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夏秋茶对中温大曲中主要微生物区系及白酒风味的影响

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安徽农业大学学报 2024年第1期51卷 138-144页

作者：肖严严程伟陈兴杰潘天全薛锡佳杨金玉杜先锋安徽农业大学茶与食品科技学院农业农村部江淮农产品精深加工与资源利用重点实验室安徽省农产品加工工程实验室合肥230036 安徽金种子酒业股份有限公司阜阳236023

为探究夏秋茶对酒曲中主要微生物区系和酒体香气物质的影响,在制曲过程中添加不同量的夏秋茶(5%、10%和15%)制备茶型大曲,选择15%茶型大曲并添加夏秋茶酿制茶香型白酒(原酒),设置普通大曲和普通浓香型白酒(原酒)作为对照组。对普通大曲... 详细信息

为探究夏秋茶对酒曲中主要微生物区系和酒体香气物质的影响,在制曲过程中添加不同量的夏秋茶(5%、10%和15%)制备茶型大曲,选择15%茶型大曲并添加夏秋茶酿制茶香型白酒(原酒),设置普通大曲和普通浓香型白酒(原酒)作为对照组。对普通大曲、5%、10%和15%茶型大曲中主要微生物数量和发酵性能进行了对比分析,相较于普通大曲,5%、10%和15%茶型大曲中细菌数量有不同程度减少,霉菌数量有10倍量级的增加,其中15%茶型大曲霉菌数量达到1.9×10^(5) CFU·g^(-1),5%和10%茶型大曲酵母菌数量均有增加;3种茶型大曲的发酵力和糖化力也有显著增加。通过顶空固相微萃取-气相色谱-质谱联用技术(Headspace solid phase microextraction gas-chromatography mass-spectrometry,HS-SPME-GC-MS)对2种白酒中香气成分进行检测,并结合正交偏最小二乘判别分析(Orthogonal partial least squares discriminant analysis,OPLS-DA)筛选2种白酒的差异香气物质,最终确定了茶香型白酒中的4种差异香气物质,分别是庚酸乙酯、月桂酸乙酯、癸酸乙酯和苯甲酸乙酯。由于夏秋茶的添加对微生物进行选择性培养,使得霉菌和酵母菌分别成为发酵前期、发酵后期的优势菌种,并且代谢利用夏秋茶中的内含成分产生更多的酸类物质,最终形成庚酸乙酯、月桂酸乙酯、癸酸乙酯和苯甲酸乙酯等香气物质。结果为夏秋茶资源的增值利用以及茶香型白酒的开发研究提供依据。

关键词：夏秋茶茶型大曲茶香型白酒气相色谱-质谱联用庚酸乙酯

Two congenital coronary abnormalities affecting heart function： anomalous origin of the left coronary artery from the pulmonary artery and congenital left main coronary artery atresia

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Chinese Medical Journal 2014年第21期127卷 3724-3731页

作者： xiao yanyan Jin Mei Han Ling Ding Wenhong Zheng Jianyong Sun Chufan Lyu Zhenyu Department of Pediatric Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China Department of Cardiology Navy General Hospital of Pepole's Liberation Army Beijing 100000 China

Background The anomalous origin of the left coronary artery （LCA） from the pulmonary artery （ALCAPA） and congenital left main coronary artery atresia （CLMCA-A） are two kinds of very rare coronary heart diseases which affect heart function *** study aimed to retrospectively illustrate the clinical features and therapy experience of ALCAPA and CLMCA-A *** From April 1984 to July 2012,in Beijing Anzhen Hospital,23 patients were diagnosed with ALCAPA and 4 patients with *** summarized the clinical data of the 27 cases and retrospectively analyzed the clinical manifestation,diagnosis,and treatments of these two kinds of congenital coronary *** The 23 patients （13 males and 10 females,aged ranging from 2.5 months to 65 years） identified with ALCAPA were classified into infantile type （age of onset younger than 12 months,16 cases） and adult type （age of onset older than 12 months,7 cases）.Four patients were diagnosed with CLMCA-A （three males and one female,aged ranging from 3 months to 2 years）.The main clinical manifestations of infantile-type ALCAPA and CLMCA-A include repeated respiratory tract infection,heart failure,dyspnea,feeding intolerance,diaphoresis,and failure to *** these two congenital coronary abnormalities might be misdiagnosed as endocardial fibroelastosis,dilated cardiomyopathy,and acute myocardial *** for the adult-type ALCAPA,cardiac murmurs and discomfort of the precordial area are the most common presentations and might be misdiagnosed as coronary heart disease,myocarditis,or patent ductus *** ECG examination：Infantile-type ALCAPA and CLMCA-A showed abnormal Q waves with T wave inversion in leads I,avL,and V4-V6,especially in lead ***,ECG of adult-type ALCAPA lacked distinct *** chest radiography：pulmonary congestion and cardiomegaly were the most common findings in infantile-type ALCAPA and CLMCA-A,while pulmonary artery segment dilation was more common in a

关键词： congenital coronary abnormalities ALCAPA coronary artery atresia

Synergistic Effect of Nitrogen/Phosphorus Co-Doping and Molybdenum Carbide Induced Electron Redistribution of Carbon Layer to Boost Hydrogen Evolution Reaction

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Chinese Journal of Chemistry 2024年第1期42卷 55-60页

作者： Jiamin xiao Peng Li yanyan Sun Heng Liu Javid Khan Handong Zhang Han Zhou Yaqiong Su Shuangyin Wang Lei Han College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean EnergyHunan UniversityChangshaHunan 410082China School of Chemistry Engineering Research Center of Energy Storage Materials and Devices Ministry of EducationXi'an Key Laboratory of Sustainable Energy Materials ChemistryState Key Laboratory of Electrical Insulation and Power EquipmentXi'an Jiaotong UniversityXi'anShaanxi 710049China School of Materials Science and Engineering Central South UniversityChangshaHunan 410083China state Key Laboratory of Chem/Bio-Sensingand Chemometrics College of Chemistry and Chemical EngineeringHunan University ChangshaHunan 410082China Laboratory of Inorganic Materials and Catalysis Department of Chemical Engineering and ChemistryEindhoven University of Technology P.O.Box5135600 MB EindhovenThe Netherlands

The development of highly efficient non-precious-metal-based electrocatalysts for the hydrogen evolution reaction is imperative for promoting the large-scale application of electrochemical water ***,nitrogen/phosphorus co-doped carbon nanorods encapsulated Mo_(2)C nanoparticles(Mo_(2)C@PNc)have been prepared by pre-phosphating treatment in combination of the coordination with polydopamine and the subsequent *** phosphating temperature has a significant effect on the content of phosphorus within the resultant Mo_(2)C@PNC,and the optimal catalyst delivers superior HER activity with the low overpotential of 104 mV at a current density of 10 mAcm^(-2) and good stability for 8 h,which has been theoretically demonstrated to originate from the synergistic effect between P doping and Mo_(2)C induced electron redistribution of nitrogen-doped carbon layer.

关键词： Molybdenum carbide N/P co-doped carbon Hydrogen evolution Synergistic effect Electron redistribution Comprehensive

How topography and neighbor shape the fate of trees in subtropical forest restoration:Environmental filtering and resource competition drive natural regeneration

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Forest Ecosystems 2024年第1期11卷 73-86页

作者： Haonan Zhang Xingshuo Zhang Yingying Lv yanyan Ni Baokun Xu Xiangnan Han xiao Cao Qingpei Yang Wanggu Xu Zhedong Qian Innovative Research Team for Forest Restoration Mechanisms Nanjing Institute of Environmental SciencesMinistry of Ecology and Environment(MEE)Nanjing 210042China College of Forestry Jiangxi Agricultural UniversityNanchang 330045China

The structure of plant communities at local scales depends on both the spatial heterogeneity of abiotic environmental factors and the biotic interactions within the ***,although environmental filtering due to microtopographic heterogeneity and resource competition among plants caused by spatial variation in tree density and size are considered to be very important in explaining the mechanisms of community assembly,their effects on the processes of individual mortality and recruitment in natural forest regeneration,as well as their relative contributions,are still poorly *** address this,we established a 12-ha permanent plot in a subtropical evergreen broad-leaved forest area and measured microtopographic variables such as elevation,slope,aspect,and terrain position index(TPI)using a total *** monitored the individual mortality and recruitment in forest natural regeneration through repeated surveys at 5-year *** fitted spatial covariance models to jointly use multiple factors from three groups of variables(microtopographic effect,neighborhood density effects,neighborhood size effects)as explanatory variables to analyze their roles in driving the mortality and recruitment of all individual and 12 dominant species in forest natural regeneration at the neighborhood *** results show that:(1)In the crucial early stages of secondary forest restoration,natural regeneration is influenced by a synergy of environmental filtering,due to microtopographic heterogeneity,and resource competition among plants.(2)For distinct species responses,evergreen dominant species'mortality is largely explained by neighborhood effects,while deciduous species are more affected by topographic ***,the adverse effects of larger conspecific trees on younger trees indicate a pattern of competitive pressure leading to mortality among regenerating trees,such pattern emphasis the influence of parent trees on natural regeneration.(3)As trees g

关键词： Natural regeneration Microtopography Neighborhood effects Mortality and recruitment

Oxygen vacancy promoting artificial atom(RuPd)by d-orbital coupling for efficient water dissociation

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Nano Research 2024年第8期17卷 7045-7052页

作者： Ruofan Shen yanyan Liu Shuling Liu Shuyan Guan Huanhuan Zhang Sehrish Mehdi Saima Ashraf Ting-Hui xiao Erjun Liang Jianchun Jiang Yongfeng Wang Baojun Li Laboratory of Zhongyuan Light School of PhysicsZhengzhou UniversityZhengzhou 450001China Key Laboratory of Materials Physics Ministry of EducationSchool of PhysicsZhengzhou UniversityZhengzhou 450001China College of Chemistry Zhengzhou UniversityZhengzhou 450001China College of Science Henan Agricultural UniversityZhengzhou 450002China Department of Chemistry Tsinghua UniversityBeijing 100084China National Engineering Lab.for Biomass Chemical Utilization Institute of Chemical Industry of Forest ProductsCAFNanjing 210042China Center for Carbon-based Electronics and Key Laboratory for the Physics and Chemistry of Nanodevices Department of ElectronicsPeking UniversityBeijing 100871China

Rational design of highly active catalysts for breaking hydrogen-oxygen bonds is of great significance in energy chemical reactions involving ***,an efficient strategy for the artificial atom(RuPd)established by d-orbital coupling and adjusted by oxygen vacancy(V_(O))is verified for water *** an experimental verification,the turnover frequency of RuPd-TiO_(2)-VO(RuPdTVO)catalyst in ammonia borane hydrolysis reaches up to 2750 min^(−1)(26,190 min−1 based on metal dispersion)in the absence of alkali,exceeding the highest active catalysts(Rh-based catalysts).The d-orbital coupling effect between Ru and Pd simulates the outer electronic structure of *** transfer from V_(O) to(RuPd)constructs an electron-rich state of active sites that further enhances the ability of the artificial atom to dissociate *** work provides an effective electronic regulation strategy from V_(O) and artificial atom constructed by d-orbital coupling effect for efficient water dissociation.

关键词： ammonia borane hydrolysis d-orbital coupling oxygen vacancy artificial atom water dissociation

NeurDB: an AI-powered autonomous data system

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Science China(Information Sciences) 2024年第10期67卷 129-150页

作者： Beng Chin OOI Shaofeng CAI Gang CHEN yanyan SHEN Kian-Lee TAN Yuncheng WU xiaokui xiao Naili XING Cong YUE Lingze ZENG Meihui ZHANG Zhanhao ZHAO School of Computing National University of Singapore College of Computer Science and Technology Zhejiang University Department of Computer Science and Engineering Shanghai Jiao Tong University School of Information Renmin University of China School of Computer Science and Technology Beijing Institute of Technology

In the wake of rapid advancements in artificial intelligence(AI), we stand on the brink of a transformative leap in data systems. The imminent fusion of AI and DB(AI×DB) promises a new generation of data systems, which will relieve the burden on end-users across all industry sectors by featuring AI-enhanced functionalities, such as personalized and automated in-database AI-powered analytics, and selfdriving capabilities for improved system performance. In this paper, we explore the evolution of data systems with a focus on deepening the fusion of AI and DB. We present NeurDB, an AI-powered autonomous data system designed to fully embrace AI design in each major system component and provide in-database AI-powered analytics. We outline the conceptual and architectural overview of NeurDB, discuss its design choices and key components, and report its current development and future plan.

关键词： AI$\times$DB in-database AI intelligent data system

老年2型糖尿病合并肌少症患者中医证素临床特点分析

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天津中医药 2024年第10期41卷 1233-1240页

作者：肖岩岩许嘉慧田静陈媛周天锴王超陈驰韩煦陈清光赵进东徐隽斐陆灏上海中医药大学附属曙光医院内分泌科上海200021 安徽中医药大学第一附属医院内分泌科合肥230031

[目的]分析老年2型糖尿病合并肌少症患者中医证素分布规律和组合特点,为中医辨证论治提供客观、科学的参考依据。[方法]通过横断面调查,收集200例老年2型糖尿病合并肌少症患者的四诊及相关信息,分析目标患者的一般情况,采用证素辨证法,... 详细信息

[目的]分析老年2型糖尿病合并肌少症患者中医证素分布规律和组合特点,为中医辨证论治提供客观、科学的参考依据。[方法]通过横断面调查,收集200例老年2型糖尿病合并肌少症患者的四诊及相关信息,分析目标患者的一般情况,采用证素辨证法,运用频数、R型聚类分析等统计方法,以证素辨证理论为基础,得出该疾病的证素、证型分布特征及组合规律。[结果]纳入患者男女比例约为5∶2,男性患者明显多于女性患者。老年2型糖尿病合并肌少症患者主要集中于身体质量指数(BMI)正常组。老年2型糖尿病合并肌少症病位证素以肝(44.5%)、肾(41.0%)、脾(18.0%)为主,病性证素以血虚(80.1%)、阴虚(64.0%)、气虚(48.5%)、阳虚(43.5%)为主,血虚尤其多见。聚类分析可将该病证聚为3种证型:肝阴血虚(67.0%)、肾阳气虚(26.0%)、脾胃痰湿气滞血瘀(7.0%)。[结论]2型糖尿病合并肌少症在老年人群中,病位侧重于肝,与肾、脾密切相关,病性侧重于血虚,与阴虚、气虚、阳虚密切相关。临证注意老年人特点,辨证病位以肝、脾、肾为先,以补虚为主,尤其是补血,本研究结果在一定程度上反映了老年2型糖尿病肌少症主要证素特点,对该病临床中医辨证治疗有一定的参考价值。

关键词： 2型糖尿病肌少症中医证素

Effects of probiotics， prebiotics and synbiotics supplementation on cardiovascular risk factors in patients with type 2 diabetes mellitus: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials

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Food Science and Human Wellness 2024年

作者： yanyan Tian Jiayue Xia Lihua Li Ligang Yang Hua xiao Guoping Gao Yuanyuan Wang Chen Zhang Tiange Bu Guiju Sun Department of Nutritional Sciences， University of Toronto Key Laboratory of Environmental Medicine and Engineering of Ministry of Education， Department of Nutrition and Food Hygiene， School of Public Health， Southeast University Lianshui People's Hospital Affiliated to Kangda College of Nanjing Medical University Gong'an County People's Hospital

A systematic review and meta-analysis study was conducted to assess the effectiveness of probiotic/prebiotic/synbiotic supplementation on the effects of cardiovascular risk factors in patients with type 2 diabetes mellitus (T2DM) based on data from randomized controlled trials (RCTs). We searched electronic databases including PubMed， Cochrane Library， Embase， and Web of Science to identify clinical trials published up to 31 March 2023. Data was pooled using a random-effects model if significant heterogeneity (I2> 50%)， otherwise use a fixed-effects model. Fifty-six trials that included 3 317 patients were enrolled for analysis. Meta-analysis reported that probiotic/prebiotic/synbiotic supplementation significantly reduced systolic blood pressure (SBP) (weighted mean difference (WMD): -3.57 mmHg， 95% confidence interval (CI): -5.36， -1.78; P = 0.000)， diastolic blood pressure (DBP) (WMD: -2.05 mmHg， 95% CI: -3.07， -1.04; P = 0.000)， triglycerides (TG) (WMD: -16.10 mg/dL， 95% CI: -20.16， -12.05; P = 0.000)， total cholesterol (TC) (WMD: -14.00 mg/dL， 95% CI: -20.46， -7.55; P = 0.000)， low-density lipoprotein cholesterol (LDL-C) (WMD: -7.03 mg/dL， 95% CI: -9.25， -4.81; P = 0.000)， fasting plasma glucose (FPG) (WMD: -16.57 mg/dL， 95% CI: -20.39， -12.74; P = 0.000)， hemoglobin A1c (HbA1c) (WMD: -0.44%， 95% CI: -0.68， -0.20; P = 0.000)， insulin (standardized mean difference (SMD): -0.37， 95% CI: -0.53， -0.21; P = 0.000)， homeostatic model assessment of insulin resistance (HOMA-IR) (WMD: -1.05， 95% CI: -1.56， -0.54; P = 0.000)， C-reactive protein (CRP) (SMD: -0.35， 95% CI: -0.57， -0.13; P = 0.002)， tumor necrosis factor-α (TNF-α) (SMD: -1.07， 95% CI: -1.57， -0.56; P = 0.000)， interleukin-6 (IL-6) (SMD: -0.37 ， 95% CI: -0.61， -0.13; P = 0.003) levels， they also increased the high-density lipoprotein cholesterol (HDL-C) (WMD: 3.70 mg/dL， 95% CI: 1.80， 5.60; P = 0.000) levels in T2DM patients， as compared to the placebo groups. This meta-analysis supports the use of probiotic

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Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity

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National Science Review 2024年第7期11卷 80-94页

作者： Pan Liu Can Yue Bo Meng Tianhe xiao Sijie Yang Shuo Liu Fanchong Jian Qianhui Zhu Yuanling Yu yanyan Ren Peng Wang Yixin Li Jinyue Wang Xin Mao Fei Shao Youchun Wang Ravindra Kumar Gupta Yunlong Cao Xiangxi Wang CAS Key Laboratory of Infection and Immunity National Laboratory of MacromoleculesInstitute of BiophysicsChinese Academy of Sciences University of Chinese Academy of Sciences Cambridge Institute of Therapeutic Immunology&Infectious Disease(CITIID) University of Cambridge Biomedical Pioneering Innovation Center(BIOPIC) Peking University Changping Laboratory Joint Graduate Program of Peking-Tsinghua-NIBS Academy for Advanced Interdisciplinary Studies Peking University Peking-Tsinghua Center for Life Sciences Tsinghua University Chinese Academy of Medical Sciences&Peking Union Medical College

Selective pressures have given rise to a number of SARS-CoV-2 variants during the prolonged course of the COVID-19 pandemic. Recently evolved variants differ from ancestors in additional glycosylation within the spike protein receptor-binding domain(RBD). Details of how the acquisition of glycosylation impacts viral fitness and human adaptation are not clearly understood. Here, we dissected the role of N354-linked glycosylation, acquired by BA.2.86 sub-lineages, as a RBD conformational control element in attenuating viral infectivity. The reduced infectivity is recovered in the presence of heparin sulfate, which targets the‘N354 pocket’ to ease restrictions of conformational transition resulting in a ‘RBD-up’ state, thereby conferring an adjustable infectivity. Furthermore, N354 glycosylation improved spike cleavage and cell–cell fusion, and in particular escaped one subset of ADCC antibodies. Together with reduced immunogenicity in hybrid immunity background, these indicate a single spike amino acid glycosylation event provides selective advantage in humans through multiple mechanisms.

关键词： coronavirus glycosylation viral fitness adjustable infectivity co-factor usage viral evolution conformational modulator