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Injectable and in situ foaming shape-adaptive porous Bio-based polyurethane scaffold used for cartilage regeneration

引用

Bioactive Materials 2024年第9期39卷 1-13页

作者： Abudureheman Bahatibieke Shuai Wei Han Feng Jianming Zhao Mengjiao Ma Junfei Li Yajie Xie Kun Qiao yanseng wang Jiang Peng Haoye Meng Yudong Zheng School of Materials Science and Engineering University of Science and Technology BeijingBeijing100083China Institute of Orthopaedics Chinese PLA General HospitalBeijing100853China Department of Orthopedics The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu215004China Hebei North University Zhangjiakou075000Hebei ProvinceChina

Irregular articular cartilage injury is a common type of joint trauma,often resulting from intense impacts and other factors that lead to irregularly shaped wounds,the limited regenerative capacity of cartilage and the mismatched shape of the scaffods have contributed to unsatisfactory therapeutic *** injectable materials are a traditional solution to adapt to irregular cartilage defects,they have limitations,and injectable materials often lack the porous microstructures favorable for the rapid proliferation of cartilage *** this study,an injectable porous polyurethane scaffold named PU-BDO-Gelatin-Foam(PUBGF)was *** injection into cartilage defects,PUBGF forms in situ at the site of the defect and exhibits a dynamic microstructure during the initial two *** dynamic microstructure endows the scaffold with the ability to retain substances within its interior,thereby enhancing its capacity to promote ***,the chondral repair efficacy of PUBGF was validated by directly injecting it into rat articular cartilage injury *** injectable PUBGF scaffold demonstrates a superior potential for promoting the repair of cartilage defects when compared to traditional porous polyurethane *** substance retention ability of this injectable porous scaffold makes it a promising option for clinical applications.

关键词： Injectable In situ forming Polyurethane Cartilage repair Tissue engineering

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