺寸模式泄露问题。Eurus通过结合多服务器ORAM架构、更新槽机制和细树路径淘汰技术,提供了强正向和反向隐私保护,防止敏感关键字和文件信息被泄露。多服务器ORAM隐藏了搜索和访问模式,更新槽机制混淆了文件标识符,细树路径淘汰技术打乱了文件的实际排列顺序。实验结果表明,Eurus在实现隐私保护的同时,提高了搜索和更新效率,搜索性能较现有方案提升了约46%,更新性能提升了4.73倍。

关键词：可搜索加密尺寸模式 ORAM

IVF-ET治疗中卵巢过度刺激综合征的列线图预测模型构建与应用性验证

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中国计划生育和妇产科 2024年第3期16卷 57-61,F0003页

作者：李小妹李秀霞黄艳宇右江民族医学院附属医院生殖医学中心广西百色533000 右江民族医学院护理学院

目的探讨不孕患者行体外受精-胚胎移植(in vitro fertilization-embryo transfer,IVF-ET)治疗所致卵巢过度刺激综合征(ovarian hyperstimulation syndrome,OHSS)的影响因素,并构建与验证IVF-ET治疗后发生OHSS风险预测模型。方法回顾性分析2020年1月至2022年12月右江民族医学院附属医院接受IVF-ET治疗的150例不孕患者临床资料,将IVF-ET治疗后发生OHSS的患者纳入发生组,未发生OHSS的患者纳入未发生组。采用单因素和多因素Logistic回归分析法确定IVF-ET治疗后发生OHSS的独立影响因素,利用确定的独立影响因素构建列线图预测模型,从C指数、受试者工作曲线(ROC)、校准曲线三个维度评判列线图预测模型效能。结果接受IVF-ET治疗的150例不孕患者中,15例发生OHSS,占比10%,未发生135例,占比90%。Logistic回归分析结果显示,多囊卵巢综合征、注射hCG扳机10000 IU、Gn总使用量是不孕患者IVF-ET治疗后发生OHSS的危险因素(OR>1,P0.60,说明以上指标为预测IVF-ET治疗后发生OHSS提供价值。利用以上独立影响因素构建列线图预测模型,危险因素分值相加所得数值即为IVF-ET治疗后发生OHSS的概率,验证结果显示,校准曲线的C-index值为0.990,表明该列线图预测模型预测效能良好。结论采用IVF-ET治疗后发生OHSS的独立危险因素构建列线图预测模型,独立危险因素包括多囊卵巢综合征、注射hCG扳机10000 IU、Gn总使用量,基础卵泡刺激素水平是其保护因素,该模型可直接预测IVF-ET治疗后发生OHSS的概率,为后续治疗与护理提供理论支持。

关键词：不孕患者体外受精-胚胎移植卵巢过度刺激综合征危险因素预测模型构建

慢性胃炎阴虚证证素分布及肠道菌群差异性研究

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云南中医药大学学报 2024年第2期47卷 33-39页

作者：谢嵛嵛朱龙胡莹莹黄琰钰黄伟荣林雪娟福建中医药大学福建中医药大学中医证研究基地福建省2011中医健康管理协同创新中心福建福州350122 福建中医药大学附属晋江中医院福建晋江362200

目的探讨慢性胃炎阴虚证患者的证素分布情况及肠道菌群差异性,为慢性胃炎患者临床诊断提供参考依据。方法共收集慢性胃炎阴虚证患者52例,其中慢性萎缩性胃炎(chronic atrophic gastritis,CAG)阴虚证患者35例,慢性非萎缩性胃炎(chronic... 详细信息

目的探讨慢性胃炎阴虚证患者的证素分布情况及肠道菌群差异性,为慢性胃炎患者临床诊断提供参考依据。方法共收集慢性胃炎阴虚证患者52例,其中慢性萎缩性胃炎(chronic atrophic gastritis,CAG)阴虚证患者35例,慢性非萎缩性胃炎(chronic non-atrophic gastritis,CNAG)阴虚证患者17例,以及健康人31例。采用证素辨证方法分析慢性萎缩性胃炎与慢性非萎缩性胃炎阴虚证的证素分布差异,并运用16S rRNA高通量测序方法进行肠道微生物检测,寻找差异菌群,分析慢性萎缩性胃炎与慢性非萎缩性胃炎阴虚证的证素分布与肠道菌群差异性的关系。结果 (1)证素分布情况:慢性萎缩性胃炎阴虚证的常见病位证素为胃、肝、脾;常见兼夹病性证素为热、气滞、痰、湿、食积、气虚、阳虚、阳亢。慢性非萎缩性胃炎阴虚证的常见病位证素为胃、肝、脾;常见兼夹病性证素为:热、气滞、痰、湿、食积、气虚、血虚、阳虚。两组间各病位证素分布无明显差异;兼夹病性证素在积分的比较中,痰证素(P<0.05)具有统计学意义。(2)物种组成情况:属水平上,与健康组相比,CAG阴虚组在卟啉单胞菌属和经黏液真杆菌属上的丰度明显增加(P<0.01);在嗜胨菌属和Eubacterium_hallii_group菌属上的丰度增加(P<0.05);CNAG阴虚组在卟啉单胞菌属和嗜胨菌属上的丰度明显增加(P<0.01),在放线菌属上的丰度增加(P<0.05),在Lachnospiraceae_UCG010、UCG003菌属和丁酸球菌属的丰度上减少(P<0.05)。相比CAG阴虚组,CNAG阴虚组在经黏液真杆菌属的丰度上明显减少(P<0.01);而CAG阴虚组在厌氧菌属、粪球菌属和丁酸球菌属的丰度上相较于CNAG阴虚组出现明显富集(P<0.05)。LEfse分析共获得17个生物标记物,CAG阴虚组4个,CNAG阴虚组11个,健康组2个。结论 CAG与CNAG阴虚组的证素分布存在差异,其肠道菌群的多样性及特定菌群丰度存在差异,肠道菌群失调与慢性胃炎的发展密切相关。

关键词：慢性萎缩性胃炎慢性非萎缩性胃炎阴虚证证素肠道菌群

Effect of Ni content on the wear behavior of Al-Si-Cu-Mg-Ni/SiC particles composites

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International Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 374-383页

作者： yanyu Liu Lina Jia Wenbo Wang Zuheng Jin Hu Zhang School of Materials Science and Engineering Beihang UniversityBeijing 100191China Ningbo Institute of Technology Beihang UniversityNingbo 315100China Qingdao Research Institute of Beihang University Qingdao 266000China Research Institute for Frontier Science Beihang UniversityBeijing 100191China

In recent years,the addition of Ni has been widely acknowledged to be capable of enhancing the mechanical properties of Al-Si ***,the effect of Ni on the wear behaviors of Al-Si alloys and Al matrix composites,particularly at elevated temperat-ures,remains an understudied *** this study,Al-Si-Cu-Mg-Ni/20wt%SiC particles(SiCp)composites with varying Ni contents were prepared by using a semisolid stir casting *** effect of Ni content on the dry sliding wear behavior of the prepared compos-ites was investigated through sliding tests at 25 and 350℃.Results indicated that theθ-Al_(2)Cu phase gradually diminished and eventually disappeared as the Ni content increased from 0wt%to 3wt%.This change was accompanied by the formation and increase inδ-Al_(3)CuNi andε-Al_(3)Ni phases in *** hardness and ultimate tensile strength of the as-cast composites improved,and the wear rates of the composites decreased from 5.29×10^(−4)to 1.94×10^(−4)mm^(3)/(N∙m)at 25℃and from 20.2×10^(−4)to 7×10^(−4)mm^(3)/(N∙m)at 350℃with the increase in Ni content from 0wt%to 2wt%.The enhancement in performance was due to the presence of strengthening network structures and additional Ni-containing phases in the ***,the wear rate of the 3Ni composite was approximately two times higher than that of the 2Ni composite due to the fracture and debonding of theε-Al_(3)Ni *** wear,delamination wear,and oxidation wear were the predominant wear mechanisms of the investigated composites at 25℃,whereas delamination wear and oxid-ation wear were dominant during sliding at 350℃.

关键词： Al matrix composite microstructure sliding test high temperature wear mechanism

High-entropy rare earth stannate ceramics:Acid corrosion resistant radiative cooling materials with high atmospheric transparency window emissivity and high near-infrared solar reflectivity

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Journal of Advanced Ceramics 2024年第5期13卷 630-640页

作者： Tao Chen Yanyan He yanyu Pan Kaixian Wang Minzhong huang Liyan Xue Yazhu Li Fan Yang Yanchun Zhou Heng Chen Fujian Institute of Research on the Structure of Matter Chinese Academy of SciencesFuzhou 350002China College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350117China Xiamen Institute of Rare Earth Materials Haixi InstitutesChinese Academy of SciencesXiamen 361021China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstitutesChinese Academy of SciencesXiamen 361021China Key Laboratory of Rare Earths Ganjiang Innovation AcademyChinese Academy of SciencesGanzhou 341000China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China

In response to the development of the concepts of“carbon neutrality”and“carbon peak”,it is critical to developing materials with high near-infrared(NIR)solar reflectivity and high emissivity in the atmospheric transparency window(ATW;8–13μm)to advance zero energy consumption radiative cooling *** regulate emission and reflection properties,a series of high-entropy rare earth stannate ceramics(HE-RE_(2)Sn_(2)O_(7):(Y_(0.2)La_(0.2)Nd_(0.2)Eu_(0.2)Gd_(0.2))_(2)Sn_(2)O_(7),(Y_(0.2)La_(0.2)Sm_(0.2)Eu_(0.2)Lu_(0.2))_(2)Sn_(2)O_(7),and(Y_(0.2)La_(0.2)Gd_(0.2)Yb_(0.2)Lu_(0.2))_(2)Sn_(2)O_(7))with severe lattice distortion were prepared using a solid phase reaction followed by a pressureless sintering method for the first *** distortion is accomplished by introducing rare earth elements with different cation radii and *** as-synthesized HE-RE_(2)Sn_(2)O_(7)ceramics possess high ATW emissivity(91.38%–95.41%),high NIR solar reflectivity(92.74%–97.62%),low thermal conductivity(1.080–1.619 W·m^(−1)·K^(−1)),and excellent chemical *** the one hand,the lattice distortion intensifies the asymmetry of the structural unit to cause a notable alteration in the electric dipole moment,ultimately enlarging the ATW *** the other hand,by selecting difficult excitation elements,HE-RE_(2)Sn_(2)O_(7),which has a wide band gap(Eg),exhibits high NIR solar ***,the multi-component design can effectively enhance radiative cooling ability of HE-RE_(2)Sn_(2)O_(7)and provide a novel strategy for developing radiative cooling materials.

关键词： radiative cooling materials high-entropy ceramics(HECs) rare earth stannate(RE_(2)Sn_(2)O_(7)) high atmospheric transparency window emissivity high near-infrared(NIR)solar reflectivity

ⅢA-ⅡB multicomponent perovskite rare earth ferrites with promising electromagnetic wave absorption properties

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Journal of Rare Earths 2024年第6期42卷 1118-1127,I0005页

作者： Yanyan He Tao Chen yanyu Pan Minzhong huang Kaixian Wang Liyan Xue Yazhu Li Fengzhi Tan Fan Yang Tongkuan Xu Heng Chen School of Light Industry and Chemical Engineering Dalian Polytechnic UniversityDalian116034China Xiamen Institute of Rare EarthMaterials Haixi InstitutesChinese Academy of SciencesXiamen36021China Fujian Institute of Research on the Structure of Matter Chinese Academyof SciencesFuzhou350002China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou350108China Xiamen Key-Laboratoryof Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamen361021China Key Laboratory of Rare Earths Ganjiang Innovation AcademyChinese Academy of SciencesGanzhou3410ooChina

Perovskite-type rare-earth ferrites(REFeO_(3))are promising materials for absorbing electromagnetic(EM)wave ***,insufficient dielectric loss and poor impedance matching are key factors that limit the broader implementation of REFeO_(3).Herein,a series of multicomponent perovskite-type ferrites with strong EM wave absorption capabilities was *** the synergistic effect of chemical constitution regulation and entropy regulation,optimization of the dielectric loss and impedance matching is achieved by strengthening the structural defect mechanism,thus further adjusting the EM wave absorption *** with(LaGdSmNdBa)FeO_(3)(HE-1)and(LaGdPrSmNdBa)FeO_(3)(HE-2),(LaGdBa)FeO_(3)(ME-1)and(LaGdSmBa)FeO_(3)(ME-2)exhibit favorable performance,with optimal minimum reflection loss(RL_(min))of-56.35 dB(at 11.12 GHz)and-63.25 dB(at 7.22 GHz)and effective absorption bandwidth(EAB)of 4.46 and 4.72 GHz,*** multicomponent design provides a new strategy for the development of EM wave absorption materials.

关键词： Rare earths Multicomponent design Rare earth ferrites Entropy regulation Electromagnetic wave absorption

Cetus: an efficient symmetric searchable encryption against file-injection attack with SGX

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Science China(Information Sciences) 2021年第8期64卷 195-212页

作者： yanyu huang Siyi LV Zheli LIU Xiangfu SONG Jin LI Yali YUAN Changyu Dong College of Cyber Science and the College of Computer Science Tianjin Key Laboratory of Network and Data Security TechnologyNankai University School of Computer Science and Technology Shandong University School of Computer Science Guangzhou University Department of Computer Science University of G?ttingen School of Computing Newcastle University

Symmetric searchable encryption(SSE) allows the users to store and query their private data in the encrypted database. Many SSE schemes for different scenarios have been proposed in the past few years, however, most of these schemes still face more or fewer security issues. Using these security leakages,many attacks against the SSE scheme have been proposed, and especially the non-adaptive file injection attack is the most serious. Non-adaptive file injection attack(NAFA) can effectively recover some extremely important private information such as keyword plaintext. As of now, there is no scheme that can effectively defend against such attacks. We first propose the new security attribute called toward privacy to resist nonadaptive file injection attacks. We then present an efficient SSE construction called Cetus to achieve toward privacy. By setting up a buffer and designing the efficient oblivious reading algorithm based on software guard extensions(SGX), we propose the efficient one-time oblivious writing mechanism. Oblivious writing protects the update pattern and allows search operations to be performed directly on the data. The experiment results show that Cetus achieves O(aw) search time and O(1) update communication. The practical search time, communication, and computation overheads incurred by Cetus are lower than those of state-of-the-art.

关键词： searchable encryption SGX technique file injection attack forward/toward privacy cloud databases

PRRSV degrades MDA5 via dual autophagy receptors P62 and CCT2 to evade antiviral innate immunity

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Virologica Sinica 2024年第2期39卷 264-276页

作者： Ruiqi Sun yanyu Guo Lilin Zhang Huixia Zhang Boxuan Yin Xiaoyang Li Changyan Li Liu Yang Lei Zhang Zexing Li Jinhai huang School of Life Sciences Tianjin UniversityTianjin300072China

Porcine reproductive and respiratory syndrome virus(PRRSV)is a major economically devastating pathogen that has evolved various strategies to evade innate *** of antiviral interferon largely promotes PRRSV immunoevasion by utilizing cytoplasmic melanoma differentiation-associated gene 5(MDA5),a receptor that senses viral *** this study,the downregulated transcription and expression levels of porcine MDA5 in PRRSV infection were observed,and the detailed mechanisms were *** found that the interaction between P62 and MDA5 is enhanced due to two factors:the phosphorylation modification of the autophagic receptor P62 by the upregulated kinase CK2αand the K63 ubiquitination of porcine MDA5 catalyzed by the E3 ubiquitinase TRIM21 in PRRSV-infected *** a result of these modifications,the classic P62-mediated autophagy is ***,porcine MDA5 interacts with the chaperonin containing TCP1 subunit 2(CCT2),which is enhanced by PRRSV *** interaction promotes the aggregate formation and autophagic clearance of MDA5-CCT2-nsp3 independently of *** summary,enhanced MDA5 degradation occurs in PRRSV infection via two autophagic pathways:the binding of MDA5 with the autophagy receptor P62 and the aggrephagy receptor CCT2,leading to intense innate immune *** research reveals a novel mechanism of immune evasion in PRRSV infection and provides fundamental insights for the development of new vaccines or therapeutic strategies.

关键词： Porcine reproductive and respiratory syndrome virus(PRRSV) nsp3 Autophagy MDA5