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儿童原发性恶性颅外生殖细胞肿瘤复发的风险因素分析

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中国小儿血液与肿瘤杂志 2024年第1期29卷 22-26页

作者：赵华张园吴爽闵燕平刘玉峰徐学聚郑州大学第一附属医院儿童血液肿瘤科郑州450052

目的探讨儿童原发性恶性颅外生殖细胞肿瘤(MGCT)复发的危险因素。方法回顾性分析2010年1月—2019年12月郑州大学第一附属医院诊断并治疗MGCT患儿的临床资料,使用Logistic回归法分析其复发的高危因素;使用Kaplan-Meier法统计其总生存率(... 详细信息

目的探讨儿童原发性恶性颅外生殖细胞肿瘤(MGCT)复发的危险因素。方法回顾性分析2010年1月—2019年12月郑州大学第一附属医院诊断并治疗MGCT患儿的临床资料,使用Logistic回归法分析其复发的高危因素;使用Kaplan-Meier法统计其总生存率(OS)、无事件生存率(EFS)。结果共109例MGCT患儿,5年的OS率、EFS率分别为(91.3±2.8)%、(86.5±3.4)%;复发率为12.8%,主要的复发部位为骶尾部(9/14)。复发组与未复发组相比,在发病部位(χ^(2)=18.45,P<0.01)、COG分期(χ^(2)=11.32,P<0.01)、是否转移(χ^(2)=12.80,P<0.01)、肝转移(χ^(2)=15.29,P<0.01)和肺转移(χ^(2)=9.57,P<0.001)等方面存在差异。Logistic回归分析示骶尾部为其复发的独立危险因素;复发组的OS(59.1±1.4)%低于未复发组(95.7±2.1)%;未完整切除肿瘤组的OS(65.8±1.4)%低于完整切除组(94.5±2.4)%,差异均有统计学意义。结论复发、未完整切除肿瘤的MGCT患儿预后差,骶尾部为MGCT患儿复发的独立危险因素。

关键词：恶性颅外生殖细胞肿瘤复发骶尾部手术

Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma

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Signal Transduction and Targeted Therapy 2022年第3期7卷 829-839页

作者： Panpan Zhang Qiuping He Yaqin Wang Guanqun Zhou Yupei Chen Linglong Tang yuan Zhang Xiaohong Hong yanping Mao Qingmei He Xiaojing Yang Na Liu Jun Ma Department of Radiation Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangzhou 510060China Max-Planck Center for Tissue Stem cell Research and Regenerative Medicine Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory)Guangzhou 510530People's Republic of China

Metastasis and recurrence account for 95%of deaths from nasopharyngeal carcinoma(NPC).Cancer stem cells(CSCs)are regarded as one of the main reasons for tumor cell resistance to clinical therapy,and cancer metastasis or recurrence,while little is known about CSCs in NPC.The present study uncovers a subpopulation of cells labeled as CD45 EPCAM PROCR4 in NPC biopsy samples that exhibit stem cell-like characteristics.A relatively low number of these cells initiate xenograft tumors in mice.

关键词： nasopharyngeal cancer metastasis

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黄甲综合征1例并文献复习

疑难病杂志 2024年第5期23卷 613-614页

作者：刘燕平刘志韩英娜王晶王长远首都医科大学宣武医院急诊科北京100053

报道1例黄甲综合征患者的临床资料,并进行文献复习。

关键词：黄甲综合征胸腔积液淋巴水肿诊断治疗

Flue Gas Water Recovery by Indirect Cooling Technology for Large-Scale Applications: A Review

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Journal of Thermal Science 2020年第5期29卷 1223-1241页

作者： ZHONG Wei JI Wenhui CAO Xiaoling yuan yanping School of Mechanical Engineering Southwest Jiaotong UniversityChengdu 610031China

With social development and economic enhancement,energy is facing significant worldwide demand,and fossil fuels are the prime energy sources for various energy systems over past decades.Furthermore,among fuel-consumed applications,power plants are the primary source of energy consumption.There is a lot of waste heat and steam accompanied by the latent heat produced in the exhaust flue gas.Therefore,the latent heat recovery from the flue gas plays an important role in increasing the efficiency of the system and saving water.To recover the heat and mass in power plants,three primary methods are proposed to condense the vapor based on previous studies:(1)flue gas condensation technology,(2)liquid desiccant-based dehydration(LDD)technology and(3)membrane technology.This paper mainly reviews and summaries the indirect cooling technology in flue gas condensation technology.The numerical simulation and theory of flue gas condensation are introduced.Different heat exchanger types and conducted experiments are also summarized.The performance of the indirect cooling technology is affected not only by its own configuration and design but also by the flue gas inlet temperature,velocity,water vapor mass fraction,etc.The major concerns and outlook of practical applications for further study are attributed to the heat exchanger size and cost,acid corrosion,ash accumulation in flue gas,etc.

关键词： flue gas condensation water recovery heat exchanger power plants

基于中性粒细胞胞外诱捕网研究隔药灸减轻克罗恩病大鼠结肠炎症的效应机制

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Journal of Acupuncture and Tuina Science 2024年第3期22卷 173-183页

作者：路驰徐静陆嫄吴璐一包春辉马喆钟蕊王照钦孙可鑫郑寒丹翁志军黄艳吴焕淦杨燕萍(译) Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai Research Institute of Acupuncture and Meridian Shanghai 200030China 不详

目的:从中性粒细胞胞外诱捕网(NETs)参与克罗恩病(CD)进展的角度,阐释隔药灸减轻CD大鼠肠道炎症的效应机制。方法:将大鼠随机分为正常组、模型组、隔药灸组和美沙拉嗪组。除正常组外,其余大鼠采用2,4,6-三硝基苯磺酸制备CD模型。正常组... 详细信息

目的:从中性粒细胞胞外诱捕网(NETs)参与克罗恩病(CD)进展的角度,阐释隔药灸减轻CD大鼠肠道炎症的效应机制。方法:将大鼠随机分为正常组、模型组、隔药灸组和美沙拉嗪组。除正常组外,其余大鼠采用2,4,6-三硝基苯磺酸制备CD模型。正常组和模型组不治疗仅做与其他组相同的固定。隔药灸组予以隔药灸气海和双侧天枢穴。美沙拉嗪组接受美沙拉嗪肠溶片灌胃治疗。比较各组大鼠一般情况,苏木精-伊红染色观察结肠组织病理学变化并评分。采用ABC酶联免疫吸附测定法检测各组大鼠血清中性粒细胞胞外诱捕网DNA(NETs-DNA)、中性粒细胞弹性蛋白酶DNA(NE-DNA)、过氧化物酶DNA(MPO-DNA)浓度,采用免疫荧光和实时定量聚合酶链反应技术观察各组大鼠结肠组织瓜氨酸化组蛋白3(citH3)、MPO和NE蛋白和mRNA的表达。结果:与正常组比较,模型组结肠黏膜溃疡深达肌层,上皮不完整,杯状细胞明显减少,可见大量炎性细胞浸润,结肠黏膜损伤指数(CMDI)评分显著增加(P<0.01),模型组血清NETs-DNA、NE-DNA、MPO-DNA浓度均增加(P<0.05),模型组结肠组织NE、citH3和MPO蛋白和mRNA表达均上调(P<0.01或P<0.05);与模型组相比,隔药灸组和美沙拉嗪组结肠黏膜上皮修复,杯状细胞明显增多,可见少量炎性细胞浸润,CMDI评分明显降低(P<0.01),隔药灸组和美沙拉嗪组血清NETs-DNA、NE-DNA、MPO-DNA浓度均下降(P<0.05),隔药灸组和美沙拉嗪组NE、citH3和MPO蛋白和mRNA表达下调(P<0.01或P<0.05)。结论:隔药灸能降低血清中性粒细胞NETs复合物的浓度,抑制结肠组织中的NETs复合物的蛋白和mRNA表达,可能是隔药灸缓解CD结肠黏膜炎症的机制之一。

关键词：隔药灸疗法药饼灸疗法炎症性肠病克罗恩病中性粒细胞胞外诱捕网

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纳滤后浓盐水用于海盐生产对制卤的影响

盐科学与化工 2024年第6期53卷 41-43页

作者：毕李刚马海永安延平张庆龙刘建锐袁浩郭競雄唐山三友盐化有限公司河北唐山063605

浓盐水纳滤后,将高钙离子、镁离子盐卤水用于海盐生产,文章从定性、定量方面对其在制卤蒸发浓缩过程中的影响进行了理论分析,为项目决策提供相应的支撑。

关键词：纳滤浓盐水制卤

Coupling atom ensemble and electron transfer in PdCu for superior catalytic kinetics in hydrogen generation

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Nano Research 2023年第7期16卷 9012-9021页

作者： Xinru Zhao Yanyan Liu Huiyu yuan Hao Wen Huanhuan Zhang Saima Ashraf Shuyan Guan Tao Liu Sehrish Mehdi Ruofan Shen Xianji Guo yanping Fan Baozhong Liu Baojun Li College of Chemistry and Chemical Engineering Henan Polytechnic UniversityJiaozuo 454000China College of Science Henan Agriculture UniversityZhengzhou 450002China College of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China Research Center of Green Catalysis College of ChemistryCollege of Mechanical and Power EngineeringZhengzhou UniversityZhengzhou 450001China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Centre for Nanoscience and TechnologyBeijing 100190China State Collaborative Innovation Center of Coal Work Safety and Clean-efficiency Utilization Jiaozuo 454003China Department of Chemistry Tsinghua UniversityBeijing 100084China

The design of high-performance catalysts is the key to the efficient utilization of hydrogen energy.In this work,a PdCu nanoalloy was successfully anchored on TiO_(2)encapsulated with carbon to construct a catalyst.Outstanding kinetics of the hydrolysis of ammonia borane(turnover frequency of 279 mol·min^(-1·)mol_(Pd)^(-1))ranking the third place among Pd-based catalysts was achieved in the absence of alkali.Both experimental research and theoretical calculations reveal a lower activation energy of the B-H bond on the PdCu nanoalloy catalyst than that on pristine Pd and a lower activation energy of the O-H bond than that on pristine Cu.The redistribution of d electron and the shift of the d-band center play a critical role in increasing the electron density of Pd and improving the catalytic performances of Pd_(0.1)Cu_(0.9)/TiO_(2)-porous carbon(Pd_(0.1)Cu_(0.9)/T-PC).This work provides novel insights into highly dual-active alloys and sheds light on the mechanism of dual-active sites in promoting borohydride hydrolysis.

关键词： PdCu nanoalloy d-band holes ensemble effect borohydride hydrolysis dual-active sites

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胃癌患者围手术期营养状况及体成分变化

中国实用护理杂志 2024年第10期40卷 772-779页

作者：王鸿丁志杰叶雅芳林丽惠康丹丹袁雁平李蕾厦门大学附属中山医院临床营养科厦门361104 厦门大学附属中山医院胃肠外科厦门361004 厦门大学公共卫生学院分子疫苗和分子诊断学国家重点实验室厦门361004

目的调查胃癌患者围手术期营养风险、营养不良发生率以及三大供能营养素摄入量,分析体成分变化及影响因素,为围手术期营养管理提供理论依据。方法采用横断面调查研究方法,以定点连续抽样法选取2021年6月至2023年5月在厦门大学附属中山... 详细信息

目的调查胃癌患者围手术期营养风险、营养不良发生率以及三大供能营养素摄入量,分析体成分变化及影响因素,为围手术期营养管理提供理论依据。方法采用横断面调查研究方法,以定点连续抽样法选取2021年6月至2023年5月在厦门大学附属中山医院胃肠外科行胃癌根治术的105例患者为研究对象,分别采用营养风险筛查评分2002(NRS 2002)和患者主观整体营养评估法(PG-SGA)进行筛查和评估,采用24 h膳食回顾法、饮食日记法等调查营养素摄入量,用生物电阻抗法测量人体成分。结果105例患者中男78例,女27例,年龄(61.5±10.3)岁。胃癌患者术前营养风险发生率83.8%(88/105),营养不良发生率82.9%(87/105)。术前、术后能量摄入分别为(1646.1±321.5)、(1317.2±365.8)kcal(1 kcal=4.184 kJ),与目标量(1896.7±262.9)kcal相比,差异均有统计学意义(t=6.23、8.29,均P<0.05)。术前患者体质量、肌肉量、骨骼肌、脂肪量、骨骼肌指数分别为(51.5±9.6)、(40.8±6.0)、(23.6±4.0)、(8.3±4.9)kg和6.7±0.8,术后为(50.0±9.1)、(39.8±6.0)、(22.8±3.6)、(7.8±5.2)kg和6.5±0.8,2组比较差异均有统计学意义(t值为2.89~10.61,均P<0.05)。Logistic多因素回归分析显示,手术时间(OR=3.984,95%CI 1.433~11.080,P<0.05)及能量满足度(OR=0.053,95%CI 0.005~0.610,P<0.05)为骨骼肌量下降程度的独立影响因素。结论胃癌患者围手术期营养状况差,营养素摄入不足,体内肌肉和脂肪消耗加速。医护人员需及时对胃癌患者进行全面营养评估,加强个体化营养治疗,促进机体康复。

关键词：胃肿瘤围手术期营养风险营养不良营养素肌少症

Community-Based User Domain Model Collaborative Recommendation Algorithm

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Tsinghua Science and Technology 2013年第4期18卷 353-359页

作者： Fulan Qian yanping Zhang yuan Zhang Zhen Duan the School of Computer Science and Technology Anhui University the School of Electronic and Information Engineering Anhui Jianzhu University

Collaborative Filtering （CF） is a commonly used technique in recommendation systems. It can promote items of interest to a target user from a large selection of available items. It is divided into two broad classes： memory-based algorithms and model-based algorithms. The latter requires some time to build a model but recommends online items quickly, while the former is time-consuming but does not require pre-building time. Considering the shortcomings of the two types of algorithms, we propose a novel Community-based User domain Collaborative Recommendation Algorithm （CUCRA）. The idea comes from the fact that recommendations are usually made by users with similar preferences. The first step is to build a user-user social network based on users＇ preference data. The second step is to find communities with similar user preferences using a community detective algorithm. Finally, items are recommended to users by applying collaborative filtering on communities. Because we recommend items to users in communities instead of to an entire social network, the method has perfect online performance. Applying this method to a collaborative tagging system, experimental results show that the recommendation accuracy of CUCRA is relatively good, and the online time-complexity reduces to O.（n）.

关键词： collaborative recommendation tagging system community-based recommendation system