检索结果-南通市图书馆

Gypenoside ameliorates insulin resistance and hyperglycemia via the AMPK-mediated signaling pathways in the liver of type 2 diabetes mellitus mice

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2022年第5期11卷 1347-1354页

作者： Mengxue Song Dehong Tan Bin Li yanqun wang Lin Shi College of Food Science Shenyang Agricultural UniversityShenyang 110866China Key Laboratory of Healthy Food Nutrition and Innovative Manufacturing of Liaoning Province Shenyang Agricultural UniversityShenyang 110866China

Gynostemma pentaphyllum,also called"Southern Ginseng"in China,is a traditional Asian folk medicinal ***(Gps)are the biologically active constituents of ***,which have been reported with hypoglycemic ***,the underlying mechanisms are *** effects of two Gps(Gp-Ⅰand Gp-Ⅱ)on type 2 diabetic mellitus(T2DM)mice,induced by high-fat and high-sugar diet and streptozotocin,were evaluated to explore the mechanism of their hypoglycemic *** reduced fasting blood glucose and serum lipids,as well as significantly improved T2DM mice glucose tolerance and insulin resistance(IR).After Gps treatment,the severity of liver injury was reduced and liver glycogen content *** addition,Gps promoted the phosphorylation of adenosine monophosphate-activated protein kinase(AMPK),and downregulated the key proteins phosphoenolpyruvate carboxy kinase and glucose-6 phosphatase,in the AMPK signaling ***,our study suggests that Gps mediate hepatic gluconeogenesis and improve IR via activating AMPK signaling pathway in T2DM mice.

关键词： Gypenosides Gynostemma pentaphyllum Diabetes Insulin resistance Gluconeogenesis Adenosine monophosphate-activated protein kinase(AMPK)

Biotransformation and pharmacological activities of platycosides from Platycodon grandiflorum roots

在线全文

学校读者我要写书评

暂无评论

Chinese Herbal Medicines 2024年第3期16卷 392-400页

作者： Lin Shi Tong Cui Xinyue wang Rina Wu Junrui Wu yanqun wang Weiming wang College of Food Science Shenyang Agricultural UniversityShenyang 110866China Institute of Chinese Materia Medica Heilongjiang Academy of Chinese Medicine SciencesHarbin 150036China

In Northeast China,Goubao pickle is a popular food fermented from the roots of Platycodon grandiflorum as the main material,offering a unique flavor and rich nutritional *** in roots of *** may play a crucial role in determining the quality of Goubao pickle through microorganism ***,biotransfermation of platycosides has not been reviewed during *** this study,we reviewed platycosides in chemical diversity,metabolic processes in vivo,biotransformation of platycosides in vitro,and pharmacological ***,we also discussed how to improve the bioactive secondary platycosides we desire by regulating enzymes from microorganisms in the future.

关键词： biotransformation Goubao pickle microorganisms pharmacological activities platycosides Platycodon grandiflorum(Jacq.)A.DC

Structural characteristics of the SARS-CoV-2 Omicron lineages BA.1 and BA.2 virions

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第4期8卷 1381-1383页

作者： Xiaoyu Ma yanqun wang Yuanzhu Gao Yiliang wang An Yan Jiantao Chen Lu Zhang Peiyi wang Jincun Zhao Zheng Liu Cryo-electron Microscopy Center Southern University of Science and TechnologyShenzhenGuangdongChina State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Health and Quarantine Laboratory Guangzhou Customs District Technology CentreGuangzhouChina Guangzhou Laboratory Bio-IslandGuangzhouChina Institute of Infectious disease Guangzhou Eighth People’s Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina

Dear Editor,Variants of concern(VOCs)of SARS-CoV-2 have increased transmissibility,virulence,and *** emergence of new VOCs continues to pose great challenges to public *** detailed structures of the intact Omicron viruses remain *** this study,we report the architecture of both Omicron BA.1 and BA.2 lineages using cryo-electron tomography(cryo-ET).The subtomogram averaging of viral spikes,in both pre-fusion and postfusion conformations are also investigated.

关键词： characteristics Omi resistance.

Phosphorus Recovery as Struvite from the Supernatant of Anaerobic Digestion in Wastewater Treatment Plant

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Science and Engineering 2010年第1期4卷 14-19页

作者： Gang Xue Yanan Liu yanqun wang School of Environmental Science and Engineering Donghua University Shanghai 201620 China

Phosphorus is an irreplaceable and depletable element. Furthermore, it has an almost one-way circulation on earth, so it is necessary to close the phosphorus cycle loop. Phosphorus could be recovered as struvite, which is a good slow-released fertilizer for agriculture. The supernatant of anaerobic digestion used to treat sludge from wastewater treatment plant is one main source from which phosphorus can be recovered. Studies have proven that phosphorus recovery from digester supematant is a feasible choice to preserve phosphorus rock technically and economically. A modified ＂PHOSNIX＂ P-recovery process was applied under the operating conditions of a 9.0 pH value and a 1.8 mg： P ratio with the influent of the centrate coming from the sludge centrifuge of the Songjiang Wastewater Treatment Plant in Shanghai. More than 80% influent phosphorus was recovered as struvite. Crystal products with good purity and low heavy metal content were gained. The largest crystal had a length of up to 0.26 mm. It was found in our study that the reaction time did not play an important role in crystal growth. Therefore, the optimization of the reaction condition for crystal growth should be examined in future study.

关键词： Phosphorus recovery struvite supernatant anaerobic digestion wastewater treatment plant.

Antigenic characterization of SARS-CoV-2 Omicron subvariants XBB.1.5,BQ.1,BQ.1.1,BF.7 and BA.2.75.2

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第4期8卷 1372-1374页

作者： Airu Zhu Peilan Wei Miao Man Xuesong Liu Tianxing Ji Jiantao Chen Canjie Chen Jiandong Huo yanqun wang Jincun Zhao State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina University Hospital and Center for Biomedicine and Innovations Faculty of MedicineMacao University of Science and TechnologyMacao SARChina Clinical Laboratory Medicine Department The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina Guangzhou laboratory BioislandGuangzhouChina Shanghai Institute for Advanced Immunochemical Studies School of Life Science and TechnologyShanghaiTech UniversityShanghaiChina

Dear Editor,Recently,a number of new Omicron subvariants related to BA.4/5 and BA.2.75 have emerged and shown remarkable antibody evasion capacities,in particular BF.7,BQ.1,BQ.1.1,BA.2.75.2,XBB and XBB.1.5.1 Unsurprisingly,these new subvariants are quickly gaining prevalence *** fact,some of them have outcompeted BA.5 in the USA according to CDC’s national genomic surveillance data in which,as of 6th February 2023,XBB.1.5,BQ.1.1,BQ.1,XBB and BF.7 have achieved a dominance of 66.4%,19.9%,7.3%,2.3%and 0.5%in the USA,as compared to 0.5%for *** this report,using plasma samples collected from individuals following different vaccination strategies and COVID-19 convalescent donors,we performed pseudoviral neutralization assays to confirm severe reductions in neutralization titers against BF.7,BQ.1,BQ.1.1,BA.2.75.2,XBB and XBB.1.5 in comparison to other Omicron *** and XBB.1.5 were shown to be remarkably resistant to plasma neutralization in all tested *** comparing the differential neutralization profiles,we found that a heterologous booster with an aerosolized vaccine following 2 doses of inactivated vaccine seemed to be superior to other vaccination strategies.

关键词： doses vaccination fir

硝化甘油在α-Al_2O_3(0001)和γ-Al_2O_3(110)表面吸附的理论计算

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高等学校化学学报 2017年第8期38卷 1383-1389页

作者：王艳群王宝山李伟长江大学化学与环境工程学院荆州434023 武汉大学化学与分子科学学院武汉430072 湖北航天化学技术研究所固体推进剂高能与安全技术重点实验室襄阳441003

选取硝化甘油(NG)和氧化铝(Al_2O_3)分别作为推进剂中的含能增塑剂和燃料表面的模型,研究了含硝酸酯类增塑剂与推进剂中燃烧剂表面的微观作用机理.采用基于密度泛函理论的第一性原理方法和全电子双数值基组研究了NG在α-Al_2O_3(0001)和... 详细信息

选取硝化甘油(NG)和氧化铝(Al_2O_3)分别作为推进剂中的含能增塑剂和燃料表面的模型,研究了含硝酸酯类增塑剂与推进剂中燃烧剂表面的微观作用机理.采用基于密度泛函理论的第一性原理方法和全电子双数值基组研究了NG在α-Al_2O_3(0001)和γ-Al_2O_3(110)表面的吸附作用.计算结果表明,NG可以在α-Al_2O_3(0001)和γ-Al_2O_3(110)表面发生强烈化学吸附;吸附导致相应的O—NO_2键被明显拉长并断裂,无能垒自发产生NO_2自由基,该解离过程放出大量的热,吸附能高达约175.7 kJ/mol;NG在完全羟基化的α-Al_2O_3(0001)和γ-Al_2O_3(110)表面上的吸附明显减弱,从强烈的化学吸附转变成以氢键作用为主的物理吸附,吸附能只有约50.0 kJ/mol;而在部分羟基化的α-Al_2O_3(0001)和γ-Al_2O_3(110)表面上可以同时发生物理吸附和化学吸附,且两种机制并不存在明显的协同或催化作用.

关键词：硝化甘油氧化铝表面吸附密度泛函理论相容性

Dynamics of neutralizing antibody responses to SARS-CoV-2 in patients with COVID-19: an observational study

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2021年第6期6卷 1869-1875页

作者： Xin Xu Sheng Nie yanqun wang Quanxin Long Hong Zhu Xiaoyong Zhang Jian Sun Qinglang Zeng Jincun Zhao Li Liu Ling Li Ailong Huang Jinlin Hou Fan Fan Hou State Key Laboratory of Organ Failure Research National Clinical Research Center for Kidney DiseaseGuangdong Provincial Clinical Research Center for Kidney DiseaseNanfang HospitalSouthern Medical UniversityGuangzhouChina State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina Key Laboratory of Molecular Biology on Infectious Diseases Ministry of EducationChongqing Medical UniversityChongqingChina The People's Hospital of Honghu HonghuChina Kingmed Medical Laboratory GuangzhouChina

Our understanding of the protective immunity,particularly the long-term dynamics of neutralizing antibody(NAbs)response to SARS-CoV-2,is currently *** enrolled a cohort of 545 COVID-19 patients from Hubei,China,who were followed up up to 7 months,and determined the dynamics of NAbs to SARS-CoV-2 by using a surrogate virus neutralization test(sVNT).In our validation study,sVNT IC50 titers and the neutralization rate measured at a single dilution(1:20)were well correlated with FRNT titers(r=0.85 and 0.84,respectively).The median time to seroconversion of NAbs was 5.5 days post onset of *** rate of positive sVNT was 52% in the first week,reached 100% in the third week,and remained above 97% till 6 months post ***,NAbs peaked in the fourth week and only a quarter of patients had an estimated peak titer of>*** declined with a half-time of 61 days(95%CI:49-80 days)within the first two months,and the decay deaccelerated to a half-time of 104 days(95%CI:86-130 days)*** peak levels of NAbs were positively associated with severity of COVID-19 and age,while negatively associated with serum albumin *** observation that the low-moderate peak neutralizing activity and fast decay of NAbs in most naturally infected individuals called for caution in evaluating the feasibility of antibody-based therapy and vaccine *** response positively correlated with disease severity,warning for the possibility of repeat infection in patients with mild COVID-19.

关键词： patients protective immunity

Immune responses to SARS-CoV-2 infection in Humans and ACE2 humanized mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fundamental Research 2021年第2期1卷 124-130页

作者： Airu Zhu Zhao Chen yanqun wang Qiuhui Zeng Jing Sun Zhen Zhuang Fang Li Jingxian Zhao Jincun Zhao Nanshan Zhong State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510120China

The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)represents a major public health threat *** into protective and pathogenic aspects of SARS-CoV-2 immune responses is critical to work out effective therapeutics and develop vaccines for controlling the ***,we review the present literature describing the innate and adaptive immune responses including innate immune cells,cytokine responses,antibody responses and T cell responses against SARS-CoV-2 in human infection,as well as in AEC2-humanized mouse *** also summarize the now known and unknown about the role of the SARS-CoV-2 immune *** better understanding the mechanisms that drive the immune responses,we can tailor treatment strategies at specific disease stages and improve our response to this worldwide public health threat.

关键词： SARS-CoV-2 Innate immune response Humoral immune responses T cell response Mouse model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

超声波处理对北五味子多糖抗氧化活性的影响

食品科学 2016年第3期37卷 66-70页

作者：汪艳群孟宪军沈阳农业大学食品学院辽宁沈阳110866

利用超声波对北五味子多糖进行改性,从而提高其抗氧化活性。以羟自由基(·OH)及1,1-二苯基-2-三硝基苯肼(1,1-diphenyl-2-picrylhydrazyl,DPPH)自由基清除率为指标,考察了超声波处理功率、超声波处理时间对北五味子多糖抗氧化活性的影... 详细信息

利用超声波对北五味子多糖进行改性,从而提高其抗氧化活性。以羟自由基(·OH)及1,1-二苯基-2-三硝基苯肼(1,1-diphenyl-2-picrylhydrazyl,DPPH)自由基清除率为指标,考察了超声波处理功率、超声波处理时间对北五味子多糖抗氧化活性的影响。结果表明:超声波处理功率、处理时间对北五味子多糖抗氧化活性有显著影响。最佳超声波处理功率为330 W、处理时间为20 min。经此条件处理后,·OH清除率由74.34%提高到87.05%,半抑制浓度(IC50)为10.7 mg/m L;DPPH自由基清除率由84.43%提高到95.05%,IC50<2 mg/m L。适当的超声波处理可以提高北五味子多糖的抗氧化活性。

关键词：北五味子多糖抗氧化超声波