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重组脑利钠肽治疗急性左心衰的疗效及对患者血清NT-proBNP、cTnⅠ、H-FABP的影响研究

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数理医药学杂志 2022年第10期35卷 1558-1560页

作者：吕菲菲杨艳鹏王天宝刘毓王佩佩郑州大学附属郑州中心医院郑州450007

目的:研究重组脑利钠肽的作用机制及在急性左心衰(ALVF)临床治疗中的应用价值。方法:将我院收治的80例ALVF患者随机分为CG组40例和CG+NT组40例,两组患者实施相同方案的常规治疗,并在此基础上CG患者联合硝普钠治疗,CG+NT组患者联合重组... 详细信息

目的:研究重组脑利钠肽的作用机制及在急性左心衰(ALVF)临床治疗中的应用价值。方法:将我院收治的80例ALVF患者随机分为CG组40例和CG+NT组40例,两组患者实施相同方案的常规治疗,并在此基础上CG患者联合硝普钠治疗,CG+NT组患者联合重组脑利钠肽治疗。对比两组患者的临床疗效,并于治疗前后分别检测心肌损伤指标(NT-proBNP、cTnT、H-FABP)和心肌纤维化指标(TGF-β1、CTGF),并随访统计远期(6个月)不良心血管事件的发生率。结果:CG+NT组患者临床总有效率为87.5%,高于CG组的75%(P<0.05)。治疗后,CG+NT组患者血清NT-proBNP、cTnⅠ、H-FABP均低于CG组(P<0.05),血清TGF-β1、CTGF均低于CG组(P<0.05)。CG+NT组患者远期不良心血管事件的发生率为7.5%,低于CG组的20%(P<0.05)。结论:在常规治疗的基础上联合应用重组脑利钠肽可有效减轻ALVF患者心肌损伤程度,并可通过预防心肌纤维化的进展而抑制心室重构,进而提高患者整体疗效,改善远期预后。

关键词：急性左心衰重组脑利钠肽心肌损伤心肌纤维化心室重构

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仓储烟叶霉变防治研究进展

昆明学院学报 2021年第3期43卷 11-15页

作者：罗云陈斌郭绍坤杨延鹏杨磊洪波周继来徐兴阳红云红河烟草(集团)有限责任公司云南昆明650022 云南省烟草公司昆明市公司宜良分公司云南宜良652100 云南省烟草公司昆明市公司云南昆明650051

尽管我国烟草企业投入了大量人力、物力和资金进行仓储烟叶防霉工作,但是仓储烟叶霉变严重的状况仍未得到有效控制,烟叶损耗仍然十分严重,现已成为烟叶仓储工作亟待解决的一大难题.近年来,广大科技人员对仓储烟叶霉变防治技术进行了大... 详细信息

尽管我国烟草企业投入了大量人力、物力和资金进行仓储烟叶防霉工作,但是仓储烟叶霉变严重的状况仍未得到有效控制,烟叶损耗仍然十分严重,现已成为烟叶仓储工作亟待解决的一大难题.近年来,广大科技人员对仓储烟叶霉变防治技术进行了大量研究.为此,综述了核辐射和微波技术防霉、密封降氧技术防霉、生物防霉剂和植物提取物防霉、化学防霉剂和熏蒸剂防霉等防霉技术的研究进展,以期为烟草行业仓储烟叶防霉技术的研究和应用提供参考.

关键词：仓储烟叶霉变防治研究进展

Effect of preparation method on the bimetallic NiCu/SAPO-11 catalysts for the hydroisomerization of n-octane

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Journal of Energy Chemistry 2019年第1期28卷 23-30页

作者： Zhichao yang Yunqi Liu yanpeng Li Lingyou Zeng Zhi Liu Xueying Liu Chenguang Liu State Key Laboratory of Heavy Oil Processing Key Laboratory of Catalysis China National Petroleum Corp. (CNPC) China University of Petroleum (East China)

The bimetallic NiCu/SAPO-11 catalysts were prepared by co-impregnation, sequential impregnation, coprecipitation, and mechanical mixing methods. Powder X-ray diffraction, nitrogen adsorption-desorption,temperature-programmed desorption of ammonia, transmission electron microscopy, temperatureprogrammed reduction of hydrogen, and X-ray photoelectron spectroscopy were used to characterize the physicochemical properties of the catalysts. The catalytic performance of the catalysts was assessed by the hydroisomerization of n-octane. Results indicated that the conversion of n-octane and selectivity to n-octane isomers were related to the preparation methods of the catalysts. The catalysts with Ni-Cu alloy effectively restrained the hydrogenolysis reaction that decreases the selectivity of isomerization. The catalyst prepared by the mechanical mixing of NiO and CuO hardly formed Ni-Cu alloy, showing obvious hydrogenolysis and low selectivity to n-octane isomers. The unbalance between the metal and acid sites resulted in the low conversion of n-octane and selectivity to n-octane isomers. Among all the catalysts,the catalyst prepared by the co-impregnation method exhibited high catalytic activity and selectivity to n-octane isomers.

关键词： Ni-Cu/SAPO-11 Bimetallic Preparation method Hydroisomerization Hydrogenolysis n-Octane

Dynamic tensile and failure behavior of bi-directional reinforced GFRP materials

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Acta Mechanica Sinica 2020年第2期36卷 460-471页

作者： Zishang Liu Zhe yang Yuchao Chen yangyang Yu yanpeng Wei Maohui Li Chenguang Huang Institute of Mechanics Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China CRRC Qingdao Sifang Co. LTDQingdao 266111China The Quartermaster Research Institute of Engineering and Technology Beijing 100010China

In this paper,a series of static/dynamic tensile tests are performed for glass fiber reinforced plastic(GFRP)*** the combination of high-speed photography and digital image correlation(DIC)technology,true stress-strain curves in different directions and strain rates are *** also obtained the dynamic failure strain of the material in different directions,which are used to accurately describe the dynamic tensile and failure behavior of the *** experimental results show that there is a stiffness change point N in three directions under different strain rate(10-3 s-1,10 s-1,100 s-1)tensile *** stiffness before and after N point is recorded as Einitial and Echanged *** values of Echanged in weft direction and warp direction are about 30%to 50%of Einitial,while Echanged in tilt direction is only about 10%of *** fiber has the highest strength in the weft direction and the tilt direction has the lowest *** the combination of high-speed photography and DIC technology,the dynamic failure parameters of different directions under the strain rate of 100 s-1 are *** dynamic failure strains in three directions are 0.245,0.373 and 0.341,*** parameters are verified by impact three-point bending *** works can more accurately describe the dynamic mechanical behavior of glass fiber reinforced plastic(GFRP)composites and provide reference for the design of GFRP structures.

关键词： Solid mechanics Dynamic failure strain Digital image correlation Strain rate effect Stiffness

A Novel Method for Studying the Re-Swelling Capacity of Superabsorbent Polymers in An Artificial Crack

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Journal of Wuhan University of Technology(Materials Science) 2020年第5期35卷 996-1002页

作者： LIU Juanhong yang Haitao XUE yanpeng LAI Zhaogui JI Hongguang College of Civil and Resource Engineering University of Science and Technology'BeijingBeijing 100083China Beijing Key Laboratory of Urban Underground Space Engineering University of Science and Technology BeijingBeijing 100083China State Key Laboratory of High-efficient Mining and Safety of Metal MinesMinistry of EducationUniversity of Science and TechnologyBeijingBeijing 100083China National Center for Materials Service Safety University of Science and Technology BeijingBeijing 100083China

Re-swelling capacity is a key factor influencing the self-sealing efficiency of superabsorbent polymers (SAPs) in *** this paper,a new parameter (re-swelling ratio,η),the volume ratio of the crack which was filled with the expansive SAPs and the dry SAPs,was given to quantify the re-swelling capacity of a single SAPs *** innovative immersion test was used to study the η value of SAPs in the hardened cement paste with an artificial ***,the influence of the crack width and particle size on the sealing efficiency of SAPs in the cracked paste was investigated by a water permeability *** results showed that the mass ratios of the expansive SAPs in an artificial crack were less than those in a free *** η value of SAPs in the hardened paste with an artificial crack increased with the increase of the crack width due to the restricting effects of the *** expansive SAPs in the cracked paste could totally seal or partly seal the crack within the original ***,the sealing efficiency of SAPs slightly increased with the rise of the crack width (0.25 to 0.5 mm) and the reduction of the particle *** research demonstrates that the crack width in concrete and the particle size of SAPs are the key factors influencing the re-swelling behavior of SAPs which should be taken into consideration when designing the self-sealing concrete containing SAPs.

关键词： superabsorbent polymers re-swelling crack self-sealing concrete

Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue Mu Ning Zhang Dongyu Wei Guoqing yang Lilingxuan Yao Xinyue Xu yang Li Junhui Xue Zuoming Zhang Tao Chen Aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

Corrosion Behavior of Steel Fibers in Reactive Powder Concrete with High Volume of Mineral Admixtures

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Journal of Wuhan University of Technology(Materials Science) 2020年第3期35卷 541-550页

作者： yang Haitao LIU Juanhong XUE yanpeng ZHOU Yucheng JI Hongguang College of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China Beijing Key Labo-ratory of Urban Underground Space Engineering University of Science and Technology BeijingBeijing 100083China State Key Lab-oratory of High-efficient Mining and Safety of Metal Mines Ministry of EducationUniversity of Science and Technology BeijingBeijing 100083China National Center for Materials Service Safety University of Science and Technology BeijingBeijing 100083China

The corrosion behavior and the effects of temperature on critical chloride content (Ccrit) of steel fibers in RPC were analyzed by a pH meter, ion chromatography, mercury intrusion porosimetry (MIP), and electrochemical techniques. It was found that the suspension pH value, the chloride binding capacity, and the total porosity of RPC were lower than those of high-performance concrete (HPC). The pore structure of RPC mainly consisted of gel pores. The Ccrit values of steel fibers in RPC and HPC at 20 ℃ were 1% and 2%, respectively. When the temperature reached 50 ℃, the Ccrit value of steel fibers in HPC decreased significantly, whereas it remained unchanged in RPC. The corrosion rate of corroded fibers in both RPC and HPC started to decrease with the rise in temperature.

关键词： corrosion steel fibers chloride reactive powder concrete critical chloride content

Energy-Efficient and Secure Power Allocation and Trajectory Optimization for UAV-Enabled Data Collection in Wireless Sensor Networks

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Journal of Communications and Information Networks 2022年第3期7卷 324-332页

作者： Dong Wang Yanping yang Xiaoming Li Changqing Wang Falei Liu yanpeng Hu Army Academy of Artillery and Air Defense Hefei 230031China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China School of Automation and Electrical Engineering University of Science and Technology BeijingBeijing 100083China

Using unmanned aerial vehicles(UAVs)to collect data in wireless sensor networks(WSNs)has advantages of controllable mobility and flexible ***,there are potential challenges of energy limitation and data security which may limit such *** cope with these challenges,a complicated and intractable optimization problem is formulated,which maximizes the performance metric of secrecy energy efficiency(EE)subject to the constraints of secrecy rate,maximum power,and ***,an energy-efficient and secure solution is developed to improve the secrecy EE of the UAV-enabled data collection in the WSNs by joint optimizing the UAV’s trajectory and velocity along with the sensors’*** proposed solution is an iterative algorithm based on the optimization approaches of alternating optimization,successive convex approximation,and fractional *** results demonstrate that the proposed solution scheme is effective for improving the secrecy EE while guaranteeing the data security.

关键词： unmanned aerial vehicles wireless sensor networks physical layer security secrecy energy efficiency trajectory optimization power allocation

The V1 region of gp120 is preferentially selected during SIV/HIV transmission and is indispensable for envelope function and virus infection

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Virologica Sinica 2016年第3期31卷 207-218页

作者： yanpeng Li Ulf Dittmer Yan Wang Jiping Song Binlian Sun Rongge yang Research Group of HIV Molecular Epidemiology and Virology Center for Emerging Infectious DiseasesState Key Laboratory of VirologyWuhan Institute of VirologyChinese Academy of Sciences Institute for Virology University Hospital EssenUniversity of Duisburg-Essen

A transmission bottleneck occurs during each human immunodeficiency virus(HIV) transmission event, which allows only a few viruses to establish new infection. However, the genetic characteristics of the transmitted viruses that are preferentially selected have not been fully elucidated. Here, we analyzed amino acids changes in the envelope protein during simian immunodeficiency virus(SIV)/HIV deep transmission history and current HIV evolution within the last 15–20 years. Our results confirmed that the V1V2 region of gp120 protein, particularly V1, was preferentially selected. A shorter V1 region was preferred during transmission history, while during epidemic, HIV may evolve to an expanded V1 region gradually and thus escape immune recognition. We then constructed different HIV-1 V1 mutants using different HIV-1 subtypes to elucidate the role of the V1 region in envelope function. We found that the V1 region, although highly variable, was indispensable for virus entry and infection, probably because V1 deletion mutants exhibited impaired processing of gp160 into mature gp120 and gp41. Additionally, the V1 region affected Env incorporation. These results indicated that the V1 region played a critical role in HIV transmission and infection.

关键词： simian immunodeficiency virus(SIV) human immunodeficiency virus(HIV) transmission selection V1 loop Env function