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Vibration-reduced anxiety-like behavior relies on ameliorating abnormalities of the somatosensory cortex and medial prefrontal cortex

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Neural Regeneration Research 2024年第6期19卷 1351-1359页

作者： Afzal Misrani Sidra Tabassum Tintin Wang Huixian Huang Jinxiang Jiang Hongjun Diao yanping zhao Zhen Huang Shaohua Tan Cheng Long Li Yang South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research Panyu Central Hospital School of Life Sciences Guangzhou University School of Life Sciences South China Normal University Guangzhou Hongai Cultural Development Inc. 5. Yinguo Health Management Team College of Biophotonics South China Normal University

Tibetan singing bowls emit low-frequency sounds and produce perceptible harmonic tones and vibrations through manual tapping. The sounds the singing bowls produce have been shown to enhance relaxation and reduce anxiety. However, the underlying mechanism remains unclear. In this study, we used chronic restraint stress or sleep deprivation to establish mouse models of anxiety that exhibit anxiety-like behaviors. We then supplied treatment with singing bowls in a bottomless cage placed on the top of a cushion. We found that unlike in humans, the combination of harmonic tones and vibrations did not improve anxietylike behaviors in mice, while individual vibration components did. Additionally, the vibration of singing bowls increased the level of N-methyl-D-aspartate receptor 1 in the somatosensory cortex and prefrontal cortex of the mice, decreased the level of γ-aminobutyric acid A(GABA) receptor α 1 subtype, reduced the level of CaMKII in the prefrontal cortex, and increased the number of GABAergic interneurons. At the same time, electrophysiological tests showed that the vibration of singing bowls significantly reduced the abnormal low-frequency gamma oscillation peak frequency in the medial prefrontal cortex caused by stress restraint pressure and sleep deprivation. Results from this study indicate that the vibration of singing bowls can alleviate anxiety-like behaviors by reducing abnormal molecular and electrophysiological events in somatosensory and medial prefrontal cortex.

关键词： anxiety medial prefrontal cortex parvalbumin interneuron pressure somatosensory cortex Tibetan singing bowl vibration

Capital flows, economic growth and the real effective exchange rate: Evidence from China

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Economic and Political Studies 2023年第1期11卷 123-147页

作者： Xin Tian Jakob de Haan yanping zhao Faculty of Economics and Business University of GroningenGroningenthe Netherlands CESifo MunichGermany School of Economics Ocean University of ChinaQingdaoChina Institute of Marine Economy Ocean University of ChinaQingdaoChina

This paper examines the Granger causal relationship between capital flows and economic growth in China over the period 1998Q1–2019Q2,allowing for real effective exchange rate(REER)effects.As parameter instability tests indicate structural changes,we use bootstrap rolling window causality tests,which suggest that the causal nexus between capital flows and GDP growth is time-varying.We find that the causal links between foreign direct investments(FDIs)and GDP growth are hardly affected by the REER,whereas the REER plays a more important role in affecting the causal connections between portfolio investments and other investments and GDP growth.Our results suggest that cumulative portfolio inflows and cumulative other investment inflows harm GDP growth,whereas cumulative portfolio outflows and cumula-tive other investment outflows positively affect GDP growth.

关键词： Capital flows real effective exchange rate GDP growth rate bootstrap Granger causality test parameter instability test time-varying causality

解决全球经常账户失衡:指责中国抑或重视制造业?——基于人力资本结构高级化的视角

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上海财经大学学报（哲学社会科学版） 2024年第3期26卷 65-78页

作者：赵艳平梁正一马新啸中国海洋大学经济学院山东青岛266100 中国海洋大学海洋发展研究院山东青岛266100 中国海洋大学管理学院山东青岛266100 中国海洋大学中国企业营运资金管理研究中心山东青岛266100

解决人力资本结构高级化导致的经常账户失衡问题是国际经济高质量发展的关键。文章在构建经常账户—人力资本结构敏感度框架的基础上,以2007—2021年全球61个国家或地区14个制造业部门数据为研究样本,系统考察了国家制造业重视程度对人... 详细信息

解决人力资本结构高级化导致的经常账户失衡问题是国际经济高质量发展的关键。文章在构建经常账户—人力资本结构敏感度框架的基础上,以2007—2021年全球61个国家或地区14个制造业部门数据为研究样本,系统考察了国家制造业重视程度对人力资本结构高级化导致的经常账户失衡的影响。研究发现,国家重视制造业能够解决人力资本结构高级化导致的经常账户失衡问题;国家重视制造业可以提高制造业的全球竞争力和推动金融更好地服务实体经济,从而有效抑制人力资本结构高级化导致的经常账户失衡;对创新能力较强、制度质量较高、劳动力比较充裕和人力资本质量较高的国家以及劳动密集型和低技术水平行业而言,前述效果更加明显。可见,国家在重视制造业以解决人力资本结构高级化导致的经常账户失衡后,可以有效扩大就业规模和提升经济增长水平。

关键词：制造业重视程度人力资本结构全球经常账户失衡

新生儿先天性甲状腺功能减退症发生的影响因素

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中国民康医学 2024年第3期36卷 5-8页

作者：赵艳平河南省儿童医院早产儿病房河南郑州450000

目的:分析新生儿先天性甲状腺功能减退症发生的影响因素。方法:选取2019年1月至2023年1月于该院出生的215例新生儿进行横断面研究,收集新生儿的临床资料和孕母资料,根据是否发生先天性甲状腺功能减退症将其分为发生组和未发生组,采用Log... 详细信息

目的:分析新生儿先天性甲状腺功能减退症发生的影响因素。方法:选取2019年1月至2023年1月于该院出生的215例新生儿进行横断面研究,收集新生儿的临床资料和孕母资料,根据是否发生先天性甲状腺功能减退症将其分为发生组和未发生组,采用Logistic回归分析新生儿先天性甲状腺功能减退症发生的影响因素。结果:215例新生儿中,发生先天性甲状腺功能减退症105例,发生率为48.84%(105/215);两组性别、孕母孕次、孕母产次、合并妊娠期高血压、合并妊娠期糖尿病比较,差异均无统计学意义(P>0.05);发生组出生胎龄1,P<0.05),有孕期黄体酮用药史为新生儿先天性甲状腺功能减退症发生的保护因素(OR<1,P<0.05)。结论:出生胎龄<37周、出生体质量<2.5 kg、胎儿宫内窘迫、孕母年龄≥35岁、孕期存在焦虑情绪、有甲状腺疾病家族史、有孕期重金属接触史均为新生儿先天性甲状腺功能减退症发生的危险因素,有孕期黄体酮用药史为新生儿先天性甲状腺功能减退症发生的保护因素。

关键词：新生儿先天性甲状腺功能减退症影响因素

探讨胰岛素联用吡格列酮对2型糖尿病患者糖代谢与生活质量的影响

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糖尿病新世界 2024年第2期27卷 94-97页

作者：赵艳平北京丰台医院内分泌科北京100070

目的探讨胰岛素联用吡格列酮应用于2型糖尿病患者中的治疗效果。方法选取2020年3月—2023年3月北京丰台医院内分泌科收治的88例2型糖尿病患者为研究对象,按照抽签法分为两组,每组44例。对照组单独应用胰岛素治疗,观察组采取胰岛素联... 详细信息

目的探讨胰岛素联用吡格列酮应用于2型糖尿病患者中的治疗效果。方法选取2020年3月—2023年3月北京丰台医院内分泌科收治的88例2型糖尿病患者为研究对象,按照抽签法分为两组,每组44例。对照组单独应用胰岛素治疗,观察组采取胰岛素联合吡格列酮治疗,比较两组患者治疗效果。结果观察组胰岛功能指标、糖代谢指标均低于对照组,差异有统计学意义(P均<0.05);观察组生活质量评分低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论胰岛素联用吡格列酮的应用,能够提高2型糖尿病患者的胰岛功能,改善其糖代谢紊乱状态,促进患者生活质量的提升。联合应用有助于降低患者不良反应的发生率,对提高用药的安全性、有效性意义显著。

关键词： 2型糖尿病胰岛素吡格列酮糖代谢生活质量

胰岛素泵与胰岛素多次注射对妊娠期糖尿病的治疗效果与安全性比较

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实用妇科内分泌电子杂志 2024年第3期11卷 71-73页

作者：赵艳平北京丰台医院内分泌科北京100070

目的探究胰岛素泵与胰岛素多次注射对妊娠期糖尿病患者的治疗效果与安全性。方法选取本院24例妊娠期糖尿病患者为研究对象,按照随机数字表法分为两组,各12例。多次注射组患者采取多次皮下注射胰岛素治疗,胰岛素泵组患者采取持续皮下胰... 详细信息

目的探究胰岛素泵与胰岛素多次注射对妊娠期糖尿病患者的治疗效果与安全性。方法选取本院24例妊娠期糖尿病患者为研究对象,按照随机数字表法分为两组,各12例。多次注射组患者采取多次皮下注射胰岛素治疗,胰岛素泵组患者采取持续皮下胰岛素输注治疗。比较两组患者用药前后的血糖水平、用药期间低血糖发生率及妊娠结局。结果用药前,两组患者血糖水平比较差异无统计学意义(P>0.05)。用药后,胰岛素泵组患者的空腹血糖、餐后2h血糖、糖化血红蛋白水平明显低于多次注射组患者,差异有统计学意义(P0.05)。胰岛素泵组患者用药期间低血糖发生率低于多次注射组患者,自然分娩率高于多次注射组,差异有统计学意义(P<0.05)。结论相较于胰岛素多次注射给药,胰岛素泵给药能够有效控制妊娠期糖尿病患者的血糖水平,不良反应发生率更低,可以提高自然分娩率,具有较高的临床应用与推广价值。

关键词：胰岛素泵胰岛素多次注射妊娠期糖尿病血糖水平

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债券市场对外开放对企业资本配置效率的影响

国际商务（对外经济贸易大学学报） 2024年第3期 76-94页

作者：赵艳平郭欣然黄友星中国海洋大学经济学院山东青岛266100 中国海洋大学海洋发展研究院山东青岛266100 中国海洋大学中国企业营运资金管理研究中心山东青岛266100

本文基于2004—2021年中国A股上市企业年度数据,考察债券市场对外开放对企业资本配置效率的影响。研究发现,债券市场对外开放可以有效提高企业资本配置效率。机制检验结果表明,债券市场对外开放通过缓解企业融资约束、改善企业治理和缓... 详细信息

本文基于2004—2021年中国A股上市企业年度数据,考察债券市场对外开放对企业资本配置效率的影响。研究发现,债券市场对外开放可以有效提高企业资本配置效率。机制检验结果表明,债券市场对外开放通过缓解企业融资约束、改善企业治理和缓解信息不对称三条渠道提高企业资本配置效率。异质性分析表明,债券市场对外开放对非国有企业、规模以下企业、高行业竞争度企业和高资本密集度企业资本配置效率的影响大于国有企业、规模以上企业、低行业竞争度企业和低资本密集度企业。

关键词：债券市场对外开放资本配置效率融资约束企业治理信息不对称

Edge localized modes suppression via edge E × B velocity shear induced by RF sheath of ion cyclotron resonance heating in EAST

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Science China(Physics,Mechanics & Astronomy) 2022年第3期65卷 71-76页

作者： XinJun Zhang Chu Zhou XiaoLan Zou TianYang Xia YanLong Li ChengMing Qin XianZu Gong Qing Zang MingHui Li Tao Zhang ShouXin Wang HaiQing Liu Guillaume Urbanczyk Adi Liu YanMing Duan yanping zhao JinPing Qian Robert Isaac Pinsker MinYou Ye BaoNian Wan Institute of Plasma Physics Chinese Academy of Sciences(ASIPP)Hefei 230031China School of Nuclear Sciences and Technology University of Science and Technology of ChinaHefei 230026China CEA IRFMSaint-Paul-les-Durance F-13108France Key Laboratory of Optoelectronic Devices and Systems College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China General Atomics San Diego CA 92186-5608USA

The control of large edge localized modes(ELMs) is a critical issue for the successful operation of future burning plasma devices,such as the international thermonuclear experimental reactor(ITER) and China fusion engineering test reactor(CFETR). In this paper, we present a new active and effective means of ELM suppression using ion cyclotron resonant heating(ICRH) on the experimental advanced superconducting tokamak(EAST). We obtained the key role of the external E × B velocity shear near the pedestal top and the scrape-off-layer(SOL) induced by the RF sheath potential of ICRH in ELM suppression. The experimental results showed a positive correlation between the RF sheath and the E × B shear rate in SOL. BOUT++ simulations indicate that increased E × B velocity shear rates in the pedestal and SOL regions promote ELM suppression;thereby, supporting the experimental observations on EAST. These findings suggest a new simple approach to access the ELM suppressed regimes in plasma with low torque input as ITER baseline discharges.

关键词： ion cyclotron resonant heating RF sheath edge localized mode suppression E×B velocity shear

Exploration and practice of general practitioner responsibility system in an urban community of Shanghai

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Family Medicine and Community Health 2015年第4期3卷 15-22页

作者： Yan Wu yanping zhao Xiaoxia Huang Junyan Wang Huilin Xu Hualin Su Center for Disease Control MinhangShanghai 201105China

Objective:The Minhang district of Shanghai was selected as the subject and its public health management model was investigated.Methods:Minhang became a pilot location for the implementation of the general practitioner responsibility system(GPRS)in 2011.Since then,the management model of public health services in the district has gradually merged with the GPRS through a series of actions:the adjustment of organizations and the coordination mechanism in community public health services,the integration of basic public health services and clinic practice,the establishment of an informationized Internet service platform,comprehensive budgeting management of public health service programs,and performance assessment management of health workers.Results:By the end of 2014,the number of residents who had a contractual relationship with a general practitioner(GP)in Minhang had reached 1.4367 million and all of them had family health records.Compared with 2010,both the rate of maternal management and the rate of children management stayed at high level(≥96%),the rate of hypertension management increased(40.73%vs.28.70%),the rate of blood pressure control increased(82.13%vs.77.51%),the incidence of diabetes decreased(21.93%vs.37.85%),the rate of effective control of blood glucose for dia-betic patients increased(82.43%vs.62.77%),and the rate of child health management increased(99.79%vs.91.54%).Conclusion:The GPRS has helped to create a better community health environment.How-ever,the development of this system is limited by several factors,including the following:the shortage of GPs,most GPs do not have good public health service skills and a correct public health concept,unclear division of different services,and imperfect department coordination.

关键词： General practitioner Center for Disease Control Minhang Shanghai