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Journal of Innovative Optical Health Sciences 2017年第3期10卷 97-106页

作者： Haibo Zhang Guohua Geng yanrong chen Fengjun Zhao Yuqing Hou Huangjian Yi Shunli Zhang Jingjing Yu Xiaowei He School of Information Sciences and Technology Northwest University Xi'an Shannxi 710027P.R.China School of Physics and Information Technology Shaanxi Normal University Xi'an Shannxi 710062P.R.China

As an emerging molecular imaging modality,cone-beam X-ray luminescence computed tomog-raphy(CB-XLCT)uses X-ray-excitable probes to produce near-infrared(NIR)luminescence and then reconst ructs three-dimensional(3D)distribution of the probes from surface measurements.A proper photon-transportation model is critical to accuracy of ***,we presented a systematic comparison between the common-used Monte Carlo model and simplified spherical harmonics(SPN).The performance of the two methods was evaluated over several main spec-trums using a known XLCT *** designed both a global measurement based on the cosine similarity and a locally-averaged relative error,to quantitatively assess these *** results show that the SP_(3) could reach a good balance between the modeling accuracy and computational efficiency for all of the tested emission ***,the SP_(1)(which is equivalent to the difusion equation(DE))can be a reasonable alternative model for emission wavelength over *** vivo experiment further demonstrates the reconstruction perfor-mance of the SP:and *** study would provide a valuable guidance for modeling the photon-transportation in CB-XLCT.

关键词： Cone-beam X-ray luminescence computed tomography photon-transportation model .simplified spherical harmonics approximation diffusion equations.

Cancer-associated fibroblasts derived fibronectin extra domain A promotes sorafenib resistance in hepatocellular carcinoma cells by activating SHMT1

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Genes & Diseases 2024年第6期11卷 510-524页

作者： Yan Dong yanrong chen Yijie Wang Xiang Zhao Ruiyang Zi Jie Hao Qiong Ding Haoran Jiang Xuesong Wang Fanghao Lu Houjie Liang Zhihao Wei Jianjun Li Department of Oncology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Brain Research Center and State Key Laboratory of Trauma Burnsand Combined InjuryThird Military Medical University(Army Medical University)Chongqing 400038China

Resistance to sorafenib,an effective first-line treatment for advanced hepatocellular carcinoma(HCC),greatly compromised the prognosis of *** extracellular matrix is one of the most abundant components of the tumor *** acting as a physical barrier,it remains unclear whether cell interactions and signal transduction mediated by the extracellular matrix contribute to sorafenib *** the analysis of primary HCC organoid RNA-seq data combined with in vivo and in vitro experiments validation,we discovered that fibronectin extra domain A(FN-EDA)derived from cancer-associated fibroblasts played a critical role in sorafenib ***,FN-EDA stimulates the up-regulation of the key one-carbon metabolism enzyme SHMT1 in HCC cells via the TLR4/NF-κB signaling pathway,thereby countering the oxidative stress induced by ***,we reinforced the clinical significance of our discoveries by conducting in vivo assays with an immunodeficiency subcutaneous xenograft tumor model,which was established using primary cancer-associated fibroblasts derived from clinical HCC tissues,and through the analysis of HCC samples obtained from The Cancer Genome Atlas(TCGA)*** findings suggest that targeting the FN-EDA/SHMT1 pathway could be a potential strategy to improve sorafenib responsiveness in HCC patients.

关键词： Cancer-associated fibroblasts Fibronectin extra domain A Hepatocellular carcinoma Serine hydroxymethyl transferase1 Sorafenib resistance

浅谈前寒武纪条带状铁建造的沉积-变质成矿过程

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岩石学报 2021年第1期37卷 253-268页

作者：李旭平陈妍蓉山东省沉积成矿作用实验室山东科技大学地球科学与工程学院青岛266510

条带状铁建造(BIF)是3.5~1.8Ga前陆架和洋盆的常见沉积物。前寒武纪条带状铁建造构成了世界上重要的铁矿资源。虽然它们成矿过程及其演化的许多方面的问题仍未解决,但人们普遍认为,它们沉积方式的长期变化与地球的环境和地球化学演化有... 详细信息

条带状铁建造(BIF)是3.5~1.8Ga前陆架和洋盆的常见沉积物。前寒武纪条带状铁建造构成了世界上重要的铁矿资源。虽然它们成矿过程及其演化的许多方面的问题仍未解决,但人们普遍认为,它们沉积方式的长期变化与地球的环境和地球化学演化有关。条带状铁建造记录了前寒武纪古海洋、古环境、大气条件和细菌代谢条件以及铁的来源和沉积过程。大型BIF沉积与大火成岩省有成因联系,其铁的来源与火山物质加入的海底热液体系有关,或有陆缘岩石风化的无机物产物加入,越靠近陆缘,陆源碎屑物质加入的越多。然而,在太古宙到古元古代期间,BIF沉积的深水盆地中陆源物质的加入很少。那时的铁建造沉积在缺氧的海洋中,通过微生物的光合作用、无氧光合氧化和紫外光线辐射氧化等机制对溶解的二价铁进行氧化,从而形成三价铁氢氧化物和氧化物的沉积。大多数BIF大型矿床,自其在沉积环境中形成以来,它们在从太古宙直至中生代的漫长的地质历史演化过程中经历了铁矿的品位由低到高转化的复杂地质过程,一般经历了深部交代变质作用的除硅、除碳酸岩矿物的富集成矿和浅部风化富集成矿过程。许多BIF铁矿经历了从绿片岩相到角闪岩相变质作用,但到达的压力条件都不是很高,这或许与俯冲的高密度BIF铁矿难以折返的动力学机制有关。迄今为止,变质作用、尤其是高级变质作用对成矿过程的影响研究较少,是今后值得关注的领域。

关键词： BIF铁矿太古宙到早元古代沉积过程变质作用成矿作用

NUPR1 promotes the proliferation and metastasis of oral squamous cell carcinoma cells by activating TFE3-dependent autophagy

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1797-1807页

作者： Tengfei Fan Xiaoning Wang Sheng Zhang Ping Deng Yi Jiang Yidan Liang Sheng Jie Qing Wang Chuwen Li Guocai Tian Zhen Zhang Zhenhu Ren Bo Li yanrong chen Zhijing He Yan Luo Mingliang chen Hanjiang Wu Zhengping Yu Huifeng Pi Zhou Zhou Zhiyuan Zhang Department of Oral and Maxillofacial-Head Neck Oncology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology Research Unit of Oral and Maxillofacial Regenerative Medicine Chinese Academy of Medical SciencesShanghaiChina Department of Oral and Maxillofacial Surgery Zhang Zhiyuan Academician WorkstationHainan Western Central HospitalShanghai Ninth People’s HospitalDanzhouHainanChina Department of Oral and Maxillofacial Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunanChina Department of Oral Pathology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Occupational Health Third Military Medical UniversityChongqingChina Department of Pathology The Second Xiangya Hospital of Central South UniversityChangshaHunanChina School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Oral and Maxillofacial Surgery Affiliated Hospital of Guilin Medical UniversityGuilinGuangxi Zhuang Autonomous RegionChina Institute of Pathology and Southwest Cancer Centre Southwest HospitalThird Military Medical UniversityChongqingChina and 10Department of Emergency MedicineFirst Affiliated Hospital and Department of Environmental MedicineSchool of Public HealthSchool of MedicineZhejiang UniversityHangzhouZhejiangChina

Oral squamous cell carcinoma(OSCC)is the most common type of oral malignancy,and metastasis accounts for the poor prognosis of *** is considered to facilitate OSCC development by mitigating various cellular stresses;nevertheless,the mechanisms of autophagy in OSCC cell proliferation and metastasis remain *** our study,high-sensitivity label-free quantitative proteomics analysis revealed nuclear protein 1(NUPR1)as the most significantly upregulated protein in formalin-fixed paraffin-embedded tumour samples derived from OSCC patients with or without lymphatic metastasis.

关键词： metastasis squamous prognosis

社交媒体接触对社会运动参与的影响研究——基于政治自我概念的交互效应

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新闻界 2020年第2期 69-79页

作者：曹钺陈彦蓉复旦大学新闻学院上海200433 重庆大学新闻学院一法学院重庆401331

社交媒体在全球社会运动与政治变革中发挥的作用已引起高度关注,不过其具体的影响机制仍不明确且充满争议。本文利用TCS2015年的数据,使用Logistic回归模型对社交媒体接触(自变量)与线上、线下社会运动参与(因变量)之间的关系进行实证分... 详细信息

社交媒体在全球社会运动与政治变革中发挥的作用已引起高度关注,不过其具体的影响机制仍不明确且充满争议。本文利用TCS2015年的数据,使用Logistic回归模型对社交媒体接触(自变量)与线上、线下社会运动参与(因变量)之间的关系进行实证分析,并引入"政治自我概念"中的一系列心理变量(政治知识、政治兴趣、内在政治效能感、外在政治效能感)对个体性差异进行检验。研究发现,社交媒体展现出显著的、不可被抵消的动员效应。政治知识不会单独对社会运动参与程度产生影响,但可以与社交媒体产生交互效应,放大其对运动参与的正向效应。内在政治效能感既会对社会运动参与产生正向影响,又能强化社交媒体的动员效应。线上、线下两种运动模式的作用机制大致类似,但存在微妙的差异。上述结果部分支持了研究假设,反映出社会运动往往是个体心理与新媒介工具共同作用的结果。这些结论放置于台湾社会的现实政治语境中,可以带来思考与启发。

关键词：社交媒体社会运动政治自我概念交互效应

早期中国互联网的技术隐喻与话语实践(1987-2003)

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新闻界 2021年第9期 75-85,96页

作者：陈彦蓉曹钺重庆大学新闻学院重庆401331 复旦大学新闻学院上海200433

20世纪90年代以来,早期中国互联网超常规模的创新扩散一直是西方学界津津乐道的议题。不同于传统上聚焦互联网接入与使用情况的测量,本文从认知语言学"隐喻"的视角切入,将技术的创新扩散视为一种意义整合的社会过程,并围绕特定事件与案... 详细信息

20世纪90年代以来,早期中国互联网超常规模的创新扩散一直是西方学界津津乐道的议题。不同于传统上聚焦互联网接入与使用情况的测量,本文从认知语言学"隐喻"的视角切入,将技术的创新扩散视为一种意义整合的社会过程,并围绕特定事件与案例重访了1987-2003年间关于中国互联网的历史叙事。研究发现,这一时期中国社会生成出诸如"盗火""信息高速公路""知识英雄""第二人生""广场""江湖""家园"等多种隐喻。其背后是国家政府、市场经济、网民群体、国际势力等多元行动者在具体历史语境下的复杂互动,并且民族主义作为意识形态的"纽结点"缝合了诸隐喻之间的裂痕与间隙,使隐喻体系保持了整体的连贯。以上也揭示出早期中国互联网在全球与本土、国家与社会、集体与个体之间所形成的微妙平衡以及其历史意义。

关键词：互联网史隐喻话语实践多元互动

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添加剂对劣质煤燃烧特性和灰渣熔融性的影响

煤炭转化 2015年第1期38卷 69-74页

作者：陈艳容李浩杰重庆大学动力工程学院低品位能源利用技术及系统教育部重点实验室

利用热重-微分分析仪和灰熔点测试仪,研究了O2/CO2和O2/N2气氛下添加剂对重庆南桐高灰分劣质烟煤燃烧特性和煤灰灰渣熔融温度的影响,并进行了动力学分析.结果表明,添加剂CaCl2,Ca(OH)2和CaCO3均能有效地增加煤粉反应表面的活性,降低煤... 详细信息

利用热重-微分分析仪和灰熔点测试仪,研究了O2/CO2和O2/N2气氛下添加剂对重庆南桐高灰分劣质烟煤燃烧特性和煤灰灰渣熔融温度的影响,并进行了动力学分析.结果表明,添加剂CaCl2,Ca(OH)2和CaCO3均能有效地增加煤粉反应表面的活性,降低煤粉反应表观活化能、煤粉点燃温度和燃尽温度,提高煤粉可燃性指数C和燃尽指数Cb,但三种添加剂对煤粉燃烧促进作用有差异,其促进性能大小顺序为CaCl2>Ca(OH)2>CaCO3.添加剂CaCl2的加入能够提高煤粉的燃烧效率.添加剂Ca(OH)2和CaCO3的加入显著降低了煤灰熔融点温度,增加煤灰结渣可能性,而添加剂CaCl2的加入对煤灰灰渣熔融点温度降低不明显.CaCl2作为劣质煤燃烧添加剂,具有较好的综合性能.

关键词：添加剂劣质煤燃烧熔融温度动力学分析

非深度学习类MR化学交换饱和转移成像(CEST-MRI)定量方法研究进展

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中国介入影像与治疗学 2023年第8期20卷 502-506页

作者：陈雁蓉陈一兵宋小磊西北大学信息科学与技术学院陕西西安710127 清华大学医学院北京100084

MR化学交换饱转移成像(CEST-MRI)对活体组织内与水发生化学交换的质子进行成像,可用于检测肿瘤和神经系统疾病等引发的代谢变化。本文就非深度学习类CEST-MRI定量方法研究进展进行综述。

关键词：化学交换饱和转移成像磁共振成像

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Chest CT quantitative parameters in patients with acute exacerbation of chronic obstructive pulmonary disease:Correlations with blood eosinophil level

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中国医学影像技术 2024年第8期40卷 1189-1193页

作者： YANG Lu SHENG Yadan YANG Kai HE Liyu GU Huihui SUN Guoqing chen Weiting ZHU Bingjie chen yanrong JIN chenwang Department of Medical Imaging the First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061China School of Medical Technology Shaanxi University of Chinese MedicineXianyang 712046China Department of Medical Imaging Ankang People's HospitalAnkang 725000China

Objective To observe the correlations of chest CT quantitative parameters in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with blood eosinophil(EOS)*** Chest CT data of 162 AECOPD patients with elevated eosinophils were retrospectively *** patients were divided into low EOS group(n=105)and high EOS group(n=57)according to the absolute counting of blood *** quantitative CT parameters,including the number of whole lung bronchi and the volume of blood vessels,low-attenuation area percentage(LAA%)of whole lung,of left/right lung and each lobe of lung,as well as the luminal diameter(LD),wall thickness(WT),wall area(WA)and WA percentage of total bronchial cross-section(WA%)of grade 3 to 8 bronchi were compared between *** correlations were performed to analyze the correlations of quantitative CT parameters with blood EOS *** LAA%of the whole lung,of the left/right lung and each lobe of lung,as well as of the upper lobe of right lung LD grade 4,middle lobe of right lung WT grade 5,upper lobe of right lung WA grade 4,middle lobe of right lung WA grade 5 and lower lobe of left lung WA grade 3 in low EOS group were all higher than those in high EOS group(all P<0.05).Except for the upper lobe of right lung LD grade 4,the above quantitative CT indexes being significant different between groups were all weakly and negatively correlated with blood EOS level(r=-0.335 to-0.164,all P<0.05).Conclusion Chest CT quantitative parameters of AECOPD patients were correlated with blood EOS level,among which LAA%,a part of WT and WA were all weakly negatively correlated with blood EOS level.

关键词： pulmonary disease,chronic obstructive eosinophils tomography,X-ray computed

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土遗址病害研究新进展与展望

敦煌研究 2022年第2期 136-148页

作者：孙满利陈彦榕沈云霞西北大学文化遗产学院陕西西安710127

我国土遗址资源丰富,“十一五”以来,开展了大量土遗址病害研究,取得了重要进展。系统总结梳理了“十一五”以来土遗址病害研究的新进展,结果表明:干旱区土遗址病害认识逐步深入,分类体系逐步形成,但系统性、区域性规律的总结与研究以... 详细信息

我国土遗址资源丰富,“十一五”以来,开展了大量土遗址病害研究,取得了重要进展。系统总结梳理了“十一五”以来土遗址病害研究的新进展,结果表明:干旱区土遗址病害认识逐步深入,分类体系逐步形成,但系统性、区域性规律的总结与研究以及潮湿地区土遗址病害研究相对较少;新技术在土遗址调查中发挥的作用和效果还不明显,调查手段急需取得较大突破;土遗址病害机理研究不断深入,但多以定性和单因素作用机制研究为主,研究方法急需突破。定量劣化过程机制和多因素耦合作用机制研究将会成为土遗址保护技术研发的突破口。

关键词：土遗址保护病害机理