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Progress in Natural Science:Materials International 2020年第3期30卷 437-442页

作者： yanyan fan Hongbin Zhao Feng Wei Yi Yang Tianling Ren Hailing Tu State Key Laboratory of Advanced Materials for Smart Sensing General Research Institute for Nonferrous Metals GRIMAT Engineering Institute Co. Ltd General Research Institute for Nonferrous Metals Institute of Microelectronics Tsinghua University Beijing National Research Center for Information Science and Technology (BNRist) Tsinghua University

High performance flexible pressure sensors have received tremendous attention due to the potential applications in wearable electronics and humanoid ***,a low-cost,time-saving fabrication strategy is reported to efficiently construct highly sensitive and scalable pressure sensors based on *** flexible pressure sensor was prepared through a dip coating approach where the graphene ink was used as the active material and textile with ordered network structure,serves as the flexible support *** increasing the number of layers of the textile,the pressure sensor could achieve a high linear sensitivity value of 0.23 kPa;,a broad pressure range from 0 to 140 kPa,and a durability over 800 *** was found that the network structure of the graphene-textile contributed to the enhancement of the sensing performance due to the piezoresistive effect resulting from the deformation of conductive ***,by virtue of its exceptional properties,it is demonstrate that the high performance flexible pressure sensor could be further used to detect human physiological signals,such as wrist pulse,finger press detection and walking state monitoring,indicating its promising potential to flexible and wearable electronics.

关键词： Graphene ink Pressure sensor Flexible device Network structure textile Piezoresistive effect

Recent Advances in Super-Resolution Fluorescence Imaging and Its Applications in Biology

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Journal of Genetics and Genomics 2013年第12期40卷 583-595页

作者： Rongcheng Han Zhenghong Li yanyan fan Yuqiang Jiang Institute of Genetics and Developmental Biology Chinese Academy of Sciences Institute of Opto-Electronic Materials and Technology South China Normal University

Fluorescence microscopy has become an essential tool for biological research because it can be minimally invasive, acquire data rapidly, and target molecules of interest with specific labeling strategies. However, the diffraction-limited spatial resolution, which is classically limited to about 200 nm in the lateral direction and about 500 nm in the axial direction, hampers its application to identify delicate details of subcellular structure. Extensive efforts have been made to break diffraction limit for obtaining high-resolution imaging of a biological specimen. Various methods capable of obtaining super-resolution images with a resolution of tens of nanometers are currently available. These super-resolution techniques can be generally divided into three primary classes：（1） patterned illumination- based super-resolution imaging, which employs spatially and temporally modulated illumination light to reconstruct sub-diffraction structures; （2） single-molecule localization-based super-resolution imaging, which localizes the profile center of each individual fluo- rophore at subdiffraction precision; （3） bleaching/blinking-based super-resolution imaging. These super-resolution techniques have been utilized in different biological fields and provide novel insights into several new aspects of life science. Given unique technical merits and commercial availability of super-resolution fluorescence microscope, increasing applications of this powerful technique in life science can be expected.

关键词： Super-resolution Bio-imaging Fluorescence microscopy Optical diffraction limit

Breast secretory carcinoma: a clinicopathologic study of four cases

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The Chinese-German Journal of Clinical Oncology 2009年第6期8卷 329-331页

作者： Yihua Chen Juan Li Yi Jian yanyan fan Department of Pathology General Hospital of Chengdu Military Command Chengdu 610083 China Department of Pathology Chengdu Medical College Chengdu 610083 China

Objective: To explore the clinicopathologic features of secretory carcinoma of breast (SCB). Methods: Four cases of SCB were analyzed by light microscopy, histochemistry, immunohistochemistry and electron microscopy. The clinical data were also analyzed. Special staining of periodic acid-Schiff reaction with diastase pretreatment, immunohistochemical staining of ER, PR, HER-2, p53, MIB-1, S-100, p63, CK8/18 and EMA by En Vision method were performed. Results: Solid, cribriform, tubular, or papillary architecture may be seen. Tumor forms cystic spaces filled with abundant pale pink secretory material, positive with diastase resistant periodic acid-Schiff (PAS-DR) stains. Tumor cells were small with bland nuclei and abundant pale, eosinophilic cytoplasm, rare mitotic activity and necrosis. Immunohistochemically, tumor cells were positive for CK8/18, EMA, negative for S-100, p63 and variable partially positive for p53, ER, PR, HER-2 and MIB-1. Under electron microscopy, the tumor cells possessed numerous membrane-bound secretory vacuoles in cytoplasm lined by microvilli. Conclusion: SCB is a rare, low-malignant neoplasm. SCB have pathology, clinical picture, treatment, follow-up, immunohistochemical and genetic features that distinguish them from invasive ductal carcinomas of the usual type.

关键词： breast neoplasms secretory carcinoma histochemistry immunohistochemistry ultramicrostructure

物元可拓法在地铁盾构施工安全风险评估中的应用

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安全与环境学报 2023年第6期23卷 1779-1790页

作者：樊燕燕王瑞兰州交通大学土木工程学院兰州730070

针对地铁盾构施工安全风险评估结果不完善、精确度不高等问题,采用DEMATEL ISM法与物元可拓评估模型相结合,对地铁盾构施工安全风险进行科学合理的评估。首先,以文献整理为基础,结合工程实际,从人员及管理、机械设备、施工材料、施工技... 详细信息

针对地铁盾构施工安全风险评估结果不完善、精确度不高等问题,采用DEMATEL ISM法与物元可拓评估模型相结合,对地铁盾构施工安全风险进行科学合理的评估。首先,以文献整理为基础,结合工程实际,从人员及管理、机械设备、施工材料、施工技术及施工环境5个方面建立地铁盾构施工安全风险评估指标体系;其次,采用DEMATEL ISM法分析关键影响因素和影响程度以及因素间的层级结构;再次,考虑指标间的关联影响,引用shapley值法确定指标权重,采用物元可拓法构建地铁盾构施工安全风险评估模型;最后,对宁波地铁3号线一期句章鄞州客运区间应用所建模型进行实例分析,结果表明,其风险评估等级为“中度风险”。其中,人员及管理、施工技术及施工环境所属风险等级相对较高,该区间盾构施工时管理人员应重点监测地质环境,并严格做好地基加固等施工技术工作。

关键词：安全工程地铁盾构法 DEMATEL ISM分析法 shapley值法物元可拓法风险评估

基于DSR-灰云模型的西北城市抗震韧性评估

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防灾减灾工程学报 2022年第6期42卷 1191-1202页

作者：樊燕燕刘轩谷兰州交通大学土木工程学院甘肃兰州730070

城市抗震系统是一个复杂的系统,对其进行韧性评估是检验城市系统抗震能力的重要手段。在分析城市抗震系统构成的基础上,结合DSR模型,从抗灾因素、承灾因素和恢复因素三方面构建城市系统抗震韧性评估指标体系。为解决指标体系中存在的模... 详细信息

城市抗震系统是一个复杂的系统,对其进行韧性评估是检验城市系统抗震能力的重要手段。在分析城市抗震系统构成的基础上,结合DSR模型,从抗灾因素、承灾因素和恢复因素三方面构建城市系统抗震韧性评估指标体系。为解决指标体系中存在的模糊性、随机性及灰色不确定等复杂问题,引入灰色白化权函数云模型,结合各指标的灰云模型图,计算各指标实际的聚类系数,最后根据最大隶属度原则计算出城市的抗震韧性评估等级。以西北地区14座城市为例,验证该方法的可行性和合理性,结果表明:兰州市与武威市的城市抗震韧性等级为Ⅳ级,白银、天水、张掖、平凉、酒泉、庆阳及定西7市的城市抗震韧性等级为Ⅲ级,嘉峪关、金昌、陇南、合作与临夏5市的城市抗震韧性等级为Ⅱ级,研究成果可为城市抗震韧性评估提供一种新方法。

关键词：城市抗震韧性 DSR模型灰云模型韧性评估

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小学德育教材中“问题”的比较研究——基于人教社两套小学三年级德育教材

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上海教育科研 2009年第11期 64-66页

作者：章乐范燕燕上海师范大学教育学院 200234 南京市中山小学 210007

通过"问题"呈现位置的比较,发现"问题"从利于教向利于学转变,从灌输向对话转变;通过"问题"类型的比较,发现"问题"从认知取向向情感取向转变,从知、情、行比例严重失调向三者协调转变,而且新教材更加重视综合型问题;通过"问题"表述的比较... 详细信息

通过"问题"呈现位置的比较,发现"问题"从利于教向利于学转变,从灌输向对话转变;通过"问题"类型的比较,发现"问题"从认知取向向情感取向转变,从知、情、行比例严重失调向三者协调转变,而且新教材更加重视综合型问题;通过"问题"表述的比较,发现"问题"从练习味向生活味转变,从图文结合以文为主向图文结合以图为主转变,从第二人称表述为主向第一人称表述为主转变。

关键词：问题小学德育德育教材

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子宫内膜癌与宫颈癌淋巴结转移分布的比较

中国肿瘤临床 2009年第21期36卷 1216-1218,1224页

作者：范艳艳付艳贾赞慧郑桂英吉林大学第一医院妇产科长春市130021 吉林大学第二医院妇产科

目的:分析子宫内膜癌淋巴结转移模式并比较子宫内膜癌与宫颈癌淋巴结转移分布的不同。方法:回顾性分析接受系统的盆腔和腹主动脉旁淋巴结切除的104例子宫内膜癌以及253例宫颈癌患者淋巴结转移情况,比较二者的不同。结果:与宫颈癌相比,... 详细信息

目的:分析子宫内膜癌淋巴结转移模式并比较子宫内膜癌与宫颈癌淋巴结转移分布的不同。方法:回顾性分析接受系统的盆腔和腹主动脉旁淋巴结切除的104例子宫内膜癌以及253例宫颈癌患者淋巴结转移情况,比较二者的不同。结果:与宫颈癌相比,子宫内膜癌淋巴结转移率较高(22.1%vs 16.2%),并且子宫内膜癌的淋巴结转移与病理分级(G1:12.1%;G2:21.4%;G3:34.5%)、肌层浸润深度(≤1/2:11.9%>1/2:29%)有关;子宫内膜癌单纯盆腔淋巴结转移率偏低(34.8%vs 68.3%),单纯腹腔淋巴结转移率偏高(4.3%vs0),盆腹淋巴结共同受累的发生率偏高(60.9%vs 31.7%)。宫颈癌中腹主动脉旁淋巴结转移的患者100%有盆腔淋巴结转移,而内膜癌93.3%的腹主动脉旁淋巴结阳性的患者有盆腔淋巴结转移。内膜癌与宫颈癌最易受累淋巴结均为闭孔淋巴结(内膜癌:73.9%、宫颈癌:70.7%),受累最少的均为腹股沟淋巴结(内膜癌:8.7%、宫颈癌:7.3%),与宫颈癌相比,子宫内膜癌腹主动脉旁淋巴结(65.2%vs31.7%)、骶前淋巴结(21.7%vs17.1%)的受累几率较高,而髂外淋巴结受累的几率偏低(17.4%vs41.5%)。结论:子宫内膜癌淋巴结转移方式不同于宫颈癌,虽然内膜癌主要向盆腔淋巴结转移,但是仍然存在直接向腹主动脉旁淋巴结转移的病例并且各病理分级的内膜癌均有淋巴结转移的可能。

关键词：子宫内膜癌淋巴结转移盆腔淋巴结腹腔淋巴结宫颈癌

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腰椎间盘突出症保守治疗疗效研究

中国卫生标准管理 2015年第10期6卷 215-216页

作者：范岩岩武警黑龙江省总队第一支队卫生队哈尔滨150075

目的：研究探讨保守治疗腰椎间盘突出症的临床效果。方法采用我单位2008年4月-2013年4月收治的腰椎间盘突出症患者60例为研究对象。所有患者均采用保守治疗的方法进行指标，观察患者的临床治疗效果。结果治疗结果显示，患者的治疗效果... 详细信息

目的：研究探讨保守治疗腰椎间盘突出症的临床效果。方法采用我单位2008年4月-2013年4月收治的腰椎间盘突出症患者60例为研究对象。所有患者均采用保守治疗的方法进行指标，观察患者的临床治疗效果。结果治疗结果显示，患者的治疗效果较为显著，其中治愈的有49例，好转的有7例，治疗无效的有4例，所有患者治疗有效率为93.3%。结论腰椎间盘突症患者在治疗的过程中采用保守治疗的方法能够明显改善患者腰椎间盘突出症的疼痛感。针对腰椎间盘突出症患者，保守治疗方法不仅易于患者接受，还能够为患者提供更全面的服务。

关键词：腰椎间盘突出症保守治疗疗效