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The study of antibacterial activity of cationic poly(β-amino ester)regulating by amphiphilic balance

Chinese Chemical Letters 2025年第02期36卷 332-336页

作者： Chong liu ling li Jiahui Gao yanwei li Nazhen Zhang Jing Zang Cong liu Zhaopei Guo Yanhui li Huayu Tian School of Materials Science and Engineering Changchun University of Science and Technology School of Materials Science and Engineering Xiamen University of Technology Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences College of Chemistry and Chemical Engineering Xiamen University

It is well known that cationic polymers have excellent antimicrobial capacity accompanied with high biotoxicity, to reduce biotoxicity needs to decrease the number of cationic groups on polymers, which will influence antimicrobial activity. It is necessary to design a cationic polymer mimic natural antimicrobial peptide with excellent antibacterial activity and low toxicity to solve the above dilemma. Here,we designed and prepared a series of cationic poly(β-amino ester)s(PBAEs) with different cationic contents, and introducing hydrophobic alkyl chain to adjust the balance between antimicrobial activity and biotoxicity to obtain an ideal antimicrobial polymer. The optimum one of synthesized PBAE(hydrophilic cationic monomer:hydrophobic monomer = 5:5) was screened by testing cytotoxicity and minimum inhibitory concentration(MIC), which can effectively kill S. aureus and E. coli with PBAE concentration of15 μg/m L by a spread plate bacteriostatic method and dead and alive staining test. The way of PBAE killing bacterial was destroying the membrane like natural antimicrobial peptide observed by scanning electron microscopy(SEM). In addition, PBAE did not exhibit hemolysis and cytotoxicity. In particular, from the result of animal tests, the PBAE was able to promote healing of infected wounds from removing mature S. aureus and E. coli on the surface of infected wound. As a result, our work offers a viable approach for designing antimicrobial materials, highlighting the significant potential of PBAE polymers in the field of biomedical materials.

关键词： Amphiphilic balance Antimicrobial Cationic polymers Michael addition polymerization Poly(β-amino ester)s

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The formation and precipitation mechanism of two ordered patterns of embedded convection in stratiform cloud

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Science China Earth Sciences 2012年第1期55卷 113-125页

作者： li yanwei NIU ShengJie Key Laboratory for Atmospheric Physics and Environment of China Meteorological Administration Nanjing University of Information Science&TechnologyNanjing 210044China

Although convection embedded in stratiform cloud is often disordered, it is ordered under certain weather conditions. In particular, there are two forms of ordered convection: embedded convection with a ladder-like pattern and that with a parallel pattern. However, there is little literature regarding these patterns. Because stratiform clouds with embedded convection are major objects for weather-modification studies, it is important to explore the formation/development and characteristic precipitation of embedded convection from the perspective of cloud and precipitation physics. In this paper, using observation data, we simulate a large-scale precipitation event in China for July 19-21, 2007, employing the mesoscale Weather Research and Forecasting (WRF) model (V2.2). The rainfall-related clouds are analyzed through simulation, with particular focus being given to the genesis of embedded convection, the precipitation and microphysical properties. The results show that the WRF model can simulate features of this kind of nephsystem, indicating a close relationship between convection genesis and the 500 hPa trough and low-level convergence line. In such a favorable weather situation, there are two ordered patterns of embedded con- vection in the nephsystem, one being a group of convection centers arranged at different altitudes in a ladder-like manner and the other being a group of convection centers with a parallel pattern. In the first case, rainfall also has a ladder feature, with precipitation being highest for the top convection and reducing to the base convection. This implies that the higher the convection develops, the more active the microphysics in warmand cold-cloud processes is, leading to greater precipitation; i.e. rainfall in a ladder-like distribution. In the second case, rainfall decreases step by step from south to north, with the precipitation depending strongly on the cloud-water content therein. The two patterns of embedded convection and their p

关键词： numerical modeling embedded convection ladder-like distribution parallel distribution

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Structure, Optical Property and Thermal Stability of Copper Nitride Films Prepared by Reactive Radio Frequency Magnetron Sputtering

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Journal of Materials Science & Technology 2011年第5期27卷 403-407页

作者： Jianrong Xiao yanwei li Aihua Jiang College of Science Guilin University of Technology Guilin 541004 China College of Chemistry and Bioengineering Guilin University of Technology Guilin 541004 China

Copper nitride （Cu3N） films were prepared by reactive radio frequency magnetron sputtering at various nitrogen partial pressures, and the films were annealed at different temperatures. The crystal structure of the films was identified by X-ray diffraction technique. The Cu3N films have a cubic anti-ReO3 structure, and lattice constant is 0.3855 nm. With increasing nitrogen partial pressure, the Cu3N films are strongly textured with the crystal direction [100]. The atomic force microscope images show that the films presence a smooth and compact morphology with nanocrystallites of about 70 nm in size. The films were further characterized by UV-visible spectrometer, and the optical band gap of the films was calculated from the Tauc equation. The typical value of optical band gap of the films is about 1.75 eV, and it increases with increasing nitrogen partial pressure. The thermal property of the films was measured by thermogravimetry, and the decomposition temperature of the films was about 530 K.

关键词： Cu3N films X-ray diffraction Structure Optical property Decompositiontemperature

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Design of low power 4×40 Gb/s laser diode driver for parallel optical transmission systems

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Science China(Information Sciences) 2017年第8期60卷 246-248页

作者： Yingmei CHEN Zhen ZHANG Jiquan li Hui WANG Pengxia WANG yanwei li Institute of Radio Frequency & Opto-Electronic Integrated Circuits Southeast University School of Integrated Circuits Southeast University

Compared with conventional electrical interconnection technology,optical interconnection has the merits of anti-interference,small signal loss,long transmission distance and so ***,parallel optical interconnects become the crucial technique to solve the problem of large capacity data transmission in high-speed transmission *** parallel mode can decrease transmit rate of every optical fiber,reduce the demands for optical devices and decrease the cost of optical interconnects[1–3].

关键词： of is on VCSEL Design of low power 4 Gb/s laser diode driver for parallel optical transmission systems for

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Applied anatomy of the cervical region of the recurrent laryngeal nerve

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Neural Regeneration Research 2008年第6期3卷 663-665页

作者： Changchu Wu Xing Guo yanwei li Anatomy Division Medical College Jishou University Jishou 416000 Hunan Province China Anatomy Division Shaoyang Medical College Shaoyang 422000 Hunan Province China

BACKGROUND AND OBJECTIVE： To avoid recurrent laryngeal nerve （RLN） injury during thyroid surgery, it is important to identify the nerve and to follow its projection carefully to discriminate it from the inferior thyroid artery. DESIGN, TIME AND SETTING： All studies were performed at the Anatomy Division of Shaoyang Medical College from May 2003 to May 2004 with repeated measurement design. MATERIALS： Fifty embalmed adult corpses, comprising 20 females and 30 males, were obtained by donation. METHODS AND MAIN OUTCOME MEASURES： The projection, branches, and the relationship of the RLN to the inferior thyroid artery were observed. RESULTS： The RLN in all cases ascended through the tracheoesophageal groove at the isthmus superior levels of the thyroid gland. However, the RLN in 14 cases were situated inferior to the isthmus of the thyroid gland; 11 cases were to the right side and 2 cases to the left side, projected in the tracheoesophageal groove, and ascended away from the groove after 4.5-6.5 mm. The RLN typically ramified at the thyroid isthmus plane （44 cases, 44% of all cases）. The RLN branches were variable. Type 2 rami were most common in the RLN, accounting for 55%; the second most common was RLN branches with no rami. RLN braches with type 3 rami, 4 rami, and 5 rami were less common. Approximately 54% of nerves were situated behind the main branch artery. The nerves located adjacent to the arteries, and between the arterial branches, were similar; the former applied to 19 cases, accounting for 19%, whereas the latter applied to 18 cases, accounting for 18%. Left nerves behind the artery, and right nerves before the artery, were more common. There were significant differences between the left and right nerves （P 〈 0.01）. CONCLUSION： There was not a significant difference in the projection of the RLN, while a significant difference in the number of RLN branches existed. In addition, the anatomical relationship of the RLN and the inferior thyroid artery exhibited

关键词： recurrent laryngeal nerve inferior thyroid artery applied anatomy

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儿童早期易怒:特性、评估、风险因素与干预

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心理发展与教育 2025年第1期41卷 135-144页

作者：李艳玮黄一依翟清灼周文沁袁宗金南京晓庄学院幼儿师范学院南京211171 南京市太平巷幼儿园南京210002 宝应县望直港镇中心幼儿园扬州225811 南京师范大学心理学院南京210097

易怒是多种精神障碍常见的临床表现,被认为是重要的跨疾病诊断依据。文章梳理了易怒的内涵,指出易怒是儿童早期常见的个性特质,早期易怒具有损伤性和发展性,并在此基础上介绍了儿童早期易怒的评估、风险因素和心理干预。文章提出未来研... 详细信息

易怒是多种精神障碍常见的临床表现,被认为是重要的跨疾病诊断依据。文章梳理了易怒的内涵,指出易怒是儿童早期常见的个性特质,早期易怒具有损伤性和发展性,并在此基础上介绍了儿童早期易怒的评估、风险因素和心理干预。文章提出未来研究应关注以下方面:(1)建立多模态、多指标的易怒评估体系;(2)着重探讨“认知×情绪”共同作用视角下易怒的复杂作用机制、易怒与风险因素之间的双向作用机制;(3)重视对儿童早期易怒的干预,设计满足个性化需求的多维度人机交互式方案。

关键词：易怒儿童早期情绪失调风险因素干预

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Metal-free diatomaceous carbon-based catalyst for ultrafast and anti-interference Fenton-like oxidation

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Chinese Chemical Letters 2024年第12期35卷 351-355页

作者： Kexin Yin Jingren Yang yanwei li Qian li Xing Xu Shandong Key Laboratory of Water Pollution Control and Resource Reuse School of Environmental Science and EngineeringShandong UniversityQingdao 266237China Environment Research Institute Shandong UniversityQingdao 266237China State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants Shanghai Academy of Environmental SciencesShanghai 200233China

Herein,a diatomite biomorphic Si-O doped carbon-based catalyst(DB-SiOC)was prepared using natura mineral diatomite as the silicon source and porous *** results showed that the metal-free DB SiOC catalyst exhibited ultrafast oxidation towards chlorophenol(CP)via peroxymonosulfate(PMS)activa tion,which was almost one order of magnitudes than most of carbon-based *** DB-SiOC/PMS system also showed the high ability to resist the interference of environmental *** radicals(^(·)OH and SO_(4)^(·–))exhibited a very small contribution to the CP oxidation while the electron transfer processe(ETP)played the major role in the DB-SiOC/PMS *** electron shuttles from the electron-donating CP molecules to the adjacent DB-SiOC/PMS^(*)could be efficiently triggered via Si-O bonds as bridges,mak ing it possible for ultrafast oxidation of *** addition,the hollow-disc shaped DB-Si OC provided the biomorphic DE structures with abundant pores for enriching the PMS and pollutants,thus further ac celerating the oxidation *** work provided a new routine for the fabrication of Si-O doped carbon-based catalysts with excellent Fenton-like catalytic activity,which would greatly promote thei application prospects in Fenton-like systems.

关键词： Peroxymonosulfate Diatomite Si-O doping Fenton-like reaction Electron transfer process(ETP)

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Effective Potential of a Two-State Model for Molecular Motor

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Communications in Theoretical Physics 2005年第2期43卷 377-381页

作者： HANYing-Rong ZHAOTong-Jun ZHAN-Yong yanwei-li SchoolofScience HebeiUniversityofTechnologyTianjin300130China SchoolofScience HebeiUniversityofTechnologyTianjin300130China／／SchoolofElectricalEngineeringHebeiUniversityofTechnologyTianjin300130China SchoolofElectricalEngineering HebeiUniversityofTechnologyTianjin300130China

We study force generation and motion of molecular motors using a simple two-state model in the *** and periodic potential is adopted to describe the interaction between motor proteins and filaments that are periodic and polar. The current and the slope of the effective potential as functions of the temperature and transition rates are calculated in the two-state model. The ratio of the slope of the effective potential to the current is also calculated. It is shown that the directed motion of motor proteins is relevant to the effective potential. The slope of the effective potential corresponds to an average force. The non-vanishing force therefore implies that detailed balance is broken in the process of transition between different states.

关键词： Brownian particle directed motion Fokker-Planck equation effective potential detailed balance

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Analysis of High-Cr Cast Iron/Low Carbon Steel Wear-resistant Laminated Composite Plate Prepared by Hot-rolled Symmetrical Billet

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Computer Modeling in Engineering & Sciences 2018年第10期117卷 109-123页

作者： yanwei li Yugui li Peisheng Han Shun Wang Zhengyi Jiang Xiaogang Wang Shanxi Provincial Key Laboratory of Metallurgical Device Design Theory and Technology(State Key Laboratory Cultivation Base of Province-Ministry Co-Construct) Taiyuan University of Science and TechnologyTaiyuanChina School of Mechanical Materials and Mechatronic EngineeringUniversity of WollongongWollongong NSW2522Australia

This study developed a new technology for preparing high-chromium cast iron(HCCI)/low-carbon steel(LCS)wear-resistant composite plates by hot rolling at a 1050°C and a rolling speed of 0.2 m/*** effects of different rolling reductions(30%,45%,and 60%)on the microstructure(interface and HCCI layer)and mechanical properties(bonding strength,hardness,and wear resistance)of the composite plate were *** images showed that when the reduction was increased,no impurities and interlayers were found between the microscopic interfaces after hot rolling,and the bonding interface exhibited a wave-like *** analysis showed that the Cr element diffusion between two metals after hot rolling was promoted when the reduction was increased,thereby improving the bonding quality under the same rolling temperature and rolling *** showed that due to the stress release effect of the LCS of the cladded layer,the macro-slab shape after hot rolling performed well,and the brittle HCCI layer underwent thermoplastic deformation without ***,the increase of rolling reduction improved the bonding *** the rolling reduction was increased,the volume fraction of Cr-carbides in the HCCI layer also increased,resulting in an increase of hardness and wear-resistance.

关键词： High chromium cast iron symmetrical billet hot rolled laminated composite plate

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High-Throughput physiology-based stress response phenotyping:Advantages,applications and prospective in horticultural plants

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Horticultural Plant Journal 2021年第3期7卷 181-187页

作者： yanwei li Xinyi Wu Wenzhao Xu Yudong Sun Ying Wang Guojing li Pei Xu Institute of Vegetables Zhejiang Academy of Agricultural SciencesHangzhou 310021China College of life Sciences China Jiliang UniversityHangzhou 310018China Huaiyin Institute of Agricultural Sciences of Xuhuai Region in Jiangsu Jiangsu 223001China

Phenomics is a new branch of science that provides high-throughput quantification of plant and animal traits at systems *** last decade has witnessed great successes in high-throughput phenotyping of numerous morphological traits,yet major challenges still exist in precise phenotyping of physiological traits such as transpiration and *** to the highly dynamic nature of physiological traits in responses to the environment,appropriate selection criteria and efficient screening systems at the physiological level for abiotic stress tolerance have been largely absent in *** this review,the current status of phenomics techniques was briefly summarized in horticultural ***,the emerging field of high-throughput physiology-based phenotyping,which is referred to as“physiolomics”,for drought stress responseswas *** addition to analyzing the advantages of physiology-based phenotyping overmorphology-based approaches,recent examples that applied high-throughput physiological phenotyping to model and non-model horticultural plants were revisited and *** on the collective findings,we propose that high-throughput,non-destructive,and automatic physiological assays can and should be used as routine methods for phenotyping stress response traits in horticultural plants.

关键词： Phenomics Physiolomics Isohydric/anisohydric Abiotic stress

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