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Traditional Chinese Medicine in the treatment of recurrent respiratory tract infections in children: an overview of systematic reviews and Meta-analyses

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Journal of Traditional Chinese Medicine 2024年第5期44卷 871-884页

作者： DENG Yasheng HAN Siyin XI Lanhua HUANG Hui LIANG Tianwei ZHENG Yiqing FAN yanping LIN Jiang School of Basic Medical Sciences Guangxi University of Chinese Medicine School of Basic Medical Sciences Guangxi University of Chinese MedicineGuangxi Key Laboratory of Marine Drugs Department of Pharmacy Hainan Traditional Chinese Medicine Hospital

OBJECTIVE: To evaluate and summarise the evidence from published Meta-analyses/systematic reviews(MAs/SRs) of Traditional Chinese Medicine(TCM) in the treatment of recurrent respiratory tract infections(RRTIs) and to provide a scientific basis for the clinical treatment of RRTIs with TCM. METHODS: Studies were retrieved from Chinese and English databases including the China National Knowledge Infrastructure, Wanfang database, China Science and Technology Journal Database, SinoM ed, PubM ed, Web of Science, the Cochrane Library and EMbase from their establishment date to March 2023. Involved studies were screened, extracted, and evaluated for quality by two researchers independently. The a measurement tool to assess systematic reviews(AMSTAR) 2 scale was used for methodological quality evaluation, as well as the preferred reporting items for systematic reviews and Meta-analyses(PRISMA) 2020 statement for report quality evaluation, the risk of bias in systematic reviews(ROBIS) tool for risk of bias, and the grading of recommendations, assessment, development and evaluation(GRADE) quality assessment tool for evidence quality. RESULTS: Twenty MAs/SRs studies were included, including analyses of 274 original studies involving 38 335 patients with RRTIs. The AMSTAR 2 scale evaluation results showed that 19 studies were of very low quality and one of moderate quality. The ROBIS evaluation results showed that 11 MAs/SRs were at high risk and nine at low risk of bias. The PRISMA 2020 report quality showed the included studies had scores between 23.5 and 35.5, among them one with high quality, 17 with moderate quality and two with low quality. The GRADE system results showed that among 126 outcome indicators, only 17 had moderate quality of evidence, 27 had low quality, 82 had very low quality, and none had high quality. CONCLUSIONS: The MAs/SRs methodological quality of using TCM for treatment RRTIs is generally poor, the quality of reports as well as of evidence is generall

关键词： Meta-analysis child medicine, Chinese traditional randomized controlled trial respiratory tract infections systematic review

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Polyphyllin Ⅰ enhances tumor necrosis factor-related apoptosis-inducing ligand-induced inhibition of human osteosarcoma cell growth via downregulating the Wnt/β-catenin pathway

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Journal of Traditional Chinese Medicine 2024年第2期44卷 251-259页

作者： CHANG Junli ZHAO Fulai SUN Xingyuan MA xiaoping ZHAO Peng ZHOU Chujie SHI Binhao GU Wenchao WANG Yongjun YANG yanping Spine Disease Institute Longhua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200032China Department of Diagnostic and Interventional Radiology University of TsukubaIbaraki 315-0114Japan

OBJECTIVE:To investigate the synergistic effects of polyphyllin Ⅰ(PPⅠ)combined with tumor necrosis factorrelated apoptosis-inducing ligand(TRAIL)on the growth of osteosarcoma cells through downregulating the Wnt/β-catenin signaling ***:Cell viability,apoptosis and cell cycle distribution were examined using cell counting kit-8 and flow cytometry *** morphology of cancer cells was observed with inverted phase contrast *** migration and invasion abilities were examined by xCELLigence real time cell analysis DP system and transwell *** expressions of poly(adenosine diphosphate-ribose)polymerase,C-Myc,Cyclin B1,cyclin-dependent kinases 1,N-cadherin,Vimentin,Active-β-catenin,β-catenin,p-glycogen synthase kinase 3β(GSK-3β)and GSK-3βwere determined by Western blotting ***:PPⅠ sensitized TRAIL-induced decrease of viability,migration and invasion,as well as increase of apoptosis and cell cycle arrest of MG-63 and U-2 OS osteosarcoma *** synergistic effect of PPⅠwith TRAIL in inhibiting the growth of osteosarcoma cells was at least partially realized through the inactivation of Wnt/β-catenin signaling ***:The combination of PPⅠ and TRAIL is potentially a novel treatment strategy of osteosarcoma.

关键词： osteosarcoma tumor necrosis factor-related apoptosis-inducing ligand Wnt signaling pathway beta-catenin polyphyllinⅠ

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Non-coding RNAs expression in SARS-CoV-2 infection:pathogenesis,clinical significance,and therapeutic targets

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Signal Transduction and Targeted Therapy 2024年第1期9卷 55-78页

作者： xiaoxing Liu Wandi Xiong Maosen Ye Tangsheng Lu Kai Yuan Suhua Chang Ying Han Yongxiang Wang Lin Lu yanping Bao Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)100191 BeijingChina Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research Peking University100871 BeijingChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan University570228 HaikouChina Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of Sciences650204 KunmingYunnanChina National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence Peking UniversityBeijing 100191China Institute of Brain Science and Brain-inspired Research Shandong First Medical University&Shandong Academy of Medical Sciences250117 JinanShandongChina Department of Neurology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina School of Public Health Peking University100191 BeijingChina

The coronavirus disease 2019(COVID-19)pandemic has been looming globally for three years,yet the diagnostic and treatment methods for COVID-19 are still undergoing extensive exploration,which holds paramount importance in mitigating future *** non-coding RNAs(ncRNAs)display aberrations in the context of ***,microRNAs(miRNAs),long non-coding RNAs(lncRNAs),and circular RNAs(circRNAs)exhibit a close association with viral infection and disease *** this comprehensive review,an overview was presented of the expression profiles of host ncRNAs following SARS-CoV-2 invasion and of the potential functions in COVID-19 development,encompassing viral invasion,replication,immune response,and multiorgan deficits which include respiratory system,cardiac system,central nervous system,peripheral nervous system as well as long ***,we provide an overview of several promising host ncRNA biomarkers for diverse clinical scenarios related to COVID-19,such as stratification biomarkers,prognostic biomarkers,and predictive biomarkers for treatment *** addition,we also discuss the therapeutic potential of ncRNAs for COVID-19,presenting ncRNA-based strategies to facilitate the development of novel *** an in-depth analysis of the interplay between ncRNA and COVID-19 combined with our bioinformatic analysis,we hope to offer valuable insights into the stratification,prognosis,and treatment of COVID-19.

关键词： invasion therapeutic infection

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智能化电网谐波分析监测仪研制

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振动与冲击 1999年第4期18卷 59-61,62页

作者：毛谦敏肖艳萍中国计量学院浙江大学

本文提出了一种以ＭＣＳ－９６单片机为核心，利用锁相技术实现整周期同步采样，运用ＦＦＴ算法进行数据分析而实现的工业电网谐波分析监测仪的设计方案。

关键词：谐波单片机锁相环电网谐波分析仪数据分析

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Development of a stable attenuated double-mutant of tobacco mosaic virus for cross-protection

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Journal of Integrative Agriculture 2024年第7期23卷 2318-2331页

作者： xiaojie Xu Shaoyan Jiang Chunju Liu Xujie Sun Qing Zhu Xiuzhai Chen Pengchao Jiang Fenglong Wang yanping Tian Xiangdong Li The Engineering Research Institute of Agriculture and Forestry Ludong UniversityYantai 264025China Laboratory of Plant Virology Department of Plant PathologyCollege of Plant ProtectionShandong Agricultural UniversityTai’an 271018China Weifang Tobacco Corporation Weifang 261031China Linyi Tobacco Corporation Linyi 276000China Tobacco Research Institute Chinese Academy of Agricultural SciencesQingdao 266101China

Tobacco(Nicotiana tabacum)and tomato(Solanum lycopersicum)are two major economic crops in *** mosaic virus(TMV;genus Tobamovirus)is the most prevalent virus infecting both ***,some widely cultivated tobacco and tomato cultivars are susceptible to TMV and there is no effective strategy to control this ***-protection can be a safe and environmentally friendly strategy to prevent viral ***,stable attenuated TMV mutants are *** this study,we found that the substitutions in the replicase p126,arginine at position 196(R^(196))with aspartic acid(D),glutamic acid at position 614(E^(614))with glycine(G),serine at position 643(S^(643))with phenylalanine(F),or D at position 730(D^(730))with S,significantly reduced the virulence and replication of ***,only the mutation of S^(643) to F reduced the RNA silencing suppression activity of TMV p126.A double-mutant TMV-E614G-S643F induced no visible symptom and was genetically stable through six successive passages in tobacco ***,our results showed that TMV-E614G-S643F double-mutant could provide effective protection against the wild-type TMV infection in tobacco and tomato *** study reports a promising mild mutant for cross-protection to control TMV in tobacco and tomato plants.

关键词： cross-protection double-mutant p126 tobacco mosaic virus virulence

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Harnessing sub-comb dynamics in a graphene-sensitized microresonator for gas detection

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Frontiers of Optoelectronics 2024年第2期17卷 11-21页

作者： Yupei Liang Mingyu Liu Fan Tang Yanhong Guo Hao Zhang Shihan Liu yanping Yang Guangming Zhao Teng Tan Baicheng Yao Key Laboratory of Optical Fiber Sensing and Communications(Ministry of Education) University of Electronic Science and Technology of ChinaChengdu 611731China Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China Engineering Center of Integrated Optoelectronic&Radio Meta-Chips University of Electronic Science and TechnologyChengdu 611731China

Since their inception, frequency combs generated in microresonators, known as microcombs, have sparked significant scientific interests. Among the various applications leveraging microcombs, soliton microcombs are often preferred due to their inherent mode-locking capability. However, this choice introduces additional system complexity because an initialization process is required. Meanwhile, despite the theoretical understanding of the dynamics of other comb states, their practical potential, particularly in applications like sensing where simplicity is valued, remains largely untapped. Here, we demonstrate controllable generation of sub-combs that bypasses the need for accessing bistable regime. And in a graphene-sensitized microresonator, the sub-comb heterodynes produce stable, accurate microwave signals for high-precision gas detection. By exploring the formation dynamics of sub-combs, we achieved 2 MHz harmonic comb-to-comb beat notes with a signal-to-noise ratio (SNR) greater than 50 dB and phase noise as low as – 82 dBc/Hz at 1 MHz offset. The graphene sensitization on the intracavity probes results in exceptional frequency responsiveness to the adsorption of gas molecules on the graphene of microcavity surface, enabling detect limits down to the parts per billion (ppb) level. This synergy between graphene and sub-comb formation dynamics in a microcavity structure showcases the feasibility of utilizing microcombs in an incoherent state prior to soliton locking. It may mark a significant step toward the development of easy-to-operate, systemically simple, compact, and high-performance photonic sensors.

关键词： Microresonator Optical frequency comb Graphene Gas sensing

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关于钢直尺检定及示值误差测量不确定度评定

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计量与测试技术 2018年第7期45卷 108-110页

作者：肖燕萍广州市从化质量技术监督检测所广东广州510900

钢直尺是最为简单的长度测量工具,普通钢直尺的长度规格有6种,分别为150mm、300mm、500(600)mm、1000mm、1500mm、2000mm。钢直尺自身刻画线的间距有0.5mm或1mm,同时刻线的宽度大约为(0.1~0.25)mm,因此在测量时会产生读数误差,这也是为... 详细信息

钢直尺是最为简单的长度测量工具,普通钢直尺的长度规格有6种,分别为150mm、300mm、500(600)mm、1000mm、1500mm、2000mm。钢直尺自身刻画线的间距有0.5mm或1mm,同时刻线的宽度大约为(0.1~0.25)mm,因此在测量时会产生读数误差,这也是为何只能读出毫米数的原因。钢直尺的检定需要在读数显微镜在辅助下才可更为准确的进行判断,测量不确定度的评定对钢直尺示值误差具有直接性的影响。

关键词：钢直尺示值误差不确定度评定

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耳穴压豆法治疗心肾不交型睡眠障碍临床研究

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中国中医药现代远程教育 2021年第15期19卷 106-108页

作者：肖艳平赣州市人民医院中医科江西赣州341000

目的观察耳穴压豆法治疗心肾不交型睡眠障碍的临床效果。方法选择2018年1月—2019年1月赣州市人民医院收治的100例心肾不交型睡眠障碍患者,按随机数字表法分为试验组(50例)和对照组(50例)。对照组给予艾司唑仑片治疗,试验组在此基础上... 详细信息

目的观察耳穴压豆法治疗心肾不交型睡眠障碍的临床效果。方法选择2018年1月—2019年1月赣州市人民医院收治的100例心肾不交型睡眠障碍患者,按随机数字表法分为试验组(50例)和对照组(50例)。对照组给予艾司唑仑片治疗,试验组在此基础上给予耳穴压豆法治疗。比较2组的入睡时间、睡眠时间、睡眠效率及匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)总分。结果治疗前,2组的入睡时间、睡眠时间、睡眠效率及PSQI总分比较,差异无统计学意义(P>0.05);试验组治疗后的入睡时间早于对照组,睡眠时间长于对照组,睡眠效率高于对照组,PSQI总分低于对照组,差异均有统计学意义(P<0.05)。结论对心肾不交型睡眠障碍患者施以耳穴压豆法治疗,可改善患者的睡眠质量,值得推广应用。

关键词：耳穴压豆法心肾不交不寐睡眠障碍

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高职艺术设计专业课堂教学中“边缘人”的转化培养

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包装学报 2015年第4期7卷 93-96页

作者：肖燕萍湘西民族职业技术学院民族艺术系湖南吉首416000

高职艺术设计专业中的"边缘人"容易被老师和同学所忽视,处于课堂教学的边缘状态,不能得到有效培养。这类个体或群体有着专业情结淡薄、集体观念缺失、自卑心理严重、自律性不稳定的特征。边缘人可以通过课堂管理规范的刺激转化、教师民... 详细信息

高职艺术设计专业中的"边缘人"容易被老师和同学所忽视,处于课堂教学的边缘状态,不能得到有效培养。这类个体或群体有着专业情结淡薄、集体观念缺失、自卑心理严重、自律性不稳定的特征。边缘人可以通过课堂管理规范的刺激转化、教师民主教育的外在转化、职业情境教学的隐性转化、自我主体意识的内在转化等策略进行转化培养。

关键词：边缘人高职艺术设计专业课堂教学转化培养

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萘普生钠/磷酸钙骨水泥药物缓释体系的研究

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药学学报 2000年第1期35卷 44-47页

作者：黄粤刘昌胜邵慧芳肖艳平华东理工大学技术化学物理研究所上海200237

目的：研究以磷酸钙骨水泥为载体、定点缓释萘普生钠的体系，为该体系的临床应用提供指导。方法：载药磷酸钙骨水泥固化后，用Ｘ衍射、凝结时间测试等方法评价其操作特性，用紫外光谱研究药物在３７℃模拟体液中的缓释动力学。结果：药... 详细信息

目的：研究以磷酸钙骨水泥为载体、定点缓释萘普生钠的体系，为该体系的临床应用提供指导。方法：载药磷酸钙骨水泥固化后，用Ｘ衍射、凝结时间测试等方法评价其操作特性，用紫外光谱研究药物在３７℃模拟体液中的缓释动力学。结果：药物的引入未影响材料的操作性能，该体系的药物缓释符合Ｈｉｇｕｃｈｉ模型。结论：对药物采取适当的包埋，并通过调节固液比、药物包埋量等条件可达到药物控制释放的目的。

关键词：磷酸钙骨水泥骨修复药物缓释萘普生钠

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