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Potential factors and mechanism of particulate matters explosive increase induced by free radicals oxidation

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Journal of Environmental Sciences 2019年第7期31卷 205-213页

作者： Guoying Wang Shiming Jia Xiuli Niu Haoqi Tian yanrong Liu Zhong Xie Chao Liu yucan Dong Ying Su Jianglei yu Gaofeng Shi Xuefu Chen Lan Li Peng Zhang School of Petrochemical Engineering Lanzhou University of Technology Gansu Province Food Inspection Institute

Atmospheric particulate pollution in China has attracted much public ***, the particle number concentration increases sharply in a short time period,which is defined as a "particulate matter explosive increase". Heavy particulate matter pollution not only reduces visibility but also has an adverse effect on human health. Hence,there is an urgent need to discover the causes of particulate matter explosive *** this campaign, the particle number concentration and free radicals were measured at a tall building on the campus of Lanzhou University of Technology. Additionally, we examined a series of chemicals to reproduce the observed particulate matter explosive increase in a smog chamber to determine its potential factors. Then, we analyzed the mechanism of particulate matter explosive increase in the presence of free radicals. We found that, among the potential inorganic and organic sources analyzed, a mixture of organic and SO_2 in the research region had a major effect on particulate matter explosive increase. Moreover, free radical oxidation has a large effect, especially in the formation of organic particulates.

关键词： Particulate matter pollution Particle number concentration Explosive increase Free radical oxidation

Cholinergic dysfunction-induced insufficient activation of alpha7 nicotinic acetylcholine receptor drives the development of rheumatoid arthritis through promoting protein citrullination via the SP3/PAD4 pathway

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1600-1615页

作者： Changjun Lv Minghui Sun Yilei Guo Wenxin Xia Simiao Qiao yu Tao yulai Fang Qin Zhang yanrong Zhu yusufu Yalikun yufeng Xia Zhifeng Wei yue Dai Department of Pharmacology of Chinese Materia Medica School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 211198China Division of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic SurgeryNanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China

Both cholinergic dysfunction and protein citrullination are the hallmarks of rheumatoid arthritis(RA),but the relationship between the two phenomena remains *** explored whether and how cholinergic dysfunction accelerates protein citrullination and consequently drives the development of *** function and protein citrullination levels in patients with RA and collageninduced arthritis(CIA)mice were *** both neuron-macrophage coculture system and CIA mice,the effect of cholinergic dysfunction on protein citrullination and expression of peptidylarginine deiminases(PADs)was assessed by *** key transcription factors for PAD4 expression were predicted and *** dysfunction in the patients with RA and CIA mice negatively correlated with the degree of protein citrullination in synovial *** cholinergic or alpha7 nicotinic acetylcholine receptor(a7nAChR)deactivation and activation resulted in the promotion and reduction of protein citrullination in vitro and in vivo,***,the activation deficiency of a7nAChR induced the earlier onset and aggravation of ***,deactivation of a7nAChR increased the expression of PAD4 and specificity protein-3(SP3)in vitro and in *** results suggest that cholinergic dysfunction-induced deficient a7nAChR activation,which induces the expression of SP3 and its downstream molecule PAD4,accelerating protein citrullination and the development of RA.

关键词： Rheumatoid arthritis Citrullination Cholinergic dysfunction a7nAChR Peptidylarginine deiminase 4 Specificity protein-3 Collagen-induced arthritis Neuron-macrophage coculture system

All-climate aqueous Na-ion batteries using “water-in-salt” electrolyte

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Science Bulletin 2022年第2期67卷 161-170,M0004页

作者： yu Zhang Jie Xu Zhi Li yanrong Wang Sijia Wang Xiaoli Dong Yonggang Wang Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New EnergyiChEM(Collaborative Innovation Center of Chemistry for Energy Materials)Fudan UniversityShanghai 200433China College of Pharmacy Henan University of Chinese MedicineZhengzhou 450046China

Aqueous Na-ion batteries have been extensively studied for large-scale energy storage systems. However,their wide application is still limited by their inferior cycle stability(<3000 cycles) and poor temperature tolerance. Furthermore, many of the reported high rate behaviors are achieved at a low mass loading(<3 mg cm^(-2)) of the electrodes. Herein, we propose an aqueous Na-ion battery which includes a Ni-based Prussian blue(NiHCF) cathode, a carbonyl-based organic compound, 5,7,12,14-pentacenetetrone(PT)anode and a “water-in-salt” electrolyte(17 mol kg^(-1)NaClO_(4)in water). Its operation involves the reversible coordination reaction of the PT anode and the extraction/insertion of Na;in the NiHCF cathode. It is demonstrated that the wide internal spaces of the PT anode and NiHCF cathode can not only buffer the volumetric change induced by Na;storage, but also enable fast kinetics. The full cell exhibits a supercapacitor-like rate performance of 50 A g^(-1)(corresponding to a discharge or charge within 6.3 s)and a super-long lifespan of 15,000 cycles. Moreover, the excellent rate performance can still be preserved even with a high mass loading of the electrodes(15 mgNiHCFcm^(-2)and 8 mgPTcm^(-2)).Especially, the cell can work well in a wide temperature range, from-40 to 100 °C, showing a typical all-climate operation.

关键词： Aqueous Na-ion batteries All-climate Long lifespan “Water-in-salt”electrolyte

Fluorescence Fiber-Based Fire Alarm System

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Fluorescence Fiber-Based Fire Alarm System

NUPR1 promotes the proliferation and metastasis of oral squamous cell carcinoma cells by activating TFE3-dependent autophagy

第十二届全国光散射学术会议

作者： Weimin Sun Libo yuan yanrong Xiang Yang Zhang Lei yu Qiang Liu School of Science Harbin Engineering University School of Information Communication Harbin Engineering University

＜正＞Effective detection of potential fire hazards is important in industry,and especially in aerospace *** fiber methods may offer alternatives to well-established conventional devices and a fluorescence-based fire alarm system has been developed specially to address this *** aim has been to investigate and develop a simple yet effective scheme to determine the presence of a localized

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来源： cnki会议评论

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cnki会议

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1797-1807页

作者： Tengfei Fan Xiaoning Wang Sheng Zhang Ping Deng Yi Jiang Yidan Liang Sheng Jie Qing Wang Chuwen Li Guocai Tian Zhen Zhang Zhenhu Ren Bo Li yanrong Chen Zhijing He Yan Luo Mingliang Chen Hanjiang Wu Zhengping yu Huifeng Pi Zhou Zhou Zhiyuan Zhang Department of Oral and Maxillofacial-Head Neck Oncology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology Research Unit of Oral and Maxillofacial Regenerative Medicine Chinese Academy of Medical SciencesShanghaiChina Department of Oral and Maxillofacial Surgery Zhang Zhiyuan Academician WorkstationHainan Western Central HospitalShanghai Ninth People’s HospitalDanzhouHainanChina Department of Oral and Maxillofacial Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunanChina Department of Oral Pathology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Occupational Health Third Military Medical UniversityChongqingChina Department of Pathology The Second Xiangya Hospital of Central South UniversityChangshaHunanChina School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Oral and Maxillofacial Surgery Affiliated Hospital of Guilin Medical UniversityGuilinGuangxi Zhuang Autonomous RegionChina Institute of Pathology and Southwest Cancer Centre Southwest HospitalThird Military Medical UniversityChongqingChina and 10Department of Emergency MedicineFirst Affiliated Hospital and Department of Environmental MedicineSchool of Public HealthSchool of MedicineZhejiang UniversityHangzhouZhejiangChina

Oral squamous cell carcinoma(OSCC)is the most common type of oral malignancy,and metastasis accounts for the poor prognosis of *** is considered to facilitate OSCC development by mitigating various cellular stresses;nevertheless,the mechanisms of autophagy in OSCC cell proliferation and metastasis remain *** our study,high-sensitivity label-free quantitative proteomics analysis revealed nuclear protein 1(NUPR1)as the most significantly upregulated protein in formalin-fixed paraffin-embedded tumour samples derived from OSCC patients with or without lymphatic metastasis.

关键词： metastasis squamous prognosis

维普期刊数据库评论

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维普期刊数据库

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反应器内增刚聚丙烯的研究进展

石油化工 2006年第12期35卷 1193-1196页

作者：王彦荣于鲁强谷汉进中国石油化工股份有限公司北京化工研究院北京100013

综述了高刚性聚丙烯的性能及反应器内聚丙烯增刚的主要方法,主要从聚合工艺进展、催化剂体系选择、催化剂改性(催化剂预聚改性成核法和聚合改性)和反应器内添加成核剂等方面介绍了反应器内高刚性聚丙烯最新研究进展及其发展前景。

关键词：刚性聚丙烯成核剂催化剂反应器

Protective effect of oxysophoridine on cerebral ischemia/reperfusion injury in mice

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Neural Regeneration Research 2013年第15期8卷 1349-1359页

作者： Hongbo Wang yuxiang Li Ning Jiang Xiaoping Chen Yi Zhang Kuai Zhang Tengfei Wang Yinju Hao Lin Ma Chengjun Zhao yanrong Wang Tao Sun Jianqiang yu Department of Pharmacology Ningxia Medical University College of Nursing Ningxia Medical University Shanghai Pudong New Area Gongli Hospital Ningxia Key Laboratory of Craniocerebral Diseases of Ningxia Hui Autonomous Region School of Basic Medical Sciences Ningxia Medical University Key Laboratory of Reproduction and Genetics of Ningxia Medical University Collaborative Innovation Center of Ningxia Hui Autonomous Region for Medicines

Oxysophoridine, a new alkaloid extracted from Sophora alopecuroides L., has been shown to have a protective effect against ischemic brain damage. In this study, a focal cerebral ischemia/reperfusion injury model was established using middle cerebral artery occlusion in mice. Both 62.5, 125, and 250 mg/kg oxysophoridine, via intraperitoneal injection, and 6 mg/kg nimodipine, via intragastric administration, were administered daily for 7 days before modeling. After 24 hours of reperfusion, mice were tested for neurological deficit, cerebral infarct size was assessed and brain tissue was collected. Results showed that oxysophoridine at 125, 250 mg/kg and 6 mg/kg nimodipine could reduce neurological deficit scores, cerebral infarct size and brain water content in mice. These results provided evidence that oxysophoridine plays a protective role in cerebral ischemia/reperfusion injury. In addition, oxysophoridine at 62.5, 125, and 250 mg/kg and 6 mg/kg nimodipine increased adenosine-triphosphate content, and decreased malondialdehyde and nitric oxide content. These compounds enhanced the activities of glutathione-peroxidase, superoxide dismutase, catalase, and lactate dehydrogenase, and decreased the activity of nitric oxide synthase Protein and mRNA expression levels of N-methyI-D-aspartate receptor subunit NR1 were markedly inhibited in the presence of 250 mg/kg oxysophoridine and 6 mg/kg nimodipine. Our experimental findings indicated that oxysophoridine has a neuroprotective effect against cerebral ischemia/reperfusion injury in mice, and that the effect may be due to its ability to inhibit oxidative stress and expression of the N-methyI-D-aspartate receptor subunit NR1.

关键词： neural regeneration traditional Chinese medicine brain injury oxysophoridine ischemia/reperfusion injury oxidative stress N-methyI-D-aspartate receptor neuroprotection grants-supported paper neuroregeneration

生物炭/过一硫酸盐体系同时去除Cu^2+和对硝基苯胺

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化工进展 2020年第10期39卷 4268-4274页

作者：孙鹏张凯凯张玉张延荣华中科技大学环境科学与工程学院湖北武汉430074 内蒙古科技大学能源与环境学院内蒙古包头014010

目前,重金属离子和有机污染物共存的废水处理是一个世界性的重大问题,对环境保护具有重要的意义。本研究以农业废弃物向日葵秸秆为原料,制备了一种生物炭(BC),用以活化过一硫酸盐(PMS)。BC/PMS体系实现了对水中重金属Cu^2+和有机污染物... 详细信息

目前,重金属离子和有机污染物共存的废水处理是一个世界性的重大问题,对环境保护具有重要的意义。本研究以农业废弃物向日葵秸秆为原料,制备了一种生物炭(BC),用以活化过一硫酸盐(PMS)。BC/PMS体系实现了对水中重金属Cu^2+和有机污染物对硝基苯胺(PNA)的同时去除。探究了pH、BC投加量和PMS浓度等反应条件对同时去除Cu^2+和PNA的影响。研究表明,在BC=2.0g/L、PMS=1.0mmol/L、PNA=20.0mg/L、Cu^2+=2.0mg/L和pH=3.0条件下,60min时Cu^2+和PNA同时去除效率分别为90.00%和100.00%;Cu^2+被BC/PMS体系吸附去除的同时也显著地促进了PNA的降解去除。自由基猝灭实验和电子顺磁共振光谱(EPR)实验表明,BC/PMS/Cu^2+/PNA体系降解PNA为自由基反应和非自由基反应共存过程,且以非自由基反应为主导;自由基反应是基于Cu^2+活化PMS产生SO4^·-和•OH,非自由基反应可归因于BC活化PMS产生活性物种1O2。

关键词：生物炭过一硫酸盐同时去除铜离子对硝基苯胺

旅游洞穴网络关注度的时空特征研究——以中国最美五大旅游洞穴为例

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中国岩溶 2017年第2期36卷 275-282页

作者：何小芊张艳蓉刘宇东华理工大学地质资源经济与管理研究中心南昌330013 东华理工大学资源与环境经济研究中心南昌330013 东华理工大学地球科学学院南昌330013

旅游网络关注度是旅游者需求状况和行为习惯在网络上的直观表现。基于百度指数,运用变异系数、基尼系数等定量测算方法,以中国最美五大旅游洞穴为例,对中国旅游洞穴网络关注度的时空特征进行了研究。研究结果显示:旅游洞穴在网络上的关... 详细信息

旅游网络关注度是旅游者需求状况和行为习惯在网络上的直观表现。基于百度指数,运用变异系数、基尼系数等定量测算方法,以中国最美五大旅游洞穴为例,对中国旅游洞穴网络关注度的时空特征进行了研究。研究结果显示:旅游洞穴在网络上的关注度较高,并呈现上升的态势,月变化曲线呈双"M"形;网络关注度的省际差异明显,关注度较高的区域主要是洞穴所在的省(市)、邻近省(市)以及东部经济发达省份;旅游洞穴网络关注度的高峰、低谷与国内旅游活动的季节性差异具有耦合性,洞穴的吸引力和吸引范围具有明显的区域性。研究结论为洞穴旅游的发展提供了启示:应充分重视互联网在景区营销中的作用,将网络关注度作为景区经营管理的重要工具,加强与周边景区(点)的合作。

关键词：旅游洞穴百度指数网络关注度时空特征