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Transcription factor EHF interacting with coactivator AJUBA aggravates malignancy and acts as a therapeutic target for gastroesophageal adenocarcinoma

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2119-2136页

作者： Li Peng yanyi jiang Hengxing Chen Yongqiang Wang Qiusheng Lan Shuiqin Chen Zhanwang Huang Jingyuan Zhang Duanqing Tian Yuntan Qiu Diankui Cai jiangyun Peng Daning Lu Xiaoqing Yuan Xianzhu Yang Dong Yin Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Medical Research Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Hefei Institutes of Physical Science Chinese Academy of SciencesHefei 230031China Department of Gastrointestinal Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Hepatobiliary Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhou 511442China

Transcriptional dysregulation of genes is a hallmark of tumors and can serve as targets for cancer drug ***,it is extremely challenging to develop small-molecule inhibitors to target abnormally expressed transcription factors(TFs)except for the nuclear receptor family of *** is known about the interaction between TFs and transcription cofactors in gastroesophageal adenocarcinoma(GEA)or the therapeutic effects of targeting TF and transcription cofactor *** this study,we found that ETS homologous factor(EHF)expression is promoted by a core transcriptional regulatory circuitry(CRC),specifically ELF3-KLF5-GATA6,and interference with its expression suppressed the malignant biological behavior of GEA ***,we identified Ajuba LIM protein(AJUBA)as a new coactivator of EHF that cooperatively orchestrates transcriptional network activity in ***,we identified KRAS signaling as a common pathway downstream of EHF and ***,dual targeting of EHF and AJUBA by lipid nanoparticles cooperatively attenuated the malignant biological behaviors of GEA in vitro and in *** conclusion,EHF is upregulated by the CRC and promotes GEA malignancy by interacting with AJUBA through the KRAS *** of both EHF and its coactivator AJUBA through lipid nanoparticles is a novel potential therapeutic strategy.

关键词： EHF AJUBA KRAS pathway Enhancer Core transcriptional regulatory circuitry Gastroesophageal adenocarcinoma Gastric adenocarcinoma Esophageal adenocarcinoma Transcription factor Coactivator Lipid nanoparticles

A Yb optical clock with a lattice power enhancement cavity

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Chinese Physics B 2024年第3期33卷 70-74页

作者：王春云姚远师浩森于洪浮马龙生蒋燕义 State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200062China

We construct a power enhancement cavity to form an optical lattice in an ytterbium optical *** is demonstrated that the intra-cavity lattice power can be increased by about 45 times,and the trap depth can be as large as 1400Er when laser light with a power of only 0.6 W incident to the lattice *** high trap depths are the key to accurate evaluation of the lattice-induced light shift with an uncertainty down to~1×*** probing the ytterbium atoms trapped in the power-enhanced optical lattice,we obtain a 4.3 Hz-linewidth Rabi spectrum,which is then used to feedback to the clock laser for the close loop operation of the optical lattice *** evaluate the density shift of the Yb optical lattice clock based on interleaving measurements,which is-0.46(62)*** result is smaller compared to the density shift of our first Yb optical clock without lattice power enhancement cavity mainly due to a larger lattice diameter of 344μm.

关键词： optical atomic clock optical lattice optical cavity Stark shift

面向TDI技术地面验证的激光干涉仪本底噪声分析

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量子电子学报 2024年第4期41卷 649-658页

作者：左凌云师浩森姚远蒋燕义马龙生华东师范大学精密光谱科学与技术国家重点实验室上海200241

在空间引力波探测中,由于星间激光干涉臂不等,导致激光频率噪声不能共模消除,从而使微弱的引力波信号被激光频率噪声淹没。时间延迟干涉(TDI)技术通过将激光相位数据在时间上延迟,构成虚拟等臂干涉,从而能减小激光频率噪声对引力波信号... 详细信息

在空间引力波探测中,由于星间激光干涉臂不等,导致激光频率噪声不能共模消除,从而使微弱的引力波信号被激光频率噪声淹没。时间延迟干涉(TDI)技术通过将激光相位数据在时间上延迟,构成虚拟等臂干涉,从而能减小激光频率噪声对引力波信号探测的影响。为了在地面验证TDI技术能够将激光频率噪声对引力波探测的影响降低至3×10^(-7) Hz/√Hz(傅里叶频率1 mHz处),需要分析TDI地面验证系统本底噪声的主要来源。通过实验测量和计算分析,提出了面向TDI技术地面验证的激光干涉仪的重要参数设计要求,包括激光干涉臂的臂长差、激光频率稳定度、气压稳定度、激光功率稳定度以及各部件温度稳定度等。

关键词：激光技术空间引力波探测激光干涉仪噪声分析时间延迟干涉激光频率噪声

Optical frequency division

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National Science Review 2020年第12期7卷 1801-1802页

作者： Yuan Yao yanyi jiang Longsheng Ma State Key Laboratory of Precision Spectroscopy East China Normal University

Frequency can be measured much more precisely than any other physical quantity,and much of precision metrology depends critically on the measurement of frequency and its inverse,*** electromagnetic waves（or 'light'）,oscillating at more than 1014per second,are at least 1000 times more precise for time/length measurement compared to microwave frequencies near1 ***,electronics do not respond to such rapid optical oscillations.

关键词： NOBEL LECTURE

Progress and trend of narrow-linewidth lasers

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Science China(Technological Sciences) 2013年第7期56卷 1589-1596页

作者： CHEN HaiQin jiang yanyi BI ZhiYi MA LongSheng State Key Laboratory of Precision Spectroscopy East China Normal University

High frequency stability, narrow-linewidth lasers have been long dreamed of since the invention of the laser. They have recently developed dramatically due to the advent of optical clocks. State-of-the-art narrow-linewidth lasers have been constructed by using the Pound-Drever-Hall (PDH) technique to lock the laser frequencies to the resonance of ultra-stable external optical cavities with high finesse. This paper introduces the developments of narrow-linewidth lasers, with a focus on the improvements of length stability of optical reference cavities, including optical cavity designs of vibration insensitivity and low thermal noise. Future trends and alternative methods for narrow-linewidth lasers are also discussed.

关键词： narrow-linewidth laser optical clock the Pound-Drever-Hall technique Fabry-Perot optical cavity thermal noise

Optical frequency divider with division uncertainty at the 10-21 level

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National Science Review 2016年第4期3卷 463-469页

作者： Yuan Yao yanyi jiang Hongfu Yu Zhiyi Bi Longsheng Ma State Key Laboratory of Precision Spectroscopy East China Normal University Collaborative Innovation Center of Extreme Optics Shanxi University

Optical clocks with unprecedented accuracy of 10promise innovations in many research *** applications rely to a large extent on the ability of precisely converting the frequency from one optical clock to another,or particularly to the frequencies in the iber telecom band for long-distance *** report demonstrates a low-noise,high-precision optical frequency divider,which realizes accurate optical frequency conversion and enables precise measurement of optical frequency *** measuring against the frequency ratio between the fundamental and the second harmonic of a 1064-nm laser instead of a second copy of the same system,we demonstrate that the optical frequency divider has a fractional frequency division instability of 6×10at 1 s and a fractional frequency division uncertainty of 1.4×*** remarkable numbers can support frequency division of the best optical clocks in the world without frequency-conversion-caused degradation of their performance.

关键词： optical frequency comb optical atomic clock precision measurement frequency metrology

Optical frequency synthesizer referenced to an ytterbium optical clock

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Photonics Research 2021年第2期9卷 98-105页

作者： YUAN YAO BO LI GUANG YANG XIAOTONG CHEN YAQIN HAO HONGFU YU yanyi jiang LONGSHENG MA State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200062China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Optical clocks with an unprecedented accuracy of 10-18 promise innovations in precision spectroscopy and measurement. To harness the full power of optical clocks, we need optical frequency synthesizers(OFSs) to accurately convert the stabilities and accuracies of optical clocks to other desired frequencies. This work demonstrates such an OFS referenced to an ytterbium optical clock. The OFS is based on an optical frequency comb phase-locked to a commercial rubidium microwave clock;in this way most combs can operate robustly. Despite comb frequency instability at 10^(-11), the synthesis noise and uncertainty reach 6 × 10^(-18)(1 s) and 5 × 10^(-21), respectively, facilitating frequency synthesis of the best optical clocks. In the OFS, the coherence of the OFS internal oscillator at 1064 nm is accurately transferred to a 578 nm laser for resolving the hertz-level-linewidth ytterbium clock transition(unaffected by megahertz-linewidth comb lines) and faithfully referencing the OFS to an ytterbium optical clock.

关键词： synthesis desired microwave

Automatic,long-term frequency-stabilized lasers with sub-hertz linewidth and 10-16 frequency instability

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Chinese Optics Letters 2022年第7期20卷 1-6页

作者：晏城志师浩森姚远于洪浮蒋燕义马龙生 State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200062China

We report two ultra-stable laser systems automatically frequency-stabilized to two high-finesse optical *** employing analog-digital hybrid proportional integral derivative(PID)controllers,we keep the merits of wide servo bandwidth and servo accuracy by using analog circuits for the PID controller,and,at the same time,we realize automatic laser frequency locking by introducing digital logic into the PID *** lasers can be automatically frequency-stabilized to their reference cavities,and it can be relocked in 0.3 s when interruption happens,i.e.,blocking and unblocking the laser *** automatic frequency-stabilized lasers are measured to have a frequency instability of 6×10^(-16)at 1 s averaging time and a most probable linewidth of 0.3 *** laser systems were tested for continuous operation over 11 *** ultrastable laser systems in long-term robust operation will be beneficial to the applications of optical atomic clocks and precision measurement based on frequency-stabilized lasers.

关键词： narrow-linewidth laser automatic frequency stabilization optical atomic clock gravitational wave detection

推动人的全面发展:高等教育高质量发展的最高价值取向

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贵州社会科学 2022年第2期 113-119页

作者：侯长林蒋炎益杨耀锟铜仁学院贵州铜仁554300 贵州师范大学贵州贵阳550025

推动人的全面发展是以习近平同志为核心的党中央一直特别关注的重大问题。马克思恩格斯的《共产党宣言》所涉及的众多问题归根结底也是关于人的解放尤其是人的全面发展问题。因此,十九届六中全会精神,尤其是其中关于人的全面发展的重要... 详细信息

推动人的全面发展是以习近平同志为核心的党中央一直特别关注的重大问题。马克思恩格斯的《共产党宣言》所涉及的众多问题归根结底也是关于人的解放尤其是人的全面发展问题。因此,十九届六中全会精神,尤其是其中关于人的全面发展的重要论述,对目前正在大力推进的高等教育高质量发展有很大启示。高等教育最根本的责任和使命是推动人的发展,而全面发展是人的发展的最高追求,因此,高等教育高质量发展最高的价值取向就是推动人的全面发展。作为正处在实现中华民族伟大复兴新征程上的高等教育,培养以实现中华民族伟大复兴为己任的新青年就是高等教育高质量发展的现实需求。均衡发展是高等教育高质量发展的底线和基本要求,每个人的全面发展是一切人的全面发展的条件,可见,也只有均衡发展的高等教育才能满足每个人全面发展的高等教育需求。高等教育高质量推动人的全面发展的策略主要有三点:一是构建高等教育与生产劳动相结合的方法体系;二是坚持高等教育学术自由开展的基本原则;三是建立能够实施全面发展教育的大学。

关键词：十九届六中全会精神人的全面发展高等教育高质量发展最高境界