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Allogenic microglia replacement:A novel therapeutic strategy for neurological disorders

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Fundamental Research 2024年第2期4卷 237-245页

作者： yanxia Rao Bo Peng Department of Laboratory Animal Science MOE Frontiers Center for Brain ScienceFudan UniversityShanghai 200032China Department of Neurosurgery Huashan HospitalInstitute for Translational Brain ResearchState Key Laboratory of Medical NeurobiologyMOE Frontiers Center for Brain ScienceMOE Innovative Center for New Drug Development of Immune Inflammatory DiseasesFudan UniversityShanghai 200000China Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu 226001China

Microglia are resident immune cells in the central nervous system(CNS)that play vital roles in CNS development,homeostasis and disease *** defects in microglia lead to microglial dysfunction,which in turn leads to neurological *** correction of the specific genetic defects in microglia in these disorders can lead to therapeutic *** genetic defect correction approaches are dependent on viral vectorbased genetic defect ***,the viruses used in these approaches,including adeno-associated viruses,lentiviruses and retroviruses,do not primarily target microglia;therefore,viral vector-based genetic defect corrections are ineffective in *** replacement is a novel approach to correct microglial genetic defects via replacing microglia of genetic defects with allogenic healthy *** this paper,we systematically review the history,rationale and therapeutic perspectives of microglia replacement,which would be a novel strategy for treating CNS disorders.

关键词： Microglia Replacement Microglia replacement Microglia depletion Microglia-free niche CSF1R

Automatic Generation of Artificial Space Weather Forecast Product Based on Sequence-to-sequence Model

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空间科学学报 2024年第1期44卷 80-94页

作者：罗冠霆 ZOU Yenan CAI yanxia State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190 University of Chinese Academy of Sciences Beijing 100049 Key Laboratory of Science and Technology on Environment Space Situation Awareness Chinese Academy of SciencesBeijing 100190

Both analyzing a large amount of space weather observed data and alleviating personal experience bias are significant challenges in generating artificial space weather forecast *** the use of natural language generation methods based on the sequence-to-sequence model,space weather forecast texts can be automatically *** conduct our generation tasks at a fine-grained level,a taxonomy of space weather phenomena based on descriptions is ***,our MDH(Multi-Domain Hybrid)model is proposed for generating space weather summaries in two *** model is composed of three sequence-to-sequence-based deep neural network sub-models(one Bidirectional Auto-Regressive Transformers pre-trained model and two Transformer models).Then,to evaluate how well MDH performs,quality evaluation metrics based on two prevalent automatic metrics and our innovative human metric are *** comprehensive scores of the three summaries generating tasks on testing datasets are 70.87,93.50,and 92.69,*** results suggest that MDH can generate space weather summaries with high accuracy and coherence,as well as suitable length,which can assist forecasters in generating high-quality space weather forecast products,despite the data being starved.

关键词： Space weather Deep learning Data-to-text Natural language generation

Ultrastable graphene isolated Au Ag nanoalloy for SERS biosensing and photothermal therapy of bacterial infection

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Chinese Chemical Letters 2024年第3期35卷 198-203页

作者： Shengkai Li Zhiyang Li Qing Hao Shen wang yanxia Yang Jieqiong Xu Zhiwei Yin Liang Zhang Zhuo Chen Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of BiologyAptamer Engineering Center of Hunan ProvinceHunan UniversityChangsha 410082China School of Chemistry and Chemical Engineering/Guangzhou Key Laboratory for Clean Energy and Materials/Key Laboratory for Water Quality and Conservation of the Pearl River Delta Ministry of EducationGuangzhou UniversityGuangzhou 510006China

Plasmonic metal nanomaterials with intrinsic surface–enhanced Raman scattering(SERS)and photothermal properties,especially AuAg nanoalloys with both the outstanding merits of Au and Ag nanocrystals,show huge application prospects in bacterial ***,the direct exposure of AuAg nanoalloys in external conditions probably cause undesirable reactions and poisonous metal ion leakage during SERS detection and photothermal antibacterial therapy process,which severely hinder bacterial theranostics ***,we report an ultrastable graphene–isolated AuAg nanoalloy(GAA)with AuAg core confined in few–layer graphitic shell as a versatile platform for bacterial detection and *** encapsulation of graphene ensures the good stability of AuAg core,that its superior SERS and photothermal properties are therefore further *** is used for SERS detection of two vital bacterial biomarkers(including corrosive cyanide and pyocyanin),exhibiting good SERS quantitative and multiplexing *** is further used for photothermal antibacterial therapy application,and ultrahigh antibacterial efficacies for both Gram–negative Escherichia coli and Gram–positive Staphylococcus aureus are achieved under 808 nm laser *** work proposes a valuable method to develop robust bacterial theranostic platform.

关键词： Localized surface plasmon resonance Graphitic shell isolated AuAg nanoalloy(GAA) Surface–enhanced Raman scattering(SERS) Bacterial biomarker detection Photothermal antibacterial therapy

Lead-free perovskite Cs_(2)AgBiBr_(6)photodetector detecting NIR light driven by titanium nitride plasmonic hot holes

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Photonics Research 2024年第3期12卷 522-533页

作者： ZIJIAN LIU YUYING XI WENBO ZENG TING JI WENYAN wang SITONG GUO LINLIN SHI RONG WEN yanxia CUI GUOHUI LI College of Physics College of Electronic Information and Optical EngineeringKey Laboratory of Advanced Transducers and Intelligent Control System of Ministry of EducationTaiyuan University of TechnologyTaiyuan 030024China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032China

Lead-free perovskite Cs_(2)AgBiBr_(6)manifests great potential in developing high-performance,environmentally friendly,solution-processable photodetectors(PDs).However,due to the relatively large energy bandgap,the spectrum responses of Cs_(2)AgBiBr_(6)PDs are limited to the ultraviolet and visible region with wavelengths shorter than 560 *** this work,a broadband Cs_(2)AgBiBr_(6)PD covering the ultraviolet,visible,and near infrared(NIR)range is demonstrated by incorporating titanium nitride(TiN)nanoparticles that are prepared with the assistance of self-assembled polystyrene sphere *** addition,an atomically thick Al2O3layer is introduced at the interface between the Cs_(2)AgBiBr_(6)film and TiN nanoparticles to alleviate the dark current deterioration caused by nanoparticle *** a result,beyond the spectrum range where Cs_(2)AgBiBr_(6)absorbs light,the external quantum efficiency(EQE)of the TiN nanoparticle incorporated Cs_(2)AgBiBr_(6)PD is enhanced significantly compared with that of the control,displaying enhancement factors as high as 2000 over a broadband NIR wavelength *** demonstrated enhancement in EQE arises from the photocurrent contribution of plasmonic hot holes injected from TiN nanoparticles into Cs_(2)AgBiBr_(6).This work promotes the development of broadband solution-processable perovskite PDs,providing a promising strategy for realizing photodetection in the NIR region.

关键词： perovskite titanium ultraviolet

Enhancing the Electrocatalytic Oxidation of 5-Hydroxymethylfurfural Through Cascade Structure Tuning for Highly Stable Biomass Upgrading

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Nano-Micro Letters 2024年第12期16卷 449-467页

作者： Xiaoli Jiang Xianhui Ma Yuanteng Yang Yang Liu yanxia Liu Lin Zhao Penglei wang Yagang Zhang Yue Lin Yen Wei School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026People’s Republic of China The Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing 100084People’s Republic of China School of Materials Science and Engineering North Minzu UniversityYinchuan 750021People’s Republic of China

Electrocatalytic 5-hydroxymethylfurfural oxidation reaction(HMFOR)provides a promising strategy to convert biomass derivative to highvalue-added ***,a cascade strategy is proposed to construct Pd-NiCo_(2)O_(4)electrocatalyst by Pd loading on Ni-doped Co3O4 and for highly active and stable synergistic HMF *** elevated current density of 800 mA cm^(-2)can be achieved at 1.5 V,and both Faradaic efficiency and yield of 2,5-furandicarboxylic acid remained close to 100%over 10 consecutive *** and theoretical results unveil that the introduction of Pd atoms can modulate the local electronic structure of Ni/Co,which not only balances the competitive adsorption of HMF and OH-species,but also promote the active Ni^(3+)species formation,inducing high indirect oxidation *** have also discovered that Ni incorporation facilitates the Co2+pre-oxidation and electrophilic OH*generation to contribute direct oxidation *** work provides a new approach to design advanced electrocatalyst for biomass upgrading.

关键词： 5-Hydroxymethylfurfural oxidation reaction Competitive adsorption Cascade strategy Elevated current density

AWeb Application Fingerprint Recognition Method Based on Machine Learning

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 887-906页

作者： Yanmei Shi Wei Yu yanxia Zhao Yungang Jia School of Integrated Circuit Science and Engineering Tianjin University of TechnologyTianjin300382China College of International Business Zhejiang Yuexiu UniversityShaoxing312030China School of Public Administration Zhejiang Gongshang UniversityHangzhou310018China Tianjin Branch of National Computer Network Emergency Response Technical Team/Coordination Center of China Tianjin300100China

Web application fingerprint recognition is an effective security technology designed to identify and classify web applications,thereby enhancing the detection of potential threats and *** fingerprint recognition methods,which rely on preannotated feature matching,face inherent limitations due to the ever-evolving nature and diverse landscape of web *** response to these challenges,this work proposes an innovative web application fingerprint recognition method founded on clustering *** method involves extensive data collection from the Tranco List,employing adjusted feature selection built upon Wappalyzer and noise reduction through truncated SVD dimensionality *** core of the methodology lies in the application of the unsupervised OPTICS clustering algorithm,eliminating the need for preannotated *** transforming web applications into feature vectors and leveraging clustering algorithms,our approach accurately categorizes diverse web applications,providing comprehensive and precise fingerprint *** experimental results,which are obtained on a dataset featuring various web application types,affirm the efficacy of the method,demonstrating its ability to achieve high accuracy and broad *** novel approach not only distinguishes between different web application types effectively but also demonstrates superiority in terms of classification accuracy and coverage,offering a robust solution to the challenges of web application fingerprint recognition.

关键词： Web application fingerprint recognition unsupervised learning clustering algorithm feature extraction automated testing network security

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船舶最小推进功率导则对船型研发的影响研究

中国造船 2023年第2期64卷 62-69页

作者：王艳霞郑安燃中国船舶科学研究中心上海分部上海200011

EEDI的实施已进入第二阶段,船舶最小推进功率问题在业界受到普遍关注。国际海事组织(IMO)于2021年通过了“船舶在恶劣海况下维持操纵性的最小推进功率计算导则”,提高了船舶最小推进功率履约的难度。针对船舶最小推进功率新规范的要求,... 详细信息

EEDI的实施已进入第二阶段,船舶最小推进功率问题在业界受到普遍关注。国际海事组织(IMO)于2021年通过了“船舶在恶劣海况下维持操纵性的最小推进功率计算导则”,提高了船舶最小推进功率履约的难度。针对船舶最小推进功率新规范的要求,论文基于船、机、桨匹配设计与优化,研究船型参数、螺旋桨参数和主机转速的变化对船舶最小推进功率评估的影响,提出了我国在新船设计阶段的技术应对措施,供船舶行业参考。

关键词： EEDI 恶劣海况最小推进功率船舶设计

Hybrid hard carbon framework derived from polystyrene bearing distinct molecular crosslinking for enhanced sodium storage

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Carbon Energy 2024年第7期6卷 178-190页

作者： Yuqian Qiu Guangshen Jiang yanxia Su Xinren Zhang Yuxuan Du Xiaosa Xu Qian Ye Jinbo Zhang Miaohan Ban Fei Xu Hongqiang wang State Key Laboratory of Solidification Processing Center for Nano Energy MaterialsSchool of Materials Science and EngineeringNorthwestern Polytechnical University and Shaanxi Joint Laboratory of Graphene(NPU)Xi'anChina State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhouChina Shaanxi Yanchang Petroleum(Group)Co. Ltd.Dalian Institute of Chemical Physics Xi'anClean Energy(Chemical)Research InstituteXi'anChina

Exploiting high-performance yet low-cost hard carbon anodes is crucial to advancing the state-of-the-art sodium-ion ***,the achievement of superior initial Coulombic efficiency(ICE)and high Na-storage capacity via low-temperature carbonization remains challenging due to the presence of tremendous defects with few closed ***,a facile hybrid carbon framework design is proposed from the polystyrene precursor bearing distinct molecular bridges at a low pyrolysis temperature of 800℃ via in situ fusion and embedding *** is realized by integrating triazine-and carbonylcrosslinked polystyrene nanospheres during *** triazine crosslinking allows in situ fusion of spheres into layered carbon with low defects and abundant closed pores,which serves as a matrix for embedding the well-retained carbon spheres with nanopores/defects derived from carbonyl ***,the hybrid hard carbon with intimate interface showcases synergistic Na ions storage behavior,showing an ICE of 70.2%,a high capacity of 279.3 mAh g^(-1),and long-term 500 cycles,superior to carbons from the respective precursor and other reported carbons fabricated under the low carbonization *** present protocol opens new avenues toward low-cost hard carbon anode materials for high-performance sodiumion batteries.

关键词： closed pores hybrid hard carbons hypercrosslinking polystyrenes low-temperature carbonization sodium storage

Drought weakens the positive effect of plant diversity on community biomass

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Journal of Plant Ecology 2024年第4期17卷 141-153页

作者： Yanhui Hou Xiaona Li yanxia Hu Xuwei Lu Yue Ma Wenmin Li Xiran Lü Zimo Li Yaxuan Bai Chao wang Institute of Grassland Flowers and EcologyBeijing Academy of Agriculture and Forestry SciencesBeijing 100097China College of Grassland Science Shanxi Agricultural UniversityJinzhong 030801China College of Landscape Architecture and Art Henan Agricultural UniversityZhengzhou 450002China College of Agriculture and Forestry Hebei North UniversityZhangjiakou 075000China

Drought can greatly impact the biodiversity of an ecosystem and play a crucial role in regulating its ***,the specific mechanisms by which drought mediate the biodiversity effect(BE)on community biomass in above-and belowground through functional traits remain poorly ***,we conducted a common garden experiment in a greenhouse,which included two plant species richness levels and two water addition levels,to analyze the effects of biodiversity on aboveground biomass(AGB),belowground biomass(BGB)and total biomass(TB),and to quantify the relationship between BEs and functional traits under drought *** analysis focused on partitioning BEs into above-and belowground complementarity effect(CE)and selection effect(SE)at the species level,which allowed us to better understand the impacts of biodiversity on community biomass and the underlying *** results showed that plant species richness stimulated AGB,BGB and TB through *** decreased AGB,BGB and TB,*** addition,the aboveground CE was positively associated with the variation in plant *** in above-and belowground were negatively correlated with the community mean plant height and root length,***,drought weakened the aboveground CE by decreasing variation in plant height,resulting in a reduction in AGB and *** findings demonstrate that the complementarity of species is an important regulator of community biomass in above-and belowground,the dynamics of biomass under environmental stress are associated with the response of sensitive compartments.

关键词： biodiversity effect drought plant height root length aboveground biomass belowground biomass