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Journal of Energy Chemistry 2024年第7期94卷 618-624页

作者： Zhen Dong yanying wang Dan Li Peng Wu College of Chemistry Sichuan UniversityChengdu 610064SichuanChina Analytical&Testing Centre State Key Laboratory of Hydraulics and Mountain River EngineeringSichuan UniversityChengdu 610064SichuanChina School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007HenanChina

Photo-biocatalysis,the combination of photosensitization and biocatalysis,is an emerging solution for sunlight-based renewable *** is thus important to develop light antennas with both good light har-vesting and efficient electron ***,the intriguing electrical conductivity of dsDNA and its host effect(for nucleic acid dyes to harvest light)were explored simultaneously to develop a dsDNA-based light antenna for *** SYBR Green I(SG)as the example of the nucleic acid dye,the proposed SG-dsDNA system was found to be capable for visible-light-driven reduced nicotinamide adenine dinucleotide(NADH)regeneration,and the turnover frequency of which(1.35 min^(-1))exceeded most of the existing photocatalytic *** SG can only be hosted by dsDNA,meanwhile dsDNA can be formed through hybridization between single strand DNA and its complementary strand,the pro-posed system adds an extra control of the photocatalytic activity(DNA base pairing-based switch).When integrating the SG-dsDNA system with NADH-dependent horse liver alcohol dehydrogenase(HLADH),successful synthesis of 2-phenylpropanol(a crucial intermediates of profens manufacturing)was achieved.

关键词： Photosynthesis dsDNA SYBRGreenI TICT 2-phenylpropanol

Weak Graph Map Homotopy and Its Applications

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Chinese Annals of Mathematics,Series B 2024年第2期45卷 235-252页

作者： Conglei ZHANG yanying wang Zhiguo ZHANG Yan ZHAO School of Mathematical Sciences Hebei Normal UniversityShijiazhuang 050024China Department of Basic Science Shanxi Agricultural UniversityJinzhang 030801ShanxiChina Center for Topology and Geometry based Technology School of Mathematical SciencesHebei Normal UniversityShijiazhuang 050024China School of Mathematical Sciences Hebei Normal UniversityTaiyuan 030031China School of Mathematics and Computer Science Shanxi Normal UniversityShijiazhuang 050024China School of Mathematics and Science Hebei GEO UniversityShijiazhuang 050031China

The authors introduce a notion of a weak graph map homotopy(they call it M-homotopy),discuss its properties and *** prove that the weak graph map homotopy equivalence between graphs coincides with the graph homotopy equivalence defined by Yau et al in *** difference between them is that the weak graph map homotopy transformation is defined in terms of maps,while the graph homotopy transformation is defined by means of combinatorial *** discuss its advantages over the graph homotopy *** its applications,they investigate the mapping class group of a graph and the 1-order M P-homotopy group of a pointed simple ***,they show that the 1-order M P-homotopy group of a pointed simple graph is invariant up to the weak graph map homotopy equivalence.

关键词： Weak graph map homotopy Trivial vertex Strong deformation retract Mapping class group MP-Homotopy group

Health benefits from the rapid reduction in ambient exposure to air pollutants after China's clean air actions:progress in efficacy and geographic equality

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National Science Review 2024年第2期11卷 103-113页

作者： Tao Xue Ruohan wang Meng wang yanying wang Dan Tong Xia Meng Conghong Huang Siqi Ai Fangzhou Li Jingyuan Cao Mingkun Tong Xueqiu Ni Hengyi Liu Jianyu Deng Hong Lu Wei Wan Jicheng Gong Shiqiu Zhang Tong Zhu Clean Air Asia Institute of Reproductive and Child Health National Health Commission Key Laboratory of Reproductive Health/Department of Epidemiology and Biostatistics Ministry of Education Key Laboratory of Epidemiology of Major Diseases(PKU) School of Public Health Peking University Health Science Centre State Environmental Protection Key Laboratory of Atmospheric Exposure and Health Risk Management and Center for Environment and Health Peking University Advanced Institute of Information Technology Peking University Department of Epidemiology and Environmental Health School of Public Health and Health ProfessionsUniversity at Buffalo State Key Joint Laboratory of Environment Simulation and Pollution Control College of Environmental Sciences and EngineeringPeking University Department of Earth System Science Tsinghua University School of Public Health Key Laboratory of Public Health Safety of the Ministry of Education and Key Laboratory of Health Technology Assessment of the Ministry of HealthFudan University College of Land Management Nanjing Agricultural University National&Local Joint Engineering Research Center for Rural Land Resources Use and Consolidation

Clean air actions （CAAs） in China have been linked to considerable benefits in public ***,whether the beneficial effects of CAAs are equally distributed geographically is *** high-resolution maps of the distributions of major air pollutants (fine particulate matter[PM2.5]and ozone[O3]) and population,we aimed to track spatiotemporal changes in health impacts from,and geographic inequality embedded in,the reduced exposures to PM2.5and O3from 2013 to *** used a method established by the Global Burden of Diseases *** analyzing the changes in loss of life expectancy（LLE） attributable to PM2.5and O3,we calculated the gain of life expectancy （GLE） to quantify the health benefits of the air-quality ***,we assessed the geographic inequality embedded in the GLE using the Gini index （GI）.Based on risk assessments of PM2.5and O3,during the first stage of CAAs（2013 to 2017）,the mean GLE was 1.87 *** of the sum of the GLE was disproportionally distributed in about one quarter of the population exposed （GI 0.44）.During the second stage of CAAs（2017 to 2020）,the mean GLE increased to 3.94 months and geographic inequality decreased （GI 0.18）.According to our assessments,CAAs were enhanced,from the first to second stages,in terms of not only preventing premature mortality but also ameliorating health *** enhancements were related to increased sensitivity to the health effects of air pollution and synergic control of PM2.5and *** findings will contribute to optimizing future CAAs.

关键词： clean air action public health inequality fine particulate matter ozone

Long non-coding RNA-AK138945 regulates myocardial ischemia-reperfusion injury via the miR-1-GRP94 signaling pathway

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Frigid Zone Medicine 2024年第1期4卷 31-40页

作者： yanying wang Jian Huang Han Sun Jie Liu Yingchun Shao Manyu Gong Xuewen Yang Dongping Liu Zhuo wang Haodong Li Yanwei Zhang Xiyang Zhang Zhiyuan Du Xiaoping Leng Lei Jiao Ying Zhang State Key Laboratory of Frigid Zone Cardiovascular Diseases and Pharmacology Department of Pharmacy college of Harbin Medical UniversityHarbin 150081China The Fourth Department of Medical Oncology Harbin Medical University Cancer HospitalHarbin 150040China Department of Ultrasound Imaging the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086China Cancer Institute The Affiliated Hospital of Qingdao UniversityQingdao UniversityQingdao Cancer InstituteQingdao 266071China College of Bioinformatics Science and Technology Harbin Medical UniversityHarbin 150081China

Objective:Myocardial ischemia-reperfusion injury(MIRI)is one of the leading causes of death from cardiovascular disease in humans,especially in individuals exposed to cold *** non-coding RNAs(lncRNAs)regulate MIRI through multiple *** study explored the regulatory effect of lncRNA-AK138945 on myocardial ischemia-reperfusion injury and its ***:In vivo,8-to 12-weeks-old C57BL/6 male mice underwent ligation of the left anterior descending coronary artery for 50 minutes followed by reperfusion for 48 *** vitro,the primary cultured neonatal mouse ventricular cardiomyocytes(NMVCs)were treated with 100μmol/L hydrogen peroxide(H_(2)O_(2)).The knockdown of lncRNA-AK138945 was evaluated to detect cardiomyocyte apoptosis,and a glucose-regulated,endoplasmic reticulum stress-related protein 94(GRP94)inhibitor was used to detect myocardial ***:We found that the expression level of lncRNA-AK138945 was reduced in MIRI mouse heart tissue and H2O2-treated ***,the proportion of apoptosis in cardiomyocytes increased after lncRNA-AK138945 was *** expression level of Bcl2 protein was decreased,and the expression level of Bad,Caspase 9 and Caspase 3 protein was *** further study found that miR-1a-3p is a direct target of lncRNA-AK138945,after lncRNA-AK138945 was silenced in cardiomyocytes,the expression level of miR-1a-3p was increased while the expression level of its downstream protein GRP94 was ***,treatment with a GRP94 inhibitor(PU-WS13)intensified H2O2-induced cardiomyocyte *** overexpression of FOXO3,the expression levels of lncRNA-AK138945 and GRP94 were increased,while the expression levels of miR-1a-3p were ***:LncRNA-AK138945 inhibits GRP94 expression by regulating miR-1a-3p,leading to cardiomyocyte *** transcription factor Forkhead Box Protein O3(FOXO3)participates in cardiomyocyte apoptosis induced by endoplasmic reticulum s

关键词： myocardial ischemia reperfusion lncRNA apoptosis microRNAGRP94

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改进灰色层次分析法的机动导航保障能力评估

弹箭与制导学报 2024年第1期44卷 75-83页

作者：吴北苹何晶王彦璎王晓薇空军工程大学信息与导航学院陕西西安710077 空军通信士官学校辽宁大连116600

针对未来战场样式形态的不确定性和机动性,机场的快速部署需求日益迫切,机动导航保障能力的高低直接影响和制约航空兵快速、机动的作战能力。文中针对机动导航保障能力评估的“小数据”“贫信息”不确定性特点,综合考虑机动部署条件下... 详细信息

针对未来战场样式形态的不确定性和机动性,机场的快速部署需求日益迫切,机动导航保障能力的高低直接影响和制约航空兵快速、机动的作战能力。文中针对机动导航保障能力评估的“小数据”“贫信息”不确定性特点,综合考虑机动部署条件下装备、环境影响因素及导航保障人员能力要求,建立了机动导航保障能力评估指标体系,提出了基于改进的灰色层次分析法的机动导航保障评估方法,构建了评估模型,为降低主观因素影响,从专家评分数据着手,应用3标度构造判断矩阵,将定性指标与定量指标区分细化构建评估样本矩阵。最后,实例结果表明,采用改进的3标度灰色层次分析法,判断矩阵的构建不需要一致性检验,评估计算步骤简化的同时,克服了评估中外界影响因素的复杂性、主观判断的模糊性和人为打分的随机性影响。

关键词：导航灰色层次保障能力评估

基于IGWO-BP-PID的管廊吊具液压缸同步控制研究

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机床与液压 2024年第7期52卷 80-86页

作者：林朝王衍英张耀东马华兵王刚锋中交二公局第六工程有限公司陕西西安710075 中交雄安投资有限公司河北雄安071000 中国雄安集团基础建设有限公司河北雄安071000 长安大学道路施工技术与装备教育部重点实验室陕西西安710064

综合管廊吊装吨位重且存在偏载起吊的不利工况,易发生危险事故。为保证管廊节段偏载吊装工况下的安全稳定性,提高吊具液压缸组的同步控制精度,提出IGWO-BP-PID与状态差值反馈同步控制策略。通过分析专用吊具结构及液压原理,将液压缸按... 详细信息

综合管廊吊装吨位重且存在偏载起吊的不利工况,易发生危险事故。为保证管廊节段偏载吊装工况下的安全稳定性,提高吊具液压缸组的同步控制精度,提出IGWO-BP-PID与状态差值反馈同步控制策略。通过分析专用吊具结构及液压原理,将液压缸按纵向分为2组。通过在GWO中对灰狼位置进行更新,实现IGWO对BP-PID参数的优化。采用3种控制器进行系统控制分析,验证IGWO-BP-PID的控制效果。最后,采用IGWO-BP-PID与状态差值反馈相结合的同步控制策略,对吊具液压缸组进行AMESim/Simulink联合仿真,并与试验数据进行对比分析。研究结果表明:IGWO-BP-PID控制器无超调量、具有更好的控制效果;相比于常规PID控制,该方法缩短了液压缸组震荡调节时间,同步控制精度更高;试验验证了管廊吊具同步控制策略的有效性,满足工程施工要求。

关键词：液压缸组管廊吊具同步控制改进灰狼算法

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雄安新区村落命名特点及地名景观特征分析

齐鲁师范学院学报 2024年第2期39卷 77-84页

作者：吴坚王彦颖张清华民政部地名研究所北京100054 齐鲁师范学院地理与旅游学院山东济南250200

将雄安新区村落地名作为分析对象,通过整理分析,总结村落地名的命名特点,可以在一定程度上反映出该地区村落形成的历史进程。研究发现,雄安新区村落主要形成于宋、明、清三个时期,地名命名以使用居民姓氏为主,体现了该地区村落以移民为... 详细信息

将雄安新区村落地名作为分析对象,通过整理分析,总结村落地名的命名特点,可以在一定程度上反映出该地区村落形成的历史进程。研究发现,雄安新区村落主要形成于宋、明、清三个时期,地名命名以使用居民姓氏为主,体现了该地区村落以移民为主的形成方式,而不同命名方式的复合使用则反映了村落变化的历史过程。在此基础上,根据雄安新区独特的自然环境和历史上军事活动频繁的特点,选取其中与水和军事有关的两类村落地名,借助地理信息系统中的移动搜索法和反距离加权插值法分析两类地名的比重和分布趋势,研究不同类型地名景观,揭示雄安新区村落临水而居的形成过程和分布特征,以及历史上军事活动对村落形成的影响。

关键词：雄安新区村落地名地理信息系统地名景观

Enhancing the compatibility of the amyloid-dye hybrid nanostructure for improved photo-biocatalysis

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Journal of Energy Chemistry 2023年第3期78卷 430-437,I0012页

作者： Zhen Dong yanying wang Qin Yang Dan Li Peng Wu College of Chemistry Sichuan UniversityChengdu 610064SichuanChina Analytical&Testing Centre State Key Laboratory of Hydraulics and Mountain River EngineeringSichuan UniversityChengdu 610064SichuanChina College of Biomass Science and Engineering Sichuan UniversityChengdu 610064SichuanChina School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007HenanChina

Artificial photosynthesis is significant for renewable energy generation,sustainable development,and environmental ***-protein hybrids are promising for developing photosynthesis mimics(e.g.,photo-biocatalysis),but their performances are far lower than the plant photosystems,partially because of the incompatibility between dye and the protein matrix that limits excited state electron transfer of the included ***,using ThT-insulin amyloid assembly as a model system,we proposed that increasing the dye-protein compatibility could lead to the improved photo-biocatalytic performance.A ThT derivative,ThTPD,was designed with the same electron acceptor but extended π-conjugated donor *** integrated into the insulin amyloid,the extended π-conjugated donor structure allowed increased binding affinity and energy with the amyloid matrix,thus better electron transport to the mediator to drive the photocatalytic ***,compared with ThT, ThTPD exhibited improved light absorption and longer excited state *** photo-biocatalytic performance of ThTPD-insulin amyloid was greatly improved as compared with that of ThT in reduced nicotinamide adenine dinucleotide(NADH) *** integrating with NADH-dependent L-glutamate reductase,the efficiency of the ThTPD-insulin amyloid hybrid was 2.8-fold higher than that of ThT in glutamate generation,showing promising feature in biocatalytic solar-to-chemical conversion.

关键词： Photo-biocatalysis Dye-protein assembly Insulin amyloid ThT Compatibility

预制菜生产过程中的食品安全风险及控制措施分析

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现代食品 2024年第4期30卷 160-162页

作者：吴亮刘杰董建锋王艳英承德市食品药品检验检测中心河北承德067101

预制菜是一种便捷的食品,其方便快捷、易于储存,越来越受到消费者的欢迎。然而,随着预制菜产业的快速发展,食品安全问题也逐渐显现。因此,本文探讨了预制菜生产过程中的食品安全风险问题,并提出了相关安全控制措施,以期促进预制菜行业... 详细信息

预制菜是一种便捷的食品,其方便快捷、易于储存,越来越受到消费者的欢迎。然而,随着预制菜产业的快速发展,食品安全问题也逐渐显现。因此,本文探讨了预制菜生产过程中的食品安全风险问题,并提出了相关安全控制措施,以期促进预制菜行业的可持续发展。

关键词：预制菜生产过程安全风险控制措施

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基于环磷酸腺苷/蛋白激酶A/环磷酸腺苷反应元件结合蛋白通路探究丙泊酚对局灶性脑缺血再灌注大鼠神经功能改善机制

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陕西医学杂志 2024年第4期53卷 455-461页

作者：王岩英周进国刘晓宁王芳张光信邯郸市第一医院麻醉科河北邯郸056002

目的:基于环磷酸腺苷/蛋白激酶A/环磷酸腺苷反应元件结合蛋白(cAMP/PKA/CREB)通路探究丙泊酚对局灶性脑缺血再灌注大鼠神经功能的改善机制。方法:采用改良线栓法缺血2 h,再灌注24 h建立大鼠脑缺血再灌注损伤(CIRI)模型,将造模成功大鼠... 详细信息

目的:基于环磷酸腺苷/蛋白激酶A/环磷酸腺苷反应元件结合蛋白(cAMP/PKA/CREB)通路探究丙泊酚对局灶性脑缺血再灌注大鼠神经功能的改善机制。方法:采用改良线栓法缺血2 h,再灌注24 h建立大鼠脑缺血再灌注损伤(CIRI)模型,将造模成功大鼠随机分为模型组和丙泊酚低(1 mg/ml)、中(2.5 mg/ml)、高剂量(5 mg/ml)组,各12只,另设含有12只大鼠的假手术组。分组后即开始给药,1次/d,共4周,末次给药12 h后,采用改良神经功能评分(mNSS)法进行神经缺损评分;采用TTC染色法检测脑梗死面积;HE、Nissl染色进行神经元细胞及尼氏小体形态学观察;Tunel法进行神经元细胞凋亡检测;Elisa法检测脑组织cAMP、脑源性神经营养因子(BDNF)、神经生长因子(NGF)含量;免疫荧光法检测脑组织环磷酸腺苷(cAMP)、p-PKA、p-CREB阳性细胞数及其蛋白共表达阳性细胞数;Western blot法检测脑组织PKA、p-PKA、CREB、p-CREB蛋白表达量。结果:模型组大鼠比较假手术组大鼠的mNSS评分、脑梗死面积百分比显著增加(均P<0.05),HE染色和Nissl染色可见明显的神经元细胞损伤和尼氏小体破坏,脑组织cAMP、BDNF、NGF含量和PKA、p-PKA、CREB、p-CREB蛋白表达量显著下降,模型组大鼠比较假手术组大鼠的cAMP、p-PKA、p-CREB阳性细胞数和蛋白共表达阳性细胞数也明显下降(均P<0.05)。与模型组比较,丙泊酚给药组大鼠mNSS评分、脑梗死面积百分比显著降低(均P<0.05),HE染色和Nissl染色可见神经元细胞损伤和尼氏小体破坏有不同程度改善,脑组织cAMP、BDNF、NGF含量和PKA、p-PKA、CREB、p-CREB蛋白表达量显著升高(均P<0.05),cAMP、p-PKA、p-CREB阳性细胞数及其蛋白共表达阳性细胞数均显著升高(均P<0.05)。结论:丙泊酚可能通过cAMP/PKA/CREB通路改善CIRI大鼠神经功能。

关键词：丙泊酚局灶性脑缺血再灌注损伤神经功能环磷腺苷蛋白激酶A 环磷腺苷效应元件结合蛋白