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Deep neural network based on multi-level wavelet and attention for structured illumination microscopy

Journal of Innovative Optical Health Sciences 2024年第2期17卷 12-23页

作者： yanwei Zhang Song Lang Xuan cao Hanqing Zheng Yan Gong School of Biomedical Engineering(Suzhou)Division of Life Sciencesand Medicine University of Science and Technology of China Hefei Anhui230026P.R.China Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences Suzhou Jiangsu 215163P.R.China School of Physical Science and Technology Suzhou University of Science and Technology Suzhou Jiangsu 215009P.R.China

Structured illumination microscopy(SIM)is a popular and powerful super-resolution(SR)technique in biomedical research.However,the conventional reconstruction algorithm for SIM heavily relies on the accurate prior knowledge of illumination patterns and signal-to-noise ratio(SNR)of raw images.To obtain high-quality SR images,several raw images need to be captured under high fluorescence level,which further restricts SIM’s temporal resolution and its applications.Deep learning(DL)is a data-driven technology that has been used to expand the limits of optical microscopy.In this study,we propose a deep neural network based on multi-level wavelet and attention mechanism(MWAM)for SIM.Our results show that the MWAM network can extract high-frequency information contained in SIM raw images and accurately integrate it into the output image,resulting in superior SR images compared to those generated using wide-field images as input data.We also demonstrate that the number of SIM raw images can be reduced to three,with one image in each illumination orientation,to achieve the optimal tradeoff between temporal and spatial resolution.Furthermore,our MWAM network exhibits superior reconstruction ability on low-SNR images compared to conventional SIM algorithms.We have also analyzed the adaptability of this network on other biological samples and successfully applied the pretrained model to other SIM systems.

关键词： Super-resolution reconstruction multi-level wavelet packet transform residual channel attention selective kernel attention

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Atomic layer deposition in advanced display technologies:from photoluminescence to encapsulation

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International Journal of Extreme Manufacturing 2024年第2期6卷 65-82页

作者： Rong Chen Kun cao yanwei Wen Fan Yang Jian Wang Xiao Liu Bin Shan State Key Laboratory of Intelligent Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiPeople’s Republic of China State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiPeople’s Republic of China

Driven by the growing demand for next-generation displays,the development of advanced luminescent materials with exceptional photoelectric properties is rapidly accelerating,with such materials including quantum dots and phosphors,etc.Nevertheless,the primary challenge preventing the practical application of these luminescent materials lies in meeting the required durability standards.Atomic layer deposition(ALD)has,therefore,been employed to stabilize luminescent materials,and as a result,flexible display devices have been fabricated through material modification,surface and interface engineering,encapsulation,cross-scale manufacturing,and simulations.In addition,the appropriate equipment has been developed for both spatial ALD and fluidized ALD to satisfy the low-cost,high-efficiency,and high-reliability manufacturing requirements.This strategic approach establishes the groundwork for the development of ultra-stable luminescent materials,highly efficient light-emitting diodes(LEDs),and thin-film packaging.Ultimately,this significantly enhances their potential applicability in LED illumination and backlighted displays,marking a notable advancement in the display industry.

关键词： atomic layer deposition display luminescent encapsulation

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Strong Anisotropic Order Parameters at All-Nitride Ferromagnet/Superconductor Interfaces

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Chinese Physics Letters 2024年第2期41卷 102-111页

作者： Qiao Jin Meng Yang Guozhu Song Nan Zhao Shengru Chen Haitao Hong Ting Cui Dongke Rong Qianying Wang Yiyan Fan Chen Ge Can Wang Jiachang Bi yanwei cao Liusuo Wu Shanmin Wang Kui-Juan Jin Zhi-Gang Cheng Er-Jia Guo Beijing National Laboratory for Condensed Matter Physics and Institute of PhysicsChinese Academy of SciencesBeijing 100190China Department of Physics&Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Department of Physics Southern University of Science and TechnologyShenzhen 518055China Songshan Lake Materials Laboratory Dongguan 523808China Ningbo Institute of Materials Technology&Engineering Chinese Academy of SciencesNingbo 315201China

Proximity effects between superconductors and ferromagnets(SC/FM)hold paramount importance in comprehending the spin competition transpiring at their interfaces.This competition arises from the interplay between Cooper pairs and ferromagnetic exchange interactions.The proximity effects between transition metal nitrides(TMNs)are scarcely investigated due to the formidable challenges of fabricating high-quality SC/FM interfaces.We fabricated heterostructures comprising SC titanium nitride(TiN)and FM iron nitride(Fe_(3)N)with precise chemical compositions and atomically well-defined interfaces.The magnetoresistance of Fe_(3)N/TiN heterostructures shows a distinct magnetic anisotropy and strongly depends on the external perturbations.Moreover,the superconducting transition temperatureT_(C) and critical field of TiN experience notable suppression when proximity to Fe_(3)N.We observe the intriguing competition of interfacial spin orientations near𝑇T_(C)(∼1.25 K).These findings not only add a new materials system for investigating the interplay between superconductor and ferromagnets,but also potentially provide a building block for future research endeavors and applications in the realms of superconducting spintronic devices.

关键词： proximity Superconductor titanium

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The status,limitation and improvement of adoptive cellular immunotherapy in advanced urologic malignancies

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Chinese Journal of Cancer Research 2015年第2期27卷 128-137页

作者： Haoqing Shi Xiangjie Qi Bin Ma yanwei cao Lina Wang Lijiang Sun Haitao Niu Department of Urology Affiliated Hospital of Qingdao University Department of Urology People's Hospital of Linzi District Medical College of Qingdao University

In recent years, immunotherapy has been gradually established as the fourth frequently adopted antitumor therapy, following surgery, chemotherapy and radiotherapy, for advanced urologic malignancies with an improved understanding of theoretical basis, such as molecular biology and immunology. Thereinto, adoptive cellular immunotherapy （ACI） has become one of the hotspots, which comprises a variety of treatment approaches, such as TIL, CIK cell, ~＇~ T cell, CAR-engineered T cell and Allogeneie stem cell transplantation （alloSCT）. Although preclinical efficacy has been demonstrated remarkably, clinical trials could not consistently show the benefit due to multi-factors in complex immnnosuppressive microenvironment in vivo compared to that of in vitro. Here we review some timely aspects of ACI for advanced urologic malignancies, and describe the current status and limitation of immunotherapy from the cellular level. It＇s our expectation to provide prompting consideration of novel combinatorial ACI strategies and a resurgence of interest in ACI for advanced urologic malignancies.

关键词： Adoptive cellular immunotherapy （ACI） limitation improvement urologic malignancies

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Ceria supported Ru^(0)-Ru^(δ+) clusters as efficient catalyst for arenes hydrogenation

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Chinese Chemical Letters 2021年第2期32卷 770-774页

作者： yanwei cao Huan Zheng Gangli Zhu Haihong Wu Lin He State Key Laboratory for Oxo Synthesis and Selective Oxidation(OSSO) Suzhou Research Institute of LICPLanzhou Institute of Chemical Physics(LICP)Chinese Academy of Sciences(CAS)Lanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Henan Province Key Laboratory of New Opto-Elecrronic Functional Materials College of Chemistry and Chemical EngineeringAnyang Normal UniversityAnyang 455000China

Selective hydrogenation of aromatic amines,especially chemicals such as aniline and bis(4-aminocyclohexyl)methane for non-yellowing polyurethane,is of particular interests due to the extensive applications.To conquer the existing difficulties,in selective hydrogenation,,the Ru^(0)-Ru^(δ+)/CeO2 catalyst with solid frustrated Lewis pairs was developed for aromatic amines hydrogenation with excellent activity and selectivity under relative milder conditions.The morphology,electronic and chemical properties,especially the Ru^(O)-Ru^(δ+) clusters and reducible ceria were characterized by X-ray diffraction(XRD),transmission electron microscopy(TEM),sca nning electronic microscopy(SEM),X-ray photoelectron sp ectroscopy(XPS),CO_(2) tempe rature programmed deso rption(CO_(2)-TPD),H_(2) tempe rature programmed reduction(H_(2)-TPR),H_(2) diffuse reflectance Fourier transform infrared spectroscopy(H_(2)-DRIFT),Raman,etc.The 2% Ru/CeO_(2) catalyst exhibited good conversion of 95% and selectivity greater than 99% toward cyclohexylamine.The volcano curve describing the activity and Ru state was found.Owning to the "acidic site isolation" by surrounding alkaline sites,condensation between the neighboring amine molecules could be effectively suppressed.The catalyst also showed good stability and applicability for other aromatic amines and heteroarenes containing different functional groups.

关键词： Ceria Ruthenium Clusters Amines Hydrogenation

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超临界二氧化碳相变做功发射技术研究

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兵器装备工程学报 2024年第4期45卷 224-228页

作者：陈延伟曹明磊李奇中国船舶集团有限公司第七一三研究所郑州450015

超临界二氧化碳相变做功发射技术具有安全性高、成本低、清洁环保、烧蚀小等优势,近年来已成为气体炮、发射箱/筒以及无人机发射回收装置领域的热门研究课题。阐述了超临界二氧化碳相变做功发射技术的最新研究进展,分析了产品技术特点... 详细信息

超临界二氧化碳相变做功发射技术具有安全性高、成本低、清洁环保、烧蚀小等优势,近年来已成为气体炮、发射箱/筒以及无人机发射回收装置领域的热门研究课题。阐述了超临界二氧化碳相变做功发射技术的最新研究进展,分析了产品技术特点和典型应用场景,梳理了当前超临界二氧化碳相变做功发射的关键技术,提出了工程化建议与解决途径,为相关领域的研究人员提供了参考信息和解决思路。

关键词：超临界二氧化碳相变致裂管发射技术气体炮相变激发

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头颈联合3D-TOF-MRA人工智能辅助压缩感知序列的优化

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磁共振成像 2024年第4期15卷 139-144,152页

作者：袁畅张煜堃曹家骏宋清伟苗延巍大连医科大学附属第一医院放射科大连116011

目的通过比较施加不同加速因子(acceleration factors,AF)的并行采集(parallel imaging,PI)、压缩感知(compressed sensing,CS)、人工智能-压缩感知(artificial intelligence compressed sensing,ACS)技术的头颈联合三维时间飞跃法磁共振血管成像(three-dimensional time-of-fight magnetic resonance angiography,3D-TOF-MRA)的图像质量,选取优化序列。材料与方法前瞻性招募24例健康志愿者,以PI的AF为3(PI 3)、CS的AF分别为4和6(CS 4、CS 6)以及ACS的AF分别为4、6、8、10(ACS 4、ACS 6、ACS 8、ACS 10)进行头颈联合3D-TOF-MRA扫描。扫描时间:PI 3=8 min 40 s;CS 4=6 min 38 s;CS 6=4 min 9 s;ACS 4=5 min 24 s;ACS 6=4 min 30 s;ACS 8=4 min 13 s;ACS 10=3 min 24 s。分别在双侧大脑中动脉(middle cerebral artery,MCA)M1段、双侧颈内动脉(internal carotid artery,ICA)C4段、颈动脉分叉处下5个层面的双侧颈总动脉(common carotid artery,CCA)以及MCA及ICA同一层面的颞叶白质,CCA同一层面的胸锁乳突肌作为背景区域勾画感兴趣区(regions of interest,ROI),记录信号强度(signal intensity,SI)及标准差(standard deviation,SD),从而计算信噪比(signal-to-noise ratio,SNR)与对比噪声比(contrast-to-noise ratio,CNR)。采用四分法和五分法分别对整体图像质量以及颅内动脉、颈部大动脉进行评分。以组内相关系数(intra-class correlation coefficient,ICC)比较两名放射医师之间及同一名放射医师内客观评价结果的一致性,Kappa检验比较两名放射医师之间及同一名放射医师内主观评价结果的一致性,若一致性良好,则选取其中一位医师的客观评分及主观评分进行后续统计分析。采用单因素方差分析或Kruskal-Wallis检验对客观评分以及主观评分进行总体差异比较,若差异具有统计学意义则进行两两比较。结果与PI技术比较显示,ACS 4~ACS 8的SNR_(L-MCA),ACS 8、ACS 10的CNR_(L-MCA),ACS 4、ACS 6、ACS 10的CNR_(R-MCA),ACS 4~ACS 10的SNR_(R-MCA)、SNR_(L-CCA)、CNR_(L-CCA),ACS 6~ACS 10的SNR_(R-CCA)、CNR_(R-CCA)均高于PI 3,差异具有统计学意义(P0.05)。除颈部大动脉图像外,主观评分统计结果均为ACS 4~ACS 10与CS 6差异具有统计学意义(P<0.05),优于CS 6。结论与PI及CS技术相比,ACS技术拥有更短的扫描时间,更好的图像质量。ACS 8为最优序列,扫描时间比PI 3缩短51%。

关键词：并行采集压缩感知人工智能-压缩感知头颈联合三维时间飞跃法磁共振血管成像磁共振成像

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干旱半干旱区典型林分持水性能比较研究

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水土保持研究 2024年第3期31卷 239-246页

作者：韩青池孙凯裴志永陈宏伟曹艳伟孙小添内蒙古农业大学能源与交通工程学院呼和浩特010018 鄂尔多斯市林业和草原局内蒙古鄂尔多斯017000 鄂尔多斯市科技事业发展中心内蒙古鄂尔多斯017000

[目的]水分供给是制约干旱及半干旱区发展的决定因素,科学评估干旱半干旱区典型林分的持水性能是规划防护林建设,调控林分结构与进行树种选择的重要依据。[方法]以库布齐沙漠鄂尔多斯造林总场内5种典型人工林为研究对象,利用野外收获法... 详细信息

[目的]水分供给是制约干旱及半干旱区发展的决定因素,科学评估干旱半干旱区典型林分的持水性能是规划防护林建设,调控林分结构与进行树种选择的重要依据。[方法]以库布齐沙漠鄂尔多斯造林总场内5种典型人工林为研究对象,利用野外收获法与室内浸水法分析林冠层、林下植被层、枯落物层及土壤层持水性能,引入模糊物元模型,结合欧式贴近度对不同林分持水性能进行定量评价。[结果](1)不同树种间林冠持水能力差异显著,表现为杨树旱柳混交林>榆树林>杨树林>沙柳林>樟子松林,林分持水量介于2.36~9.98 t/hm^(2)。(2)各林分林下植被的持水量介于0.84~3.66 t/hm^(2),生物量介于1.33~3.92 t/hm^(2),生物量表现出与持水量相同的变化趋势。(3)枯落物持水量介于1.96~29.25 t/hm^(2),生物量介于1.43~13.62 t/hm^(2),对数函数和幂函数可较好表现枯落物的动态持水量和动态吸水率。(4)各林分间土壤毛管持水量介于543.80~645.71 t/hm^(2),饱和持水量介于562.87~694.78 t/hm^(2),杨柳混交林土壤容重低于其他纯林,同时孔隙度比其他林分高。(5)欧式贴近度大小排序为杨柳混交林(0.805 6)>沙柳林(0.387 7)>榆树林(0.374 7)>杨树林(0.357 2)>樟子松林(0.163 2),欧式贴近度越大,林分持水性能越强,5种林型中杨柳混交林持水能力最强,樟子松林最差。[结论]建议未来经营干旱半干旱区人工防护林建设中,适当提高混交林比例,并尝试通过更多林分合理搭配进行防护林建设保护。

关键词：干旱半干旱区林分持水性能模糊物元模型欧式贴近度

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δ-连环蛋白高表达状态对乳腺癌患者化疗后短期脑认知功能影响的静息态功能MRI研究

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磁共振成像 2024年第2期15卷 56-62页

作者：薛明团杜伟曹家骏宋段张俊毅苗延巍大连医科大学附属第一医院放射科大连116011 内蒙古赤峰学院附属医院CT、MR科赤峰024000 内蒙古赤峰学院附属医院病理科赤峰024000

目的利用静息态功能MRI探讨δ-连环蛋白(catenin)不同表达状态的乳腺癌患者采用蒽环联合环磷酰胺(anthracyclines cyclophosphamide,AC)化疗方案2个周期后的脑认知功能改变。材料与方法前瞻性收集66例经病理证实乳腺癌并首次进行标准化... 详细信息

目的利用静息态功能MRI探讨δ-连环蛋白(catenin)不同表达状态的乳腺癌患者采用蒽环联合环磷酰胺(anthracyclines cyclophosphamide,AC)化疗方案2个周期后的脑认知功能改变。材料与方法前瞻性收集66例经病理证实乳腺癌并首次进行标准化化疗患者,根据组织血清δ-catenin水平,分为δ-catenin高表达组31例和低表达组35例,同时收集健康对照(healthy control,HC)组36例。所有受试者在化疗前及2个化疗周期后进行神经心理学评分并行脑静息态功能MRI、3D-T1加权成像,分析脑静息态功能MRI指标,包括低频振幅(amplitude of low frequency fluctuation,ALFF)值、分数低频振幅(fractional amplitude of low frequency fluctuation,fALFF)值、局部一致性(regional homogeneity,ReHo)值,并对患者化疗前后神经心理学评分以及脑静息态功能MRI指标进行对比分析。结果化疗前δ-catenin高表达组人表皮生长因子受体2(human epidermal growth factor receptor 2,HER-2)显著高于低表达组,差异有统计学意义(P<0.05)。乳腺癌患者化疗前后神经心理学评分显示,δ-catenin高表达组患者化疗后癌症治疗认知功能评估(Functional Assessment of Cancer Therapy-Cognitive,FACT-Cog)总分、感知认知能力(Perceived Cognitive Abilities,PCA)、简易智力状态检查评分(Mini Mental State Examination,MMSE)、蒙特利尔认知评估评分(Montreal Cognitive Assessment,MOCA)、数字符号转化测验(Digital Symbol Substitution Test,DSST)以及中文听觉词语学习测验(Auditory Verbal Learning Test,AVLT)、数字连线实验B(Line-B)评分较化疗前差异有统计学意义,而低表达组只有AVLT-长时记忆(AVLT-long)评分差异有统计学意义(P均<0.05)。与化疗前相比,化疗2周期后部分脑区ALFF及ReHo值改变差异有统计学意义(P<0.05)。δ-catenin低表达组患者化疗后右侧前扣带和旁扣带脑回ALFF值下降,而δ-catenin高表达组右侧小脑半球4-5区、双侧脑岛、左侧舌回化疗后ALFF值下降。ReHo指标中,δ-catenin低表达组患者化疗后左侧眶部额下回ReHo值下降;而δ-catenin高表达组则左侧缘上回、左侧三角部额下回ReHo值下降(P均<0.05)。结论δ-catenin高表达进一步加重化疗对乳腺癌患者脑认知功能的损伤,主要涉及执行认知功能调控等相关脑区。

关键词：乳腺癌 δ-连环蛋白化疗相关认知障碍纵向研究静息态脑功能磁共振成像

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人工智能-压缩感知技术在颅脑3D T2-FLAIR序列采集及脑白质高信号评价中的应用

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磁共振成像 2024年第2期15卷 135-139,146页

作者：曹家骏刘娜钟美梦袁畅张煜堃苗延巍宋清伟大连医科大学附属第一医院放射科大连116011

目的探究不同的基于人工智能压缩感知(artificial intelligence-assisted compressed sensing,ACS)加速因子对颅脑3D T2WI液体衰减反转恢复(3D T2WI fluid-attenuated inversion-recovery,3D T2-FLAIR)序列图像质量的影响,并获取最优化的扫描方案。材料与方法前瞻性纳入健康青年志愿者(healthy control,HC)25例、脑白质高信号(white matter hyperintensity,WMH)患者15例,HC组分别以并行采集(parallel imaging,PI)技术(加速因子为3,F3)和不同加速因子(3、4、5、6、7、8)ACS技术采集颅脑3D T2-FLAIR图像,测量双侧半卵圆中心、双侧尾状核、胼胝体压部、双侧红核、双侧黑质、脑桥、双侧小脑的信号强度以及标准差,并计算图像的信噪比(signal to noise ratio,SNR)和对比噪声比(contrast to noise ratio,CNR)。采用五分法对图像质量进行主观评分。采用组内相关系数(intra-class correlation coefficient,ICC)、Kappa检验比较前后两次测量及观察者间主观评分的一致性。对不同加速因子的图像的SNR、CNR及主观评分采用Friedman秩和检验进行对照分析,综合评判后得出最佳的ACS加速因子;WMH组分别以F3及最佳ACS加速因子采集颅脑3D T2-FLAIR图像,并由两名经验丰富的诊断医师对脑白质病灶数目、Fazekas分级进行评估,采用独立样本t检验、Mann-Whitney U检验进行对照分析。结果HC组中,不同3D T2-FLAIR的SNR、CNR及主观评分差异具有统计学意义(P均0.05),其余图像SNR、CNR及主观评分差异均具有统计学意义(P均0.05)。结论以ACS技术采集颅脑3D T2-FLAIR可在保证图像质量和序列诊断效能的前提下缩短扫描时间,选取的最优加速因子为ACS4。

关键词：人工智能-压缩感知压缩感知磁共振成像脑加速采集

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