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Genetic pathways in cerebral palsy:a review of the implications for precision diagnosis and understanding disease mechanisms

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Neural Regeneration Research 2024年第7期19卷 1499-1508页

作者： Yiran Xu Yifei Li Seidu A.Richard yanyan Sun Changlian Zhu Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center Institute of Neuroscience and The Third Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina National Health Council(NHC)Key Laboratory of Birth Defects Prevention Henan Key Laboratory of Population Defects PreventionZhengzhouHenan ProvinceChina Department of Human Anatomy School of Basic Medicine and Institute of NeuroscienceZhengzhou UniversityZhengzhouHenan ProvinceChina Center for Brain Repair and Rehabilitation Institute of Neuroscience and PhysiologyUniversity of GothenburgGothenburgSweden

Ce rebral palsy is a diagnostic term utilized to describe a group of permanent disorders affecting movement and *** with cerebral palsy are often only capable of limited activity,resulting from non-progressive disturbances in the fetal or neonatal *** disturbances severely impact the child’s daily life and impose a substantial economic burden on the *** cerebral palsy encompasses various brain injuries leading to similar clinical outcomes,the unde rstanding of its etiological pathways remains incomplete ow.ng to its complexity and *** review aims to summarize the current knowledge on the genetic factors influencing cerebral palsy *** is now widely acknowledged that genetic mutations and alterations play a pivotal role in cerebral palsy development,which can be further influenced by environmental fa *** pite continuous research endeavors,the underlying fa ctors contributing to cerebral palsy remain are still ***,significant progress has been made in genetic research that has markedly enhanced our comprehension of the genetic factors underlying cerebral palsy *** r,these genetic factors have been categorized based on the identified gene mutations in patients through clinical genotyping,including thrombosis,angiogenesis,mitochondrial and oxidative phosphorylation function,neuronal migration,and cellular ***,exploring targeted genotypes holds potential for precision *** conclusion,advancements in genetic research have substantially improved our understanding of the genetic causes underlying cerebral *** breakthroughs have the potential to pave the way for new treatments and therapies,consequently shaping the future of cerebral palsy research and its clinical *** investigation of cerebral palsy genetics holds the potential to significantly advance treatments and management *** elucidating the underlying cellular mechanisms,w

关键词： cerebral palsy environmental factors etiology genetic factors genetic mutation movement disorder spastic diplegia

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Adjusting oxygen vacancy of VO_(2)·xH_(2)O nanoarray architectures for efficient NH_(4)^(+) storage

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Nano Research 2024年第4期17卷 2646-2654页

作者： Jia’ni Gong Pengfei Bai Jingjing Sun yanyan Liu Xueying Dong Tao Hu Changgong Meng Yifu Zhang School of Chemistry Dalian University of TechnologyDalian 116024China School of Chemistry and Materials Sciences CAS Key Laboratory of Materials for Energy ConversionCAS Center for Excellence in NanoscienceUniversity of Science and Technology of ChinaHefei 230026China College of Environmental and Chemical Engineering Dalian UniversityDalian 116622China

Aqueous rechargeable batteries are the promising energy storge technology due to their safety,low cost,and environmental *** ion(NH_(4)^(+))is an ideal charge carrier for such batteries because of its small hydration radius and low molar *** this study,VO_(2)·xH_(2)O with rich oxygen defects(d-HVO)is designed and synthesized,and it exhibits unique nanoarray structure and good electrochemical performances for NH_(4)^(+)*** and calculation results indicate that oxygen defects in d-HVO can enhance the conductivity and diffusion rate of NH_(4)^(+),leading to improved electrochemical *** most significant improvement is observed in d-HVO with 2 mmol thiourea(d-HVO-2)(220 mAh·g^(-1) at 0.1 A·g^(-1)),which has a moderate defect content.A full cell is assembled using d-HVO-2 as the anode and polyaniline(PANI)as the cathode,which shows excellent cycling stability with a capacity retention rate of 80%after 1000 cycles and outstanding power density up to 4540 w·kg^(-1).Moreover,the flexible d-HVO-2||PANI battery,based on quasi-solid electrolyte,shows excellent flexibility under different bending *** study provides a new approach for designing and developing high-performance NH_(4)^(+)storage electrode materials.

关键词： hydrate vanadium dioxide oxygen defects ammonium-ion battery anode material

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Ion migration in 3D metal halide perovskite field effect transistors

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Electron 2024年第2期2卷 85-97页

作者： Jinghai Li yanyan Gong william w.Yu School of Chemistry and Chemical Engineering Shandong UniversityJinanChina Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion Science Center for Material Creation and Energy ConversionInstitute of Frontier and Interdisciplinary ScienceShandong UniversityQingdaoChina State Key Laboratory of Biobased Material and Green Papermaking Qilu University of Technology(Shandong Academy of Sciences)JinanChina

3D perovskite materials are advancing rapidly in the field of photovoltaics and light-emitting diodes,but the development in field effect transistors(FETs)is limited due to their intrinsic ion *** migration in perovskite FETs can screen the electric field of the gate and affect its modulation,as well as influence the charge carriers transport,leading to non-ideal device characteristics and lower device ***,we provide a concise review that explains the mechanism of ion migration,summarizes the strategies for suppressing ion migration,and concludes with a discussion of the future prospects for 3D perovskite FETs.

关键词： 3D metal halide perovskite field effect transistors ion migration

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Numerical simulation of the influence factors of NO_(x) emission on a w-type radiant tube

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Baosteel Technical Research 2024年第1期18卷 1-7页

作者： LIU yanyan Research Institute Baoshan Iron&Steel Co.Ltd.Shanghai 201999China

The radiant tube burner was modeled and analyzed by the numerical simulation method to investigate the influence factors and rules of NO_(x) emissions in a w-type radiant *** factors,which include air preheating temperature,excess air coefficient,and fuel gas composition,were modified to study their effects on NO_(x) emissions under varying working *** results were compared with the theoretical calculation value based on chemical reaction equilibrium theory and the onsite experimental value to verify the simulation *** results show that NO_(x) emissions rise with increasing air preheating ***_(x) production increases to an extreme value and then decreases during the oxygen-poor to oxygen-enriched process with the rise of the excess air *** the proportion of coke oven gas in the fuel gas raises the combustion temperature as well as the NO_(x) *** the thermal efficiency and NO_(x) emissions should be ***,the recommended values based on the simulation results are as follows:the air preheating temperature should not exceed 400℃,the excess air coefficient should be between 1.1 and 1.2,and the volume fraction of the coke oven gas should not exceed 30%.

关键词： w-type radiant tube NO_(x) combustion numerical simulation

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High-entropy rare earth stannate ceramics:Acid corrosion resistant radiative cooling materials with high atmospheric transparency window emissivity and high near-infrared solar reflectivity

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Journal of Advanced Ceramics 2024年第5期13卷 630-640页

作者： Tao Chen yanyan He Yanyu Pan Kaixian w.ng Minzhong Huang Liyan Xue Yazhu Li Fan Yang Yanchun Zhou Heng Chen Fujian Institute of Research on the Structure of Matter Chinese Academy of SciencesFuzhou 350002China College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350117China Xiamen Institute of Rare Earth Materials Haixi InstitutesChinese Academy of SciencesXiamen 361021China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstitutesChinese Academy of SciencesXiamen 361021China Key Laboratory of Rare Earths Ganjiang Innovation AcademyChinese Academy of SciencesGanzhou 341000China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China

In response to the development of the concepts of“carbon neutrality”and“carbon peak”,it is critical to developing materials with high near-infrared(NIR)solar reflectivity and high emissivity in the atmospheric transparency window(ATw;8–13μm)to advance zero energy consumption radiative cooling *** regulate emission and reflection properties,a series of high-entropy rare earth stannate ceramics(HE-RE_(2)Sn_(2)O_(7):(Y_(0.2)La_(0.2)Nd_(0.2)Eu_(0.2)Gd_(0.2))_(2)Sn_(2)O_(7),(Y_(0.2)La_(0.2)Sm_(0.2)Eu_(0.2)Lu_(0.2))_(2)Sn_(2)O_(7),and(Y_(0.2)La_(0.2)Gd_(0.2)Yb_(0.2)Lu_(0.2))_(2)Sn_(2)O_(7))with severe lattice distortion were prepared using a solid phase reaction followed by a pressureless sintering method for the first *** distortion is accomplished by introducing rare earth elements with different cation radii and *** as-synthesized HE-RE_(2)Sn_(2)O_(7)ceramics possess high ATw emissivity(91.38%–95.41%),high NIR solar reflectivity(92.74%–97.62%),low thermal conductivity(1.080–1.619 w·m^(−1)·K^(−1)),and excellent chemical *** the one hand,the lattice distortion intensifies the asymmetry of the structural unit to cause a notable alteration in the electric dipole moment,ultimately enlarging the ATw *** the other hand,by selecting difficult excitation elements,HE-RE_(2)Sn_(2)O_(7),which has a wide band gap(Eg),exhibits high NIR solar ***,the multi-component design can effectively enhance radiative cooling ability of HE-RE_(2)Sn_(2)O_(7)and provide a novel strategy for developing radiative cooling materials.

关键词： radiative cooling materials high-entropy ceramics(HECs) rare earth stannate(RE_(2)Sn_(2)O_(7)) high atmospheric transparency window emissivity high near-infrared(NIR)solar reflectivity

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Understanding the combustion behavior of electric bicycle batteries and unveiling its relationship with fire extinguishing

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Journal of Energy Chemistry 2024年第4期91卷 609-618页

作者： Zhanglong Yu Xueling Shen Ran Xu Zheng w.ng Zengming wan Mingyang Chen Yi Cui yanyan Fang Xiaoli Ma China Automotive Battery Research Institute Co. Ltd.Beijing 101407China China Grinm Group Co. Ltd.Beijing 100088China Ministry of Industry and Information Technology Equipment Industry Development CenterBeijing 100846China Hefei Guoxuan High-tech Power energy Co. Ltd.Hefei 230000AnhuiChina

In this study,a detailed analysis of the combustion behaviors of the lithium iron phosphate(LFP)and lithium manganese oxide(LMO)batteries used in electric bicycles was *** research included quantitative measurements of the combustion duration,flame height,combustion temperature,heat release rate,and total heat *** results indicated that LMO batteries exhibited higher combustion temperatures of 600–700°C,flame heights of 70–75 cm,a significantly higher heat release rate of40.1 k w(12 Ah),and a total heat release of 1.04 MJ(12 Ah)compared to LFP batteries with the same *** on these experimental results,a normalized total heat release(NORTHR)parameter was proposed,demonstrating good universality for batteries with different *** this parameter,quantitative calculations and optimization of the extinguishing agent dosage were conducted for fires involving these two types of batteries,and the method was validated by extinguishing fires for these two types of battery packs with water-based extinguishing fluids.

关键词： Combustion behavior Electric bicycle Lithium-ion battery Fire extinguishing Normalized total heat release

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以稻壳热解炭制备镧负载多孔炭复合电极材料

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高等学校化学学报 2024年第4期45卷 1-9页

作者：隋光辉程岩岩南昌师范学院化学与食品科学学院南昌330032

利用稻壳热解炭为原料制备镧负载多孔炭复合电极材料(La/PCs),先将稻壳热解炭分离出炭前驱体,再采用原位活化/负载的方法制备一系列镧负载多孔炭复合电极材料,分别考察了煅烧温度和浸渍比对其吸附性能和电化学性能的影响.采用X射线衍射(... 详细信息

利用稻壳热解炭为原料制备镧负载多孔炭复合电极材料(La/PCs),先将稻壳热解炭分离出炭前驱体,再采用原位活化/负载的方法制备一系列镧负载多孔炭复合电极材料,分别考察了煅烧温度和浸渍比对其吸附性能和电化学性能的影响.采用X射线衍射(XRD)、X射线光电子能谱(XPS)、扫描电子显微镜/X射线能谱仪(SEM-EDS)和Brunauer-Emmett-Teller比表面积(BET)法研究了该系列镧负载多孔炭复合电极材料的金属结构与价态、元素组成及表面形貌,并分析了孔结构与电容值之间可能存在的关系.结果表明,在6 mol/L KOH电解液中,La/PC_900/10材料的电容值为269.45 F/g.在电流密度为0.5 A/g时,由其组装的对称超级电容器具有23.45 w·h/kg的能量密度,此时的功率密度为0.70 kw/kg,并且循环5000次后的电容保持率为86.41%.La/PC_900/10良好的电容性能显示了其作为碳基电极应用于高性能超级电容器的潜力.研究结果为稻壳热解炭的利用和镧在新能源材料领域的应用提供了一条可行路径.

关键词：稻壳热解炭镧负载多孔炭复合电极

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液压支柱钢表面激光再制造工艺参数的多目标优化

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激光与光电子学进展 2024年第5期61卷 305-311页

作者：王燕燕何炜舒林森陕西理工大学机械工程学院陕西汉中723000 陕西省工业自动化重点实验室陕西汉中723000

为了获得奥氏体不锈钢在液压支柱钢表面激光熔覆的最佳工艺参数,选取工艺参数激光功率、扫描速度、送粉速度为输入变量,将熔覆层质量作为评价指标建立数学模型,设计了16组正交实验。利用自适应混沌粒子群算法进行寻优,对熔覆层宏观形貌... 详细信息

为了获得奥氏体不锈钢在液压支柱钢表面激光熔覆的最佳工艺参数,选取工艺参数激光功率、扫描速度、送粉速度为输入变量,将熔覆层质量作为评价指标建立数学模型,设计了16组正交实验。利用自适应混沌粒子群算法进行寻优,对熔覆层宏观形貌和显微组织进行实验分析,验证优化后的工艺参数的合理性与准确性,并将综合评价值相近的两组试件进行对比。结果表明:激光功率为1200 w、扫描速度为13 mm/s、送粉速度为1.72 g/min是最佳的工艺参数组合;采用自适应混沌粒子群算法对工艺参数进行优化,能够有效地改善熔覆层的宏观缺陷和表面性能,证明了该优化算法在激光熔覆领域应用的可行性。

关键词：激光熔覆多目标优化主成分分析法自适应混沌粒子群算法

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Al-10Si-xMg喷铸铝合金的组织及导热性能

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特种铸造及有色合金 2024年第8期44卷 1108-1113页

作者：王剑朱艳艳宁珍珍湖北文理学院理工学院襄阳441800 武汉理工大学襄阳示范区湖北隆中实验室襄阳441106

采用喷铸成形工艺制备Al-10Si-xMg合金,研究了Mg含量对铸态与T6态试样微结构、热导率与硬度的影响。结果表明,Mg元素促进铸态合金中α-Al基体球化,抑制枝晶形成,减少共晶Si相偏聚,进而显著提升T6态合金组织中共晶Si相分布的均匀性。共... 详细信息

采用喷铸成形工艺制备Al-10Si-xMg合金,研究了Mg含量对铸态与T6态试样微结构、热导率与硬度的影响。结果表明,Mg元素促进铸态合金中α-Al基体球化,抑制枝晶形成,减少共晶Si相偏聚,进而显著提升T6态合金组织中共晶Si相分布的均匀性。共晶Si组织的优化减小电子散射,降低Mg固溶对电子散射的作用,使T6态Mg含量为0.4%(质量分数,下同)合金获得399.2 cm^(2)/(V∙s)的高电子迁移率,热导率为172.4 w/(m∙K),较Al-10Si合金降低约5.5%。同时,由于共晶Si与Mg2Si析出相的强化作用,合金的硬度显著增大,T6态Mg含量为0.4%合金的维氏硬度为1.13 GPa,较Al-10Si提升约126%。研究表明,适量Mg元素能够平衡Al-Si合金的导热与力学性能,从而获得良好的综合性能。

关键词： Al-Si合金喷铸热导率硬度 T6热处理

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儿童医院视角下药学人员科研指标评价体系的构建

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中国药房 2024年第18期35卷 2193-2198页

作者：高艳李欣高翔孙燕燕天津市儿童医院(天津大学儿童医院)药剂科天津300134 天津市儿童出生缺陷防治重点实验室天津300134

目的构建适用于儿童医院药学人员的科研指标评价体系,为药学人员的科研能力评价提供技术支持和参考依据。方法运用文献/文本调研法,查找科研管理的相关文献、政策法规和研究报告;采用头脑风暴法梳理关键要素,逐级分解各级指标。在此基础... 详细信息

目的构建适用于儿童医院药学人员的科研指标评价体系,为药学人员的科研能力评价提供技术支持和参考依据。方法运用文献/文本调研法,查找科研管理的相关文献、政策法规和研究报告;采用头脑风暴法梳理关键要素,逐级分解各级指标。在此基础上,使用专家访谈法,明确关键要素,初步拟定三级指标评价体系,并据此制作函询问卷。最后运用德尔菲法,通过3项筛选标准[重要性赋值>3.5、变异系数<25%、不重要百分比(包括不太重要和很不重要)<50%],建立药学人员科研指标评价体系。结果两轮专家函询均发放问卷36份,回收36份,回收率和有效率均为100%。两轮函询专家的判断系数平均值为0.912,熟悉程度平均值为0.747,专家权威系数平均值为0.830。经过第二轮函询后,一级指标的肯德尔协调系数为0.269,二级指标为0.379,三级指标为0.460,均显著高于第一轮专家函询结果(P<0.01)。最终确定了药学人员科研指标评价体系一级指标4个、二级指标18个、三级指标62个。结论本研究所选儿童医院药学专家权威性较高、专业覆盖面广;构建的药学人员科研指标评价体系具有一定的标准性和规范性,可为药学人员的专业水平考核、科研能力评价提供有力参考。

关键词：科研能力评价评价指标体系儿童医院儿科药师

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