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Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liver disease: a translational approach

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Frontiers of Medicine 2022年第5期16卷 745-759页

作者： Liang Dai Jingjuan Xu Baocheng Liu yanqi dang Ruirui Wang Lijie Zhuang Dong Li Lulu Jiao Jianying Wang Lei Zhang Linda LDZhong Wenjun Zhou Guang Ji Institute of Digestive Diseases Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Clinical Research Academy Peking University Shenzhen HospitalShenzhen 518032China Department of Integrated Traditional and Western Medicine Jinling HospitalMedical School of Nanjing UniversityNanjing 210002China Shanghai Innovation Centre of TCM Health Service Shanghai University of Traditional Chinese MedicineShanghai 201203China Sanlin Health Centre of Pudong New District Shanghai 200120China Zhangjiang Health Centre of Pudong New District Shanghai 201203China Beicai Health Centre of Pudong New District Shanghai 201204China Hong Kong Chinese Medicine Study Centre Hong Kong Baptist UniversityHong Kong 999077China

Lingguizhugan Decoction(LGZG)has been investigated in basic studies,with satisfactory effects on insulin resistance in non-alcoholic fatty liver disease(NAFLD).This translational approach aimed to explore the effect and underlying mechanism of LGZG in clinical setting.A randomized,double-blinded,placebo-controlled trial was performed.A total of 243 eligible participants with NAFLD were equally allocated to receive LGZG(two groups:standard dose and low dose)or placebo for 12 weeks on the basis of lifestyle *** primary efficacy variable was homeostasis model assessment of insulin resistance(HOMA-IR).Analyses were performed in two populations in accordance with body mass index(BMI;overweight/obese,BMI 24 kg/m^(2);lean,BMI<24 kg/m^(2)).For overweight/obese participants,low-dose LGZG significantly decreased their HOMA-IR level compared with placebo(0.19(1.47)versus 0.08(1.99),P=0.038).For lean subjects,neither dose of LGZG showed a superior effect compared with *** DNA immunoprecipitation sequencing and real-time qPCR found that the DNA N6-methyladenine modification levels of protein phosphatase 1 regulatory subunit 3A(PPP1R3A)and autophagy related 3(ATG3)significantly increased after LGZG intervention in overweight/obese ***-dose LGZG effectively improved insulin resistance in overweight/obese subjects with *** underlying mechanism may be related to the regulation of DNA N6-methyladenine modification of PPP1R3A and *** subjects may not be a targeted population for LGZG.

关键词： insulin resistance non-alcoholic fatty liver disease Chinese herbal medicine randomized controlled trial DNA N6-methyladenine modification

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A Review on Flow Boiling of the Fluid with Lower Boiling Point in Micro-Channels

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Journal of Thermal Science 2024年第1期33卷 1-17页

作者： ZHANG Zhiqiang JIA Li dang Chao Beijing Key Laboratory of Flow and Heat Transfer of Phase Changing in Micro and Small Scale School of MechanicalElectronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China

With the advancement of micro machining technology,the high-heat-flux removal from miniature electronic devices and components has become an attractive *** boiling in micro-channels is an optimal form of heat transfer and has been widely employed in high-heat-flux cooling *** comprehensively-reviewed article focused on the available recent literatures of experimental investigation regarding the flow boiling heat transfer and unstable behaviors of the fluid with lower boiling point in *** thermal-fluid characteristics and potential heat transfer mechanisms of low-boiling-point fluids flow boiling in different narrow passages were summarized and *** literatures regarding the pressure drop and occurrence of the unstable phenomena existing in two-phase flow boiling process were also *** emphasis was given to the heat transfer enhancement methods as well as instability elimination,and various methods such as modification of surface and channel flow geometries were *** future researches in the field of micro-scale flow boiling were suggested.

关键词： flow boiling lower boiling point fluids mini/micro-channels instabilities enhancement suppression

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Optimal impulsive rendezvous for highly elliptical orbits using linear primer vector theory

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Chinese Journal of Aeronautics 2024年第3期37卷 194-207页

作者： Maozhang ZHENG Jianjun LUO Zhaohui dang National Key Laboratory of Aerospace Flight Dynamics Northwestern Polytechnical UniversityXi’an 710072China

In this paper,minimum-fuel rendezvous is investigated for the case in which the reference orbit is highly *** this end,the well-known Tschauner-Hempel equations are used to describe the relative motions between rendezvous spacecraft and the ***’s primer vector theory is then applied on this linear but time-varying *** analytical solution of the required primer vector for this problem is then derived by using a recently developed *** the existing non-optimal solutions which don’t satisfy the conditions,the methods are further designed to improve the performance by shifting impulses or adding a new ***,two algorithms are developed for free-impulse time-fixed rendezvous *** first algorithm can determine the globally optimal trajectory with the optimal number of *** second one enables for fast trajectory *** proposed algorithms have been successfully applied to coplanar and three-dimensional rendezvous problems in which the target is flying on highly elliptical orbits.

关键词： Orbital transfer Optimal trajectory Primer vector Tschauner-Hempel equations Globally planning Fast planning

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Nash-equilibrium strategies of orbital TargetAttacker-Defender game with a non-maneuvering target

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Chinese Journal of Aeronautics 2024年第10期37卷 365-379页

作者： Yifeng LI Xi LIANG Zhaohui dang School of Astronautics Northwestern Polytechnical UniversityXi’an 710072China Beijing Institute of Astronautical Systems Engineering Beijing 100076China

This study investigates the orbital Target-Attacker-Defender(TAD)game problem in the context of space *** this game,the Attacker and the Defender compete for a Target that is unable to maneuver due to its original mission *** paper establishes three TAD game models based on the thrust output capabilities:unconstrained thrust output,thrust constrained by an upper bound,and fixed thrust *** models are then solved using differential game theory to obtain Nash equilibrium solutions for the game problems,and the correctness and effectiveness of the solution methods are verified through ***,an analysis of the winning mechanisms of the game is conducted,identifying key factors that influence the game’s outcomes,including weight coefficients in payoffs,the maximum thrust acceleration limit,and the initial game *** the unique characteristics of space missions,a specific focus is given to the analysis of the Defender’s initial states in the hovering formation and in-plane circling formation,revealing overall success patterns for defense strategies from these two *** summary,this study provides valuable insights into the control strategies and winning mechanisms of orbital TAD games,deepening our understanding of these games and offering practical guidance to improve success rates in real-world scenarios.

关键词： Target-Attacker-Defender problem Differential game TPBVP Continuous thrust Orbital game

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Characterizing the complete mitochondrial genome of Psephenothrips eriobotryae dang&Qiao(Thysanoptera:Phlaeothripidae)with massive gene arrangement in Phlaeothripidae

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Zoological Systematics 2024年第2期49卷 116-128页

作者： Lihong dang Chengwen Li Dongxue Wang Yuxin Gao Linpeng Zhao Bin Zhang School of Biological Science&Engineering Shaanxi University of TechnologyHanzhong 723000China Engineering Research Center of Quality Improvement and Safety Control of Qinba Special Meat Products Universities of Shaanxi ProvinceHanzhong 723000China Shaanxi Changqing National Nature Reserve Changqing JiayuanNo.176Hanzhong 723000China College of Life Sciences&Technology Inner Mongolia Normal UniversityHohhot 010022China

Each species within the order Thysanoptera has a distinct mitochondrial gene order displaying a high level of gene rearrangement,particularly massive in *** understand the evolutionary patterns of rearrangement in this family,we sequenced the complete mitochondrial genome of Psephenothrips eriobotryae,a notable potential pest of loquat *** mitogenome is a circular DNA molecule(15,413 bp in size)composed of 37 genes:13 PCGs,22 tRNAs,two rRNAs,and two putative control regions(CRs).By comparing with the ancestral mitogenome of arthropods,*** exhibits notable gene rearrangement ***,it shares four conserved gene blocks with three closely related species in *** the phylogenetic tree,*** was clustered with these three leaffeeding Phlaeothripinae *** presence of more similar conserved gene blocks probably indicates a strong correlation between gene rearrangements and the phylogeny within ***,the mitogenome of *** shows some characteristics:(a)two putative CRs in which CR2 is the copy of partial CR1 with 99.62%sequence similarity,and CR1 consists of two 237 bp repeat unites;(b)high A+T content of 82.6%in overall base composition;(c)trn S1 lacking a complete dihydrouridine(DHU)arm;(d)the protein coding gene,atp8 started with TTG instead of the more common ATN,while nad3 terminated by TAG rather than TAA;(e)translocations and inversions observed in fifteen of the 37 genes.

关键词： Mitogenome structure phylogenetic relationships Liothrips-lineage repeat regions

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Triad-displaced ULAs configuration for non-circular sources with larger continuous virtual aperture and enhanced degrees of freedom

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Journal of Systems Engineering and Electronics 2024年第1期35卷 81-93页

作者： SHAIKH Abdul Hayee dang Xiaoyu HUANG Daqing College of Electronic and Information Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China

Non-uniform linear array(NULA)configurations are well renowned due to their structural ability for providing increased degrees of freedom(DOF)and wider array aperture than uniform linear arrays(ULAs).These characteristics play a significant role in improving the direction-of-arrival(DOA)estimation ***,most of the existing NULA geometries are primarily applicable to circular sources(CSs),while they limitedly improve the DOF and continuous virtual aperture for noncircular sources(NCSs).Toward this purpose,we present a triaddisplaced ULAs(Tdis-ULAs)configuration for *** TdisULAs structure generally consists of three ULAs,which are appropriately *** proposed antenna array approach fully exploits the non-circular characteristics of the *** the same number of elements,the Tdis-ULAs design achieves more DOF and larger hole-free co-array aperture than its sparse array ***,the number of uniform DOF,optimal distribution of elements among the ULAs,and precise element positions are uniquely determined by the closed-form ***,the proposed array also produces a filled resulting *** simulations are conducted to show the performance advantages of the proposed Tdis-ULAs configuration over its counterpart designs.

关键词： direction-of-arrival(DOA)estimation sparse array non-circular source(NCS) sum co-array difference co-array degrees of freedom(DOF)

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Tailoring of a robust asymmetric aramid nanofibers/MXene aerogel film for enhanced infrared thermal camouflage and Joule heating performances

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Nano Research 2024年第3期17卷 1990-1998页

作者： Wanbin dang Wei Guo Wenting Chen Qiuyu Zhang Key Laboratory of Special Functional and Smart Polymer Materials of Ministry of Industry and Information Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China

The development of infrared(IR)surveillance technology has led to a growing interest in thermal ***,the trade-off relationship between low IR-emissivity and thermal insulation hinders the advance of thermal camouflage ***,guided by multi-physics simulation,we show a design of asymmetric aramid nanofibers/MXene(ANF/MXene)aerogel film that realizes high-efficient thermal camouflage *** rationale is that the asymmetric structure contains a thermal-insulation three-dimensional(3D)network part to prevent effective heat transfer and a low IR-emissivity(~0.3)dense surface layer to suppress radiative heat *** is remarkable that the synergy mechanism in the topology structure contributes to over 40%reduction of target radiation ***,the tailored asymmetric ANF/MXene aerogel film also enables sound mechanical properties such as a Young’s modulus of 44.4 MPa and a tensile strength of 1.3 MPa,superior to most aerogel *** also exhibits great Joule heating performances including low driving voltage(4 V),fast thermal response(<10 s),and long-term stability,further enabling its versatile thermal camouflage *** work offers an innovative design concept to configure multifunctional structures for next-generation thermal management applications.

关键词： asymmetric aerogel film low infrared(IR)-emissivity thermal insulation IR thermal camouflage Joule heating performance

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Erythrocytes serve as a template to create nanozymes with uniform Fe single-atom sites for healing bacteria-infected wound

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Science China(Life Sciences) 2024年第9期67卷 2048-2050页

作者： Thinh Viet dang Moon Il Kim Department of BioNano Technology Gachon UniversitySeongnam 13120Republic of Korea

Bacterial infection is recognized as one of the biggest global health threats,causing millions of people's death every year(Wang et al.,2020).Traditional antibiotics-based therapies have been widely utilized to control this issue(Kohanski et al.,2010);however,their excessive use leads to the emergence of antibioticresistant bacteria,endangering to human health(Levy and Marshall,2004).

关键词： template healing utilized

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Parametric formation control of multiple nanosatellites for cooperative observation of China Space Station

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Astrodynamics 2024年第1期8卷 77-95页

作者： Hao Zhou Bohan Jiao Zhaohui dang Jianping Yuan School of Astronautics Northwestern Polytechnical UniversityXi’an710072China National Key Laboratory of Aerospace Flight Dynamics Northwestern Polytechnical UniversityXi’an710072China

This study proposes a parametric formation control method for the cooperative observation of the China Space Station(CSS)using multiple ***,a simplified geometrical model of the CSS is constructed using fundamental solids,such as the capsule body and ***,the spacecraft formation configuration for the observation mission is characterized by a three-dimensional(3D)Lissajous curve using related design parameters under the full-coverage observation requirements of specific parts,such as the CSS connecting section and collision avoidance ***,a double-layer control law is designed for each nanosatellite,in which the upper layer is a distributed observer for recognizing the target formation configuration parameters,and the lower layer is a trajectory-tracking controller to make the nanosatellite converge to its temporary target position calculated from the upper layer’s *** closed-loop control stability is proven under the condition that the communication network topology of the nanosatellite cluster contains a directed spanning ***,the control method is verified by numerical simulation,where the CSS connecting section is selected as the observation target,and ten small nanosatellites are assumed to perform the cooperative observation *** simulation results demonstrate that the double-layer control law is robust to single-point communication failures and suitable for the accompanying missions of large space objects with multiple nanosatellites.

关键词： China Space Station(CSS) cooperative observation parametric formation 3D Lissajous curve double-layer system

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Molecular mechanisms of stress resistance in sorghum: Implications for crop improvement strategies

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Journal of Integrative Agriculture 2024年第3期23卷 741-768页

作者： Hongxiang Zheng Yingying dang Xianmin Diao Na Sui Shandong Provincial Key Laboratory of Plant Stress/College of life Sciences Shandong Normal UniversityJinan 250014China Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China

Abiotic stresses, such as drought, salt, extreme temperatures, and heavy metal pollution, are the main environmental factors that limit crop growth and yield. Sorghum, a C4 grass plant with high photosynthetic efficiency, can grow in adverse environmental conditions due to its excellent stress resistance characteristics. Therefore, unraveling the stress-resistance mechanism of sorghum could provide a theoretical basis for developing and cultivating various stress-resistant crops. This understanding could also help to create a conducive environment for using marginal soil in agriculture and ensuring food security. In this review, we discuss the adaptation mechanisms of sorghum under drought, salinity, temperature, and soil heavy metal stresses, the specific response to stress, the screening of sorghum-resistant germplasm, and the identification and functional analysis of the relevant genes and quantitative trait loci(QTL). In addition, we discuss the application potential of different stress-tolerant sorghum germplasms reported to date and emphasize the feasibility and potential use in developing and promoting highly stress-tolerant sorghum in marginal soil.

关键词： abiotic stress C4 plants QTL sorghum stress resistance yield stability

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