检索结果-南通市图书馆

Intra-Articular injection of acid-sensitive stearoxyl-ketal-dexamethasone microcrystals for long-acting arthritis therapy

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2021年第2期16卷 213-221页

作者： Yang Xu Ziqi Chen Zunkai Xu yanyan du Jianghao Han Xiaoyong Yuan Shubiao Zhang Shutao Guo Key Laboratory of Functional Polymer Materials of Ministry of Education State Key Laboratory of Medicinal Chemical Biology and Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin 300071China Key Laboratory of Biotechnology and Bioresources Utilization of Ministry of Education Dalian Minzu UniversityDalian 116600China Clinical College of Ophthalmology Tianjin Medical UniversityTianjin Eye HospitalTianjin Key Laboratory of Ophthalmology and Visual ScienceTianjin Eye InstituteTianjin 300022China

Despite advances in treatment of chronic arthritis,there is still a strong need for the development of long-acting formulations that can enable local and sustained drug release at the inflamed *** this work,we fabricated microcrystals of an acid-sensitive stearoxyl-ketal-dexamethasone prodrug for treatment of *** of the prodrug with two sizes were successfully engineered and showed pH-dependent hydrolysis kinetics in *** a collagen-induced arthritis rat model,we evaluated the influence of particle size and injection dose on anti-inflammatory effect after intra-articular *** prodrug demonstrated long-acting anti-arthritis effects with good *** results indicate ketal-based prodrugs are promising for the development of long-acting injectables and may stimulate the development of new treatments for chronic diseases.

关键词： Microcrystals Dexamethasone Prodrugs Long-acting formulations Arthritis

Research and Development Situation of International Biomass Energy Based on Bibliometrics

在线全文

学校读者我要写书评

暂无评论

Meteorological and Environmental Research 2014年第7期5卷 57-60页

作者： du yanyan Guo Binmei Shi Jiahiu Institute of Scientific and Technical Information of China

Taking ISI Web of Science thesis database as the data source of document retrieval, and biomass energy and related words as the index words, a retrieval of papers from 2000 to 2013 was conducted, and the research and development situation of international biomass energy were analyzed from aspects of quantity, region, organization, sources, subject and influence. The results show that the number of papers on biomass energy research presented the linear growth as a whole over the past years. United States, China, Germany and Canada had become the focus countries of the study of biomass energy. Environmental science and ecology, agronomy, engineering and bio-technology, etc. had become the key areas of biomass energy research. Highly cited papers in the field of biomass energy had published in Nature, Science, Chemical Reviews and so forth, which shows that biomass energy research has become an international hot spot.

关键词： Biomass Energy Bibliometdcs Development situation China

Effect of nutritional intervention on nonalcoholic fatty liver disease in overweight and obese patients

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of nutritional intervention on nonalcoholic fatty liv...

中国营养学会第十五届全国营养科学大会

作者： yanyan du Qihua Zhao Yusheng Shu Department of Clinical Nutrition Northern Jiangsu People's Hospital Clinical Medical College Yangzhou University Department of Thoracic Surgery North Jiangsu People's Hospital

To analyze the therapeutic effect of nutritional intervention on non-alcoholic fatty liver disease in the patients of overweight and obese. Methods 167 cases were recruited and 9 cases were dropped out in this study. Observed and recorded the changes of the body weight, waist circumference, Aspartate aminotransferase, Alanine aminotransferase, triglycerides, and Cholesterol of these patients after 2 months. Results All the indicators were decreased compared with those before nutrition intervention;The decline degree of body weight, waist circumference, Aspartate aminotransferase, Alanine aminotransferase, and triglycerides in the obese group(BMI≥28 kg/m) were lower than those in the obese group(24 kg/m≤BMI5%), but there was no statistical significance. Conclusion Nutritional intervention is effective in improving the clinical indicators of both overweight and obese patients with Non-alcoholic fatty liver disease, and the effect is not affected by the Body Mass Index of patients and the speed of weight loss before intervention. Therefore, overweight or obese patients with Non-alcoholic fatty liver disease are encouraged to actively conduct the nutritional intervention.

关键词： Nutrition intervention overweight obesity Nonalcoholic fatty liver disease

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

俄罗斯师范教育现代化再出发：方向与措施

教育研究 2015年第9期36卷 146-151页

作者：杜岩岩辽宁师范大学田家炳教育书院大连116029

经过二十余年的改革探索,当前俄罗斯师范教育现代化进程受阻:一方面,由于教师职业声望下降和传统培养模式局限,导致未来教师能力不足,无法满足基础教育需要;另一方面,由于封闭单一的教育体制困境无法突破。为此,俄罗斯教育与科学部实施... 详细信息

经过二十余年的改革探索,当前俄罗斯师范教育现代化进程受阻:一方面,由于教师职业声望下降和传统培养模式局限,导致未来教师能力不足,无法满足基础教育需要;另一方面,由于封闭单一的教育体制困境无法突破。为此,俄罗斯教育与科学部实施了旨在提高教师培养质量的师范教育现代化工程,并通过引入全纳教育理念,更新教育内容和实践环节,创新体制机制等措施推进师范教育现代化的进程。

关键词：俄罗斯师范教育现代化

在线全文

学校读者我要写书评

暂无评论

俄罗斯研究型大学的战略规划与竞争力管理

教育科学 2013年第4期29卷 91-96页

作者：杜岩岩辽宁师范大学田家炳教育书院暨教育学院辽宁大连116029

本文在探讨俄罗斯大学战略管理新趋势的基础上,着重对《2009-2020年俄罗斯国立高等经济大学发展规划》及《2009-2011发展规划实施总结报告》文本进行系统分析,旨在进一步揭示出俄罗斯研究型大学的战略框架及其竞争力管理策略。

关键词：俄罗斯研究型大学战略规划竞争力管理

在线全文

学校读者我要写书评

暂无评论

俄罗斯工程教育全球战略的目标及实施路径

教育研究 2016年第4期37卷 134-139页

作者：杜岩岩辽宁师范大学田家炳教育书院暨教育学院

俄罗斯工程教育面临着国际工程教育全球化和国内发展新型工业化的双重挑战。从学位体制与欧洲接轨、引进CDIO教育模式、创建"三重螺旋"协同创新模式和加入世界两大工程教育认证体系等方面进行一系列的国际化改革,体现出俄罗斯工程教育... 详细信息

俄罗斯工程教育面临着国际工程教育全球化和国内发展新型工业化的双重挑战。从学位体制与欧洲接轨、引进CDIO教育模式、创建"三重螺旋"协同创新模式和加入世界两大工程教育认证体系等方面进行一系列的国际化改革,体现出俄罗斯工程教育全球战略的目标定位合理、战略措施切实可行和质量保障体系健全等特点。受俄罗斯工程教育全球战略的启发,我国工程教育应以全球化和新工业革命为导向,重构工程教育体系;瞄准全球工程教育前沿,全面创新教育模式与机制;积极推动创新创业教育改革,培养国际化高端技术人才。

关键词：俄罗斯工程教育全球战略