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Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

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World Journal of Clinical Oncology 2025年第1期16卷 25-33页

作者： Jiang-Yu bian Yu-Fang Feng Wen-Ting He Tong Zhang Department of Oncology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of Oncology The Fourth Clinical Medical College of Xinjiang Medical UniversityUrumqi 830001China Department of Oncology Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830001China

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor *** the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal ***,we further explored the survival benefits in the population with BRAF V600E mutant *** To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal *** A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December *** patients were divided into two *** A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,*** analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

关键词： Metastatic colorectal cancer BRAF V600E mutation Integrated Chinese and Western medicine Cohort study

ImSpiRE: image feature-aided spatial resolution enhancement method

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Science China Life Sciences 2025年第01期 272-283页

作者： Yuwei Hua Yizhi Zhang Zhenming Guo Shan bian Yong Zhang State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center Institute for Regenerative MedicineDepartment of NeurosurgeryShanghai East HospitalShanghai Key Laboratory of Signaling and Disease ResearchFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji University

The resolution of most spatially resolved transcriptomic technologies usually cannot attain the single-cell level, limiting their applications in biological discoveries. Here, we introduce ImSpiRE, an image feature-aided spatial resolution enhancement method for in situ capturing spatial transcriptome. Taking the information stored in histological images, ImSpiRE solves an optimal transport problem to redistribute the expression profiles of spots to construct new transcriptional profiles with enhanced resolution, together with extending the gene expression profiles into unmeasured regions. Applications to multiple datasets confirm that ImSpiRE can enhance spatial resolution to the subspot level while contributing to the discovery of tissue domains, signaling communication patterns, and spatiotemporal characterization.

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How to Deal with the Trade-off between Development and Decarbonization for Rural Logistics in China?Evidence from Jiangsu

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Journal of Systems Science and Systems Engineering 2023年第6期32卷 656-686页

作者： Xiaoyu bian Jing Xu School of Economics and Management Jiangsu University of Science and TechnologyZhenjiang212013China Business School Yangzhou UniversityYangzhou225009China

Rural logistics faces a dilemma between development and high carbon emissions in *** assess the tension between rural logistics development and carbon emissions from the perspective of policy guidance by modeling a rural logistics system using Jiangsu’s *** simulate the development trend of Jiangsu rural logistics under carbon abatement policies from 2021–2030,with a focus on promoting its development while simultaneously reducing carbon emissions at a minimal *** findings show that rural logistics will move towards high carbon emissions without a carbon abatement policy,while the huge tax pressure of carbon reduction policies reduces the profitability of rural logistics,leading to a trade-off between development and *** the perspective of implementation timing and manner of carbon abatement policies implementation,we propose a pathway for securing the profitability of rural logistics and resolving the trade-off.

关键词： Rural logistics carbon emissions policy guidance decarbonization development trade-off

Surface and Interface Engineering for Advanced Nanofiltration Membranes

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Chinese Journal of Polymer Science 2022年第2期40卷 124-137页

作者： bian-bian Guo Cheng-Ye Zhu Zhi-Kang Xu Ministry of Education Key Laboratory of Macromolecular Synthesis and FunctionalizationKey Laboratory of Adsorption and Separation Materials&Technologies of Zhejiang ProvinceDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Nanofiltration has been attracting great attention in alleviating the global water crisis because of its high efficiency,mild operation,and strong *** decades,it remains a challenge to break the upper limit of performance and establish the formation-structureproperty relationship for nanofiltration *** feature article summarizes our recent progress in the preparation of high-performance thin-film composite(TFC)nanofiltration membranes,focusing on the mussel-inspired deposition method and the optimized interfacial polymerization(IP).By accelerating the oxidation of polydopamine and equilibrating the rate of aggregation and deposition processes,the mussel-inspired deposition method realizes the rapid and uniform formation of selective coatings or *** deposition systems endow the selective layer with rich chemical structures and easy post-functionalization,highlighting its potential in water *** for optimizing the conventional IP,the rapid polycondensation of amine and acid chloride groups is slowed down to enable the controllability of IP at the water-organic *** homogeneity and integrity of the TFC membranes are improved by constructing a uniform reaction platform and introducing a viscous medium to control the amine diffusion,which facilitates the water permeability and promotes the separation *** have proposed a series of practical strategies for improving TFC membranes and might provide more inspiration for other nanofiltration techniques.

关键词： Nanofiltration Thin-film composite membranes Mussel-inspired deposition Interfacial polymerization

Torsional static and vibration analysis of functionally graded nanotube with bi-Helmholtz kernel based stress-driven nonlocal integral model

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Applied Mathematics and Mechanics(English Edition) 2021年第3期42卷 425-440页

作者： Peiliang bian Hai QING State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China

A torsional static and free vibration analysis of the functionally graded nanotube(FGNT)composed of two materials varying continuously according to the power-law along the radial direction is performed using the bi-Helmholtz kernel based stress-driven nonlocal integral *** differential governing equation and boundary conditions are deduced on the basis of Hamilton’s principle,and the constitutive relationship is expressed as an integral equation with the bi-Helmholtz *** nominal variables are introduced to simplify the differential governing equation,integral constitutive equation,and boundary *** than transforming the constitutive equation from integral to differential forms,the Laplace transformation is used directly to solve the integro-differential *** explicit expression for nominal torsional rotation and torque contains four unknown constants,which can be determined with the help of two boundary conditions and two extra constraints from the integral constitutive relation.A few benchmarked examples are solved to illustrate the nonlocal influence on the static torsion of a clamped-clamped(CC)FGNT under torsional constraints and a clamped-free(CF)FGNT under concentrated and uniformly distributed torques as well as the torsional free vibration of an FGNT under different boundary conditions.

关键词： integro-differential equation bi-Helmholtz kernel stress-driven nonlocal integral model Laplace transform technique free vibration

基于SVR-LSTM的人体上肢运动遮挡轨迹补偿方法

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郑州大学学报（理学版） 2025年第1期57卷 1-7页

作者：彭金柱刘涵菲卞英楠郑州大学电气与信息工程学院河南郑州450001 河南交通职业技术学院物流学院河南郑州451460

在人机协作过程中,由于光照条件等环境因素和机器人设备摆放等遮挡原因,导致使用基于视觉的运动捕捉设备对人体运动进行捕捉时时间序列的轨迹数据有缺失,进而导致意图识别不准确,增加了机器人运动的不确定性。因此,提出了一种基于支持... 详细信息

在人机协作过程中,由于光照条件等环境因素和机器人设备摆放等遮挡原因,导致使用基于视觉的运动捕捉设备对人体运动进行捕捉时时间序列的轨迹数据有缺失,进而导致意图识别不准确,增加了机器人运动的不确定性。因此,提出了一种基于支持向量回归(support vector regression,SVR)和长短期记忆(long short-term memory,LSTM)的人体上肢运动时间序列轨迹缺失补偿方法。采用网格搜索法对SVR模型中的参数进行优化来完善历史样本数据集,结合长短期记忆网络对短、长时间序列轨迹缺失的预测补全更精确的优势,将SVR模型补全的历史样本数据集输入LSTM模型训练,进一步降低补偿误差。实验结果表明,在三维空间350 mm的运动尺度范围内,轨迹缺失程度为10%时,SVR-LSTM模型补偿轨迹的平均误差是0.14 mm;轨迹缺失程度为30%时,SVR-LSTM模型补偿轨迹的平均误差是0.47 mm。

关键词：遮挡轨迹时间序列意图识别轨迹补偿 SVR-LSTM模型

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An explicit time domain solution for ground stratum response to harmonic moving load

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Acta Mechanica Sinica 2006年第5期22卷 469-478页

作者： Xuecheng bian Yunmin Chen College of Civil Engineering and Architecture Zhejiang University Hangzhou 310027 China

Based on the thin layer method originally proposed in frequency domain, an explicit time domain semi-analytical solution has been developed for simulating three-dimensional layered ground responses to harmonic moving loads. The Fourier-Laplace transforms were applied to derive the transformed solution that satisfied the boundary conditions of horizontal infinities. The eigenvalue decomposition was performed with respect to Laplace parameter to express the ground motion corresponding to the eigenmodes. The formulation for each eigenmode incorporating the moving load expression was transformed back into time domain analytically, and the global system responses were given by means of the general mode superposition method. The proposed explicit time domain solution is suitable for studying various types of moving load acting on or inside the ground. In this paper a moving harmonic load with rectangular distribution was adopted to demonstrate the ground response simulation. Two illustrative examples for moving load with speeds below or above the ground Rayleigh wave velocity were presented to test the computational accuracy and efficiency of the proposed approach. A parametric study was also performed to investigate the influences of soil properties on the ground responses.

关键词： Moving harmonic load Thin layer method Laplace transform Fourier transform Layered soils

Parameter optimization of controllable local degree of freedom for reducing vibration of flexible manipulator

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Chinese Journal of Aeronautics 2013年第2期26卷 487-494页

作者： bian Yushu Gao Zhihui School of Mechanical Engineering and Automation Beihang University State Key Laboratory for Robotics and System (HIT) Harbin Institute of Technology

Parameter optimization of the controllable local degree of freedom is studied for reducing vibration of the flexible manipulator at the lowest possible cost. The controllable local degrees of freedom are suggested and introduced to the topological structure of the flexible manipulator, and used as an effective way to alleviate vibration through dynamic coupling. Parameters introduced by the controllable local degrees of freedom are analyzed and their influences on vibration reduction are investigated. A strategy to optimize these parameters is put forward and the corresponding optimization method is suggested based on Particle Swarm Optimization （PSO）. Simulations are conducted and results of case studies confirm that the proposed optimization method is effective in reducing vibration of the flexible manipulator at the lowest possible cost.

关键词： Degrees of freedom Flexible manipulators Optimization Particle Swarm Optimization Vibration control

Global Continuity Adjustment and Local Shape Optimization Technique for Complex Trimmed Surface Model

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Chinese Journal of Mechanical Engineering 2010年第2期23卷 225-232页

作者： bian Keke KE Yinglin The State Key Lab of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China

Smoothly stitching multiple surfaces mainly represented by B-spline or NURBS together is an extremely important issue in complex surfaces modeling and reverse engineering. In recent years, a lot of progress has been made in smooth join of non-trimmed surface patches, while there has been seldom research on smoothly stitching trimmed surface patches together. This paper studies the problem of global continuity adjustment, damaged hole repair and local shape optimization for complex trimmed surface model, and presents a uniform scheme to deal with continuity adjustment of trimmed surfaces and geometric repair of local broken region. Constrained B-spline surface refitting technique and trim calculation are first utilized to achieve global G^1 continuity, and then local shape optimization functional is adopted to reduce fitting error and improve local quality of refitted surface patch. The proposed approach is applied to a discontinuity ship hull surface model with an irregular hole, and the result demonstrates the validation of our method. Furthermore, on the premise of global continuity, the proposed locally repairing damaged surface model provides a better foundation for following research work, such as topology recovery technique for complex surface model after geometric repair.

关键词： computer aided geometric design(CAGD) geometric continuity trimmed surface surface fitting shape optimization reverse engineering