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风电叶片不同预埋结构端面承载性能仿真分析

天津科技 2024年第7期51卷 82-84,88页

作者：闫小强苏小虎杨延鹏薛浩鹏易华东方电气(天津)风电叶片工程有限公司天津300450 富琛(天津)企业管理有限公司天津300450

利用ANSYS有限元软件,对风电叶片叶根端面3种结构形式进行有限元建模和仿真计算,对比结构下叶根预埋螺栓套界面的响应载荷,探讨叶根端面结构不同对承载的影响,为后续大型风电叶片设计开发提供理论依据。结果表明,在极限承载方面,预埋螺... 详细信息

利用ANSYS有限元软件,对风电叶片叶根端面3种结构形式进行有限元建模和仿真计算,对比结构下叶根预埋螺栓套界面的响应载荷,探讨叶根端面结构不同对承载的影响,为后续大型风电叶片设计开发提供理论依据。结果表明,在极限承载方面,预埋螺栓套凸出叶根玻璃钢端面结构的界面载荷最低;在疲劳承载方面,预埋螺栓套低于叶根玻璃钢端面结构的界面载荷变化率最小。综合考虑承载性能和结构工艺性能,预埋螺栓套与叶根玻璃钢端面齐平结构拥有较好的应用前景。

关键词：风电叶片叶片预埋螺栓套静力有限元仿真

Variation in assimilable organic carbon formation during chlorination of Microcystis aeruginosa extracellular organic matter solutions

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Journal of Environmental Sciences 2016年第7期28卷 1-6页

作者： Xingbin Sun Ting Yuan Huishan Ni yanpeng Li yang Hu Department of Environmental Science Northeast Forestry University

This study investigated the chlorination of Microcystis aeruginosa extracellular organic matter（EOM） solutions under different conditions, to determine how the metabolites produced by these organisms affect water safety and the formation of assimilable organic carbon（AOC）. The effects of chlorine dosages, coagulant dosage, reaction time and temperature on the formation of AOC were investigated during the disinfection of *** metabolite solutions. The concentration of AOC followed a decreasing and then increasing pattern with increasing temperature and reaction time. The concentration of AOC decreased and then increased with increasing chlorination dosage, followed by a slight decrease at the highest level of chlorination. However, the concentration of AOC decreased continuously with increasing coagulant dosage. The formation of AOC can be suppressed under appropriate conditions. In this study, chlorination at 4 mg/L, combined with a coagulant dose of 40 mg/L at 20°C over a reaction time of 12 hr, produced the minimum AOC.

关键词： Microcystis aeruginosa Chlorination Assimilable organic carbon(AOC)

单一酸密闭消解-电感耦合等离子体法测定催化剂中Pt、Pd含量

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石油炼制与化工 2024年第6期55卷 164-171页

作者：李明哲周勇杨彦鹏王子健王涛聂骥赖婷婷谢莉王杰广中石化石油化工科学研究院有限公司北京100083

建立了单一酸密闭消解-电感耦合等离子体发射光谱(ICP-OES)分析方法,测定催化重整(简称重整)生成油脱烯烃催化剂中的Pt、Pd含量。研究了前处理和消解条件对催化剂消解的影响,对比了单一酸消解法和常规混合酸消解法的消解效果,系统讨论... 详细信息

建立了单一酸密闭消解-电感耦合等离子体发射光谱(ICP-OES)分析方法,测定催化重整(简称重整)生成油脱烯烃催化剂中的Pt、Pd含量。研究了前处理和消解条件对催化剂消解的影响,对比了单一酸消解法和常规混合酸消解法的消解效果,系统讨论了Pt和Pd分析谱线选择依据、Al基体对测定元素影响的原因、杂质元素和Pt、Pd元素间干扰对测定结果的影响。确定了单一酸消解的前处理和消解条件为:在空气气氛下,将催化剂样品于550℃灼烧4 h后研磨至粒径120μm以下;称取样品0.2 g,加3 mL浓盐酸,在密闭消解罐内于180℃消解6 h。所建立的方法与常规混合酸消解法相比,简便快捷,结果准确,同时还具有用酸量少、对实验人员和环境友好的优点,可应用于重整生成油脱烯烃催化剂中Pt质量浓度为2.08~12500μg/g、Pd质量浓度为2.67~12500μg/g范围内Pt、Pd含量的精准测定。

关键词：电感耦合等离子体发射光谱脱烯烃催化剂单一酸铂钯

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Zr掺杂氧化铝的制备及其催化重整性能

石油炼制与化工 2024年第8期55卷 65-73页

作者：鲍梦宁杨彦鹏苗成林王涛周昕瞳臧高山王嘉欣中石化石油化工科学研究院有限公司北京100083

采用烷氧基铝水解法,制备Zr掺杂的高纯氢氧化铝,考察Zr掺杂量对其比表面积、孔结构的影响。以该Zr掺杂氢氧化铝为原料,通过挤条法制备含Zr氧化铝载体,进一步负载Pt制备重整催化剂,以石脑油为原料,考察了Zr含量对催化剂性能的影响,并对... 详细信息

采用烷氧基铝水解法,制备Zr掺杂的高纯氢氧化铝,考察Zr掺杂量对其比表面积、孔结构的影响。以该Zr掺杂氢氧化铝为原料,通过挤条法制备含Zr氧化铝载体,进一步负载Pt制备重整催化剂,以石脑油为原料,考察了Zr含量对催化剂性能的影响,并对其影响机理进行探讨。结果表明:Zr的引入会改变γ-Al_(2)O_(3)载体的L酸强度,从而改变催化剂上金属中心和酸性中心的比例,当Zr的质量分数为0.20%~0.33%时,催化剂的酸性中心和金属中心具有较好的协同性,在石脑油重整反应中表现出较高的活性和芳烃选择性。

关键词： Zr掺杂氧化铝石脑油催化重整

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拖拉机用同步器的规格选型及配套设计

拖拉机与农用运输车 2023年第1期50卷 70-74页

作者：鞠超闻浩楠康健杨彦朋董文华拖拉机动力系统国家重点实验室河南洛阳471039 洛阳拖拉机研究所有限公司河南洛阳471039

随着拖拉机用户对整机操作使用品质要求的逐步提高,同步器在拖拉机上的应用将会越来越广泛。对拖拉机中常用的同步器类型及结构进行了简要介绍,对同步器规格选型的依据、变速箱相关零件的配套设计及在拖拉机上的试验进行了重点阐述。

关键词：拖拉机同步器规格选型配套设计

Nanoparticles for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei yang Di Lu Jiuping Wu Fuming Liang Huayi Wang Junjie yang Ganggang Zhang Chen Wang Yanlian yang Ling Zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi Wang Xiaofei Niu Yingkai Wang yang Liu Cheng yang Xuyi Chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

Tracing enterococci persistence along a pork production chain from feed to food in China

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Animal Nutrition 2022年第2期9卷 223-232页

作者： Jianfei Zhao Rui Liu yanpeng Sun Xiaojun yang Junhu Yao College of Animal Science and Technology Northwest Agriculture&Forestry UniversityYangling712100China

The prevalence and transmission of vancomycin-resistant Enterococcus(VRE)in enterococci being as probiotics has been neglected in the scientific *** application of enterococci in feed,food and health products may cause VRE transmission through the food *** study evaluated phenotypic resistance of Enterococcus species to 20 antibiotics along a pork production chain from feed to *** also assessed the genetic diversity of Enterococcus faecium isolates.A total of 510 samples(feed,n=70;swine manure,n=400;swine carcasses,n=20,and retail pork,n=20)were collected in Beijing,China.A total of 328 enterococci isolates with 275 *** and 53 Enterococcus faecalis were identified using 16 S *** susceptibility to all enterococci isolates was conducted using the KeB method for 20 antibiotics from 9 *** sequence typing(MLST)was conducted on the *** isolates to survey the dissemination of enterococci in the pig *** results showed that only 26 enterococci isolates were sensitive to the 20 antibiotics,while half of the isolates(164/328)had acquired multi-drug *** resistant rate to furazolidone was 68.60%,followed by 42.99%to *** vancomycin-resistant *** isolates were isolated from feed origin and 2 from manure origin,with minimum inhibitory concentrations to vancomycin of 1,024,64,and 64 mg/mL,*** MLST outcomes showed that the 275 *** isolates belonged to 11 sequence types(ST)including ST40,ST60,ST94,ST160,ST178,ST296,ST361,ST695,ST726,ST812 and *** ST of the feedsourced VRE was ST1014,while the 2 manure-sourced VRE was ***1014 evolved from ST78,which was the dominant clonal complex in most cities of China,leading to the spreading of *** findings revealed the potential safety hazards of commercial probiotic enterococci in China and showed that there is a risk of the VRE horizontally transferring from feed to food.

关键词： Antimicrobial resistance Multilocus sequence typing Vancomycin-resistant enterococci

Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma yang Qu Jiaxin Ren Yingying Sun Zhen-Ni Guo Yi yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents