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A quantification model of Traditional Chinese Medicine syndromes in children with idiopathic precocious puberty and early puberty

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Journal of Traditional Chinese Medicine 2013年第5期33卷 630-636页

作者： yanyan lin Yuanyuan Xue Jian Yu Yonghong Wang Wen Sun yanyan Sun Yumin Shi Yiqun Zhang Hong Hu Department of Traditional Chinese Medicine Children's Hospital of Fudan University

OBJECTIVE:To establish a quantification model of Traditional Chinese Medicine(TCM)syndromes by sampling patients undergoing idiopathic precocious puberty(IPP)and early ***:A questionnaire for classifying and quantifying TCM syndromes was designed and *** the results were analyzed;the relationship between 3 types of syndrome and 47symptoms were ***,the frequency distribution of each symptom or sign was *** mathematics was used to develop a quantification model ofTCM ***:We found that precocious puberty had 3types of syndrome,including hyperactivity of fire due to Yin deficiency(Syndrome I),depressed liver Qi transforming into fire(Syndrome II),and end retention of damp heat(Syndrome III).In the IPP group,Syndrome I was the most common principal syndrome(100%).Forty-six patients(43.81%)werediagnosed with Syndrome I accompanied by Syndrome II and 11(10.48%)were diagnosed with Syndrome I accompanied by Syndrome *** the early puberty group,Syndrome I was also the main syndrome(98.39%).The degrees of most symptoms were mild to *** tongue was the most common tongue manifestation(62.86%prevalence)in the IPP *** most common pulse manifestations were slippery pulse,thread pulse,and taut *** Asymptotic Normalization Coefficient(ANC)method was used to quantify the TCM syndromes in 167 *** accuracy rate reached 91%,comparable to expert ***:We find that there are 3 types of syndrome in the IPP group and in the early puberty *** I(hyperactivity of fire due to Yin deficiency)is the main syndrome in the two *** may be an appropriate for quantification model ofTCM syndromes.

关键词： Puberty precocious Medicine Chinese traditional Symptom complex Fuzzy mathematics Cluster analysis Asymptotic normalization coefficient

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Diphylleia Grayi-Inspired Intelligent Temperature-Responsive Transparent Nanofiber Membranes

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Nano-Micro Letters 2024年第4期16卷 67-78页

作者： Cengceng Zhao Gaohui Liu yanyan lin Xueqin Li Na Meng Xianfeng Wang Shaoju Fu Jianyong Yu Bin Ding Shanghai Frontier Science Research Center of Advanced Textiles College of TextilesDonghua UniversityShanghai 201620People’s Republic of China

Nanofiber membranes(NFMs) have become attractive candidates for next-generation flexible transparent materials due to their exceptional flexibility and breathability. However, improving the transmittance of NFMs is a great challenge due to the enormous reflection and incredibly poor transmission generated by the nanofiber-air interface. In this research, we report a general strategy for the preparation of flexible temperature-responsive transparent(TRT) membranes,which achieves a rapid transformation of NFMs from opaque to highly transparent under a narrow temperature window. In this process, the phase change material eicosane is coated on the surface of the polyurethane nanofibers by electrospray technology. When the temperature rises to 37 ℃, eicosane rapidly completes the phase transition and establishes the light transmission path between the nanofibers, preventing light loss from reflection at the nanofiber-air interface. The resulting TRT membrane exhibits high transmittance(> 90%), and fast response(5 s). This study achieves the first TRT transition of NFMs, offering a general strategy for building highly transparent nanofiber materials, shaping the future of next-generation intelligent temperature monitoring, anti-counterfeiting measures, and other high-performance devices.

关键词： Biomimetic Transparent Nanofibrous membrane Temperature response Phase change materials

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Effect of Yiqiyangyin recipe on heparanase and nephrin in rats with adriamycin-induced nephropathy

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Journal of Traditional Chinese Medicine 2013年第3期33卷 334-342页

作者： Wen Sun Yongrui He Jian Yu yanyan lin Yonghong Wang Xia Gao Ying Wang Zhonghua Zhao Xueguang Liu Department of Traditional Chinese Medicine Children's Hospital of Fudan University Department of Nephrology Children's Hospital of Fudan University Pediatric Institute Children's Hospital of Fudan University Department of Pathology Shanghai medical college of Fudan University

OBJECTIVE： To discuss the mechanism of Yiqiyang- yin recipe in rats with adriamycin （ADR）-induced ne- phropathyo METHODS： We randomly divided 30 Sprague-Daw- ley rats into 5 groups： control, model, glucocorti- coid, Chinese herb, and Chinese herb plus glucocor- ticoid groups. The 24-h urine volume was collected on days 7, 14, 21, and 28 after ADR injection, and all rats were killed on day 28. We measured the 24-h levels of urinary protein, serum cholesterol, and se- rum triglycerides, and renal function of all rats by using routine biochemical methods. Pathological changes in the rat kidneys were observed under light and electron microscopes. Heparanase （HPA） mRNA expression levels were measured using re-al-time fluorescence-quantitative polymerase chain reaction. Urine levels of HPA in all groups were measured using enzyme-linked immunosor- bent assay. The expression of nephrin was detected by immunohistochemical staining and quantitative- ly analyzed using Motic image analysis 3.2 software. RESULTS： The levels of urinary protein and serum triglycerides and cholesterol in rats with ADR-in- duced nephropathy increased on day 14. The se- rum albumin levels simultaneously decreased. All the changes reached the peak on day 28. Examina- tion under the light microscope showed inflamma- tory cells and slight fibroplasia in the renal intersti- tium in the model group, but fewer inflammatory cells were observed in the intervention groups than those in the model group. Examination under the electron microscope showed extensive fusion of foot processes in ADR rats. HPA mRNA expres- sion was higher in the model group than that in the control group. The HPA mRNA levels in the in- tervention groups, especially in the Chinese herb group, and Chinese herb plus glucocorticoid group were significantly lower than the level in the model group. The HPA expression levels correlated signifi- cantly with the proteinuria level. No significant dif- ference was found in the HPA level in urin

关键词： Benefiting Qi for nourishing Yin Chi-nese medical formula Doxorubicin Proteinuria Heparanase Nephrin

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Synthesis of 2-Methyl-4-methoxyaniline from o-Nitrotoluene Using Pt/C and Acidic Ionic Liquid as Catalyst System

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Chinese Journal of Chemical Engineering 2013年第6期21卷 701-704页

作者： LIU Yingxin LI Xiying FANG yanyan ZHANG lin Research and Development Base of Catalytic Hydrogenation College of Pharmaceutical Science Zhejiang universityof Technology Hangzhou 310032 China

2-Methyl-4-methoxyaniline （MMA） was synthesized by one-pot method through the hydrogenation and Bamberger rearrangement of o-nitrotoluene in methanol using acidic ionic liquid and 3% Pt/C as catalyst system. The effects of ionic liquid type, dosage of ionic liquid and 3% Pt/C, reaction temperature and reaction pressure on o-nitrotoluene conversion and MMA selectivity were investigated. The results indicated that the imidazolium-based acidic ionic liquid which contains SO3H-functionalized cation showed higher selectivity to MMA than other acidic ionic liquids used in this work. Using 1-（propyl-3-sulfonate）-3-methylimidazolium hydrosulfate （[HSO3-pmim][HSO4]） as the acid catalyst, the selectivity to MMA was as high as 67.6% at 97.8% of o-nitrotoluene conversion. As 3% Pt/C increased from 0.01 g to 0.025 g, the selectivity to MMA decreased from 73.4% to 62.5%, because of the hydrogenation of intermediate o-methyl-phenylhydroxylamine to o-toluidine becoming more dominant. An increase in hydrogen pressure also had obviously dramatic effect in lowering the MMA selectivity. After easy separation from the products, the catalyst system could be reused at least 3 times.

关键词： acidic ionic liquid Bamberger rearrangement 2-methyl-4-methoxyaniline o-nitrotoluene hydrogenation

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Maternal Vascular Dysfunction in Congenital Heart Defects

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Congenital Heart Disease 2023年第5期18卷 561-570页

作者： Yanli Liu Fengzhen Han Jian Zhuang Yanqiu Ou Yanji Qu yanyan lin Weina Zhang Haiping Wang Liping Huang Department of Obstetrics and Gynecology Nanfang HospitalSouthern Medical UniversityGuangzhou510515China Department of Obstetrics and Gynecology Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou510080China Prenatal Diagnosis Centre Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou510080China Department of Cardiovascular Surgery Guangdong Cardiovascular InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou510080China Global Health Research Center Guangdong Cardiovascular InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou510080China

Background:Research on fetal congenital heart defect(CHD)mostly focuses on etiology and ***,studies on maternal complications or pathophysiology are *** objective was to determine whether vascular dysfunction exists in pregnant women carrying a fetus with congenital heart ***:We conducted a case-control study.27 cases of pregnant women carrying a fetus with major CHD admitted to our hospital for delivery between April 2021 and August 2022 were *** case was matched with about 2 pregnant complication-free controls without fetal *** proangiogenic and anti-angiogenic factors and pregnancy outcomes were ***:The proangiogenic factors include vascular endothelial growth factor(VEGF)and placental growth factor(PlGF).The anti-angiogenic factors involve soluble fms-like tyrosine kinase 1(sFlt-1)and soluble endoglin(sEng).No differences were found in maternal plasma concentrations of PlGF,VEGF,and sFlt-1 between case-control groups when analyzed at 36 weeks≤gestational age(GA)<39 weeks and 39 weeks≤GA≤41 *** concentrations of sEng in maternal plasma in the fetal CHD group were significantly higher than those in the control group:0.60(0.77)vs.0.32(0.26)ng/ml at 36 weeks≤GA<39 weeks,p=0.001 and 0.75(0.55)vs.0.28(0.27)ng/ml at 39 weeks≤GA≤41 weeks,p<***:Vascular dysfunction exists in pregnant women with fetal congenital heart defects,manifesting significantly elevated sEng concentration at delivery.

关键词： Congenital heart defects vascular dysfunction placental growth factor soluble fms-like tyrosine kinase 1 vascular endothelial growth factor soluble endoglin fetus pregnancy maternal complication

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基于支持向量机与概率输出网的深度学习模型

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系统工程理论与实践 2018年第8期38卷 2147-2154页

作者：刘涵王月岭王晓林艳艳西安理工大学自动化与信息工程学院

本文提出了基于支持向量机与概率输出网络的深度学习回归模型．该回归模型利用深度学习的深层结构，以及支持向量机的泛化能力、概率输出网络中的条件概率估计特点，建立了多层支持向量机的深度学习结构，避免了深度学习的参数选择问题... 详细信息

本文提出了基于支持向量机与概率输出网络的深度学习回归模型．该回归模型利用深度学习的深层结构，以及支持向量机的泛化能力、概率输出网络中的条件概率估计特点，建立了多层支持向量机的深度学习结构，避免了深度学习的参数选择问题．其中核参数的选择域呈网格状，通过求取输出对应卢分布的累积概率分布和经验累积概率分布的K-S检验，求取一致性的P值最大对应的核参数作为支持向量机模型的核参数．对应的输出为模型提取的特征，作为下一层的输入，直至模型达到结束条件为止．仿真实验通过三个标准的回归数据集证明了本文提出模型的有效性．

关键词：支持向量机概率输出网络深度学习 K-S检验

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Beyond ribosomal function:RPS6 deficiency suppresses cholangiocarcinoma cell growth by disrupting alternative splicing

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Acta Pharmaceutica Sinica B 2024年第9期14卷 3931-3948页

作者： Wenkang Fu yanyan lin Mingzhen Bai Jia Yao Chongfei Huang Long Gao Ningning Mi Haidong Ma Liang Tian Ping Yue Yong Zhang Jinduo zhang Yanxian Ren Liyun Ding Lunzhi Dai Joseph WLeung Jinqiu Yuan Wenhua Zhang Wenbo Meng The First School of Clinical Medicne Lanzhou UniversityLanzhou 730030China Department of General Surgery the First Hospital of Lanzhou UniversityLanzhou 730030China Key Laboratory of Biotherapy and Regenerative Medicine of Gansu Province the First Hospital of Lanzhou UniversityLanzhou 730000China School of Physical Science and Technology Lanzhou UniversityLanzhou 730000China National Clinical Research Center for Geriatrics and Department of General Practice State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Division of Gastroenterology UC Davis Medical Center and Sacramento VA Medical CenterSacramentoCA 95817USA Clinical Research Center Big Data Centerthe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107China School of Life Sciences Lanzhou UniversityLanzhou 730000China

Cholangiocarcinoma(CCA)is a bile duct malignancy with a dismal *** study systematically investigated the role of the ribosomal protein S6(RPS6)gene,which is dependent in *** found that RPS6 upregulation in CCA tissues was correlated with a poor *** investigations have shown that alterations in RPS6 expression,both gain-and loss-of function could affect the proliferation of CCA *** xenograft tumor models,RPS6 overexpression enhances tumorigenicity,whereas RPS6 silencing reduces *** analysis using RNA-seq and proteomics elucidated downstream signaling pathways of RPS6 depletion by affecting the cell cycle,especially DNA *** followed by mass spectrometry has identified numerous spliceosome complex proteins associated with *** profiling revealed that RPS6 affects numerous alternative splicing(AS)events,and combined with RNA immunoprecipitation sequencing,revealed that minichromosome maintenance complex component 7(MCM7)binds to RPS6,which regulates its AS and increases oncogenic activity in *** RPS6 with vivo phosphorodiamidate morpholino oligomer(V-PMO)significantly inhibited the growth of CCA cells,patient-derived organoids,and subcutaneous xenograft *** together,the data demonstrate that RPS6 is an oncogenic regulator in CCA and that RPS6-V-PMO could be repositioned as a promising strategy for treating CCA.

关键词： Cholangiocarcinoma Ribosomal protein S6 Alternative splicing p53 Minichromosome maintenance complex component 7 Vivo morpholino Patient-derived organoids

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儿童急性淋巴细胞白血病化学治疗常规药物耐药机制的研究进展

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上海交通大学学报（医学版） 2022年第2期42卷 211-217页

作者：林艳艳许岩李慧上海交通大学医学院附属上海儿童医学中心儿科转化医学研究所国家卫生健康委员会儿童血液肿瘤重点实验室上海200127

急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)在儿童血液肿瘤中发病率最高,占比约为所有儿童癌症的三分之一。随着治疗方案的不断优化和我国医疗保障水平的持续提升,儿童ALL的治疗效果取得了显著的改善,5年以上总体生存率可达... 详细信息

急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)在儿童血液肿瘤中发病率最高,占比约为所有儿童癌症的三分之一。随着治疗方案的不断优化和我国医疗保障水平的持续提升,儿童ALL的治疗效果取得了显著的改善,5年以上总体生存率可达90%。然而临床耐药复发的出现且有效治疗手段的欠缺,导致患儿的生存期和生活质量严重下降。近年来,ALL耐药的发病和调控机制成为国内外研究的热点和难点。研究表明,ALL患儿不仅可能对某一种化学治疗(化疗)药物产生耐药,更可能存在多重耐药的棘手情况。因此,完善ALL耐药机制的研究,对改善ALL患儿的预后有重要意义。该文从儿童ALL治疗的常规化疗药物入手,回顾相关化疗药物耐药的既往文献,分别对激素类、抗代谢类(叶酸拮抗剂类、硫嘌呤类、促氨基酸代谢类)、生物碱类、蒽环类在内的多种药物耐药机制的研究现状进行综述,以期为应对儿童ALL化疗常规药物临床耐药问题提供理论基础。

关键词：急性淋巴细胞白血病儿童化学治疗耐药机制复发

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考虑干涉情况的多台龙门吊作业路径优化

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上海海事大学学报 2012年第2期33卷 47-54页

作者：林艳艳乐美龙上海海事大学科学研究院上海201306

为研究龙门吊进行出口集装箱组装载的路径优化问题,在多台龙门吊间干涉的情况下,以实现多台龙门吊运行时间、准备时间及装卸集装箱时间等在内的工作总时间最少为目标,设计混合整数规划模型.应用C#_2008编程,并调用Gurobi_4.5对实例数据... 详细信息

为研究龙门吊进行出口集装箱组装载的路径优化问题,在多台龙门吊间干涉的情况下,以实现多台龙门吊运行时间、准备时间及装卸集装箱时间等在内的工作总时间最少为目标,设计混合整数规划模型.应用C#_2008编程,并调用Gurobi_4.5对实例数据进行运算求解.分析、比较所得结果验证所建模型的有效性.

关键词：龙门吊路径优化调度集装箱堆场干涉

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考虑无功功率协调的微网二级电压控制

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中国电机工程学报 2018年第4期38卷 1084-1092页

作者：肖宏飞钱浩林艳艳范博杭州电子科技大学

该文对微网电压控制问题进行了研究,提出了协调无功功率分配的二级电压控制策略。所提的控制策略可实现无功功率分配及电压补偿。文中分别以直接电压控制、间接无功功率控制、无功–电压混合控制为目标,建立微网二级调压模型。研究表明... 详细信息

该文对微网电压控制问题进行了研究,提出了协调无功功率分配的二级电压控制策略。所提的控制策略可实现无功功率分配及电压补偿。文中分别以直接电压控制、间接无功功率控制、无功–电压混合控制为目标,建立微网二级调压模型。研究表明：直接电压控制可实现电压的精确控制但无法保证无功功率的合理分配;间接无功功率控制可实现分布式电源（distributed generation,DG）间无功功率的最合理分配,但电压控制精确略低;无功–电压混合控制在保证合理分配无功功率的前提下能获得较好的电压控制效果,且优化电压权系数可进一步提高电压控制精度,而无功功率分配系数的自由设置可增加微网运行的灵活性与自由度。

关键词：微网二级电压调整无功分配电压权系数集中控制

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