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Photonics Research 2024年第6期12卷 1303-1312页

作者： yanxian guo YE LIU CHAOCAI LUO YUE ZHANG YANG LI FEI ZHOU ZHOUYI guo ZHENGFEI ZHUANG ZHIMING LIU School of Electronic Engineering and Intelligentization Dongguan University of TechnologyDongguan 523808China Department of Physics University of Science and Technology of ChinaHefei 230026China MOE Key Laboratory of Laser Life Science&Guangdong Provincial Key Laboratory of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China

Rapid detection of pathogens present on contaminated surfaces is crucial for food safety and public health due to the high morbidity and mortality of bacterial ***,a sensitive and efficient method for on-site identification of foodborne pathogens on anisotropic surfaces was developed by using an in situ instantaneously prepared surface-enhanced Raman scattering(SERS)*** achieve this,molybdenum-doped gallic acidderived carbon dots(MCDs)are utilized as the reductant for synthesizing Au@MCDs nanohybrids within just 3 s at ambient *** synergistic effect of the electromagnetic enhancement and charge transfer of Au@MCDs enables excellent SERS performance 10 times stronger than bare Au *** bioassay platform requires less than 5 min to complete the quantitative detection of foodborne pathogens on various microbial-contaminated interfaces with a sensitivity of 10 CFU/m *** innovative strategy breaks the long-standing limitations of SERS substrates in practical use,such as the time-consuming process,interference of residual surfactants,poor surface stability,and few application scenarios,providing a promising tool for widespread applications in biomedical research and clinical diagnostics.

关键词： temperature molybdenum consuming

Rapid label-free SERS detection of foodborne pathogenic bacteria based on hafnium ditelluride-Au nanocomposites

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Journal of Innovative Optical Health Sciences 2020年第5期3卷 105-115页

作者： Yang Li yanxian guo Binggang Ye Zhengfei Zhuang Peilin Lan Yue Zhang Huiqing Zhong Hao Liu Zhouyi guo Zhiming Liu SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology&Guangdong Provincial Key Laboratory of Laser Life Science College of Biophotonics South China Normal University GuangzhouGuangdong 510631P.R.China Healthy Medical Engineering Technology Research Center Guangdong Food and Drug Vocational College Guangzhou 510520 P.R.China

Two-dimensional(2D)nanomaterials have captured an increasing attention in biophotonics owing to their excellent optical ***,2D hafnium ditelluride(HfTe_(2)),a new member of transition metal tellurides,is exploited to support gold nanoparticles fabricating HfTe_(2)-Au *** nanohybrids can serve as novel 2D surface-enhanced Raman scattering(SERS)substrate for the label-free detection of analyte with high sensitivity and *** mechanism originated from HfTe_(2) nanosheets and the electromagnetic enhancement induced by the hot spots on the nano-hybrids may largely contribute to the superior SERS effect of HfTe_(2)-Au ***,HfTe_(2)-Au nanocomposites are utilized for the label-free SERS analysis of foodborne pathogenic bac-teria,which realize the rapid and ultrasensitive Raman test of Escherichia coli,Listeria mono-cytogenes,Staphylococcus aureus and Salmonella with the limit of detection of 10 CFU/mL and the maximum Raman enhancement factor up to 1.7×10^(8).Combined with principal component analysis,HfTe_(2)-Au-based SERS analysis also completes the bacterial classification without extra treatment.

关键词： Two-dimensional nanomaterials hafnium ditelluride surface-enhanced Raman scattering foodborne pathogenic bacteria

Label-free breast cancer detection and classification by convolutional neural network-based on exosomes surface-enhanced raman scattering

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Journal of Innovative Optical Health Sciences 2023年第2期16卷 3-15页

作者： Xiao Ma Honglian Xiong Jinhao guo Zhiming Liu Yaru Han Mingdi Liu yanxian guo Mingyi Wang Huiqing Zhong Zhouyi guo MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology&Guangdong Provincial Key Laboratory of Laser Life Science Guangzhou Key Laboratory of Spectral Analysis and Functional Probes College of Biophotonics South China Normal University Guangzhou 510631 P.R.China Department of Physics and Optoelectronic Engineering Foshan University Guangdong 528011P.R.China

Because the breast cancer is an important factor that threatens women's lives and health,early diagnosis is helpful for disease screening and a good *** are nanovesicles,secreted from cells and other body fluids,which can reflect the genetic and phenotypic status of parental *** with other methods for early diagnosis of cancer(such as circulating tumor cells(CTCs)and circulating tumor DNA),exosomes have a richer number and stronger biological stability,and have great potential in early ***,it has been proposed as promising biomarkers for diagnosis of early-stage ***,distinguishing different exosomes remain is a major biomedical *** this paper,we used predictive Convolutional Neural model to detect and analyze exosomes of normal and cancer cells with surface-enhanced Raman scattering(SERS).As a result,it can be seen from the SERS spectra that the exosomes of MCF-7,MDA-MB-231 and MCF-10A cells have similar peaks(939,1145 and 1380 cm^(-1)).Based on this dataset,the predictive model can achieve 95%*** with principal component analysis(PCA),the trained CNN can classify exosomes from different breast cancer cells with a superior *** results indicate that using the sensitivity of Raman detection and exosomes stable presence in the incubation period of cancer cells,SERS detection combined with CNN screening may be used for the early diagnosis of breast cancer in the future.

关键词： Exosomes surface-enhanced Raman scattering(SERS) breast cancer convolutional neural model label-free

Lamellar hafnium ditelluride as an ultrasensitive surface-enhanced Raman scattering platform for label-free detection of uric acid

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Photonics Research 2021年第6期9卷 1039-1047页

作者： YANG LI HAOLIN CHEN yanxian guo KANGKANG WANG YUE ZHANG PEILIN LAN JINHAO guo WEN ZHANG HUIQING ZHONG ZHOUYI guo ZHENGFEI ZHUANG ZHIMING LIU MOE Key Laboratory of Laser Life Science&SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China Department of Hematology The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107China Department of Medical Biotechnology School of Basic Medical SciencesGuangzhou University of Chinese MedicineGuangzhou 510006China

The development of two-dimensional(2D)transition metal dichalcogenides has been in a rapid growth phase for the utilization in surface-enhanced Raman scattering(SERS)***,we report a promising 2D transition metal tellurides(TMTs)material,hafnium ditelluride(HfTe2),as an ultrasensitive platform for Raman identification of trace molecules,which demonstrates extraordinary SERS activity in sensitivity,uniformity,and *** highest Raman enhancement factor of 2.32×10^(6)is attained for a rhodamine 6G molecule through the highly efficient charge transfer process at the interface between the HfTe2 layered structure and the adsorbed *** the same time,we provide an effective route for large-scale preparation of SERS substrates in practical applications via a facile stripping *** application of the nanosheets for reliable,rapid,and label-free SERS fingerprint analysis of uric acid molecules,one of the biomarkers associated with gout disease,is performed,which indicates arresting SERS signals with the limits of detection as low as 0.1 mmol/*** study based on this type of 2D SERS substrate not only reveals the feasibility of applying TMTs to SERS analysis,but also paves the way for nanodiagnostics,especially early marker detection.

关键词： stripping applying adsorbed

Insights into the deep-tissue photothermal therapy in near-infrared II region based on tumor-targeted MoO2 nanoaggregates

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Science China Materials 2020年第6期63卷 1085-1098页

作者： yanxian guo Yang Li Wolun Zhang Hongru Zu Haihong Yu Dongling Li Honglian Xiong Tristan THormel Chaofan Hu Zhouyi guo Zhiming Liu Guang Provincial Key Laboratory of Laser Life Science&SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology College of BiophotonicsSouth China Normal UniversityGuangzhou510631China Guangdong Provincial Engineering Technology Research Center for Optical Agriculture College of Materials and EnergySouth China Agricultural UniversityGuangzhou 510642China Department of Physics and Optoelectronic Engineering Foshan UniversityFoshan 528000China Casey Eye Institute Oregon Health and Science UniversityPortland97239 OregonUSA

Research on deep-tissue photothermal therapy(PTT)in the near-infrared II(NIR-II,1000–1350 nm)region has bloomed in recent years,owing to higher maximum permissible exposure and deeper tissue penetration over that in the near-infrared I(NIR-I,650–950 nm)***,more details need to be uncovered to facilitate a fundamental understanding of NIR-Ⅱ***,a tumor-targeted therapeutic nanosystem based on NIR-responsive molybdenum oxide(MoO2)nanoaggregates was *** photothermal conversion capabilities of MoO2 in the NIR-I andⅡregions were investigated step by step,from a simple tissue phantom to a three-dimensional cellular system,and further to a tumor-bearing animal ***-Ⅱlaser exhibited a lower photothermal attenuation coefficient(0.541 at1064 nm)in a tissue phantom compared with its counterpart(0.959 at 808 nm),which allows it to be more capable of deeptissue PTT in vitro and in *** profile analysis elucidated a negative correlation between the microstructural collapse of tumor tissue and the penetration ***,the depth-related tumor ablation was also studied by Raman fingerprint analysis,which demonstrated the major biochemical compositional disturbances in photothermal ablated tumor tissues,providing fundamental knowledge to NIR-Ⅱdeeptissue photothermal therapy.

关键词： second near-infrared window photothermal therapy molybdenum oxide depth profile analysis Raman biochemical assay

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黄曲霉毒素对畜禽危害和脱毒方法的研究进展

中国饲料 2024年第15期 143-149页

作者：索江华张宸连艳鲜何金环王梦迪郭永鹏河南牧业经济学院河南郑州450046 新疆农业大学动物科学学院新疆乌鲁木齐830052 河南农业大学动物科技学院河南郑州450011

黄曲霉毒素是一种重要饲料安全风险因子,污染范围非常广泛,对动物健康造成严重伤害。本文综述了黄曲霉毒素的理化性质、污染现状、对畜禽的危害及有效去除黄曲霉毒素的方法,为有效控制饲料中黄曲霉毒素对动物危害提供参考。

关键词：黄曲霉毒素生物降解法脱毒方法

基于CUMS模型探究抑郁症对细菌感染的影响及作用

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中山大学学报（医学科学版） 2024年第4期45卷 567-581页

作者：徐磊赵润平陈洁云杨艳鲜郭锡龙代敏田国宝秦丽娜成都医学院检验医学院四川成都610500 中山大学中山医学院广东广州510080 中山大学热带病防治教育部重点实验室广东广州510080 中山大学附属第五医院药学部广东珠海519000 中山大学医学院免疫学教研室广东深圳518107 中山大学中山医学院法医学教研室广东广州510080 广东省法医学转化医学工程技术研究中心广东广州510080

【目的】抑郁症是一种常见的精神疾病,对患者的身体健康有着深远的影响。抑郁症与较高的细菌感染风险相关;然而,这是否是一种因果关系,以及抑郁症如何影响感染仍不清楚。因此,本研究旨在通过构建慢性不可预测轻度应激(CUMS)模型,探究抑... 详细信息

【目的】抑郁症是一种常见的精神疾病,对患者的身体健康有着深远的影响。抑郁症与较高的细菌感染风险相关;然而,这是否是一种因果关系,以及抑郁症如何影响感染仍不清楚。因此,本研究旨在通过构建慢性不可预测轻度应激(CUMS)模型,探究抑郁表型在小鼠细菌感染中的作用。【方法】小鼠经CUMS诱导4周,通过行为学测试评估抑郁表型。随后,小鼠腹腔注射肺炎克雷伯菌模拟细菌感染,感染后48 h收集血清和腹腔组织。苏木精-伊红染色(HE)观察组织病理学改变,酶联免疫吸附试验(ELISA)检测炎性因子水平。此外,对感染前收集的小鼠粪便样本进行肠道菌群16S rDNA基因测序分析,并检测未感染小鼠结肠组织中NF-κB/NLRP3信号通路的表达水平。【结果】行为学测试结果显示,与对照组相比,CUMS小鼠体质量显著降低(P<0.0001,t=5.426),蔗糖偏好率显著降低(P<0.001,t=4.937),游泳静止时间显著增加(P<0.001,t=16.37),旷场中央区域停留时间显著减少(P<0.01,t=3.575)。生存分析显示,与对照组小鼠相比,感染后CUMS小鼠的生存率显著降低(P<0.05)。HE染色结果显示,CUMS小鼠肝脏(P<0.05,t=4.025)、肾脏(P<0.05,t=2.828)、肠系膜(P<0.01,t=5.367)组织损伤程度明显加重。ELISA结果显示,炎症因子IL-6(P<0.01,t=3.365)、IL-1β(P<0.01,t=4.061)、TNF-α(P<0.01,t=4.460)和LPS(P<0.0001,t=27.24)水平升高。16S rDNA测序结果显示,CUMS小鼠肠道菌群结构发生改变,与对照组小鼠明显不同,表现出菌群失调。与对照组相比,CUMS小鼠结肠组织中NF-κB(P<0.01,t=6.825)和NLRP3(P<0.001,t=9.561)的表达水平升高。【结论】CUMS小鼠发生更严重的细菌感染。CUMS诱导的抑郁表型可能因为破坏肠道菌群组成和激活NF-κB/NLRP3信号通路,增加了小鼠对细菌感染的易感性。

关键词：抑郁症慢性不可预测轻度应激感染肠道菌群炎症

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IL-37对MHCC97H细胞CD133表达的调控作用初步研究

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影像研究与医学应用 2017年第15期1卷 37-39页

作者：黎鹏杨煜鸿邱霖陈丹蕊郭燕娴许忆恩赵经哲王森广东医科大学基础医学院组胚教研室广东东莞523808

目的:探讨IL-37对肝细胞癌的MHCC97H细胞CD133表达的影响。方法:肝癌细胞系MHCC97H细胞分为对照组和过表达IL-37组,利用lip3000试剂盒进行基因转染,PCR检测IL-37及CD133的表达。结果:过表达组IL-37m RNA上升了37%(P<0.05),显示成功过表... 详细信息

目的:探讨IL-37对肝细胞癌的MHCC97H细胞CD133表达的影响。方法:肝癌细胞系MHCC97H细胞分为对照组和过表达IL-37组,利用lip3000试剂盒进行基因转染,PCR检测IL-37及CD133的表达。结果:过表达组IL-37m RNA上升了37%(P<0.05),显示成功过表达IL-37基因。过表达组CD133 m RNA下降了48%(P<0.05),显示过表达的IL-37抑制了CD133的m RNA表达。与对照组比较,过表达IL-37组细胞形态变为圆形,细胞体积缩小,细胞的数量也减少。结论:IL-37过表达抑制MHCC97H细胞的CD133的m RNA表达及细胞生长。

关键词： IL-37 肝细胞癌 CD133

医护一体化护理对冠心病患者PCI术后心功能及心血管不良事件发生率的影响

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临床医学工程 2024年第6期31卷 745-746页

作者：冷本芹李艳霞郭晓燕刘利贤新乡市中心医院(新乡医学院第四临床学院)心血管内科河南新乡457000

目的探讨医护一体化护理对冠心病患者经皮冠状动脉介入(PCI)术后心功能及主要心血管不良事件(MACE)发生率的影响。方法选取2020年6月至2022年6月于我院接受PCI治疗的86例冠心病患者,随机分为两组各43例。术后,对照组予以常规护理,观察... 详细信息

目的探讨医护一体化护理对冠心病患者经皮冠状动脉介入(PCI)术后心功能及主要心血管不良事件(MACE)发生率的影响。方法选取2020年6月至2022年6月于我院接受PCI治疗的86例冠心病患者,随机分为两组各43例。术后,对照组予以常规护理,观察组予以医护一体化护理。比较两组的心功能和MACE发生情况。结果护理后,观察组的LVESD、LVEDD均显著低于对照组,LVEF显著高于对照组(P<0.05)。观察组的MACE发生率为4.65%,显著低于对照组的20.93%(P<0.05)。结论医护一体化护理可有效恢复冠心病患者PCI术后的心功能,减少MACE的发生。

关键词：冠心病医护一体化护理心功能主要心血管不良事件

时间护理在监测急性心肌梗死发病规律中的应用

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护士进修杂志 2007年第1期22卷 16-17页

作者：郭学苹段艳贤泰达国际心血管病医院天津300457

目的探讨时间护理在监测急性心肌梗塞发病规律中的作用。方法调查105例急性心肌梗塞住院患者的发病时段，进行Х^2检验。结果6：01-12：00、18：01～0；00这两个时段与急性心肌梗塞患者的发病规律之间有统计学意义。结论护士应掌握不同... 详细信息

目的探讨时间护理在监测急性心肌梗塞发病规律中的作用。方法调查105例急性心肌梗塞住院患者的发病时段，进行Х^2检验。结果6：01-12：00、18：01～0；00这两个时段与急性心肌梗塞患者的发病规律之间有统计学意义。结论护士应掌握不同时段急性心肌梗塞的发病规律，进行针对性的监护，提高抢救成功率。

关键词：时间护理急性心肌梗塞护理