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Potential role of PANoptosis in neuronal cell death:commentary on"PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons"

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Neural Regeneration Research 2023年第2期18卷 339-340页

作者： yanyan sun Changlian Zhu Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University ZhengzhouHenan ProvinceChina Department of Human Anatomy School of Basic MedicineZhengzhou UniversityZhengzhouHenan ProvinceChina Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Center for Brain Repair and Rehabilitation Institute of Neuroscience and PhysiologyUniversity of GothenburgGöteborgSweden

See related article,pp 357-363Extensive neuronal cell death occurs during nervous system development to remove surplus,unwanted,and damaged *** is a highly regulated physiological process that plays a pivotal role in nervous system homeostasis and normal *** some brain regions,more than half of the neurons are removed during normal development without interfering with the remaining *** gene-regulated neuronal cell deletion process is called programmed cell death(Fricker et al.,2018).

关键词： death homeostasis removed

Effect of nourishing Yin and purging fire Chinese herbal mixture on delaying light-induced premature puberty in rats

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Journal of Traditional Chinese Medicine 2024年第1期44卷 95-102页

作者： sun yanyan XUE Yuanyuan sun Wen WANG Yonghong YU Jian Department of Traditional Chinese Medicine Children's Hospital of Fudan UniversityShanghai 201102China Department of Pediatrics Zibo Central HospitalZibo 255000China

OBJECTIVE:To elucidate the mechanism of the nourishing Yin and purging fire Chinese herbal mixture(NYPF)in delaying light-induced premature puberty in ***:Twenty-one days old female SpragueDawley rats were randomly assigned to normal group(N),long light exposure group(L),NYPF and normal saline group(NS).Rats in the L,NYPF and NS groups were exposed to 16 h:350 lux light/8 h:dark,while rats in the N group were exposed to 12 h:50 lux light/12 h:*** and normal saline was administered to the rats in the NYPF group or NS group,respectively,from day *** rats in every group were sacrificed at 9 *** day 28(P28),on the day when rat's vulva opened in the L group(L-VO),on the day when the first estrous interphase occurred in rats of L group(L-E1),and on the day when the second estrous interphase occurred in rats of L group(L-E2),***:On day 34,all rats in the L group,80%of rats in the NS group,40%of rats in the N group,and 20%of rats in the NYPF group showed complete opening of the *** P28,m RNA level of hypothalamic kisspeptin(Kiss-1)in the L group was significantly higher than that in the N group(P<0.05).The rats in the L and NS groups had significantly lower hypothalamic argininephenylalanine-amide(RFamide)-related peptide 3(RFRP-3)m RNA levels than those in the N group(P<0.05),whereas RFRP-3 m RNA level was significantly higher in the NYPF group than that in the L group(P<0.05).At L-VO,the ovarian index of the L and NS groups was significantly higher than that of the N group(P<0.05)and estradiol(E2)level of the NYPF group was significantly lower than that of the N and NS groups(P<0.05);hypothalamic Kiss-1 m RNA level in the L and NS groups was significantly higher than that in the N and NYPF groups(P<0.05),whereas hypothalamic RFRP-3 m RNA level in the L,NYPF,and NS groups was significantly lower than that in the N group(P<0.05).At L-E1,E2 level of the L and NS groups was significantly higher than that of the N group(P<0.01),wher

关键词： light puberty precocious kisspeptins RFRP-3 melatonin Nourishing Yin and Purging Fire

A quantification model of Traditional Chinese Medicine syndromes in children with idiopathic precocious puberty and early puberty

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Journal of Traditional Chinese Medicine 2013年第5期33卷 630-636页

作者： yanyan Lin Yuanyuan Xue Jian Yu Yonghong Wang Wen sun yanyan sun Yumin Shi Yiqun Zhang Hong Hu Department of Traditional Chinese Medicine Children's Hospital of Fudan University

OBJECTIVE:To establish a quantification model of Traditional Chinese Medicine(TCM)syndromes by sampling patients undergoing idiopathic precocious puberty(IPP)and early ***:A questionnaire for classifying and quantifying TCM syndromes was designed and *** the results were analyzed;the relationship between 3 types of syndrome and 47symptoms were ***,the frequency distribution of each symptom or sign was *** mathematics was used to develop a quantification model ofTCM ***:We found that precocious puberty had 3types of syndrome,including hyperactivity of fire due to Yin deficiency(Syndrome I),depressed liver Qi transforming into fire(Syndrome II),and end retention of damp heat(Syndrome III).In the IPP group,Syndrome I was the most common principal syndrome(100%).Forty-six patients(43.81%)werediagnosed with Syndrome I accompanied by Syndrome II and 11(10.48%)were diagnosed with Syndrome I accompanied by Syndrome *** the early puberty group,Syndrome I was also the main syndrome(98.39%).The degrees of most symptoms were mild to *** tongue was the most common tongue manifestation(62.86%prevalence)in the IPP *** most common pulse manifestations were slippery pulse,thread pulse,and taut *** Asymptotic Normalization Coefficient(ANC)method was used to quantify the TCM syndromes in 167 *** accuracy rate reached 91%,comparable to expert ***:We find that there are 3 types of syndrome in the IPP group and in the early puberty *** I(hyperactivity of fire due to Yin deficiency)is the main syndrome in the two *** may be an appropriate for quantification model ofTCM syndromes.

关键词： Puberty precocious Medicine Chinese traditional Symptom complex Fuzzy mathematics Cluster analysis Asymptotic normalization coefficient

Creating Healthy Enterprises:the Workplace Health Action Plan in China

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China CDC weekly 2021年第20期3卷 434-437页

作者： yanyan sun Xin sun Jun Ren Boya Li National Institute of Occupational Health and Poison Control Chinese Center for Disease Control and PreventionBeijingChina.

Summary On October 21,2019,the“Notice on promoting the healthy enterprises”and“Specification of Healthy Enterprise Construction(trial)”were issued jointly by the National Patriotic Health Campaign Committee Office and six other government *** one of the objectives and tasks of the occupational health protection action(2019–2030),this multisectoral“Healthy Enterprise”Action Plan(HEAP)serves as the first“healthy cell”project carried out at the national level as an indispensable part of the Healthy China Initiative and the Healthy City Movement.

关键词： jointly Action partner

Role of apoptosis-inducing factor in perinatal hypoxic-ischemic brain injury

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Neural Regeneration Research 2021年第2期16卷 205-213页

作者： Juan Rodriguez Tao Li Yiran Xu yanyan sun Changlian Zhu Center for Brain Repair and Rehabilitation Institute of Neuroscience and PhysiologySahlgrenska AcademyUniversity of GothenburgGothenburgSweden Henan Key Laboratory of Child Brain Injury Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Anatomy School of Basic Medical ScienceZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Women’s and Children’s Health Karolinska InstitutetStockholmSweden

Perinatal complications,such as asphyxia,can cause brain injuries that are often associated with subsequent neurological deficits,such as cerebral palsy or mental *** mechanisms of perinatal brain injury are not fully understood,but mitochondria play a prominent role not only due to their central function in metabolism but also because many proteins with apoptosis-related functions are located in the *** these proteins,apoptosis-inducing factor has already been shown to be an important factor involved in neuronal cell death upon hypoxia-ischemia,but a better understanding of the mechanisms behind these processes is required for the development of more effective treatments during the early stages of perinatal brain *** this review,we focus on the molecular mechanisms of hypoxic-ischemic encephalopathy,specifically on the importance of apoptosis-inducing *** relevance of apoptosis-inducing factor is based not only because it participates in the caspase-independent apoptotic pathway but also because it plays a crucial role in mitochondrial energetic functionality,especially with regard to the maintenance of electron transport during oxidative phosphorylation and in oxidative stress,acting as a free radical *** also discuss all the different apoptosis-inducing factor isoforms discovered,focusing especially on apoptosis-inducing factor 2,which is only expressed in the brain and the functions of which are starting now to be ***,we summarized the interaction of apoptosis-inducing factor with several proteins that are crucial for both apoptosis-inducing factor functions(prosurvival and pro-apoptotic)and that are highly important in order to develop promising therapeutic targets for improving outcomes after perinatal brain injury.

关键词： apoptosis apoptosis inducing factor asphyxia cell death free radical hypoxia-ischemia mitochondria neonates oxidative stress

Reexamination of Sexual Dimorphism and Female Reproduction in the Many-Lined sun Skink Eutropis multifasciata from China

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Asian Herpetological Research 2012年第4期3卷 265-272页

作者： Yu DU yanyan sun Chixian LIN Xiang JI Hainan Key Laboratory for Herpetological Research School of Life SciencesQiongzhou University Jiangsu Key Laboratory for Biodiversity and Biotechnology College of Life SciencesNanjing Normal University

We reexamined sexual dimorphism and female reproduction in the Many-Lined sun Skink Eutropis multifasciata from Hainan,China. Our data confirm that adults are sexually dimorphic in body size and shape,with males being the larger sex and larger in head size but shorter in abdomen length than females of the same snoutvent length(SVL). The rate at which head width increased with SVL was greater in males as opposed to the previous conclusion that the rate does not differ between the sexes. Maternal size was the main determinant of reproductive investment,with larger females generally producing more,as well as larger,offspring. Females produced up to nine offspring per litter as opposed to the previously reported 2–7. Most females gave birth between March and August,a time period approximately four months longer than that(May–June) reported previously. Females with a higher fecundity tended to produce smaller offspring as opposed to the previous conclusion that females do not tradeoff offspring size against number. Litter size,neonate mass and litter mass remained remarkably constant among years,and litter mass was more tightly related to female body size than litter size or neonate mass. Smaller females could produce relatively heavier litters without a concomitant reduction in postpartum body condition.

关键词： Scincidae Eutropis multifasciata sexual dimorphism litter size neonate size reproductive output offspring size-number trade-off

Genetic pathways in cerebral palsy:a review of the implications for precision diagnosis and understanding disease mechanisms

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Neural Regeneration Research 2024年第7期19卷 1499-1508页

作者： Yiran Xu Yifei Li Seidu A.Richard yanyan sun Changlian Zhu Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center Institute of Neuroscience and The Third Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina National Health Council(NHC)Key Laboratory of Birth Defects Prevention Henan Key Laboratory of Population Defects PreventionZhengzhouHenan ProvinceChina Department of Human Anatomy School of Basic Medicine and Institute of NeuroscienceZhengzhou UniversityZhengzhouHenan ProvinceChina Center for Brain Repair and Rehabilitation Institute of Neuroscience and PhysiologyUniversity of GothenburgGothenburgSweden

Ce rebral palsy is a diagnostic term utilized to describe a group of permanent disorders affecting movement and *** with cerebral palsy are often only capable of limited activity,resulting from non-progressive disturbances in the fetal or neonatal *** disturbances severely impact the child’s daily life and impose a substantial economic burden on the *** cerebral palsy encompasses various brain injuries leading to similar clinical outcomes,the unde rstanding of its etiological pathways remains incomplete owing to its complexity and *** review aims to summarize the current knowledge on the genetic factors influencing cerebral palsy *** is now widely acknowledged that genetic mutations and alterations play a pivotal role in cerebral palsy development,which can be further influenced by environmental fa *** pite continuous research endeavors,the underlying fa ctors contributing to cerebral palsy remain are still ***,significant progress has been made in genetic research that has markedly enhanced our comprehension of the genetic factors underlying cerebral palsy *** r,these genetic factors have been categorized based on the identified gene mutations in patients through clinical genotyping,including thrombosis,angiogenesis,mitochondrial and oxidative phosphorylation function,neuronal migration,and cellular ***,exploring targeted genotypes holds potential for precision *** conclusion,advancements in genetic research have substantially improved our understanding of the genetic causes underlying cerebral *** breakthroughs have the potential to pave the way for new treatments and therapies,consequently shaping the future of cerebral palsy research and its clinical *** investigation of cerebral palsy genetics holds the potential to significantly advance treatments and management *** elucidating the underlying cellular mechanisms,w

关键词： cerebral palsy environmental factors etiology genetic factors genetic mutation movement disorder spastic diplegia

Molecular engineering and biomedical applications of ultra-sensitive fluorescent probe for Ag^(+)

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Chinese Chemical Letters 2021年第10期32卷 3066-3070页

作者： Jianfei Kan Xiaonan Zhou yanyan sun Liyuan sun Hao Chu Zhaosheng Qian Jin Zhou School of Pharmacy Maternal and Child Health Hospital of Weifang Medical UniversityWeifang Medical UniversityWeifang 261053China College of Chemistry and Life Sciences Zhejiang Normal UniversityJinhua 321004China

A series of probes KJ-x(x=1-3)with carbon chains of different lengths based on the matrix of rhodamine B were engineered to detect Ag^(+)in aqueous solution in this *** them,KJ-1 is selected as the best option after in vitro investigation in view of its most sensitive and rapid response to Ag^(+),whose possible sensing mechanism is studied by experimental investigation and theoretical *** identify the practical application of the probe,the detection of Ag^(+)in nonantibiotic fungicide Silver&Health and differentiation between normal hepatocytes and hepatoma cells using confocal imaging was conducted.

关键词： Fluorescent probe Ag^(+) Detection Imaging Theoretical calculation Cell typing Spirolactam

He-Ar isotope geochemistry of the Yaoling-Meiziwo tungsten deposit,North Guangdong Province:Constraints on Yanshanian crust-mantle interaction and metallogenesis in SE China

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Chinese Science Bulletin 2012年第10期57卷 1150-1159页

作者： ZHAI Wei sun XiaoMing WU YunShan sun yanyan HUA RenMin YE XianRen Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering Guangzhou 510006 China School of Marine Sciences Sun Yat-sen University Guangzhou 510275 China Department of Earth Sciences Sun Yat-sen University Guangzhou 510275 China Geological Survey Institute of Guangdong Nonferrous Metals Geological Survey Bureau Guangzhou 510080 China State Key Laboratory of Mineral Deposit Research Nanjing University Nanjing 210093 China Institute of Geology and Geophysics Chinese Academy of Sciences Lanzhou 730000 China

Isotopic abundances and ratios of He and Ar found in inclusion fluids in pyrites formed in the Yaoling-Meiziwo tungsten miner-alization epoch show that the concentration of 4He varies widely,from 1.54×10-7 cm3 STP/g to 2609×10-7 cm3 STP/g.3He is 0.759×10-12 cm3 STP/g-3.463×10-12 cm3 STP/g.3He/4He is 0.0043-4.362 Ra,varying from crustal to mantle *** concen-tration of 40Ar ranges from 0.624×10-7 cm3 STP/g to 8.89×10-7 cm3 STP/*** 40Ar/36Ar varies extensively,from 330 to 2952,between atmospheric and crustal or mantle radiogenic ***-derived He is present in ore-forming fluids and the calcu-lated average proportion of the mantle He is 22%;the maximum is 67%.Our research results show that mantle-derived fluids play a significant role in tungsten *** fractionation of He and Ar indicate that there was 4He-enriched air-saturated water(MSAW) in the ore-forming *** ore-forming fluid was a mixture of mantle fluid,crustal magmatic fluid and *** occurrence of a mantle component in ore-forming fluid indicates the large-scale W and Sn mineralization,including Yaol-ing-Meiziwo,in southeastern China was the result of crust and mantle *** underplating or intrusion of voluminous basaltic magma formed by partial melting of the upper mantle provided the necessary heat to cause partial melting of the crust and the generation of voluminous S-type granitic *** magmatic fluid and mantle fluid with high 3He/4He were released from magma crystallization and fractionation,mixed with the circulating modified air-saturated water,and filled the extensional tectonic fractures,leading to the formation of world-class W and Sn deposits in southeastern China.

关键词：中国东南部壳幔相互作用成矿流体同位素地球化学钨矿 Ar 广东省地幔流体